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91H

alias symbols:

tissues bone,breast,colorectum,esophagus,

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,osteosarcoma,

LncRNA 91H is the antisense of H19. It is expressed in the higher percentage of colorectal cancer, breast cancer and osteosarcoma. The high expression of 91H is significantly correlated with distant metastasis in colorectal cancer, and also correlated with advanced clinical stage, chemotherapy after surgery, and tumor size in osteosarcoma. There would be an obviously poorer prognosis if 91H expression rose in colorectal cancer and osteosarcoma patients. Functionally, 91H promotes the cellular proliferation, invasion and migration in both colorectal cancer and osteosarcoma. However, 91H is l...


AATBC

alias symbols:

tissues bladder,

cancer type bladder cancer,

LncRNA AATBC is over-expressed in bladder cancer, associated with tumor development and aggressiveness. AATBC depletion leads to an obvious inhibitory effect on the cellular growth of bladder cancer, and inhibits tumor growth in NOD/SCID mice. Knockdown of AATBC leads to an increased expression of p18 but a decreased expression of cyclin D1, CDK4, and phosphorylated retinoblastoma (Rb). It can also result in the intrinsic apoptosis of bladder cancer cells by the enhanced cleavages of poly (ADP-ribose) polymerase (PARP), caspase-9 and caspase-3. It can also enhance the phosphorylation level ...


AB073614

alias symbols:

tissues nervous system,ovary,

cancer type glioma,ovarian cancer,

LncRNA AB073614 is up-regulated in ovarian cancer (OC) and glioma. The 5-year overall survival in OC patients with high expression of AB073614 is inferior to that with low expression in both OC and glioma patients. AB073614 is more highly expressed in high-grade than low-grade glioma tissues. Level of AB073614 is a potential prognostic marker for glioma patients. Knockdown of AB073614 inhibits the proliferation and invasion of OC cells, down-regulates the cell-growth- (PCNA), metastasis- (MMP-2, 9), epithelial-mesenchymal-transition-(EMT, β-catenin, Twist, Snail and FN1), anti-apoptosis- (B...


AB209630

alias symbols:

tissues larynx,

cancer type hypopharyngeal squamous cell carcinoma,

LncRNA AB209630 is down-regulated in hypopharyngeal squamous cell carcinoma. Increased expression of AB209630 significantly inhibits the cellular growth, metastasis and invasion, but stimulates apoptosis. In addition, patients with decreased expression of AB209630 have a significantly poorer prognosis than those with high AB209630 expression.


ABHD11-AS1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA ABHD11-AS1 is up-regulated in the gastric cancer tissues as well as the gastric juice of patients with gastric cancer. ABHD11-AS1 levels in gastric juice from GC patients are associated with gender, tumor size, tumor stage, Lauren type, blood CEA levels, and have a positive correlation with CA19-9 level. Besides, ABHD11-AS1 can also be used as a diagnostic marker for gastric cancer patients.


AC006050.3-003

alias symbols:

tissues lung,

cancer type lung squamous cell cancer,

LncRNA AC006050.3-003 is lower in partial response (PR) samples compared with the progressive disease (PD) samples. It is a valuable biomarker for differentiating PR patients from PD patients and might correlate with the sensitivity of chemotherapy in lung squamous cell carcinoma patients.


AC007403.1

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA AC007403.1 is up-regulated in non-small cell lung cancer (NSCLC), and may be potential biomarkers for predicting the tumorigenesis of NSCLC.


AC096655.1-002

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA AC096655.1-002 is down-regulated in gastric carcinoma tissues. Its expression level is associated with patients' age, TNM stages, distant metastasis, differentiation, lymph node metastasis and depth of invasion. Furthermore, AC096655.1-002 may be used as a potential marker for the diagnosis of gastric adenocarcinoma.


AC096677.3-201

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA AC096677.3-201 is up-regulated in colorectal cancer (CRC). AC096677.3-201 can promote the cellular proliferation, S-phase arrest, migration and invasion, while inhibit the apoptosis in colon cancer.


AC104699.1.1

alias symbols:

tissues ovary,

cancer type ovarian cancer,

LncRNA AC104699.1.1 is down-regulated in ovarian cancer. It could significantly divide the late-stage patients into high- and low-risk groups. Moreover, the expression level of AC104699.1.1 is associated with a decreased risk of survival. Low-risk groups always have higher expression levels of AC104699.1.1 than the high-risk. In addition, AC104699.1.1 is significantly associated with patient progression-free survival. Besides, AC104699.1.1 is involved in immune- and cell cycle-associated processes.


AC130710

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA AC130710 is up-regulated in gastric cancer, and associated with tumor size, TNM stages, distal metastasis and tissue CEA expression. It has one complementary binding site in the 3′-end with miR-129-5p, and thus could be suppressed by miR-129-5p expression.


AC138128.1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA AC138128.1 is down-regulated in gastric cancer. There is no statistically significant association between AC138128.1 expression and clinical pathological features. However, it may have some potential diagnostic value.


ADAMTS9-AS2

alias symbols:

tissues nervous system,

cancer type glioma,

ADAMTS9-AS2 is an antisense overlapping lncRNA against ADAMTS9, and mostly located in the upstream of ADAMTS9. ADAMTS9-AS2 is down-regulated in glioma tissue samples and associated with poor prognosis. Its expression is positively correlated with ADAMTS9 and DNMT3A, but negatively with DNMT1. Mechanistically, it may modulate the expression of ADAMTS9. Moreover, ADAMTS9-AS2 expression levels are evidently increased in 5-aza-dC (DNA demethylating agent) groups. Overexpression of ADAMTS9-AS2 can inhibit migration and invasion of glioma cells.


AF085935

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA AF085935 increases in the serum of hepatic carcinoma (HCC) patients. AF085935 might be able to discriminate HCC or hepatitis B virus (HBV) patients from healthy controls, and even discriminate HCC patients from HBV patients.


AF339813

alias symbols:

tissues pancreas,

cancer type pancreatic cancer,

LncRNA AF339813 is significantly increased in pancreatic cancer (PC) tissues and positively regulated by NUF2. AF339813 plays a pivotal role in the proliferation and apoptosis of PC cells. With treatment of siRNA-AF339813, the expression of Caspase-3, Caspase-9 and Bax are significantly increased and Bcl-2 is significantly decreased. Besides, siRNA-AF339813 can also lead to a decrease in cyclins D1 and CDK4/CDK6.


AFAP1-AS1

alias symbols:

tissues colorectum,esophagus,liver,lung,nasopharynx,pancreas,

cancer type colorectal cancer,esophageal adenocarcinoma,esophageal squamous cell cancer,hepatic cancer,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,pancreatic ductal adenocarcinoma,

LncRNA AFAP1-AS1 is significantly up-regulated in nasopharyngeal carcinoma (NPC), lung cancer, esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma, hepatic carcinoma (HCC), pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) tissues. In these cancers, up-regulated AFAP1-AS1 is correlated with poorer overall survival and clinicopathological parameters such as tumor size, lymph node metastasis, distant metastasis, advanced clinical stage etc. Knocking down AFAP1-AS1 can prohibit proliferation, migration and invasion of these cancer cells. In HCC cells, AFAP1-A...


AGAP2-AS1

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA AGAP2-AS1 is up-regulated in non-small cell lung cancer (NSCLC), and correlated with tumor size, advanced pathological stage and poor prognosis. AGAP2-AS1 can increase NSCLC cell proliferation, migration and invasion, but inhibit NSCLC cell apoptosis. Mechanistically, AGAP2-AS1 can repress LATS2 and KLF2 transcription via binding with EZH2 and LSD1.


AI364715

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA AI364715 is down-regulated in gastric cancer tissues, and associated with tumor size, differentiation and venous invasion. Moreover, AI364715 expression level is significantly changed in dysplasia, the typical precancerous lesions. Hence, AI364715 may be a potential biomarker for the diagnosis of gastric cancer.


AK001796

alias symbols:

tissues lung,

cancer type lung cancer,

LncRNA AK001796 is over-expressed in lung cancer cells and tumor tissues but down-regulated in resveratrol-treated lung cancer cells. Moreover, AK001796 can affect cell proliferation through the cell cycle, probably attributable to promoting the G1–S phase transition.


AK027294

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA AK027294 is up-regulated in colorectal cancer. AK027294 can negatively regulate caspase-3, caspase-8, while positively regulate Bcl-2, thus inhibit colorectal cancer cell apoptosis. Besides, AK027294 can promote cell migration by positively regulating MMP12, MMP9 and TWIST


AK058003

alias symbols:

tissues breast,stomach,

cancer type breast cancer,gastric cancer,

LncRNA AK058003 is significantly higher in the breast cancer and hypoxia-induced gastric cancer. Its expression level is associated with lymph node metastasis and differentiation in breast cancer. AK058003 siRNA can reduce SNCG expression at both mRNA and protein levels. Functionally, AK058003 can promote proliferation, migration and invasion of breast cancer cells. In addition, AK058003 can promote hypoxia-induced migration and invasion of gastric cancer cells.


AK123657

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA AK123657 is decreased in colorectal cancer. Functionally, AK123657 can decrease the proliferation and invasion of colorectal cancer cells.


AK126698

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA AK126698 expression is down-regulated in human non-small cell lung cancer (NSCLC) tissues and cell lines, and correlated with a larger tumor size and advanced pathologic stage. Functionally, AK126698 overexpression represses cell proliferation and migration and induces apoptosis in NSCLC cells. Mechanistically, AK126698 inhibits Wnt/β-catenin signaling by suppressing FZD8. In addition, AK126698 exerts its biological function by negatively regulating β-catenin, c-myc and cyclin D1, and positively regulating Axin1 and E-cadherin. Moreover, downregulation of AK126698 may attribute to th...


AK294004

alias symbols:

tissues nasopharynx,

cancer type nasopharyngeal cancer,

LncRNA AK294004 is up-regulated in irradiation (IR) group indicated both by microarray and qRT-PCR, but reversal in IR + curcumin group (up-regulated by qRT-PCR while down-regulated by microarray). Mechanistically, AK294004 directly targets CCND1 using its exon 1, but not the exon 2 part, leading to the decreased of CCND1 expression.


ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid,

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer,

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


AOC4P

alias symbols:

tissues colorectum,liver,

cancer type colorectal cancer,hepatic cancer,

LncRNA AOC4P is down-regulated in hepatic carcinoma (HCC) samples and negatively correlated with smoking status, capsule invasion, vessel invasion, pathological stage and prognosis. Down-regulated expression of AOC4P can be looked as an independent prognostic factor for patients with HCC. Forced expression of AOC4P reduces cell proliferation and migration. Besides, AOC4P can bind to vimentin and enhances vimentin degradation, thus inhibit EMT. While in colon cancer, AOC4P is up-regulated. AOC4P interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its ubiquitination ...


AP001631.9

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA AP001631.9 is increased and positively correlated with the FOXM1 levels in gastric cancer cells. Overexpression of FRLnc1 enhances the migration and metastasis of gastric cancer cells.


APOC1P1-3

alias symbols:

tissues breast,

cancer type breast cancer,

LincRNA APOC1P1-3 is over-expressed in breast cancer tissues and cell lines. Hypomethylation in the C/G site may contribute to its upregulation. APOC1P1-3 expression is positively associated with tumor size. Upregulation of APOC1P1-3 inhibits cell apoptosis, but not affects cell cycles. Furthermore, the variation of APOC1P1-3 could affect caspase-3 activation. Besides, APOC1P1-3 can bind α-tubulin and modify its acetylation, thus inhibit cell apoptosis.


ARRDC1-AS1

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA ARRDC1-AS1 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


AS-RBM15

alias symbols:

tissues bone marrow,

cancer type acute myelocytic leukemia,

AS-RBM15 is an antisense lncRNA of RBM15. AS-RBM15 can promote megakaryocyte (MK) terminal differentiation. The exon 1 of AS-RBM15 is essential for MK differentiation while the repeat element in this antisense RNA is dispensable. In addition, AS-RBM15 could up-regulates RBM15 protein level. Moreover, RBM15 and AS-RBM15 are both regulated by RUNX1 and RUNX1-ETO. RUNX1 activates the transcription of RBM15 and AS-RBM15, while RUNX1-ETO in reverse.


ATB

alias symbols:

tissues breast,colorectum,kidney,liver,nervous system,pancreas,prostate,stomach,

cancer type breast cancer,colorectal cancer,gastric cancer,glioma,hepatic cancer,pancreatic cancer,prostate cancer,renal cancer,

LncRNA ATB plays a dual role in cancers. ATB is higher in breast cancer, gastric cancer, glioma, hepatocellular carcinoma, colon cancer, renal cell carcinoma and prostate carcinoma, but lower in pancreatic cancer. ATB expression is associated with clinicopathological parameters such as vascular invasion, lymph node metastasis, grades and prognosis etc.. Functionally, ATB regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ATB can regulate EMT by binding to miR-200 family members and regulate EMT markers expression level, for instance, ZE...


ATP8B5P

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA ATP8B5P is up-regulated in gastric cancer and linked to tumor grade.


BACE1-AS

alias symbols:

tissues ovary,

cancer type ovarian cancer,

LncRNA BACE1-AS in the anisomycin-treated ovarian cancer stem cells (OCSCs) is significantly elevated compared to the dimethylsulfoxide (DMSO) treated OCSCs or untreated OCSCs after 72 h. Anisomycin can stimulate expression of BACE1-AS and apoptosis-related proteins in OCSCs. Moreover, anisomycin can inhibit OCSCs xenograft growth. Accordingly, silencing of lncRNA BACE1-AS expression can weaken the effects of anisomycin in OCSCs.


BAIAP2-AS1

alias symbols:

tissues liver,

cancer type hepatic cancer,

BAIAP2-AS1 is a HBV-related-hepatocellular-carcinoma (HCC)-specific lncRNA, which up-regulated in HCC. BAIAP2-AS1 is a heat-to-head antisense lncRNA of BAIAP2. The expression of MAPKAP1 and RAF1 decreased after BAIPA2-AS1 silencing.


BALR-2

alias symbols:

tissues bone marrow,

cancer type B acute lymphoblastic leukemia,

BALR-2 is significantly up-regulated in B-acute lymphoblastic leukemia (B-ALL) patients when compared to normal CD19+ cells. Meanwhile, BALR-2 expression is significantly higher in B-ALL patients that are unresponsive to prednisone as opposed to those responsive. High BALR-2 expression is associated with inferior overall survival. In addition, BALR-2 is a nucleocytoplasmic lncRNA whose expression is regulated by glucocorticoid treatment. Knockdown of BALR-2 results in growth inhibition and increased apoptosis and increased expression of JUN and BIM.


BALR-6

alias symbols:

tissues bone marrow,

cancer type B-lymphoblastic leukemia,

During normal B cell development, lncRNA BALR-6 is dynamically expressed, with high expression in pre-B cells and subsequent down-regulation. BALR-6 knockdown inhibits proliferation of human B-acute lymphoblastic leukemia (B-ALL) cell lines. Constitutively expressed BALR-6 supports cell survival and proliferation. Moreover, BALR-6 can up-regulate SP1 and CREB1 level.


