|name||amine oxidase, copper containing 4, pseudogene|
|alias_name||ubiquitin-like plant homeodomain (PHD) and really interesting new gene (RING) finger domain-containing protein 1 (UHRF1) protein associated transcript|
|Cancer||colorectal cancer,hepatic cancer,|
LncRNA AOC4P is down-regulated in hepatic carcinoma (HCC) samples and negatively correlated with smoking status, capsule invasion, vessel invasion, pathological stage and prognosis. Down-regulated expression of AOC4P can be looked as an independent prognostic factor for patients with HCC. Forced expression of AOC4P reduces cell proliferation and migration. Besides, AOC4P can bind to vimentin and enhances vimentin degradation, thus inhibit EMT (1).
While in colon cancer, AOC4P is up-regulated. AOC4P interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its ubiquitination and degradation. Furthermore, the UHRF1–AOC4P axis up-regulates Stearoyl-CoA desaturase 1 and Sprouty 4, which are required for the survival of colon tumor cells (2).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|1||AOC4P||colorectum||colorectal cancer||up||onco||UHRF1,Stearoyl-CoA desaturase 1+,Sprouty 4+||26768845|
Expression profile in human body map
. Wang TH, Lin YS, Chen Y, Yeh CT, Huang YL, et al. (2015). Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition. Oncotarget 6(27): 23342-57. link pubmed
. Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, et al. (2016). Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. Proc Natl Acad Sci U S A 113(5): 1273-8. link pubmed