BC200

Gene basic information

symbol BCYRN1
name brain cytoplasmic RNA 1
location 2p21
alias_symbol BC200|BC200a|NCRNA00004|LINC00004
alias_name brain cytoplasmic RNA 200-alpha|non-protein coding RNA 4|long intergenic non-protein coding RNA 4
Tissuebreast,esophagus,lung,ovary,
Cancerbreast cancer,esophageal cancer,non-small-cell lung cancer,ovarian cancer,


Description

LncRNA BC200 expression is increased in breast cancer (1), where the estrogen receptor (ER) interacts with the putative estrogen response elements (EREs) in the BC200 promoter to induce its transcription. In turn, BC200 can promote breast cancer cell proliferation. Besides, BC200 is also increased in esophageal cancer tissue and correlated with poor prognosis (2). While in ovarian cancer, BC200 is down-regulated and inhibits the proliferative ability of ovarian cancer cells. Besides, BC200 is associated with cell death induced by carboplatin (3).
While in non-small cell lung cancer, BC200 is also up-regulated. High expression of BC200 originated from c-MYC’s binding to its promoter. C-MYC-activated BC200 can promote migration and invasion of A549 cells. Besides, MMP 9 and MMP 13 are positively involved with BC200 (4).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 BC200 breast breast cancer up / - 15240511
1 BC200 lung non-small-cell lung cancer up onco +c-MYC MMP9+,MMP13+ + + + 25866480
2 BC200 ovary ovarian cancer down TS chemotherapy resistance 26893717
3 BC200 esophagus esophageal cancer up / - 27143917
4 BC200 breast breast cancer up onco Bcl-x-,Bcl-xS- + 27277684

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 1 2 3 4 5 6 fpkm 0.4 0.7 6.0 1.0 0.5 0.9 0.5 0.2 0.3 2.0 0.7 0.4 2.0 0.8 0.3 0.4 BC200

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.1 0.2 0.3 0.4 0.5 0.6 fpkm BC200 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Singh R, Gupta SC, Peng WX, Zhou N, Pochampally R, et al. (2016). Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis. Cell Death Dis 7(6): e2262. link pubmed
[2]. Zhao RH, Zhu CH, Li XK, Cao W, Zong H, et al. (2016). BC200 LncRNA a potential predictive marker of poor prognosis in esophageal squamous cell carcinoma patients. Onco Targets Ther 9: 2221-6. link pubmed
[3]. Wu DI, Wang T, Ren C, Liu L, Kong D, et al. (2016). Downregulation of BC200 in ovarian cancer contributes to cancer cell proliferation and chemoresistance to carboplatin. Oncol Lett 11(2): 1189-1194. link pubmed
[4]. Hu T, Lu YR (2015). BCYRN1, a c-MYC-activated long non-coding RNA, regulates cell metastasis of non-small-cell lung cancer. Cancer Cell Int 15: 36. link pubmed



© Bioinformatics Group of XTBG