BANCR

alias symbols:

tissues colorectum,esophagus,liver,lung,others,stomach,thyroid,

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,non-small-cell lung cancer,retinoblastoma,thyroid cancer,

LncRNA BANCR expression is significantly higher in colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, melanoma, retinoblastoma and papillary thyroid carcinoma, while is lower in lung cancer. BANCR expression level is associated clinicopathological parameters such as lymph nodes metastasis and tumor stage and prognosis. Functionally, BANCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, BANCR can bind to EZH2. BANCR plays its function roles via regulating p38, JNK, NF-κB, ERK1/2, Raf-1, JN...


BC002811

alias symbols:

tissues nervous system,

cancer type astrocytoma,

LncRNA BC002811 is down-regulated in astrocytoma and significantly associated with poor patient survival.


BC016831

alias symbols:

tissues breast,

cancer type triple negative breast cancer,

LncRNA BC016831 is down-regulated in triple negative breast cancer (TNBC) and correlated with TNBC occurrence. Besides, it can be the potential biomarker for differentiating TNBC from non-TNBC.


BC032469

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA BC032469 is up-regulated in gastric cancer tissues, and is clinically associated with tumor size, differentiation and survival of gastric cancer patients. Downregulation of BC032469 results in a significant inhibition of proliferation in vitro and in vivo. Mechanistically, BC032469 could up-regulate hTERT by directly binding to miR-1207-5p and effectively functioning as a sponge for miR-1207-5p


BC040587

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA BC040587 is down-regulated in breast cancer tissues. Postmenopausal patients have a relatively low BC040587 expression. BC040587 level is significantly correlated with menopausal status, tumor differentiation and overall survival.


BC060912

alias symbols:

tissues lung,

cancer type lung cancer,

LncRNA BC060912 is expressed increasingly in human lung and other tumors. BC060912 is 1.2 kb in length and is composed of two exons. The expression of BC060912 is repressed by p53. Functionally, BC060912 suppresses cell apoptosis by interacting with the two DNA damage repair proteins, PARP1 and NPM1.


BC087858

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA BC087858 is up-regulated in non-small cell lung cancer and correlated with prognosis and acquired resistance to EGFR-TKIs. Down-regulating BC087858 partially restores gefitinib sensitivity in vitro. Functionally, BC087858 enhances cell invasion via promoting activation of PI3K/AKT pathway and EMT through the upregulation of Snail and ZEB1.


BC200

alias symbols:

tissues breast,esophagus,lung,ovary,

cancer type breast cancer,esophageal cancer,non-small-cell lung cancer,ovarian cancer,

LncRNA BC200 expression is increased in breast cancer, where the estrogen receptor (ER) interacts with the putative estrogen response elements (EREs) in the BC200 promoter to induce its transcription. In turn, BC200 can promote breast cancer cell proliferation. Besides, BC200 is also increased in esophageal cancer tissue and correlated with poor prognosis. While in ovarian cancer, BC200 is down-regulated and inhibits the proliferative ability of ovarian cancer cells. Besides, BC200 is associated with cell death induced by carboplatin. While in non-small cell lung cancer, BC200 is also up-re...


BCAR4

alias symbols:

tissues bone,breast,

cancer type breast cancer,osteosarcoma,

LncRNA BCAR4 is up-regulated in osteosarcoma tissues and correlated with large tumor size, advanced Enneking stage, lung metastasis and poor prognosis of osteosarcoma patients. Depletion of BCAR4 inhibits osteosarcoma cell proliferation and migration and inhibits GLI2-dependent gene transcription. BCAR4 transcript level is positively correlated with GLI2 target genes RPS3, IL6, MUC5AC, and TGF-β1. While in breast cancer, BCAR4 is also up-regulated. Moreover, BCAR4 can induce endocrine resistance but sensitise breast cancer to lapatinib.


BOKAS

alias symbols:

tissues esophagus,

cancer type esophageal squamous cell cancer,

LncRNA BOKAS is up-regulated in esophageal squamous cancer (ESCC) patients following radiation. It promotes WISP1 expression, a downstream target gene of Wnt/β-catenin pathway. Besides, up-regulated BOKAS can result in radioresistance of ESCC patients.


BX647187

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA BX647187 is up-regulated in prostate cancer cells, which is positively regulated by Hec1. Further studies find that BX647187 is positive with the expression of caspase-3, caspase-9 and Bax, while negative with Bcl-2. But the expression of caspase-8 has no obvious change. These results indicate that BX647187 affects apoptosis via intrinsic apoptotic pathway.


BX648207

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA BX648207 is decreased in colorectal cancer. Functionally, BX648207 can decrease colorectal cancer proliferation and invasion.


BX649059

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA BX649059 is decreased in colorectal cancer. Moreover, BX649059 can decrease colorectal cancer proliferation and invasion.


C17orf91

alias symbols:

tissues ovary,

cancer type ovarian cancer,

LncRNA C17orf91 expression is elevated in omental metastases when compared with matched primary ovarian tumors. Increased expression of C17orf91 is associated with shorter progression- free survival. C17orf91 inhibition significantly decreases migration, invasion and viability of Hey cells. Mechanistically, C17orf91 repression could reduce the expression of KLF8 and SNAI2 at mRNA level, and reduce MYC at both protein and mRNA level.


C21orF96

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA C21orF96 is over-expressed in positive lymph node and gastric cancer tissues, and associated with gross appearance, lymphatic metastasis and distal metastasis. Further studies find that C21orF96 promotes the tubular formation, migration and invasion.


CADM1-AS1

alias symbols:

tissues kidney,

cancer type renal clear cell cancer,

LncRNA CADM1-AS1 is down-regulated and correlated with the mRNA expression of CADM1 in clear cell renal cell carcinoma (ccRCC) tissues. Decreased CADM1-AS1 expression is associated with more advanced AJCC stage and is an independent predictor for overall survival. Moreover, CADM1-AS1 can prohibit cancer cell proliferation, migration, and promote apoptosis.


CAHM

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA CAHM is hypermethylation in neoplastic colorectal tissue, and blood from CRC patients. CAHM methylation correlates with of loss expression of CAHM RNA in colorectal tissue and CRC cell lines. Moreover, CAHM methylation levels in blood reflect disease severity.


CAR10

alias symbols:

tissues lung,

cancer type xuanwei lung cancer,

LncRNA CAR10 is up-regulated in Xuanwei lung cancer patients. CAR10 overexpression is associated with air pollution. A smoky coal combustion-generated carcinogen dibenz[a,h]anthracene up-regulates CAR10 by increasing transcription factor FoxF2 expression. CAR10 binds and stabilizes transcription factor Y-box-binding protein 1 (YB-1), leading to upregulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells. Moreover, CAR10 can promote cell growth and tumor growth.


CASC11

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA CASC11 is up-regulated in colorectal cancer (CRC) tissues and increased CASC11 expression in CRC is associated with tumor size, serosal invasion, lymph metastasis, and the tumor–node–metastasis (TNM) stage. Functional experiments show that CASC11 can promote CRC cell proliferation and metastasis. Furthermore, CASC11 can target heterogeneous ribonucleoprotein K (hnRNP-K) to activate WNT/β-catenin signaling in CRC cells. In addition, c-Myc can directly bind to the promoter regions of CASC11 and increase promoter histone acetylation to enhance CASC11 expression.


CASC15

alias symbols:

tissues others,

cancer type melanoma,

LncRNA CASC15 RNA is up regulated in melanoma lines and up-regulated in a xenograft model of melanoma brain metastasis. RACE identifies an alternative CASC15 transcriptional start site and multiple splice variants. Moreover, CASC15 levels increase during melanoma progression and its expression in melanoma LN metastases is an independent predictor of disease recurrence and survival. Besides, siRNA knockdown experiments reveal that CASC15 regulates melanoma cell phenotype switching between proliferative and invasive states.


CASC2

alias symbols:

tissues colorectum,kidney,lung,nervous system,

cancer type colorectal cancer,glioma,non-small-cell lung cancer,renal cancer,

LncRNA CASC2 is lower in colorectal cancer, glioma, renal cell carcinoma, non-small cell lung cancer (NSCLC). Its expression level is associated with clinicopathological parameters such as tumor size, TNM stage, prognosis etc.. Functionally, CASC2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, CASC2 can bind to miR-18a, miR-21. Besides, CASC2 negatively regulates pSTAT3 and c-Myc.


CASC8

alias symbols:

tissues lung,

cancer type lung cancer,

The single nucleotide polymorphisms (SNP) CASC8 rs10505477 is greatly related to lung cancer risk in male and adenocarcinoma subgroups in recessive model. It is also closely correlated with platinum-based chemotherapy response in dominant model. Additionally, CASC8 rs10505477 polymorphism is significantly relevant to severe hematologic toxicity in non-small-cell lung cancer (NSCLC) subgroup in dominant model and in additive model. Furthermore, rs10505477 polymorphism is greatly associated with gastrointestinal toxicity in small cell lung cancer (SCLC) and cisplatin subgroups in dominant model.


CASC9

alias symbols:

tissues esophagus,

cancer type esophageal squamous cell cancer,

LncRNA CASC9 is markedly up-regulated in esophageal squamous cell carcinoma (ESCC) tissues and cell lines. Furthermore, knockdown of CASC9 significantly suppresses cell migration and invasion. Besides, enhanced CASC9 expression level is correlated with differentiation.


CCAL

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA CCAL is up-regulated in colorectal cancer (CRC) tissues and high CCAL level is associated with poor overall survival and a worse response to adjuvant chemotherapy. Further studies reveal that CCAL promotes CRC progression by targeting activator protein 2α (AP-2α), which in turn activates Wnt/β-catenin pathway. Moreover, CCAL induces multidrug resistance (MDR) through activating Wnt/β-catenin signaling by suppressing AP-2α and further up-regulating MDR1/P-gp expression. In addition, histone H3 methylation and deacetylases contribute to the upregulation of CCAL in CRC.


CCAT1

alias symbols:

tissues bone marrow,breast,colorectum,endometrium,gallbladder,liver,lung,stomach,

cancer type acute myelocytic leukemia,breast cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,hepatic cancer,non-small-cell lung cancer,

LncRNA CCAT1 is higher in breast cancer, colorectal cancer, gallbladder cancer, gastric cancer and hepatocellular carcinoma. CCAT1 expression level is associated with clinicopathological parameters such as differentiation grade, TNM stage, lymph node metastases, prognosis etc.. Functionally, CCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Further studies reveal that CCAT1 can bind to miRNA-218-5p, c-Myc and let-7. Moreover, CCAT1 can negatively regulate Bmi1, miR-490 and positively regulate c-Myc, HMGA2 and hnRNAP1.


CCAT2

alias symbols:

tissues breast,cervix,colorectum,esophagus,liver,lung,ovary,stomach,

cancer type breast cancer,cervical cancer,cervical squamous cell cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,ovarian cancer,

LncRNA CCAT2 is higher in breast cancer, esophageal squamous carcinoma, lung cancer, gastric cancer, cervical cancer and ovarian cancer. CCAT2 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, CCAT2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, CCAT2 is involves with chemotherapy response.


CCDC26

alias symbols:

tissues bone marrow,pancreas,

cancer type myeloid leukemia,pancreatic cancer,

LncRNA CCDC26 is higher in pancreatic cancer (PC) cells and tissues. CCDC26 expression is correlated with tumor size and tumor number. Patients with higher CCDC26 expression have shorter overall survival time. Knockdown of CCDC26 suppresses PC cells proliferation and induces apoptosis via suppressing PCNA and Bcl2. In leukemia cell lines, CCDC26 is expressed in cells derived from acute myelocytic leukemia (AML), acute monocytic leukemia and chronic myelogenous leukemia (CML). Very low expression is observed in megakaryoblastic cells derived from leukemia accompanied with Down’s syndrome (C...


CCHE1

alias symbols:

tissues cervix,

cancer type cervical cancer,

LncRNA CCHE1 is up-regulated in cervical cancer tissues and predicts poor prognosis of cervical cancer patients. Correlation regression analysis shows that increased CCHE1 expression is significantly correlated with larger tumor size, advanced FIGO stage, higher SCC-Ag and uterine corpus invasion. CCHE1 promotes the proliferation of cervical cancer cells and the effect is dependent upon CCHE1 physically associating with PCNA mRNA thus to up-regulate the expression of PCNA.


CLMAT3

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA CLMAT3 is generally increased in human colorectal cancer (CRC) cell lines. Knockdown of CLMAT3 in CRC cells decreases cell growth, inhibits CRC cell cycle progression and induces apoptosis. Master G0/G1 regulators including Cdh1, CDKN1B (p27Kip1) and Skp2 are measured after CLMAT3 knockdown. The results show an increased Cdh1 expression by accelerating Skp2 degradation, which results in p27Kip accumulation.


CPS1-IT1

alias symbols:

tissues liver,others,

cancer type hepatic cancer,intrahepatic cholangiocarcinoma,

LncRNA CPS1-IT1 is down-regulated in hepatocellular carcinoma and up-regulated in intrahepatic cholangiocarcinoma. It can affect cancer cell proliferation, migration and apoptosis. Besides, it can inhibit EMT of hepatocellular carcinoma cells.


CRNDE

alias symbols:

tissues colorectum,nervous system,

cancer type colorectal cancer,glioma,

LncRNA CRNDE is higher in glioma. CRNDE overexpression facilitates cell proliferation, migration, and invasion, while inhibits glioma cells apoptosis. CRNDE can bind to miR-384 and miR-186, and suppress their function. CRNDE knockdown results in a decrease of piwi-like RNA-mediated gene silencing 4 (PIWIL4) protein. Meanwhile, CRNDE decreases the expression levels of XIAP and PAK7 by binding to miR-186 and negatively regulating it. Exon microarrays shows substantially elevated expression across exons E2, E4, In4, E5, In5 and part of E6 of CRNDE in colorectal cancer tissues. Transcript isof...


CTB-89H12.4

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA CTB-89H12.4 is up-regulated in prostate cancer cell lines. Depletion of PTEN transcript by siRNAs reduces the expression of CTB-89H12.4. The depletion of CTB-89H12.4 transcripts also reduces the expression of two other protein-coding genes (PCGs), VAPA and SERINC1, sponge-mRNAs of PTEN.


CTBP1-AS

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA CTBP1-AS is an androgen-responsive long ncRNA, located in the antisense (AS) region of C-terminal binding protein 1 (CTBP1), which is a co-repressor for androgen receptor. CTBP1-AS is predominantly localized in the nucleus and its expression is generally up-regulated in prostate cancer. CTBP1-AS promotes both hormone-dependent and castration-resistant tumor growth. Mechanistically, CTBP1-AS directly represses CTBP1 expression by recruiting the RNA-binding transcriptional repressor PSF together with histone deacetylases. CTBP1-AS also exhibits global androgen-dependent functions by in...


CTD-2108O9.1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA CTD-2108O9.1 is lower in gastric cancer tissues and cell lines. Moreover, the transwell assay shows that the number of cells capable of passing through the matrigel is significantly reduced after CTD-2108O9.1 transfection. However, CTD-2108O9.1 overexpression does not significantly influence cell proliferation and cell cycle progression. Lastly, western blot and real-time PCR analysis suggests that CTD-2108O9.1 is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level.


