|name||brain cytoplasmic RNA 1|
|alias_name||brain cytoplasmic RNA 200-alpha|non-protein coding RNA 4|long intergenic non-protein coding RNA 4|
|Cancer||breast cancer,esophageal cancer,non-small-cell lung cancer,ovarian cancer,|
LncRNA BC200 expression is increased in breast cancer (1), where the estrogen receptor (ER) interacts with the putative estrogen response elements (EREs) in the BC200 promoter to induce its transcription. In turn, BC200 can promote breast cancer cell proliferation. Besides, BC200 is also increased in esophageal cancer tissue and correlated with poor prognosis (2). While in ovarian cancer, BC200 is down-regulated and inhibits the proliferative ability of ovarian cancer cells. Besides, BC200 is associated with cell death induced by carboplatin (3).
While in non-small cell lung cancer, BC200 is also up-regulated. High expression of BC200 originated from c-MYC’s binding to its promoter. C-MYC-activated BC200 can promote migration and invasion of A549 cells. Besides, MMP 9 and MMP 13 are positively involved with BC200 (4).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|1||BC200||lung||non-small-cell lung cancer||up||onco||+c-MYC||MMP9+,MMP13+||+||+||+||25866480|
|2||BC200||ovary||ovarian cancer||down||TS||chemotherapy resistance||26893717|
Expression profile in human body map
Expression profile in TCGA
. Singh R, Gupta SC, Peng WX, Zhou N, Pochampally R, et al. (2016). Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis. Cell Death Dis 7(6): e2262. link pubmed
. Zhao RH, Zhu CH, Li XK, Cao W, Zong H, et al. (2016). BC200 LncRNA a potential predictive marker of poor prognosis in esophageal squamous cell carcinoma patients. Onco Targets Ther 9: 2221-6. link pubmed
. Wu DI, Wang T, Ren C, Liu L, Kong D, et al. (2016). Downregulation of BC200 in ovarian cancer contributes to cancer cell proliferation and chemoresistance to carboplatin. Oncol Lett 11(2): 1189-1194. link pubmed
. Hu T, Lu YR (2015). BCYRN1, a c-MYC-activated long non-coding RNA, regulates cell metastasis of non-small-cell lung cancer. Cancer Cell Int 15: 36. link pubmed