AK126698

Gene basic information

SymbolAK126698
Tissuelung,
Cancernon-small-cell lung cancer,


Description

LncRNA AK126698 expression is down-regulated in human non-small cell lung cancer (NSCLC) tissues and cell lines, and correlated with a larger tumor size and advanced pathologic stage. Functionally, AK126698 overexpression represses cell proliferation and migration and induces apoptosis in NSCLC cells. Mechanistically, AK126698 inhibits Wnt/β-catenin signaling by suppressing FZD8. In addition, AK126698 exerts its biological function by negatively regulating β-catenin, c-myc and cyclin D1, and positively regulating Axin1 and E-cadherin (1). Moreover, downregulation of AK126698 may attribute to the cisplatin resistance in NSCLC through activating Wnt signal pathway (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 AK126698 lung non-small-cell lung cancer down TS Wnt/β-catenin signaling NKD2,β-catenin + chemotherapy resistance 23741487
1 AK126698 lung non-small-cell lung cancer down TS Wnt/β-catenin pathway FZD8-,β-catenin-,-myc-,cyclin D1-,Axin1+,E-cadherin+ - + - 27445486

Literature

[1]. Fu X, Li H, Liu C, Hu B, Li T, et al. (2016). Long noncoding RNA AK126698 inhibits proliferation and migration of non-small cell lung cancer cells by targeting Frizzled-8 and suppressing Wnt/β-catenin signaling pathway. Onco Targets Ther 9: 3815-27. link pubmed
[2]. Yang Y, Li H, Hou S, Hu B, Liu J, et al. (2013). The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell. PLoS One 8(5): e65309. link pubmed



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