CTD903

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA CTD903 expression is up-regulated in colorectal cancer tissues. The higher CTD903 group shows more percentages of colon cancers comparing with rectum cancers, less mucinous tumors, and smaller tumor size. CTD903 high expression group has a significantly longer recurrence-free survival (RFS). Overexpression of CTD903 impairs cell invasion, migration and proliferation. CTD903 represses Wnt/β-catenin signaling and inhibits EMT-associated transcription factors twist and snail expression.


DACOR1

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA DACOR1 is down-regulated in colon cancer cells and DACOR1 induction appears to enhance DNA methylation at multiple loci without affecting DNMT1 protein level. Moreover, expression of DACOR1 leads to higher level of epithelial markers tight junction protein 1 (TJP1) protein, but not E-Cadherin. Besides, DACOR1 induction reduces the clonogenic potential of colon cancer cells.


DANCR

alias symbols:

tissues colorectum,liver,prostate,

cancer type colorectal cancer,hepatic cancer,prostate cancer,

LncRNA DANCR is up-regulated in colorectal cancer, hepatic cancer (HCC) and prostate cancer. Experiments show that DANCR markedly increases stemness features of HCC cells to promote tumorigenesis and intra-/extrahepatic tumor colonization. Conversely, DANCR knockdown attenuates the stem-cell properties and in-vivo interference with DANCR action leads to decreased tumor cell vitality, tumor shrinkage, and improved mouse survival. Additionally, DANCR relies largely on an association with CTNNB1. Besides, DANCR promotes prostate cancer invasion and metastasis through repressing the expression ...


DBH-AS1

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA DBH-AS1 is up-regulated in hepatocellular carcinoma (HCC) and high DBH-AS1 levels are positively correlated with tumor size and HBsAg. DBH-AS1 promotes HCC cell proliferation and tumor growth. DBH-AS1 also induces cell-cycle progression in HCC cells. Overexpression of DBH-AS1 in HepG2 cells elevates the expression of oncogenic cell-cycle regulators including CDK6, CCND1, CCNE1, but reduces the expression of cyclin-dependent protein kinase inhibitors including p16, p21, p27. Moreover, DBH-AS1 inhibits serum starvation-induced apoptosis of HCC cells. At the molecular level, DBH-AS1 act...


DILC

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA DILC is a non-coding transcript of protein coding gene DILC. It is down-regulated in liver cancer stem cells (LCSCs) and associated with poor prognosis. Lnc-DILC knockdown cells show elevated expression of LCSC markers and stemness-associated transcription factors, increased population of EpCAM+ or CD24+ cells and enhanced spheroid formation. In addition, lnc-DILC depletion facilitates hepatoma initiation and progression. These results indicate lnc-DILC could suppress LCSC expansion. Besides, lnc-DILC knockdown increases IL-6 autocrine signaling, and thus enhances the activation of I...


DLEU2

alias symbols:

tissues bone marrow,

cancer type chronic lymphocytic leukemia,

LncRNA DLEU2 is lost in CLL 13q14.3 deletion cases. Mature miR-15a/miR-16-1 are produced in a drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1. In addition, DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way.


DLX6-AS1

alias symbols:

tissues lung,

cancer type lung adenocarcinoma,

LncRNA DLX6-AS1 is significantly higher in lung adenocarcinoma (LAC) tissues compared to paired adjacent normal lung tissues. In addition, its expression level is correlated with both histological differentiation and TNM stage. Moreover, both mRNA and protein level of DLX6 are positively correlated with DLX6-AS1.


DQ786227

alias symbols:

tissues lung,

cancer type lung cancer,

The role of lncRNA DQ786227 in transformed human bronchial epithelial cells induced by benzo(a)pyrene is investigated. The transformed cell model is established using the BEAS-2B cell line, the study finds that DQ786227 is high and changed during the transformation of BEAS-2B cells. Silencing of DQ786227 expression in malignant transformed BEAS-2B cells leads to inhibition of cell proliferation and colony formation, and increased apoptosis. Moreover, DQ786227 dramatically promotes the ability of BEAS-2B-T cells to form colonies in vitro and develop tumors in nude mice.


DQ786243

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA DQ786243 is significantly up-regulated in the colorectal cancer (CRC) tissues. DQ786243 can promote CRC cell proliferation, migration and invasion, and inhibit apoptosis. Mechanistically, DQ786243 promotes cell proliferation via increasing the expression of Cyclin B1, CDC2 and p-CDC2, promotes EMT via suppressing E-cadherin expression but decreasing expression of Vimentin and N-cadherin, inhibits cell apoptosis via increasing the expression of the anti-apoptotic protein Bcl-2 but decreasing the expression of the pro-apoptotic proteins caspase-9 and caspase-3 and Bax.


EBIC

alias symbols:

tissues cervix,

cancer type cervical cancer,

LncRNA EBIC is up-regulated in cervical cancer (CC). EBIC silencing impairs CC cells migration and invasion. Moreover, EBIC can bind to EZH2. Furthermore, EBIC could inhibit E-cadherin by associating with EZH2, therefore EBIC might act as a facilitator in recruiting EZH2 to the promoter region of E-cadherin. EBIC and EZH2 may be two interdependent components of the H3K27me3 process


EGFR-AS1

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA EGFR-AS1 is up-regulated in hepatocellular carcinoma tissues and correlated with portal vein thrombosis, lymph metastasis and poor prognosis. EGFR-AS1 knockdown can decrease the expression of EGFR in vitro. In addition, growth hormone receptor (GHR) can promote the expression of EGFR and EGFR-AS1. Inhibition of EGFR-AS1 impedes cell proliferation, cell migration and EMT. EGFR-AS1 can also reduce E-cadherin and increase N-cadherin.


EGOT

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA EGOT expression is lower in breast cancer compared with the adjacent noncancerous tissues, and low levels of EGOT expression are significantly correlated with larger tumor size, more lymph node metastasis and higher Ki-67 expression. Moreover, patients with low levels of EGOT expression show significantly worse prognosis for overall survival.


ENST00000515084

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA ENST00000515084 expression is predominantly cytoplasmic. The C allele of the rs12325489C>T polymorphism in the exonic regions of ENST00000515084 is associated with a significantly increased risk of breast cancer, compared with the rs12325489TT genotype. Biochemical analysis demonstrates that the C to T base change at rs12325489C>T disrupts the binding site for miRNA-370, thereby influencing the transcriptional activity of ENST00000515084 in vitro and in vivo, further affecting cell proliferation and tumor growth.


ENST00000537266

alias symbols:

tissues thyroid,

cancer type papillary thyroid cancer,

LncRNA ENST00000537266 is up-regulated in papillary thyroid carcinoma (PTC). It can promote PTC cell proliferation and motility.


EPB41L4A-AS2

alias symbols:

tissues breast,kidney,lung,

cancer type breast cancer,lung cancer,renal cancer,

LncRNA EPB41L4A-AS2 is down-regulated in breast, renal and lung cancer. Low expression is correlated with larger tumor size, higher stage and grade, ER and PR negative expression. Besides, low expression is correlated with poorer survival of the three kinds of cancers. In addition, a better overall survival is observed in TP53 wild-type breast cancer patients with high EPB41L4A-AS2 expression, while the converse is found for breast cancer patients with a TP53 mutation. Furthermore, overexpression of EPB41L4A-AS2 inhibits tumor cell proliferation.


ERICH1-AS1

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA ERICH1-AS1 is significantly up-regulated in non-small cell lung cancer samples and can be used as diagnostic marker.


EWSAT1

alias symbols:

tissues bone,

cancer type Ewing sarcoma,

LncRNA EWSAT1 is up-regulated by EWS-FLI1 in primary pediatric human mesenchymal progenitor cells (pMPCs). Inhibition of EWSAT1 expression diminishes the ability of Ewing sarcoma cell lines to proliferate, whereas EWSAT1 inhibition has no effect on other cell types tested. In addition, heterogeneous nuclear ribonucleoprotein (HNRNPK) is an RNA-binding protein that interacts with EWSAT1 and overlap in HNRNPK-repressed genes and those repressed by EWS-FLI1 and EWSAT1.


Epist

alias symbols:

tissues esophagus,

cancer type esophageal squamous cell cancer,

LncRNA Epist is down-regulated in esophageal squamous cell carcinoma (ESCC). Epist can inhibit migration and invasion, which indicates Epist functions as a tumor suppressing lncRNA in ESCC.


FAL1

alias symbols:

tissues ovary,thyroid,

cancer type ovarian cancer,thyroid cancer,

LncRNA FAL1, its copy number and expression are correlated with outcomes in ovarian cancer. FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. The oncogenic activity of FAL1 is partially attributable to its repression of p21. FAL1-specific siRNAs significantly inhibit tumor growth. Besides, FAL1 expression is increased in thyroid cancer (PTC) and high FAL1 expression increases the risk of multifocality.


FAM74A3

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA FAM74A3 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


FAS-AS1

alias symbols:

tissues bone marrow,

cancer type B-cell lymphoma,

The alternative splicing of Fas in lymphomas is tightly regulated by a long-noncoding RNA FAS-AS1. Level of FAS-AS1 correlates inversely with production of sFas, and FAS-AS1 binding to the RBM5 inhibits RBM5-mediated exon 6 skipping. EZH2 hyper-methylates the FAS-AS1 promoter and represses the FAS-AS1 expression. EZH2-mediated repression of FAS-AS1 promoter can be released by DZNeP (3-Deazaneplanocin A) or overcome by ectopic expression of FAS-AS1, both of which increase the expression level of FAS-AS1 and correspondingly decrease expression of sFas. Treatment with Bruton's tyrosine kinase ...


FENDRR

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA FENDRR expression is down-regulated in gastric cancer tissues and cell lines, and histone deacetylation is involved in the downregulation of FENDRR. Low FENDRR group shows greater invasion depth, higher tumor stage, more frequent lymphatic metastasis and shorter overall survival than the high FENDRR expression group. FENDRR exhibits an insignificant effect on gastric cancer cell proliferation, but represses gastric cancer cell migration, invasion and metastasis. Fibronectin1 is negatively regulated by FENDRR at both mRNA and protein levels. Inhibition of FENDRR contributes to the act...


FER1L4

alias symbols:

tissues colorectum,endometrium,stomach,

cancer type colorectal cancer,endometrial cancer,gastric cancer,

LncRNA FER1L4 expression shows downregulation in colon cancer, endometrial carcinoma (EC)and gastric cancer. It is positively correlated with PTEN expression in endometrial carcinoma(EC)tissues and gastric cancer. The low FER1L4 level is associated with clinicopathologic parameters in gastric cancer and colon cancer. FER1L4 can also induce cell cycle arrest and promote cell apoptosis in these three cancer cell lines. At the molecular level, FER1L4 promotes PTEN expression with an inhibition of Akt phosphorylation. Besides, miR-106a-5p suppresses FER1L4 and PTEN.


FEZF1-AS1

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA FEZF1-AS1 is up-regulated in human colorectal carcinoma (CRC) tissues. High-level expression of FEZF1-AS1 is significantly associated with T-stage, lymph node metastasis, distant metastasis and poor prognosis in patients with CRC. FEZF1-AS1 promotes CRC cell proliferation, migration and invasion. Knockdown of FEZF1-AS1 promotes G1 arrest, but does not cause apoptosis in CRC cells. In vitro, knockdown of FEZF1-AS1 inhibits tumor growth and metastasis. At the molecular level, knockdown of FEZF1-AS1 decreases the expression of FEZF1 mRNA and protein.


FGF14-AS2

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA FGF14-AS2 is significantly down-regulated in breast cancer tissue. Reduced expression of FGF14-AS2 is correlated with larger tumor size, more lymph node metastasis and advanced clinical stage. Patients with lower FGF14-AS2 expression have a worse overall survival.


FGFR3-AS1

alias symbols:

tissues bone,

cancer type osteosarcoma,

LncRNA FGFR3-AS1 is up-regulated in osteosarcoma. Increased FGFR3-AS1 expression correlates with large tumor size, advanced Enneking stage, metastasis and poor survival. In addition, FGFR3-AS1 increases FGFR3 mRNA stability and up-regulates FGFR3 expression. Functionally, FGFR3-AS1 promotes the proliferation and cell cycle progression of osteosarcoma cells. Moreover, FGFR3-AS1 promotes xenograft tumor growth of osteosarcoma cells.


FOXCUT

alias symbols:

tissues breast,esophagus,

cancer type breast cancer,esophageal squamous cell cancer,

LncRNA FOXCUT is ove-rexpressed in basal-like breast cancer (BLBC) tissue specimens and esophageal squamous cell carcinoma, and positively correlated with FOXC1 mRNA level. FOXCUT can promote proliferation and migration in these two cancer cell lines. In addition, high expression of FOXCUT is correlated with age, poor differentiation, advanced lymph node classification, metastasis and poor prognosis in esophageal squamous cell carcinoma.


FOXD2-AS1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA FOXD2-AS1 is up-regulated in gastric cancer and linked to tumor grade, overall survival.


FR0348383

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA FR0348383 is up-regulated in over 70% of prostate cancer (PCa). FR0348383 score is correlated with an increasing probability of a positive biopsy. Multivariable logistic analysis indicates FR0348383 score is an independent predictor of PCa. In addition, the FR0348383 score would save 52.0% of avoidable biopsies without missing any high-grade cancers.


FRLnc1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA FRLnc1 expression is higher and up-regulated by FOXM1 in gastric cancer cells. FRLnc1 exhibits a significant effect on gastric cancer cell migration and metastasis. Besides, FRLnc1 positively regulates two EMT genes, TGF-β1 and Twist.


FTX

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA FTX is significantly up-regulated in colorectal cancer tissues, and correlated with differentiation grade, lymph vascular invasion, clinical stage and overall survival. Functional analyses show that upregulation of long non-coding RNA FTX significantly promotes growth, migration, invasion, and increases colony formation in colorectal cancer cells.


GAPLINC

alias symbols:

tissues colorectum,stomach,

cancer type colorectal cancer,gastric cancer,

LncRNA GAPLINC is up-regulated in gastric cancer and colorectal cancer. Up regulated GAPLINC is associated with tumor size, lymph node status and survival time of gastric cancer patients, and predicts poor prognosis of colorectal cancer. GAPLINC promotes proliferation and invasion of these two cancer cells. In gastric cancer, GAPLINC regulates cell invasion by controlling CD44 expression via competing for miR211-3p, while in colorectal cancer, GAPLINC regulates cell invasion through binding to PSF and NONO.


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach,

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


GAS6-AS1

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA GAS6-AS1 is down-regulated in non-small cell lung cancer (NSCLC) tissues. Furthermore, decreased GAS6-AS1 expression is negatively correlated with lymph node metastasis, advanced tumor node metastasis stage and prognosis. Also, GAS6-AS1 level is inversely correlated with GAS6 mRNA level.


GAS8-AS1

alias symbols:

tissues thyroid,

cancer type papillary thyroid cancer,

LncRNA GAS8-AS1 is the secondary most frequently altered gene and acts as a novel tumor suppressor in papillary thyroid carcinoma (PTC). As a mutation hotspot, the c.713A>G/714T>C dinucleotide substitution is found among most patients with GAS8-AS1 mutations and associated with advanced PTC disease. Interestingly, the wild-type GAS8-AS1 (A713T714) shows consistently higher capability to inhibit cancer cell growth compared to the mutated type (G713C714).


