AOC4P

Gene basic information

symbol AOC4P
name amine oxidase, copper containing 4, pseudogene
location 17q21.31
alias_symbol UPAT
alias_name ubiquitin-like plant homeodomain (PHD) and really interesting new gene (RING) finger domain-containing protein 1 (UHRF1) protein associated transcript
Tissuecolorectum,liver,
Cancercolorectal cancer,hepatic cancer,


Description

LncRNA AOC4P is down-regulated in hepatic carcinoma (HCC) samples and negatively correlated with smoking status, capsule invasion, vessel invasion, pathological stage and prognosis. Down-regulated expression of AOC4P can be looked as an independent prognostic factor for patients with HCC. Forced expression of AOC4P reduces cell proliferation and migration. Besides, AOC4P can bind to vimentin and enhances vimentin degradation, thus inhibit EMT (1).
While in colon cancer, AOC4P is up-regulated. AOC4P interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its ubiquitination and degradation. Furthermore, the UHRF1–AOC4P axis up-regulates Stearoyl-CoA desaturase 1 and Sprouty 4, which are required for the survival of colon tumor cells (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 AOC4P liver hepatic cancer down TS vimentin - - - + 26160837
1 AOC4P colorectum colorectal cancer up onco UHRF1,Stearoyl-CoA desaturase 1+,Sprouty 4+ 26768845

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.9 0.9 0.1 2.0 0.4 0.0 0.1 0.0 2.0 0.7 0.2 0.1 0.6 0.1 0.2 0.2 AOC4P

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Wang TH, Lin YS, Chen Y, Yeh CT, Huang YL, et al. (2015). Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition. Oncotarget 6(27): 23342-57. link pubmed
[2]. Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, et al. (2016). Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. Proc Natl Acad Sci U S A 113(5): 1273-8. link pubmed



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