BALR-2

Gene basic information

SymbolBALR-2
Tissuebone marrow,
CancerB acute lymphoblastic leukemia,


Description

BALR-2 is significantly up-regulated in B-acute lymphoblastic leukemia (B-ALL) patients when compared to normal CD19+ cells. Meanwhile, BALR-2 expression is significantly higher in B-ALL patients that are unresponsive to prednisone as opposed to those responsive. High BALR-2 expression is associated with inferior overall survival. In addition, BALR-2 is a nucleocytoplasmic lncRNA whose expression is regulated by glucocorticoid treatment. Knockdown of BALR-2 results in growth inhibition and increased apoptosis and increased expression of JUN and BIM (1).


Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 BALR-2 bone marrow B acute lymphoblastic leukemia up onco JUN-,BIM- + - chemotherapy resistance 25681502

Literature

[1]. Fernando TR, Rodriguez-Malave NI, Waters EV, Yan W, Casero D, et al. (2015). LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia. Mol Cancer Res 13(5): 839-51. link pubmed



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