GATA6-AS1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA GATA6-AS1 is down-regulated in gastric cancer, and its down-regulation is associated with poor survival in gastric cancer patients. Ectopic overexpression of GATA6-AS1 inhibits metastasis-related phenotypes and decreases the concentration of extracellular MMP9.


GClnc1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA GClnc1 is up-regulated and associated with tumorigenesis, tumor size, metastasis, and poor prognosis in gastric cancer. GClnc1 affects gastric cancer cell proliferation, invasiveness, and metastasis in multiple gastric cancer models. Mechanistically, GClnc1 binds WDR5 (a key component of histone methyltransferase complex) and KAT2A histone acetyltransferase, acting as a modular scaffold of WDR5 and KAT2A complexes to coordinate their localization and specify the histone modification pattern on the target genes, including SOD2, and consequently to alter gastric cancer cell biology.


GHET1

alias symbols:

tissues bladder,colorectum,stomach,

cancer type bladder cancer,colorectal cancer,gastric cancer,

LncRNA GHET1 is up-regulated in bladder cancer, colorectal cancer and gastric cancer. Increased GHET1 expression is correlated with advanced tumor status, grade and poor prognosis of bladder cancer and gastric cancer. Functionally, GHET1 promotes cell proliferation and invasion. Mechanistically, GHET1 negatively regulates p16 and p21, thus promoting cell proliferation. Moreover, GHET1 increases expression of vimentin, Snail, Slug, Twist, ZEB1 and fibronectin (mesenchymal marker) and decreases E-cadherin protein level (epithelial marker). As a consequence, EMT is promoted, and cancer cell in...


GHSROS

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA GHSROS transcribes from the antisense strand of the ghrelin receptor gene, growth hormone secretagogue receptor (GHSR). GHSROS is up-regulated in lung cancer tissues. Functionally, GHSROS stimulates cell migration but has little effect on cell proliferation.


GUCY1B2

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA GUCY1B2 is up-regulated in gastric cancer and linked to tumor grade.


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid,

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HAGLROS-201

alias symbols:

tissues thyroid,

cancer type papillary thyroid cancer,

LncRNA HAGLROS-201 is up-regulated in papillary thyroid carcinoma (PTC). It can promote PTC cell proliferation and motility.


HAR1A

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA HAR1A is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


HCG11

alias symbols:

tissues breast,prostate,

cancer type breast cancer,prostate cancer,

LncRNA HCG11 is up-regulated in breast cancer and its upregulation is associated with poor overall survival duo to the copy number alteration. However, LncRNA HCG11 is down-regulated in prostate cancer. Downregulation of HCG11 is correlated with the age, LN status, preoperative PSA level, Gleason score and BCR in prostate cancer. Moreover, downregulation of HCG11 can predict a poor prognosis in prostate cancer.


HEIH

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA HEIH is up-regulated in hepatic carcinoma (HCC) and can be an independent prognostic factor for HCC patients. Functionally, HEIH can promote cell invasion. Moreover, HEIH is up regulated by SP1 and positively correlated with PCNA. Besides, HEIH associates with EZH2 and that this association is required for the expression of EZH2-regulated target genes.


HIF1A-AS1

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA HIF1A-AS1 is significantly increased in tumor tissues or serum from non-small cell lung cancer (NSCLC) patients. Moreover, serum level of HIF1A-AS1 is significantly decreased after surgical treatment as compared to pre-operative.


HIF1A-AS2

alias symbols:

tissues bladder,stomach,

cancer type bladder cancer,gastric cancer,

LncRNA HIF1A-AS2 is up-regulated in gastric cancer (GC) and bladder cancer. Overexpression of HIF1A-AS2 is significantly associated with tumor invasion, lymph node metastasis, higher TNM stage and shorter overall survival (OS) time. Besides, HIF1A-AS2 can promote the proliferation of GC cells and promote cell proliferation, migration and inhibit cell apoptosis in bladder cancer.


HIF2PUT

alias symbols:

tissues bone,colorectum,

cancer type colorectal cancer,osteosarcoma,

LncRNA HIF2PUT is significantly correlated with HIF-2α in colorectal cancer (CRC) tissues. Knockdown of HIF2PUT blocks the HIF-2α expression and inhibits the CSC properties in CRC cell lines. HIF2PUT small interfering RNA transfection results in decreased stemness genes expression, retarded migration, impaired ability of colony and spheroid formation ability, and invasion of the cells. In osteosarcoma, HIF2PUT also functions as an inhibitor of osteosarcoma stem cells.


HMlincRNA717

alias symbols:

tissues lung,pancreas,stomach,

cancer type gastric cancer,non-small-cell lung cancer,pancreatic cancer,


HNF1A-AS1

alias symbols:

tissues esophagus,liver,lung,nasopharynx,stomach,

cancer type esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung adenocarcinoma,nasopharyngeal cancer,

LncRNA HNF1A-AS1 is up-regulated in lung adenocarcinoma tissues, nasopharyngeal carcinoma, oesophageal adenocarcinoma, hepatocellular carcinoma, and down-regulated in gastric cancer. HNF1A-AS1 expression levels are significantly associated with clinicopathological parameter. Further studies reveal that HNF1A-AS1 promotes cell proliferation and metastasis. Besides, HNF1A-AS1 can affect autophagy in hepatocellular carcinoma via negatively regulating ATG. At molecular level, HNF1A-AS1 regulates cell cycle via cyclin D1 and regulates EMT via regulating EMT markers. In addition, HNF1A-AS1 can bi...


HOST2

alias symbols:

tissues ovary,

cancer type epithelial ovarian cancer,

LncRNA HOST2 is up-regulated in epithelial ovarian cancer (EOC). Functionally, HOST2 promotes EOC cell migration, invasion and proliferation, while has no significant effect on the rate of cell apoptosis. HOST2 is a molecular sponge for let-7b and is repressed by let-7b. Moreover, HOST2 enhances the endogenous expression of metastasis-promoting genes that are targeted by let-7b.


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid,

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer,

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOTAIRM1

alias symbols:

tissues bone marrow,colorectum,

cancer type acute myelocytic leukemia,acute promyelocytic leukemia,colorectal cancer,

HOTAIRM1 is higher in acute myelocytic leukemia (AML), granulocytic, lower in colorectal cancer. Its expression level is associated with prognosis. It can regulate cancer cell proliferation. Moreover, it is regulated by PU.1.


HOTTIP

alias symbols:

tissues bone,colorectum,liver,lung,others,pancreas,prostate,stomach,

cancer type colorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer,

HOTTIP is higher in tongue squamous cell carcinoma,non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer(CRC), pancreatic cancer and osteosarcoma. HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis. HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, HOTTIP negatively regulates miR-125b and HOXA13, and positively regulates HOXA genes.


HOXA-AS2

alias symbols:

tissues bone marrow,stomach,

cancer type gastric cancer,promyelocytic leukemia,

LncRNA HOXA-AS2 is up-regulated in human gastric cancer (GC) tissues and promyelocytic leukemia cells. In addition, HOXA-AS2 expression is induced by IFN-γ and TNF-α in neutrophils. Overexpression of HOXA-AS2 is associated with tumor size, TNM stage and poor prognosis of GC. HOXA-AS2 promotes cell proliferation and inhibits cell apoptosis. HOXA-AS2 epigenetically silences P21, PLK3 and DDIT3 transcription by binding with EZH2.


HOXA11-AS

alias symbols:

tissues nervous system,ovary,

cancer type epithelial ovarian cancer,glioma,

HOXA11-AS acts as an oncogene in glioma and tumor suppressor gene in epithelial ovarian cancer. HOXA11-AS can regulate cancer cell proliferation, migration, invasion and apoptosis.


HOXD-AS1

alias symbols:

tissues bladder,nervous system,

cancer type bladder cancer,neuroblastoma,

LncRNA HOXD-AS1 is up-regulated in bladder cancer and neuroblastoma. HOXD-AS1 is positively correlated with tumor size, histological grade and TNM stage in bladder cancer. HOXD-AS1 can promote bladder cancer cell proliferation, migration and inhibit apoptosis. HOXD-AS1 is up-regulated by retinoic acid in SH-SY5Y neuroblastoma cell line. Besides, HOXD-AS1 expression is regulated by PI3K/Akt signaling pathway.


HULC

alias symbols:

tissues bone,bone marrow,breast,colorectum,esophagus,liver,nervous system,pancreas,stomach,

cancer type B-cell lymphoma,colorectal cancer,esophageal cancer,gastric cancer,glioma,hepatic cancer,osteosarcoma,pancreatic cancer,triple negative breast cancer,

HULC is higher in breast cancer, colorectal carcinoma, gastric cancer, liver cancer, osteosarcoma, pancreatic cancer and glioma. HULC expression level is associated with clinicopathological parameters such as staging and grading. HULC regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis, EMT. Mechanistically, HULC can bind to EZH2, CREB, IGF2BP1, CLOCK, miR-107, miR-200a-3p. Moreover, HULC negatively regulates NKD2, miR-372, miR-9, TNF-α, E-Cadherin, and positively regulates LC3-II/LC3-I, SPHK1, E2F1, Snail, ZEB1, ZO-1, pERK, pAKT, pmTOR, ESM-1, peIF4E, thereby...


IGF-IIR-AS

alias symbols:

tissues liver,

cancer type hepatic cancer,

After simultaneously transfecting both IGF-IR and LncRNA IGF-IIR-AS antisense into hepatoma cell SMMC-7721, the tumor cells show morphological and biological changes. The results reveal that IGF-IR and IGF-IIR-AS transfection can partly reverse malignant behaviors of SMMC-7721 cells.


IRAIN

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA IRAIN is increased in non-small cell lung cancer. IRAIN can promote proliferation but has no effect on cell migration and apoptosis.


JADE

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA JADE is induced after DNA damage in an ataxia-telangiectasia mutated (ATM)-dependent manner. JADE is up-regulated in human breast tumors. Knockdown of lncRNA-JADE significantly inhibits breast tumor growth. Mechanistically, JADE transcriptionally activates Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex. Consequently, lncRNA JADE induces histone H4 acetylation in the DDR.


JPH1-7

alias symbols:

tissues others,

cancer type head and neck squamous cell cancer,

LncRNA JPH1-7 levels in head and neck squamous cell carcinoma (HNSCC) is up-regulated, and associated not only with poor prognosis, methyltransferase KMT2D (MLL1) mutation and concurrent TP53 mutation and 3p deletion, but also significantly correlated to advanced tumor stage. Furthermore, higher median JPH1-7 expression is observed among HPV-negative patients and patients reporting history of smoking. Knockdown of JPH1-7 reduces the expression of EMT-promoting genes for N-cadherin and Snail, as well as anti-apoptotic gene XIAP.


KCNQ1OT1

alias symbols:

tissues liver,

cancer type hepatic cancer,

By thoroughly analyzing 510 hepatocellular carcinoma (HCC) cases and 1014 healthy controls in a Chinese population, the study identifies a novel short tandem repeat (STR) polymorphism (rs35622507) within the KCNQ1OT1 coding region and evaluates its association with HCC susceptibility. Logistic regression analysis shows that, compared with individuals carrying the homozygote 10–10 genotype, those heterozygote subjects who carry only one allele 10 have a significantly decreased risk of HCC, with the risk decreases even further in those without allele 10. Furthermore, genotype–phenotype correl...


KIAA0125

alias symbols:

tissues gallbladder,

cancer type gallbladder cancer,

LncRNA KIAA0125 is remarkably up-regulated in gallbladder (GBC). KIAA0125 can promote cell migration and invasion. Moreover, KIAA0125 can influence EMT by affecting expression of β-Catenin and Vimentin.


KRT18P55

alias symbols:

tissues stomach,

cancer type intestinal-type gastric cancer,

LncRNA KRT18P55 is up-regulated in gastric cancer (GC) cell lines and tissue samples. Additionally, increased expression of KRT18P55 is related to the progression of intestinal type. Finally, KRT18P55 shows potential diagnostic value for GC patients.


KRT7-AS

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA KRT7-AS is higher in gastric cancer and positively with KRT7 expression. KRT7-AS can control KRT7 expression at both the RNA and protein levels. In addition, by forming an RNA duplex, KRT7-AS can increase the stability of mRNA KRT7. Moreover, KRT7-AS can promote proliferation and migration of gastric cancer cells.


LA16c-313D11.11

alias symbols:

tissues endometrium,

cancer type endometrial cancer,

LncRNA LA16c-313D11.11 is down-regulated in endometrial carcinoma. Overexpression of LA16c-313D11.11 results in down-regulated expression and activity of miR-205-5p.


LCAL6

alias symbols:

tissues lung,

cancer type lung adenocarcinoma,

LncRNA LCAL6 is up-regulated in lung adenocarcinoma (LUAD) and indicates poor survival of LUAD patients. LCAL6 can promote cell proliferation. The staining of Ki67, a proliferation marker is also stronger in tumor tissues.


LEIGC

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA LEIGC is down-regulated in gastric cancer. It consists of 2659bp with two exons. LEIGC significantly inhibits cell proliferation and migration of gastric cancer cells. LEIGC enhances chemosensitivity to 5-FU in gastric cancer. Moreover, LEIGC prevents EMT of gastric cancer via regulating E-cadherin, Vimentin, Snail, Slug, Zeb and Twist.


LET

alias symbols:

tissues cervix,esophagus,gallbladder,liver,nasopharynx,stomach,

cancer type cervical cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,nasopharyngeal cancer,

LncRNA LET is lower in nasopharyngeal carcinoma, esophageal squamous cell carcinoma, gallbladder cancer, gastric cancer, hepatic carcinoma,colorectal cancer,lung squamous cell cancer, and cervical cancer. LET expression level is associated with clinicopathological parameters such as pathological grade, clinical stage, lymph node metastasis, prognosis etc.. LET regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. LET play biological functions via negatively regulating Bcl-2 and positively regulates p53, p21, caspase-3, Bax. Moreover, LET can regulate hypoxia si...


LINC00052

alias symbols:

tissues liver,

cancer type hepatic cancer,

LINC00052 is down-regulated in hepatocellular carcinoma. It can inhibit cell invasion, migration and proliferation. NTRK3 is the target gene of LINC00052. Down-expression of NTRK3 could increase cell invasion, migration and proliferation. Meanwhile, LINC00052 could regulate NTRK3 expression by forming complementary base-pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR.


LINC00115

alias symbols:

tissues lung,

cancer type lung adenocarcinoma,

LINC00115 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC00152

alias symbols:

tissues breast,kidney,liver,stomach,

cancer type breast cancer,gastric cancer,hepatic cancer,renal clear cell cancer,

LINC00152 is higher in breast cancer, gastric cancer, hepatocellular carcinoma and clear cell renal cell carcinoma. LINC00152 expression level is associated with clinicopathological parameters such as tumor size, differentiation grade, TNM stage, depth of invasion, prognosis etc.. Moreover, LINC00152 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Besides, LINC00152 can bind to EGFR and EpCAM. LINC00152 functions via negatively regulating E-cadherin, p15, p21 and positively regulating N-cadherin, Vimentin.


