Gene basic information

Cancerbreast cancer,colorectal cancer,esophageal squamous cell cancer,osteosarcoma,


LncRNA 91H is the antisense of H19. It is expressed in the higher percentage of colorectal cancer (1), breast cancer (2) and osteosarcoma (3). The high expression of 91H is significantly correlated with distant metastasis in colorectal cancer, and also correlated with advanced clinical stage, chemotherapy after surgery, and tumor size in osteosarcoma. There would be an obviously poorer prognosis if 91H expression rose in colorectal cancer and osteosarcoma patients. Functionally, 91H promotes the cellular proliferation, invasion and migration in both colorectal cancer and osteosarcoma. However, 91H is low-expressed in esophageal squamous cell carcinoma (ESCC) (4), with the higher depth of invasion, neoplastic grading and TNM. 91H expression is also associated with the density of demethylation agent, H19 ICR methylation. Moreover, it can inhibit IGF2 expression in ESCC patients.

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 91H breast breast cancer up onco IGF2+ 18794369
1 91H esophagus esophageal squamous cell cancer down TS IGF2- epigenetic modification 24706416
2 91H colorectum colorectal cancer up onco + + + - 25058480
3 91H bone osteosarcoma up onco + + + - chemotherapy resistance 27555785


[1]. Deng Q, He B, Gao T, Pan Y, Sun H, et al. (2014). Up-regulation of 91H promotes tumor metastasis and predicts poor prognosis for patients with colorectal cancer. PLoS One 9(7): e103022. link pubmed
[2]. Berteaux N, Aptel N, Cathala G, Genton C, Coll J, et al. (2008). A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression. Mol Cell Biol 28(22): 6731-45. link pubmed
[3]. Xia WK, Lin QF, Shen D, Liu ZL, Su J, et al. (2016). Clinical implication of long noncoding RNA 91H expression profile in osteosarcoma patients. Onco Targets Ther 9: 4645-52. link pubmed
[4]. Gao T, He B, Pan Y, Xu Y, Li R, et al. (2015). Long non-coding RNA 91H contributes to the occurrence and progression of esophageal squamous cell carcinoma by inhibiting IGF2 expression. Mol Carcinog 54(5): 359-67. link pubmed

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