Gene basic information

Cancercolorectal cancer,


LncRNA AK027294 is up-regulated in colorectal cancer. AK027294 can negatively regulate caspase-3, caspase-8, while positively regulate Bcl-2, thus inhibit colorectal cancer cell apoptosis. Besides, AK027294 can promote cell migration by positively regulating MMP12, MMP9 and TWIST (1)

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 AK027294 colorectum colorectal cancer up onco caspase-3- caspase-8- Bcl-2+ MMP12+ MMP9+ Twist+ - + 26820130


[1]. Niu H, Hu Z, Liu H, Hu G, Yang B, et al. (2016). Long non-coding RNA AK027294 involves in the process of proliferation, migration, and apoptosis of colorectal cancer cells. Tumour Biol 37(8): 10097-105. link pubmed

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