LINC00160

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00160 is up-regulated in breast cancer and is up-regulated by E2. Moreover, LINC00160 is direct transcriptional targets of ERα, correlated with ERα expression in clinical samples, and shows prognostic significance in relation to breast cancer survival. Besides, silencing LINC00160 would result in the reduction of proliferation.


LINC00184

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA LINC00184 is highly expressed in human hepatic carcinoma (HCC) tumors and liver cancer stem cells (CSCs). In addition, LINC00184 is required for self-renewal of liver CSCs and tumor propagation in mice. Moreover, LINC00184 associates with β-catenin and the methyltransferase EZH2, thereby promoting β-catenin methylation. Methylation suppresses the ubiquitination of β-catenin and promotes its stability, thus leading to activation of Wnt-β-catenin signaling. Accordingly, the expression of LINC00184, EZH2 and Wnt-β-catenin targets are positively correlated with cancer severity and progno...


LINC00261

alias symbols:

tissues stomach,

cancer type gastric cancer,

LINC00261 is down-regulated in gastric cancer (GC) and correlated with invasion depth, tumor stage, lymphatic metastasis and prognosis. LINC00261 exhibits an insignificant effect on GC cell proliferation, but represses GC cell migration, invasion and metastasis. LINC00261 inhibits EMT via affecting EMT markers E-cadherin, N-cadherin, Vimentin, and FN1.


LINC00265

alias symbols:

tissues lung,

cancer type lung cancer,

LINC00265 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC00310

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00310 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


LINC00312

alias symbols:

tissues nasopharynx,

cancer type nasopharyngeal cancer,

In nasopharyngeal carcinoma, one study finds LINC00312 is down regulated in cancer tissues, but another finds it up-regulated in cancer tissue. LINC00312 involves with cancer cell migration and invasion. Besides, it can act as a prognosis predictor.


LINC00323

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00323 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, their upregulation can predict recurrence.


LINC00342

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA LINC00342 is up-regulated in non-small cell lung cancer (NSCLC) and correlated with lymph node metastasis, TNM stages and poor overall survival. LINC00342 negatively correlates with PTEN, P53 and P21.


LINC00346

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00346 is up-regulated in breast cancer and its expression level is associated with poor overall survival due to the copy number alteration.


LINC00467

alias symbols:

tissues nervous system,

cancer type neuroblastoma,

N-Myc suppresses LINC00467 gene expression through directly binding to the LINC00467 gene promoter and reducing LINC00467 promoter activity. Moreover, LINC00467 reduces RD3 mRNA expression. Besides, Affymetrix microarray analysis reveals that one of genes significantly up-regulated by LINC00467 siRNA is the tumor suppressor gene DKK1. Importantly, knocking-down LINC00467 expression with siRNA in neuroblastoma cells reduces the number of viable cells and increases the percentage of apoptotic cells, while co-transfection with DKK1 siRNA would block the effects.


LINC00472

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00472 is a tumor suppressor gene in breast cancer. It can inhibit cell proliferation and migration.


LINC00473

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LINC00473 is consistently the most highly induced gene in LKB1-inactivated human primary non-small cell lung cancer (NSCLC) samples and derived cell lines. Elevated LINC00473 expression correlates with poor prognosis, and the sustained LINC00473 expression is required for the growth and survival of LKB1-inactivated NSCLC cells. Mechanistically, LINC00473 is induced by LKB1 inactivation and subsequent cyclic AMP-responsive element-binding protein (CREB)/CREB-regulated transcription coactivator (CRTC) activation.


LINC00574

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00574 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


LINC00617

alias symbols:

tissues breast,

cancer type breast cancer,

Linc00617 is up-regulated in breast cancer tissues and associated tumor grade, lymph node metastasis and overall survival. Linc00617 promotes motility and invasion of breast cancer cells. Linc00617 can also influence EMT via affecting epithelial marker E-cadherin, N-cadherin and vimentin. Besides, ectopic expression of linc00617 can increase the binding of hnRNP-K at the promoter region of stemness factor Sox2.


LINC00628

alias symbols:

tissues stomach,

cancer type gastric cancer,

LINC00628 is down-regulated in gastric cancer (GC) and functions as a GC suppressor through suppressing proliferation, migration and colony formation of cancer cells. Furthermore, LINC00628 can also suppress the tumor size in mouse xenograft models. Mechanistically, although LINC00628 can negatively modulate LRRN2 expression, the GC suppressor function of LINC00628 is not LRRN2-dependent. Importantly, LINC00628 mainly locates in the nucleus and interacts with EZH2, and modulates genes expression by regulating H3K27me3 level.


LINC00629

alias symbols:

tissues others,

cancer type choriocarcinoma,

LINC00629 is long inter-genic non-coding RNAs mapped on chromosome X (Xq26), and highly expressed in reproductive tissues. Moreover, LINC00629 expression can be indirectly regulated by methylation. Besides, LINC00629 is evenly spread in JEG-3 choriocarcinoma cell line. In addition, LINC00629 can inhibit migration and invasion in JEG-3 choriocarcinoma cell line.


LINC00654

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00654 is up-regulated in breast cancer and its expression level is associated with poor overall survival due to the copy number alteration.


LINC00657

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00657 is up-regulated in breast cancer. Its upregulation is associated with poor overall survival due to the copy number alteration. LINC00657 knockout significantly suppresses tumor cell growth and proliferation, suggesting that it plays an oncogenic role.


LINC00668

alias symbols:

tissues stomach,

cancer type gastric cancer,

LINC00668 is up-regulated in human gastric cancer tissues, and correlates with advanced invasion depth, TNM stage and poor prognosis. E2F1 can activate LINC00668 by directly binding to the LINC00668 promoter, with a positive correlation with the expression of LINC00668. Cell functional experiments show that LINC00668 can promote gastric cancer cell proliferation and accelerate cell cycle by binding to PRC2. Moreover, knockdown of LINC00668 can increase the expression of CKIs p15, p16, p21, p27 and p57.


LINC00673

alias symbols:

tissues lung,others,pancreas,

cancer type melanoma,non-small-cell lung cancer,pancreatic cancer,

LINC00673 expression is up-regulated in non-small cell lung cancer (NSCLC) tissues and associated with larger tumors, lymph node metastasis, more advanced tumors and prognosis. LINC00673 is localized in both the nucleus and cytosol. LINC00673 promotes NSCLC cell proliferation through regulating CDK6 expression. Moreover, LINC00673 silences NCALD transcription by binding with Histone demethylase lysine specific demethylase 1 (LSD1). In melanoma, LINC00673 is also up-regulated and associated with survival outcome. It can increase melanoma invasion. Further studies find that AR and Brn3a bind ...


LINC00675

alias symbols:

tissues pancreas,

cancer type pancreatic ductal adenocarcinoma,

Linc00675 is up-regulated in human pancreatic ductal adenocarcinoma (PDAC) cell lines and cancerous tissues, and significantly associated with lymph node metastasis, perineural invasion and overall survival. Besides, Linc00675 is a potential biomarker for predicting recurrence in PDAC patients. Cell functional experiments show that Linc00675 regulates proliferation of pancreatic cancer cells via negatively regulating Cyclin E and Cyclin A and positively regulating Cyclin D1 and CDK2. Moreover, Linc00675 regulates invasion ability and expression of epithelial-mesenchymal transition-related g...


LINC00704

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00704 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its u-regulation can predict recurrence.


LINC00705

alias symbols:

tissues breast,

cancer type breast cancer,

LINC00705 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its up-regulation can predict recurrence.


LINC00857

alias symbols:

tissues lung,

cancer type lung cancer,

LINC00857 is overexpressed in lung adenocarcinoma, and predicts poor patient survival. LINC00857 promotes cancer cell proliferation and invasion. Besides, LINC00857 regulates cell cycle at the G1/S phase, potentially through CCNE1 and CDK2 regulation..


LINC00963

alias symbols:

tissues prostate,

cancer type prostate cancer,

LINC00963 is up-regulated in prostate cancer. Knockdown of LINC00963 attenuates cell proliferation, motility, invasion ability, the expression of EGFR and phosphorylation levels of AKT, and promotes cell apoptosis. In addition, LINC00963 is involved in the prostate cancer transition from androgen-dependent to androgen-independent and metastasis via the EGFR signaling pathway.


LINC00974

alias symbols:

tissues liver,

cancer type hepatic cancer,

LINC00974 is up-regulated with positively correlation with KRT19 (an lncRNA beyond the Flank10kb class with protein) in hepatic carcinoma (HCC). Both LINC00974 and KRT19 expression are significantly correlated with decreased tumor differentiation grade, increased tumor size, and metastasis. LINC00974 promotes cell proliferation and invasion. Besides, LINC00974 induces an inhibition of tumor growth and metastasis. Mechanistically, LINC00974 affects KRT19 expression by acting as a competing endogenous RNA (ceRNA) to interact with miR-642. In addition, NOTCH and TGF-β signal pathways are promo...


LINC00982

alias symbols:

tissues kidney,stomach,

cancer type gastric cancer,renal clear cell cancer,

The LINC00982 expression level is lower in gastric cancer tissues and correlated with invasion depth, TNM stage, regional lymph nodes metastasis and prognosis. LINC00982 exhibits significant effect on gastric cancer proliferation and cell cycle progression by positively regulating P15 and P16 at both mRNA and protein levels. While in clear cell renal cell carcinoma (ccRCC), LINC00982 is decreased and associated with poor prognosis. Moreover, high expression of LINC00982 is associated with a decreased risk of cancer-related death in univariate regression analysis, but LINC00982 could not pre...


LINC00993

alias symbols:

tissues breast,

cancer type triple negative breast cancer,

LINC00993 is higher in triple negative breast cancer and associated with the expression levels of ANKRD30A. Furthermore, the expression of LINC00993 is also associated with the expression of the estrogen receptor.


LINC01001

alias symbols:

tissues lung,

cancer type lung cancer,

LINC01001 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC01002

alias symbols:

tissues lung,

cancer type lung cancer,

LINC01002 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC01016

alias symbols:

tissues breast,

cancer type breast cancer,

LINC01016 is up-regulated in breast cancer and is up-regulated by E2. In addition, LINC01016 is direct transcriptional targets of ERα, correlated with ERα expression in clinical samples, and shows prognostic significance in relation to breast cancer survival.


LINC01133

alias symbols:

tissues colorectum,lung,

cancer type colorectal cancer,lung squamous cell cancer,non-small-cell lung cancer,

LINC01133 is down-regulated in colorectal cancer (CRC). LINC01133 is down-regulated by TGF-β, which could inhibit epithelial–mesenchymal transition (EMT) and metastasis in CRC cells. An alternative splicing factor SRSF6 is identified to directly interact with LINC01133, which promotes EMT and metastasis in CRC cells independent of LINC01133. LINC01133 expression is positively correlated with E-cadherin, and negatively correlated with Vimentin. Moreover, low LINC01133 expression is associated with poor survival in CRC samples. While in lung cancer, LINC01133 is up-regulated and associated wi...


LINC01207

alias symbols:

tissues lung,

cancer type lung adenocarcinoma,

LINC01207 is up-regulated in lung adenocarcinoma (LAD) but no significant difference is observed in lung squamous cell cancer (LSCC). The expression level of LINC01207 is associated with TNM stage and survival time. LINC01207 can promote cell proliferation and inhibit apoptosis. Further study finds that LINC01207 inhibits apoptosis by binding to EZH2 and mediating H3K27-me3 at the promoter region of Bad.


LINC01225

alias symbols:

tissues liver,

cancer type hepatic cancer,

LINC01225 is up-regulated in hepatocellular carcinoma (HCC). High LINC01225 expression is significantly associated with tumor size, tumor differentiation grade, tumor capsular integrity, tumor TNM stage, metastasis and prognosis. LINC01225 promotes proliferation and invasion of HCC cells. Mechanism study finds LINC01225 can promote HCC growth and invasion via EGFR/MAPK pathway. More specifically, that LINC01225 could bind to EGFR, thereby increasing the protein level of EGFR.


LINC01852

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LINC01852 is greatly down-regulated in cancer tissues, and correlated with tumor diameter, lymph node metastasis and TNM stage. LINC01852 overexpression suppresses the proliferation, migration and ENT in non-small cell lung cancer (NSCLC) cell lines. Further studies find that P21 protein level is increased with LINC01852 overexpression. Moreover, LINC01852 overexpressing results in a marked increase in the E-cadherin protein level and a significantly decrease in expression of N-cadherin and vimentin.


LINP1

alias symbols:

tissues breast,

cancer type triple negative breast cancer,

LncRNA LINP1 expression is highly expressed in triple-negative breast cancer (TNBC) cell lines and distributes in both nuclear and cytoplasmic fractions of cells. Moreover, LINP1 expression is positively correlated with the RNA expression of EGFR and CDKN2A, and negatively correlated with RB1. Besides, the expression of LINP1 is significantly higher in those with TP53 mutations than with wild type (WT) TP53. In addition, LINP1 expression is activated by the EGF signaling pathway and repressed by the p53 signaling pathway. Further studies reveal that LINP1 associates with proteins in the NHE...


LOC100128164

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA LOC100128164 is down-regulated in gastric cancer and linked to tumor grade.


LOC100130476

alias symbols:

tissues esophagus,stomach,

cancer type esophageal squamous cell cancer,gastric cardia adenocarcinoma,

LOC100130476 is down-regulated in esophageal squamous cell carcinoma (ESCC) and gastric cancer. Its downregulation at least partly results from hypermethylation of CpG sites in exon 1 and its hypermethylation may have prognostic implication. Besides, it is involved with clinicopathological features.


LOC100190940

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA LOC100190940 is up-regulated in primary colorectal cancer and significantly increases cell proliferation and migration.


LOC100287225

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LOC100287225 is not only expressed in the intestinal tissue, but has also been misregulated during tumorigenesis. Moreover, the relative expression level of LOC100287225 RNA is significantly lower in tumor tissues compared with adjacent tumor-free tissues. The RNA expression level of LOC100287225 does not show significant correlation with clinical characteristics.


LOC100506178

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA LOC100506178 is significantly up-regulated in colorectal cancer and correlated with poor overall survival of the patients.


LOC100507661

alias symbols:

tissues thyroid,

cancer type thyroid cancer,

LOC100507661 is strongly up-regulated in thyroid cancer tissues relative to paired contralateral normal tissue. Moreover, LOC100507661 is easily detectable in papillary and anaplastic thyroid cancer cell lines, but not in the follicular thyroid cancer cell line. Stable overexpression of LOC100507661 promotes cell proliferation, migration, and invasion of thyroid cancer cells. In addition, Lymph node metastasis and BRAF V600E mutations are more frequent in papillary thyroid cancers with high LOC100507661 expression.


LOC105378009

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA LOC105378009 and serum and glucocorticoid-inducible kinase 1 (SGK1) are elevated in T cell either within the gastric cancer tissues or peripheral T cells, and associated with Helicobacter pylori infection and high-salt diet (HSD). Within T cells, Helicobacter pylori (Hp) infection and high-salt diet can up-regulated SGK1 expression, which in turn enhances the expression of LOC105378009 through JunB activation. Expression of LOC105378009 can further enhance transcription of SGK1 through cis-regulatory mode. Moreover, LOC105378009 can induce Th2 and Th17, whilereduce Th1 differentiatio...


