Gene basic information

Cancernasopharyngeal cancer,


LncRNA AK294004 is up-regulated in irradiation (IR) group indicated both by microarray and qRT-PCR, but reversal in IR + curcumin group (up-regulated by qRT-PCR while down-regulated by microarray). Mechanistically, AK294004 directly targets CCND1 using its exon 1, but not the exon 2 part, leading to the decreased of CCND1 expression (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 AK294004 nasopharynx nasopharyngeal cancer up / CCND1- radiation resistance 24379026


[1]. Wang Q, Fan H, Liu Y, Yin Z, Cai H, et al. (2014). Curcumin enhances the radiosensitivity in nasopharyngeal carcinoma cells involving the reversal of differentially expressed long non-coding RNAs. Int J Oncol 44(3): 858-64. link pubmed

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