Gene basic information

Cancernon-small-cell lung cancer,


LncRNA BC087858 is up-regulated in non-small cell lung cancer and correlated with prognosis and acquired resistance to EGFR-TKIs. Down-regulating BC087858 partially restores gefitinib sensitivity in vitro. Functionally, BC087858 enhances cell invasion via promoting activation of PI3K/AKT pathway and EMT through the upregulation of Snail and ZEB1 (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 BC087858 lung non-small-cell lung cancer up onco + - 27409677


[1]. Pan H, Jiang T, Cheng N, Wang Q, Ren S, et al. (2016). Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer. Oncotarget 7(31): 49948-49960. link pubmed

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