LOC389641

alias symbols:

tissues pancreas,

cancer type pancreatic ductal adenocarcinoma,

LncRNA LOC389641 is increased in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines. LOC389641 is significantly associated with TNM stage and lymph node metastasis and also an independent factor for the prognosis of PDAC individual. LOC389641 increases proliferation, migration and invasion, but inhibits apoptosis of PDAC cells. LOC389641 is positively correlated with Ki67, thus promotes cell proliferation. Moreover, LOC389641 increases tumor invasion by regulating EMT-related epithelial marker E-cadherin and the mesenchymal markers vimentin and snail. The study also finds that T...


LOC400891

alias symbols:

tissues prostate,

cancer type prostate cancer,

LOC400891 is higher in prostate cancer (PCa) tissues and cells. The patients with higher LOC400891 expression have advanced clinical features and a shorter biochemical recurrence-free survival time. Furthermore, multivariate analysis shows that the status of LOC400891 expression is an independent predictor of biochemical recurrence-free survival in PCa. Functionally, knockdown of LOC400891 could inhibit cell proliferation, migration and invasion. Mechanistically, LOC400891 is involved in the promotion of PCa cell proliferation and seems to be mediated by modulation of the PI3K-AKT-mTOR path...


LOC401317

alias symbols:

tissues nasopharynx,

cancer type nasopharyngeal cancer,

LOC401317 is the most up-regulated in nasopharyngeal carcinoma cell line (HNE2) with TP53 overexpression. Further studies indicated that LOC401317 is directly regulated by p53 and that ectopic expression of LOC401317 inhibits HNE2 cell proliferation by inducing cell cycle arrest and apoptosis. LOC401317 inhibits cell cycle progression by increasing p21 expression and decreasing cyclin D1 and cyclin E1 expression, and promotes apoptosis through the induction of poly(ADP-ribose) polymerase and caspase-3 cleavage.


LOC553137

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA LOC553137 is up-regulated in gastric cancer and linked to lymphatic metastasis.


LOC572558

alias symbols:

tissues bladder,

cancer type bladder cancer,

LOC572558 expression is markedly decreased in bladder cancer tissues and bladder cancer cell lines. Moreover, ectopic expression of LOC572558 inhibits cell proliferation and motility, induces S phase arrest of the cell cycle and promotes cell apoptosis in bladder cancer cell lines. Further studies verify that overexpression of LOC572558 is associated with dephosphorylation of AKT, MDM2 and phosphorylation of p53 protein.


LOC728228

alias symbols:

tissues lung,

cancer type lung cancer,

LncRNA LOC728228 is up-regulated in the anti-benzo(a) pyrene-7,8-diol-9,10-epoxide (anti-BPDE)-transformed human bronchial epithelial cell line (16HBE-T cells) relative to its expression in control untransformed16HBE (16HBE-N) cells. LOC728228 knockdown inhibits cell proliferation, causes G0/G1-phase cell-cycle arrest, reduces cellular migration, suppresses colony formation and inhibits tumor growth in a nude mouse xenograft model. In addition, LOC728228 knockdown also suppresses cyclin D1 expression, and the depletion of cyclin D1 induces G0/G1-phase cell-cycle arrest and inhibits cell pro...


LOC728606

alias symbols:

tissues prostate,

cancer type prostate cancer,

LOC728606 is up-regulated in prostate cancer (PCa). LOC728606 is detectable in plasma samples and increases incrementally from healthy individuals to those with localized and metastatic PCa. The study identifies a LOC728606-associated expression signature (PES), which is highly PCa-specific and activated in metastatic vs. primary PCa samples. The PES is significantly associated with androgen receptor (AR) signaling. Accordingly, AR activation dramatically up-regulates LOC728606 expression in vitro and in vivo. LOC728606 silencing significantly inhibits PCa cell proliferation and triggers ca...


LSINCT5

alias symbols:

tissues breast,ovary,stomach,

cancer type breast cancer,gastric cancer,ovarian cancer,

LSINCT5 is over-expressed in breast cancer, ovarian cancer gastric cancer and promotes cell proliferation.


LUADT1

alias symbols:

tissues lung,

cancer type lung adenocarcinoma,

LncRNA LUADT1 is up-regulated in lung adenocarcinoma (LUAD), and correlated with the tumor stage, but not with N stage or TNM stage. LUADT1 promotes cell proliferation via regulating cyclin D1, cyclin-dependent kinase 4 (CDK4), cyclin-dependent kinase 6 (CDK6) and Ki67. In addition, LUADT1 binds to SUZ12 and epigenetically inhibits p27 expression by mediating H3K27 trimethylation at the promoter region of p27.


LUCAT1

alias symbols:

tissues lung,

cancer type lung cancer,non-small-cell lung cancer,

LncRNA LUCAT1 can be induced by cigarette smoke extract (CSE) both in vitro and in vivo and is elevated in numerous lung cancer cell lines. It is located in chromosome 5 with four exons and three introns. The expression of LUCAT1 is regulated transcriptionally by nuclear factor erythroid 2-related factor (NRF2). A nuclear factor erythroid-derived 2 (NF-E2) motif is identified in the promoter region that shows binding to NRF2 after its activation. Functionally, the siRNA knockdown of LUCAT1 in human bronchial epithelial cells shows a significant potentiation of cytotoxicity induced by CSE in...


LUNAR1

alias symbols:

tissues bone marrow,

cancer type diffuse large B cell lymphoma,

LncRNA LUNAR1 is down regulated in diffuse large B-cell lymphoma. It can inhibit cell proliferation via regulating E2F1, cyclin D1 and p21


Linc-ITGB1

alias symbols:

tissues breast,gallbladder,

cancer type breast cancer,gallbladder cancer,

LncRNA linc-ITGB1 is higher in breast cancer and gallbladder cancer. It regulates cancer cell proliferation, migration and invasion via regulating Cdc25C, Cyclin B1, E-cadherin, N-cadherin, vimentin and Snail.


Llme23

alias symbols:

tissues others,

cancer type melanoma,

LncRNA Llme23 is exclusively detected in human melanoma lines. It is found to bind immobilized PSF resin. Knocking down Llme23 remarkably suppresses the malignant property of YUSAC cells, accompanied by the repressed expression of proto-oncogene Rab23.


Lnc-CC3

alias symbols:

tissues cervix,

cancer type cervical cancer,

LncRNA CC3 is up-regulated in cervical cancer and higher in stage III specimens compared to the other stages. Lnc-CC3 can promote cell migration and invasion. Moreover, it can affect EMT via increasing slug expression and reducing the expression of the epithelial cell marker E-cadherin.


Lnc34a

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA Lnc34a is enriched in colon cancer stem cells (CCSCs) and initiates asymmetric division by directly targeting the microRNA miR-34a to cause its spatial imbalance. Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent of its upstream regulator, p53. Lnc34a level affects CCSC self-renewal and colorectal cancer (CRC) growth in xenograft models. Moreover, Lnc34a is up-regulated in late-stage CRCs, contributing to epigenetic miR-34a silencing and CRC proliferation.


LncRNA67

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA67 shows elevated expression in breast cancer. LncRNA67 increases the growth of MCF-7 cells. In addition, the study finds LncRNA67 may be important for estrogen-stimulated growth.


MA-LINC1

alias symbols:

tissues breast,lung,

cancer type breast cancer,lung cancer,


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer,

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MDC1-AS

alias symbols:

tissues bladder,nervous system,

cancer type bladder cancer,glioma,

LncRNA MDC1-AS is up-regulated in bladder cancer and glioma and positively associated with MDC1. It has a role on cell proliferation.


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid,

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer,

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MFI2-AS

alias symbols:

tissues bone,

cancer type osteosarcoma,

LncRNA MFI2-AS is significantly overexpressed in human osteosarcoma tissues. Knockdown of lncRNA MFI2-AS expression suppresses cell proliferation, migration and invasion, and induces cell apoptosis. Furthermore, the expression of forkhead box P4 (FOXP4) is significantly increased and it is positively associated with MFI2-AS expression in tumor tissues. In addition, knockdown of FOXP4 expression by RNA interference strategy inhibits osteosarcoma cell proliferation, migration and invasion, and promotes cell apoptosis.


MINCR

alias symbols:

tissues bone marrow,gallbladder,

cancer type Burkitt lymphoma,gallbladder cancer,

LncRNA MINCR has the highest and most significant positively correlated with MYC expression level. It has the MYC binding regions around its transcriptional start site (TSS) in burkitt lymphoma (BL) cells and P493-6 cells, with increasing peak intensity in MYC high conditions in P493-6 cells. Moreover, MINCR has all of the marks associated with open chromatin and active transcription in normal and malignant B cells. Besides, the expression of MINCR is reduced after MYC knockdown in BL cell lines. Functionally, MINCR knockdown is associated with impairment in cell cycle progression. Differen...


MIR100HG

alias symbols:

tissues bone marrow,nervous system,

cancer type acute megakaryocytic leukemia,neuroblastoma,

LncRNA MIR100HG is higher in acute megakaryocytic leukemia (AMKL), lower in neuroblastoma. It can regulate cancer cell proliferation.


MIR31HG

alias symbols:

tissues bladder,breast,colorectum,stomach,

cancer type bladder cancer,breast cancer,colorectal cancer,gastric cancer,triple negative breast cancer,

LncRNA MIR31HG is higher in breast cancer, lower in colorectal cancer, triple negative reast Cancer, bladder cancer, and gastric cancer. It can regulate cancer cell proliferation, migration, invasion and apoptosis. Mechanistically, it can regulate E2F1 and p21.


MIR4697HG

alias symbols:

tissues lung,

cancer type lung cancer,

LncRNA MIR4697HG is up-regulated in lung adenocarcinoma and significantly associated with clinical features. MIR4697HG is expressed at higher levels in the relapsed patients.


MIR503HG

alias symbols:

tissues others,

cancer type choriocarcinoma,

LncRNA MIR503HG is long inter-genic non-coding RNAs mapped on chromosome X (Xq26) and highly expressed in reproductive tissues. Its expression can be indirectly regulated by methylation. Moreover, MIR503HG is predominantly found in nucleus. Besides, MIR503HG can inhibit migration and invasion in JEG-3 choriocarcinoma cell line.


MONC

alias symbols:

tissues bone marrow,

cancer type acute megakaryocytic leukemia,

LncRNA MONC is highly expressed in acute megakaryocytic leukemia (AMKL) blasts and is mainly localized in the nucleus and its expression is correlated with the corresponding miRNA clusters. Knockdown of MONC impedes leukemic growth of AMKL cell lines. MONC interferes with hematopoietic lineage decisions and enhances the proliferation of immature erythroid progenitor cells.


MRUL

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA MRUL, locates 400 kb downstream of ABCB1 (ATP-binding cassette, subfamily B, member 1), is significantly up-regulated in two multidrug-resistant gastric cancer (GC) cell sublines, SGC7901/ADR and SGC7901/VCR. Furthermore, the relative expression level of MRUL in GC tissues is negatively correlated with growth inhibition rates of GC specimens treated with chemotherapeutic drugs and indicates a poor prognosis for GC patients. MRUL knockdown in SGC7901/ADR and SGC7901/VCR cells leads to increased rates of apoptosis, increased accumulation, and reduced doxorubicin (Adriamycin [ADR]) rele...


MT1DP

alias symbols:

tissues liver,

cancer type hepatic cancer,


MVIH

alias symbols:

tissues breast,liver,lung,

cancer type breast cancer,hepatic cancer,non-small-cell lung cancer,

LncRNA MVIH is up-regulated in breast cancer, non-small cell lung cancer (NSCLC) and hepatocellular carcinoma and high MVIH expression is correlated with Ki67 expression. Moreover, patients with high MVIH expression levels are associated with clinicopathologic parameters. In addition, up-regulated MVIH expression promotes cell proliferation, cell cycle and cell invasion, but inhibit cell apoptosis. Mechanistically, MVIH affects cell invasion via regulating the level of MMP2 and MMP9. Furthermore, MVIH could weaken the function of PGK1 in angiogenesis inhibition by reducing the secretion of ...


NALT

alias symbols:

tissues bone marrow,

cancer type T acute lymphoblastic leukemia,

LncRNA NALT is located near NOTCH1 within 100 bp away. Upregulation of NALT is associated with NOTCH1 in human pediatric T cell acute lymphoblastic leukemia (T ALL) samples. Increased expression of NALT dramatically promotes cell proliferation in cell lines. Further xenograft tumor also indicates the growth inducing affection of NALT while could be partial reversed by gamma-secretase inhibitors (GSI). Besides, through sorting the side-population cells in T ALL cells treated with NALT shRNA could decrease the percentage of side population (SP) cell which companied by the down-regulation of N...


NAMA

alias symbols:

tissues thyroid,

cancer type papillary thyroid cancer,

LncRNA NAMA is weakly expressed in several human tissues, and the spliced forms are primarily detected in testis. It is inducible by inhibition of the MAP kinase pathway, growth arrest and DNA damage. Besides, the attenuated BRAF signal results in induction of NAMA.


NBAT1

alias symbols:

tissues breast,kidney,nervous system,

cancer type breast cancer,neuroblastoma,renal clear cell cancer,

LncRNA NBAT1 is down-regulated in breast cancer and associated with tumor metastasis and poor patient prognosis. NBAT1 can inhibit migration and invasion of breast cancer cells. Mechanistic study shows that NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. Among them, DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2-dependent manner, and responsible for NBAT1's effects on inhibiting migration and invasion of breast cancer cells. While in neuroblastoma, CpG methylation and a high-risk neuroblastoma associated ...


NEAT1

alias symbols:

tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach,

cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,

LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...


NFYC-AS1

alias symbols:

tissues lung,

cancer type lung cancer,

LncRNA NFYC-AS1 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


NKILA

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA NKILA (NF-KappaB Interacting LncRNA) is decreased and associated with breast cancer metastasis and poor patient prognosis. Mechanism studies show that NKILA is up-regulated by NF-κB, binds to NF-κB/IκB, and directly masks phosphorylation motifs of IκB, thereby inhibiting IKK-induced IκB phosphorylation and NF-κB activation. NKILA interacts with NF-κB/IκB to form a stable complex. Importantly, NKILA is essential to prevent over-activation of NF-κB pathway in inflammation-stimulated breast epithelial cells.


NONHSAT037832

alias symbols:

tissues thyroid,

cancer type thyroid cancer,

LncRNA NONHSAT037832 is significantly decreased in thyroid cancer (PTC) tissues and PTC cell lines. Down-regulated NONHSAT037832 is significantly associated with lymph node metastasis and tumor size. Moreover, NONHSAT037832 has diagnostic value.


NONHSAT123350

alias symbols:

tissues kidney,

cancer type renal clear cell cancer,

LncRNA NONHSAT123350 is down-regulated renal clear cell carcinoma (RCCC) and is involved in the pathogenesis of RCCC. Its expression level is closely related to disease-free survival (DFS) and overall survival (OS) in patients without distant metastasis.


NR_002809

alias symbols:

tissues nervous system,

cancer type astrocytoma,

LncRNA NR_002809 is up-regulated in astrocytoma and associated with advanced clinical stages and poor patient survival.


