AF339813

Gene basic information

SymbolAF339813
Tissuepancreas,
Cancerpancreatic cancer,


Description

LncRNA AF339813 is significantly increased in pancreatic cancer (PC) tissues and positively regulated by NUF2. AF339813 plays a pivotal role in the proliferation and apoptosis of PC cells. With treatment of siRNA-AF339813, the expression of Caspase-3, Caspase-9 and Bax are significantly increased and Bcl-2 is significantly decreased. Besides, siRNA-AF339813 can also lead to a decrease in cyclins D1 and CDK4/CDK6 (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 AF339813 pancreas pancreatic cancer up onco NUF2+,caspase-3-,caspase-9-,Bax-,Bcl-2+,cyclins D1+,CDK4/CDK6+ + - 26045769

Literature

[1]. Hu P, Shangguan J, Zhang L (2015). Downregulation of NUF2 inhibits tumor growth and induces apoptosis by regulating lncRNA AF339813. Int J Clin Exp Pathol 8(3): 2638-48. link pubmed



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