AFAP1-AS1

Gene basic information

symbol AFAP1-AS1
name AFAP1 antisense RNA 1
location 4p16.1
alias_symbol MGC10981
alias_name
Tissuecolorectum,esophagus,liver,lung,nasopharynx,pancreas,
Cancercolorectal cancer,esophageal adenocarcinoma,esophageal squamous cell cancer,hepatic cancer,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,pancreatic ductal adenocarcinoma,


Description

LncRNA AFAP1-AS1 is significantly up-regulated in nasopharyngeal carcinoma (NPC) (1), lung cancer (2,3), esophageal squamous cell carcinoma (ESCC) (4), esophageal adenocarcinoma (5), hepatic carcinoma (HCC) (6), pancreatic ductal adenocarcinoma (PDAC) (7) and colorectal cancer (CRC) tissues (8). In these cancers, up-regulated AFAP1-AS1 is correlated with poorer overall survival and clinicopathological parameters such as tumor size, lymph node metastasis, distant metastasis, advanced clinical stage etc. Knocking down AFAP1-AS1 can prohibit proliferation, migration and invasion of these cancer cells. In HCC cells, AFAP1-AS1 regulates cell proliferation, apoptosis and metastasis via regulating Ki67, cyclinD1, Bcl-2, MMP9 and Bax levels. In lung cancer and NPC cells, AFAP1-AS1 knockdown can up-regulate Rho/Rac GTPase family members including RhoA, Rac2, Rab10, Rab11a and Rhogdi proteins and actin binding protein Pfn1, and down-regulate RhoC, Rab11b and LIM and SH3 protein Lasp1, thus promoting cell invasion and metastasis.


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 AFAP1-AS1 esophagus esophageal adenocarcinoma up onco + + 23333711
1 AFAP1-AS1 pancreas pancreatic ductal adenocarcinoma up onco + + + - 25925763
2 AFAP1-AS1 lung lung cancer up onco actin cytokeratin signaling pathway AFAP1-,RhoA-,Rac2-,Rab10-,Rab11a-,Rhogdi-,Pfn1-,RhoC+,Rab11b+,LIM+,Lasp1+ + + - 26245991
3 AFAP1-AS1 nasopharynx nasopharyngeal cancer up onco AFAP1-,RhoA-,Rac2-,Rab10-,Rab11a-,Rhogdi-,Pfn1-,RhoC+,Rab11b+,Lasp1+ + + - 26246469
4 AFAP1-AS1 lung non-small-cell lung cancer up onco - 26463625
5 AFAP1-AS1 esophagus esophageal squamous cell cancer up / - chemotherapy resistance 26756568
6 AFAP1-AS1 liver hepatic cancer up onco Ki67+,Bcl-2+,MMP9+,Bax- + - + + - 26803513
7 AFAP1-AS1 liver hepatic cancer up onco RhoA+,Rac2+,MMP-9+,cyclinD1+,Bax- + + - 26892468
8 AFAP1-AS1 colorectum colorectal cancer up onco + - 27261589

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 2.0 0.1 0.0 0.1 0.0 AFAP1-AS1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 1 2 3 4 5 6 7 fpkm AFAP1-AS1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Bo H, Gong Z, Zhang W, Li X, Zeng Y, et al. (2015). Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma. Oncotarget 6(24): 20404-18. link pubmed
[2]. Zeng Z, Bo H, Gong Z, Lian Y, Li X, et al. (2016). AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis. Tumour Biol 37(1): 729-37. link pubmed
[3]. Deng J, Liang Y, Liu C, He S, Wang S (2015). The up-regulation of long non-coding RNA AFAP1-AS1 is associated with the poor prognosis of NSCLC patients. Biomed Pharmacother 75: 8-11. link pubmed
[4]. Zhou XL, Wang WW, Zhu WG, Yu CH, Tao GZ, et al. (2016). High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Mol Carcinog 55(12): 2095-2105. link pubmed
[5]. Wu W, Bhagat TD, Yang X, Song JH, Cheng Y, et al. (2013). Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma. Gastroenterology 144(5): 956-966.e4. link pubmed
[6]. Lu X, Zhou C, Li R, Liang Z, Zhai W, et al. (2016). Critical role for the long non-coding RNA AFAP1-AS1 in the proliferation and metastasis of hepatocellular carcinoma. Tumour Biol 37(7): 9699-707. link pubmed
[7]. Ye Y, Chen J, Zhou Y, Fu Z, Zhou Q, et al. (2015). High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma. J Transl Med 13: 137. link pubmed
[8]. Wang F, Ni H, Sun F, Li M, Chen L (2016). Overexpression of lncRNA AFAP1-AS1 correlates with poor prognosis and promotes tumorigenesis in colorectal cancer. Biomed Pharmacother 81: 152-9. link pubmed



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