NR_036575.1

alias symbols:

tissues thyroid,

cancer type thyroid cancer,

LncRNA NR_036575.1 is a ncRNA transcript of PDE4C. LncRNA NR_036575.1 is over-expressed in papillary thyroid cancer (PTC) tissues and TPC1 cells. Up-regulated NR_036575.1 is associated with tumor size and extrathyroidal extension in PTC. In addition, NR_036575.1 promotes cell proliferation and migration.


NUTF2P3-001

alias symbols:

tissues pancreas,

cancer type pancreatic cancer,

LncRNA NUTF2P3-001 is over-expressed in pancreatic cancer and chronic pancreatitis tissues, which positively correlates with tumor size, tumor differentiation, TNM stage, lymphatic invasion, distant metastasis and survival time of patients. Knockdown of lncRNA-NUTF2P3-001 inhibits viability, proliferation and invasion in pancreatic cancer cell, accompanying with decreased KRAS expression. Mechanism studies show that NUTF2P3-001 regulates KRAS expression through competitively binding with miR-3923. Moreover, NUTF2P3-001 is transcriptionally up-regulated by HIF-1α in hypoxia.


ODRUL

alias symbols:

tissues bone,

cancer type osteosarcoma,

LncRNA ODRUL is the most increasingly expressed in the doxorubicin-resistant osteosarcoma (OS) cell line. Moreover, ODRUL is higher in different doxorubicin-resistant OS cell lines and lower in different doxorubicin-sensitive OS cell lines. In addition, ODRUL is increased in specimens of OS patients with a poor chemoresponse and lung metastasis. Furthermore, ODRUL inhibition could inhibit OS cell proliferation, migration, and partly reverse doxorubicin resistance in vitro. Besides, the expression of classical drug resistance-related ATP-binding cassette, subfamily B, member 1 (ABCB1) gene i...


OR3A4

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA OR3A4 is up-regulated in gastric cancer tissues, and significantly associated with metastasis. Enhanced OR3A4 expression in gastric cancer cells promotes cell migration and invasion. Moreover, enhanced OR3A4 expression in gastric cancer cells promotes tubule formation in human umbilical vein endothelial cells (HUVECs), thus promoting vasculogenic mimicrybin and angiogenesis of gastric cancer. Mechanism studies show that OR3A4 promotes tumorigenicity and peritoneal spreading of gastric cancer involves PDLIM2 downregulation.


P2RX7-V3

alias symbols:

tissues others,

cancer type uveal melanoma,

LncRNA P2RX7-V3 (P2RX7 variant 3) is a transcriptional variant transcribed from the P2RX7 gene locus, which is expressed at a high level in uveal melanoma (UM) cells. P2RX7-V3 silencing reveals that this variant acts as a necessary UM oncoRNA. Knockdown of P2RX7-V3 expression significantly suppresses tumor growth and cancer cell migration. Moreover, knockdown of P2RX7-V3 leads to decreased vimentin and increased E-cadherin. Besides, a genome-wide cDNA array reveals that a variety of genes are dysregulated following P2RX7-V3 silencing.


PACER

alias symbols:

tissues bone,

cancer type osteosarcoma,

LncRNA PACER is over-expressed in osteosarcoma tissues and cell lines. PACER knockdown inhibits the proliferation and invasion of human osteosarcoma cells. Downregulation of PACER significantly suppresses the expression of COX-2, and the effects of PACER on cell proliferation and invasion are rescued by COX-2 overexpression. Furthermore, COX-2 activation by PACER is NF-κB-dependent. Besides, the regulation of PACER by CCCTC-binding factor (CTCF) is associated with DNA methylation status.


PANDAR

alias symbols:

tissues bladder,breast,liver,lung,stomach,

cancer type bladder cancer,breast cancer,gastric cancer,hepatic cancer,non-small-cell lung cancer,

LncRNA PANDAR is higher in breast cancer, gastric cancer, hepatocellular carcinoma and bladder cancer, and lower in lung cancer. PANDAR expression level is associated with clinicopathological parameters such as depth of invasion lymphatic metastasis, histological grade, TNM stage and prognosis etc.. Functionally, PANDAR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, PANDAR negatively regulates p16 and Bcl-2.


PART1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA PART1 is down-regulated in gastric cancer and linked to TNM stage.


PAUPAR

alias symbols:

tissues others,

cancer type uveal melanoma,

LncRNA PAUPAR is down regulated in uveal melanoma (UM). Further studies reveal that PAUPAR acts as a necessary UM suppressor and induces the silencing of HES1 expression, which significantly reduces tumor metastasis. Mechanistically, PAUPAR modulates HES1 expression by inhibiting histone H3K4 methylation.


PAX8-AS1

alias symbols:

tissues cervix,

cancer type cervical cancer,

LncRNA PAX8-AS1, a potential regulator of PAX8, contains specific single nucleotide polymorphisms (SNPs) that may represent expression quantitative trait loci (eQTLs) for PAX8. The study is conducted to identify the associations between two eQTLs SNPs (rs4848320 and rs1110839) and cervical cancer. The results reveal that variant allele T of rs4848320 and G of rs1110839 are associated with decreased risk of cervical cancer. Moreover, the haplotype containing variant alleles of the two SNPs significantly decreases the risk of cervical cancer compared to the most frequent haplotype.


PCA3

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA PCA3 is an antisense intronic lncRNA within a single PRUNE2 transcriptional unit. Levels of lncRNA PCA3 and PRUNE2 are inversely correlated in human prostate cancer specimens. Further studies reveal that PCA3 binds PRUNE2 pre-mRNA and regulates its expression. In addition, PCA3 functions as an oncogene in prostate cancer.


PCAT1

alias symbols:

tissues bladder,colorectum,esophagus,liver,lung,prostate,

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,non-small-cell lung cancer,prostate cancer,

LncRNA PCAT1 is higher in bladder cancer, esophageal squamous carcinoma colorectal cancer, hepatocellular carcinoma, lung cancer and prostate cancer. PCAT1 expression level is associated with clinicopathological parameters such as TNM stage, depth of tumor invasion, lymph node metastasis, prognosis etc.. Moreover, PCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, PCAT1 negatively regulates caspase-3.


PCAT29

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA PCAT29 is characterized along with its relationship to the androgen receptor. PCAT29 is suppressed by DHT and up-regulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increases proliferation and migration of prostate cancer cells, whereas PCAT29 overexpression confers the opposite effect and suppresses growth and metastases of prostate tumors. Finally, in prostate cancer patient specimens, low PCAT29 expression correlates with poor prognostic outcomes.


PCAT5

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA PCAT5 is up-regulated in prostate cancer and promotes growth, migration, and invasion of ERG-positive prostate cancer cells. Moreover, PCAT5 is under direct regulation by ERG.


PCAT6

alias symbols:

tissues lung,

cancer type lung cancer,

LncRNA PCAT6 is significantly increased in lung cancer tissues and correlates with metastasis and prognosis of lung cancer patients. PCAT6 significantly promotes cellular proliferation and metastasis, as well as inhibits early apoptosis of lung cancer cells. Molecular analysis reveals that PCAT6 regulates the expression of two pivotal cancer-related proteins, c-Myc and p53, in lung cancer cells. However, PCAT6 is not directly combined with c-Myc and p53 as confirmed by RNA immune-precipitation.


PCGEM1

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA PCGEM1 is up-regulated in prostate cancer and exhibits reciprocal regulation of miR-145. Transfection of the miR-145 expression vector and siRNA PCGEM1 inhibits tumor cell proliferation, migration, and invasion, and induces early apoptosis. Moreover, PCGEM1 is regulated by androgen receptor.


PCNA-AS1

alias symbols:

tissues liver,stomach,

cancer type gastric cancer,hepatic cancer,

PCNA-AS1, antisense to PCNA, is increased in gastric cancer tissues and associated with invasion. The expression level of PCNA-AS1 is also related with immunohistochemical biomarkers of BRCA1. While in hepatocellular carcinoma, PCNA-AS1 is significantly up-regulated in HCC and could promote tumor growth both in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability.


PEG10

alias symbols:

tissues bone marrow,esophagus,

cancer type diffuse large B cell lymphoma,esophageal cancer,

LncRNA PEG10 is higher in esophageal cancer tissues than in adjacent non-neoplastic tissues. This relatively high expression is significantly associated with the occurrence of lymph node metastases. Moreover, LncRNA PEG10 can promote proliferation and invasion, and inhibit apoptosis. While in diffuse large B cell lymphoma (DLBCL), PEG10 is up-regulated in DLBCL tumorous tissues and cell lines. Moreover, PEG10 is significantly correlated with B symptoms, IPI score, CHOP-like treatment and rituximab. In addition, PEG10 could be a diagnostic marker for distinguishing DLBCL from normal. Besides...


PICSAR

alias symbols:

tissues others,

cancer type cutaneous squamous cell carcinoma,

LncRNA PICSAR is up-regulated in cutaneous squamous cell carcinoma (cSCC) cells and is up-regulated by inhibition of p38α and p38δ mitogen-activated protein kinases. Further studies find that PICSAR is specifically expressed by tumor cells in cSCCs but not by keratinocytes in normal skin in vivo. Functionally, knockdown of PICSAR inhibits proliferation and migration of cSCC cells, and suppresses the growth of human cSCC xenografts in vivo. Furthermore, knockdown of PICSAR inhibits extracellular signal-regulated kinase 1/2 activity and up-regulates expression of dual specificity phosphatase ...


POU6F2-AS2

alias symbols:

tissues esophagus,

cancer type esophageal squamous cell cancer,

LncRNA POU6F2-AS2 is up-regulated in oesophageal squamous cell carcinoma (OSCC). Further studies reveal that POU6F2-AS2 is involved in the DNA damage response and regulates cells survival after ionizing radiation. Besides, POU6F2-AS2 interacts with Ybx1 protein and regulates its chromatin localization.


PRAL

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA PRAL, on chromosome 17p13.1, whose genomic alterations are significantly associated with reduced survival of hepatic carcinoma (HCC) patients. PRAL could inhibit HCC growth and induce apoptosis through p53. Subsequent investigations indicate that the three stem-loop motif at the 5' end of PRAL facilitates the combination of HSP90 with p53 and thus competitively inhibits MDM2-dependent p53 ubiquitination, resulting in enhanced p53 stability.


PRNCR1

alias symbols:

tissues colorectum,stomach,

cancer type colorectal cancer,gastric cancer,

LncRNA PRNCR1 is higher in colorectal cancer and regulates cancer cell proliferation. Single nucleotide polymorphisms (SNPs) in the lncRNA may influence the process of splicing and stability of mRNA conformation, resulting in altered cancer risk.


PTCSC2

alias symbols:

tissues thyroid,

cancer type thyroid cancer,

Transcripts of LncRNA PTCSC2 are down-regulated in papillary thyroid carcinoma (PTC). The risk allele [A] of rs965513 is significantly associated with low expression of unspliced PTCSC2, FOXE1, and TSHR in unaffected thyroid tissue. There exists a significant association of age and CLT with PTCSC2 unspliced transcript level. The correlation between the rs965513 genotype and the PTCSC2 unspliced transcript level remains significant after adjusting for age, gender, and CLT. Forced expression of PTCSC2 in the BCPAP cell line affects the expression of a subset of noncoding and coding transcript...


PTCSC3

alias symbols:

tissues thyroid,

cancer type papillary thyroid cancer,thyroid cancer,

LncRNA PTCSC3 expression is strongly down-regulated in thyroid tumor tissue. Its SNPs are associated with the risk of thyroid cancer. It can inhibit cell growth, migration, invasion, and affect the expression of genes involved in DNA replication, recombination and repair, cellular movement, tumor morphology and cell death.


PTENP1

alias symbols:

tissues liver,stomach,

cancer type gastric cancer,hepatic cancer,

LncRNA PTENP1 is a pseudogene of the tumor suppressor gene PTEN. PTENP1 and PTEN are down-regulated in several hepatocellular carcinoma (HCC) cells. Elevated level of PTENP1 and PTEN can suppress the oncogenic PI3K/AKT pathway, and inhibit cell proliferation, migration, invasion as well as induce autophagy and apoptosis. Over-expressed PTENP1 decoys oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62. In a word, PTENP1 can inhibit cell proliferation, elicit apoptosis and autophagy, and inhib...


PVT1

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid,

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer,

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...


PlncRNA-1

alias symbols:

tissues esophagus,liver,prostate,

cancer type esophageal squamous cell cancer,hepatic cancer,prostate cancer,

PlncRNA-1 is higher in esophageal squamous carcinoma, hepatic carcinoma and prostate cancer. Its expression level is associated with prognosis. Moreover, it can regulate cancer cell proliferation, invasion, apoptosis and EMT.


RCCRT1

alias symbols:

tissues kidney,

cancer type renal cancer,

LncRNA RCCRT1 is up-regulated remarkably in renal cell carcinoma (RCC), particularly in high-grade RCC tissues and is associated with clinicopathologic findings such as tumor size, pathologic T stage, tumor grade, lymph node metastasis, and distant metastasis. Furthermore, depletion of RCCRT1 expression suppresses migration and invasion in RCC cell lines.


RGMB-AS1

alias symbols:

tissues lung,

cancer type lung adenocarcinoma,non-small-cell lung cancer,

LncRNA RGMB-AS1 is down-regulated in lung adenocarcinoma, and inhibits cell proliferation, migration and invasion. Further studies show that RGMB-AS1 may down-regulate RGMB expression though interacting with the exon2 sequence of RGMB. However, other study finds that RGMB-AS1 expression is significantly higher in non-small cell lung cancer (NSCLC) tissues and inversely correlated with RGMB mRNA. Both RGMB-AS1 and RGMB expression level are associated with the occurrence of differentiation status, lymph node metastases and TNM stage.


RHPN1-AS

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA RHPN1-AS is up-regulated in gastric cancer and linked to tumor grade.


RMEL3

alias symbols:

tissues others,

cancer type melanoma,

LncRNA RMEL3 expression is increased in melanoma and subcutaneous tumors compared to primary tumors. RMEL3 expression is also significantly increased in melanomas with a BRAFV600E mutation compared to those with a wild type BRAF or triple wild type for BRAF/RAS/NF1. Reverse phase protein array (RPPA) analysis finds that RMEL3 knockdown reduces cell cycle regulators (like pRB and Cyclin-B1) and anti-apoptotic proteins (like Bcl2), but increases p27 and some pro-apoptotic proteins as the example of caspase-8 and p38.


RMRP

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA RMRP level in tissue, plasma and gastric juices from patients with gastric cancer is significantly different from those from controls. Its level is significantly associated with Borrmann type and metastasis. RMRP in Plasma and gastric juice have higher sensitivity and specificity than commonly used markers. Knockdown of RMRP significantly inhibits cell proliferation. Moreover, RMRP is a sponge of miR-206, and modulates cell cycle by regulating Cyclin D2 expression.


RMST

alias symbols:

tissues breast,

cancer type triple negative breast cancer,

LncRNA RMST is down-regulated TNBC (triple negative breast cancer) and associated with prognosis of TNBC patients. However, the difference is not statistically significant.


RP11-119F7.4

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA RP11-119F7.4 expression is significantly down-regulated in the gastric cancer tissues and significantly associated with the macroscopic type and Lauren grade. However, no statistically significant differences are observed between RP11-119F7.4 expression and patient survival.


