AATBC

Gene basic information

symbol AATBC
name apoptosis associated transcript in bladder cancer
location 21q22.3
alias_symbol
alias_name apoptosis-associated transcript in bladder cancer
Tissuebladder,
Cancerbladder cancer,


Description

LncRNA AATBC is over-expressed in bladder cancer (1), associated with tumor development and aggressiveness. AATBC depletion leads to an obvious inhibitory effect on the cellular growth of bladder cancer, and inhibits tumor growth in NOD/SCID mice. Knockdown of AATBC leads to an increased expression of p18 but a decreased expression of cyclin D1, CDK4, and phosphorylated retinoblastoma (Rb). It can also result in the intrinsic apoptosis of bladder cancer cells by the enhanced cleavages of poly (ADP-ribose) polymerase (PARP), caspase-9 and caspase-3. It can also enhance the phosphorylation level of JNK in bladder cancer cells and decrease the expression level of NRF2.


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 AATBC bladder bladder cancer up onco JNK signaling cyclin D1+,CDK4+,p18-,pRb+,caspase-9 -,caspase-3-,pJNK-,NRF2+ 25473900

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.0 0.3 0.2 0.1 0.0 0.0 0.0 2.0 0.0 0.1 0.2 0.2 0.1 0.1 0.6 0.1 AATBC

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 fpkm AATBC type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Zhao F, Lin T, He W, Han J, Zhu D, et al. (2015). Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer. Oncotarget 6(2): 1064-78. link pubmed



© Bioinformatics Group of XTBG