ADAMTS9-AS2

Gene basic information

symbol ADAMTS9-AS2
name ADAMTS9 antisense RNA 2
location 3p14.1
alias_symbol
alias_name
Tissuenervous system,
Cancerglioma,


Description

ADAMTS9-AS2 is an antisense overlapping lncRNA against ADAMTS9, and mostly located in the upstream of ADAMTS9. ADAMTS9-AS2 is down-regulated in glioma tissue samples and associated with poor prognosis. Its expression is positively correlated with ADAMTS9 and DNMT3A, but negatively with DNMT1. Mechanistically, it may modulate the expression of ADAMTS9. Moreover, ADAMTS9-AS2 expression levels are evidently increased in 5-aza-dC (DNA demethylating agent) groups. Overexpression of ADAMTS9-AS2 can inhibit migration and invasion of glioma cells (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 ADAMTS9-AS2 nervous system glioma down TS ADAMTS9+,DNMT3A+,DNMT1- - - + epigenetic modification 24833086

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.3 0.5 0.2 0.3 1.0 0.2 0.4 0.0 0.0 1.0 0.4 2.0 2.0 0.1 0.5 0.6 ADAMTS9-AS2

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.2 0.4 0.6 0.8 fpkm ADAMTS9-AS2 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Yao J, Zhou B, Zhang J, Geng P, Liu K, et al. (2014). A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells. Tumour Biol 35(8): 7935-44. link pubmed



© Bioinformatics Group of XTBG