AS-RBM15

Gene basic information

SymbolAS-RBM15
Tissuebone marrow,
Canceracute myelocytic leukemia,


Description

AS-RBM15 is an antisense lncRNA of RBM15. AS-RBM15 can promote megakaryocyte (MK) terminal differentiation. The exon 1 of AS-RBM15 is essential for MK differentiation while the repeat element in this antisense RNA is dispensable. In addition, AS-RBM15 could up-regulates RBM15 protein level. Moreover, RBM15 and AS-RBM15 are both regulated by RUNX1 and RUNX1-ETO. RUNX1 activates the transcription of RBM15 and AS-RBM15, while RUNX1-ETO in reverse (1).


Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 AS-RBM15 bone marrow acute myelocytic leukemia / / RBM15+,+RUNX1,-RUNX1,-ETO 27118388

Literature

[1]. Tran NT, Su H, Khodadadi-Jamayran A, Lin S, Zhang L, et al. (2016). The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation. EMBO Rep 17(6): 887-900. link pubmed



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