RP11-284N8.3.1

alias symbols:

tissues ovary,

cancer type ovarian cancer,

LncRNA RP11-284N8.3.1 is down-regulated in ovarian cancer. It could significantly divide late-stage patients into high- and low-risk groups. Moreover, RP11-284N8.3.1 expression level is associated with a decreased risk of survival. Low-risk groups always have higher expression level of RP11-284N8.3.1 than the high-risk groups. In addition, RP11-284N8.3.1 is significantly associated with patient progression-free survival. Besides, RP11-284N8.3.1 involves in immune- and cell-cycle-associated processes.


RP11-395G23.3

alias symbols:

tissues endometrium,

cancer type endometrial cancer,

LncRNA RP11-395G23.3 is down-regulated in endometrial carcinoma. Overexpression of RP11-395G23.3 results in down-regulated expression and activity of miR-205-5p.


RP11-397D12.4

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA RP11-397D12.4 is up-regulated in non-small cell lung cancer (NSCLC), and may be a potential biomarker for predicting the tumorigenesis of NSCLC.


RP11-434D9.1

alias symbols:

tissues breast,

cancer type triple negative breast cancer,

LncRNA RP11-434D9.1 is down-regulated in triple negative breast cancer (TNBC) and correlated with TNBC occurrence. Besides, it can be a potential biomarker to differentiate TNBC from non-TNBC.


RP11-445H22.4

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA RP11-445H22.4 is significantly increased in breast cancer. Its expression levels are correlated with estrogen receptor (ER), progesterone receptor (PR), and menopausal status of the breast cancer patients (p < 0.05). For the detection of breast cancer, the use of RP11-445H22.4 shows a remarkable improvement compared with the clinical serum carcinoembryonic antigen.


RP11-462C24.1

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA RP11-462C24.1 expression level is lower in colorectal cancer (CRC) tissues. Furthermore, its expression level is lower in CRC patients with metastasis than those without metastasis. In addition, low expression of RP11-462C24.1 significantly correlates with more distant metastasis. Besides, RP11-462C24.1 is an independent predictor for patients’ prognosis and low expression of RP11-462C24.1 has a poor disease-free survival.


RPL13AP23

alias symbols:

tissues pancreas,

cancer type pancreatic cancer,

RPL13AP23 expression level is remarkably decreased in pancreatic ductal adenocarcinoma (PDAC) tissues and associated with tumor node metastasis stage, lymph node metastasis and prognosis. Besides, enforced expression of RPL13AP23 suppresses PDAC cells' invasion. Moreover, overexpression of RPL13AP23 significantly increases both mRNA and protein level of OS-9. The lncRNA RPL13AP23 inhibits tumor invasion by suppressing HIF-1α expression through modulating OS-9 function.


RPLP0P2

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA RPLP0P2 is up-regulated in gastric cancer and negatively associated with overall survival.


RPS24P1

alias symbols:

tissues nasopharynx,

cancer type nasopharyngeal cancer,

RPS24P1 is down-regulated in metastatic nasopharyngeal carcinoma (NPC) and high RPS24P1 expression level is associated with disease progression among NPC patients.


RSU1P2

alias symbols:

tissues cervix,

cancer type cervical cancer,

LncRNA RSU1P2 is up-regulated in human cervical cancer tissues. RSU1P2 promotes the proliferation, cell cycle progression, invasion, migration, and EMT and reduces apoptosis. At molecular level, upregulation of RSU1P2 results in the downregulation of E-cadherin and the upregulation of vimentin and ICAM-1. Besides, RSU1P2, by binding let-7a, acts as a decoy to abolish the miRNA-repressing activity on IGF1R, N-myc and EphA4 3′UTR.


RUNXOR

alias symbols:

tissues bone marrow,

cancer type acute myelocytic leukemia,

LncRNA RUNXOR is transcribed as unspliced transcript from an upstream overlapping promoter. RUNXOR is up-regulated in acute myelocytic leukemia (AML) samples and in response to Ara-C treatment. RUNXOR utilizes its 3'-terminal fragment to directly interact with the RUNX1 promoter and enhancer, and participates in the orchestration of an intra-chromosomal loop. The 3' region of RUNXOR also participates in long-range inter-chromosomal interactions with chromatin regions that are involved in multiple RUNX1 translocations.


RoR

alias symbols: lincRNA-ST8SIA3, lincRNA-RoR, ROR

tissues breast,colorectum,liver,nasopharynx,nervous system,pancreas,

cancer type breast cancer,colorectal cancer,glioma,hepatic cancer,nasopharyngeal cancer,pancreatic cancer,triple negative breast cancer,

LncRNA ROR is higher in breast cancer(24922071), pancreatic cancer, colon cancer, nasopharyngeal carcinoma and lower in glioma. ROR expression level is associated with clinicopathological parameters such as tumor size, prognosis. ROR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ROR can bind to miR-145. Moreover, ROR negatively regulates E-cadherin and KLF4, while positively regulates ZEB1, ZEB2, vimentin, fibronectin, N-cadherin, and SOX11.


SAMMSON

alias symbols:

tissues others,

cancer type melanoma,

LncRNA SAMMSON is up-regulated in melanoma. SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF, NRAS or TP53 mutational status. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function.


SARCC

alias symbols:

tissues kidney,

cancer type renal cancer,

LncRNA SARCC is differentially regulated by hypoxia in a von Hippel-Lindau (VHL)-dependent manner both in renal cell carcinoma (RCC) cell culture and clinical specimens. SARCC can suppress hypoxic cell cycle progression in the VHL-mutant RCC cells while derepress it in the VHL-restored RCC cells. Mechanism dissection reveals that SARCC can post-transcriptionally regulate androgen receptor (AR) by physically binding and destablizing AR protein to suppress AR/HIF-2α/C-MYC signals. In return, HIF-2α can transcriptionally regulate the SARCC expression via binding to hypoxia-responsive elements ...


SBF2-AS1

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA SBF2-AS1 is significantly up-regulated in non-small cell lung cancer (NSCLC) and a high expression level of SBF2-AS1 is correlated with lymph node metastasis and advanced TNM stage. SBF2-AS1 promotes proliferation, migration and metastasis of NSCLC cells. At molecular level, the study finds that SBF2-AS1 controls the cell cycle by inhibiting P21 via binding to SUZ12 region of P21.


SChLAP1

alias symbols:

tissues bladder,prostate,

cancer type bladder cancer,prostate cancer,

LncRNA SChLAP1 is higher in bladder cancer and prostate cancer. SChLAP1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, SChLAP1 can bind to SWI/SNF chromatin-modifying complex and negatively regulates SNF5.


SDMGC

alias symbols:

tissues stomach,

cancer type gastric cancer,

Expression levels of LncRNA SDMGC and its target gene TRIM16 are up-regulated in the distant metastasis tissues, compared with primary gastric cancer (GC) tissues, two of which are positive correlation. SDMGC and TRIM16 can promote cell invasion and migration. However, the research finds they have little effect on proliferation, cell cycle, colony formation, and apoptosis.


SLC26A4-AS1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA SLC26A4-AS1 is down-regulated in gastric cancer and linked to tumor grade.


SMIM10L2A

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA SMIM10L2A is down-regulated in gastric cancer and positively correlated with overall survival.


SMIM10L2B

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA SMIM10L2B is down-regulated and positively correlated with overall survival.


SNHG1

alias symbols:

tissues liver,nervous system,

cancer type astrocytoma,hepatic cancer,

LncRNA SNHG1 is up-regulated in hepatocellular carcinoma (HCC) tissues and astrocytoma tissues. High SNHG1 expression is correlated with large tumor size, poor differentiation, aggressive BCLC stage, and poor prognosis. SNHG1 promotes HCC cells proliferation, cell cycle progression and inhibits HCC cells apoptosis. Further experiments reveal that SNHG1 promotes HCC cells proliferation through inhibiting p53 and p53-target genes expression.


SNHG10

alias symbols:

tissues lung,

cancer type lung cancer,

LncRNA SNHG10 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


SNHG12

alias symbols:

tissues bone,endometrium,

cancer type endometrial cancer,osteosarcoma,

SNHG12 is up-regulated in endometrial carcinoma and osteosarcoma tissues and cell lines. AMOT mRNA expression level is positively correlated with SNHG12 expression level. SNHG12 promotes cell proliferation, migration and inhibits apoptosis.


SNHG15

alias symbols:

tissues liver,stomach,

cancer type gastric cancer,hepatic cancer,

LncRNA SNHG15 is up-regulated in gastric cancer (GC) and hepatocellular carcinoma (HCC). Furthermore, increased SNHG15 expression is correlated with clinicopathologic feature and prognosis. Functionally, SNHG15 expression can promote cell proliferation and invasion and inhibit apoptosis. Mechanistically, SNHG15 promotes cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression.


SNHG20

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA SNHG20 is remarkably up-regulated in hepatocellular carcinoma (HCC) tissues. The expression of SNHG20 is associated with tumor size, clinical stage, overall survival, disease-free survival and prognosis. Functionally, SNHG20 significantly promotes cellular proliferation, migration, and invasion.


SNHG3

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA SNHG3 is significantly up-regulated in hepatocellular carcinoma (HCC) tissues, which is consistent with the results of two independent HCC cohorts from The Cancer Genome Atlas (TCGA) and Oncomine databases. Furthermore, SNHG3 expression is significantly correlated with tumor size, portal vein tumor thrombus and relapse. The high expression level of SNHG3 is markedly correlated with overall survival, recurrence-free survival and disease-free survival. Besides, multivariate analysis indicates that SNHG3 expression is an independent prognostic factor for HCC patients.


SNHG5

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA SNHG5 is significantly down-regulated in gastric cancer (GC), and significantly associated with the formation of a tumor embolus and tumor, node and metastasis (TNM) stage. Functionally, SNHG5 suppresses GC cell proliferation and metastasis. Furthermore, SNHG5 exerts its function through interacting with MTA2, preventing the translocation of MTA2 from the cytoplasm into the nucleus. SNHG5 overexpression leads to significant increase in the acetylation levels of histone H3 and p53, indicating that SNHG5 might affect acetylation by trapping MTA2 in the cytosol, thereby interfering with...


SOCS2-AS1

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA SOCS2-AS1 is higher in castration-resistant prostate cancer model cells, i.e. long-term androgen-deprived (LTAD) cells, than in parental androgen-dependent LNCaP cells. SOCS2-AS1 promotes castration-resistant and androgen-dependent cell growth. Moreover, SOCS2-AS1 knockdown up-regulates genes related to the apoptosis pathway, including tumor necrosis factor superfamily 10 (TNFSF10), and sensitizes prostate cancer cells to docetaxel treatment. Besides, SOCS2-AS1 promotes androgen signaling by modulating the epigenetic control for AR target genes including TNFSF10.


SOX2OT

alias symbols:

tissues breast,colorectum,esophagus,liver,lung,

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,lung cancer,

LncRNA SOX2OT is higher in breast cancer, lung cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma and colorectal cancer. SOX2OT expression level is negatively correlated with prognosis. SOX2OT regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, Sox2ot positively regulates EZH2, Cyclin B1, Cdc2, SOX2 and OCT4.


SPRY4-IT1

alias symbols:

tissues bladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach,

cancer type bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer,

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma, glioma, melanoma, colorectal cancer, bladder cancer(25973088), clear cell renal cell carcinoma, lower in non-small cell lung cancer (NSCLC), but has dual roles in gastric cancer. SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc.. Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, SPRY4-IT1 negatively regulates E-cadherin, ZO-1 and positively re...


SRA

alias symbols:

tissues breast,

cancer type breast cancer,

 LncRNA SRA, locates on chromosome 5q31.3 and contains five exons and four introns. It is a non-coding transcript of protein coding gene SRA1. The study evaluates the association between two haplotype tagging SNPs (htSNPs) (rs10463297, rs801460) of the whole LncRNA SRA sequence and breast cancer risk. The results show that rs10463297 TC genotype significantly increases BC risk compared with CC genotype in both the codominant and recessive genetic models. Both TC, TC + CC genotypes of rs10463297 and GA, AA, GA+AA genotypes of rs801460 are significantly associated with estrogen receptor (ER) ...


SRHC

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA SRHC is down-regulated in hepatocellular carcinoma (HCC) and a lower SRHC expression level is significantly more frequent in tissues with a high serum of a-fetoprotein level and a low degree of differentiated tumors. Furthermore, the promoter region of SRHC contains a CpG-rich island, and SRHC is down-regulated in tumors by DNA methylation.


SUMO1P3

alias symbols:

tissues bladder,stomach,

cancer type bladder cancer,gastric cancer,

LncRNA SUMO1P3 is significantly up-regulated in bladder cancer tissues and gastric cancer. Moreover, up-regulated SUMO1P3 expression is correlated with clinicopathological parameters. Furthermore, SUMO1P3 can promote cell proliferation, migration and inhibit apoptosis of bladder cancer cells.


T-ALL-R-LncR1

alias symbols:

tissues bone marrow,

cancer type T acute lymphoblastic leukemia,

LncRNA T-ALL-R-LncR1 is a non-coding transcript of protein coding gene PAWR. LncRNA T-ALL-R-LncR1 is not observed in human normal tissues, while in some tumor tissues indeed. T-ALL-R-LncR1 is markedly expressed in neoplastic T lymphocytes. T-ALL-R-LncR1 knockdown predisposes Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies reveal that T-ALL-R-LncR1 knockdown facilitates the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells.


TATDN1

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA TATDN1 is highly expressed in 95D cells and non-small cell lung cancer (NSCLC) tumor tissues compared to 95C cells. Knockdown of TATDN1-1 by shRNA significantly inhibits cell proliferation, adhesion, migration and invasion in 95D cells. Further mechanism study shows that TATDN1 knockdown suppresses the expression of E-cadherin, HER2, β-catenin and Ezrin. Moreover, knockdown of TATDN1 also inhibits tumor growth and metastasis in a 95D mouse model in vivo by inhibiting β-catenin and Ezrin.


TC0100223

alias symbols:

tissues ovary,

cancer type ovarian cancer,

LncRNA TC0100223 is downregulated in ERα+ ovarian cancer tissues and correlated with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade.


TC0101441

alias symbols:

tissues ovary,

cancer type ovarian cancer,

LncRNA TC0101441 is upregulated in ERα+ ovarian cancer tissues and correlated with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade. Furthermore, multivariate analysis indicates that TC0101441 is an independent prognostic factor for overall survival.


TC0101686

alias symbols:

tissues ovary,

cancer type ovarian cancer,

LncRNA TC0101686 is downregulated in ERα+ ovarian cancer tissues and correlated with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade.


TCF7

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA TCF7 that is highly expressed in hepatic carcinoma (HCC) tumors and liver cancer stem cells (CSCs). LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Moreover, IL-6 transcriptionally activates the expression of lncTCF7 in HCC cells by activating STAT3, a transcription activator which binds to the promoter region of lncTCF7. Furthermore, knocking-down STAT3 and inhibiting STAT3 activation reduce TCF7 expression. Important...


TCL6

alias symbols:

tissues kidney,

cancer type renal clear cell cancer,

LncRNA TCL6 is decreased in clear cell renal cell carcinoma (ccRCC). Kaplan-Meier analysis indicates that reduced expression of TCL6 is associated with pTNM stage and poor prognosis. Moreover, TCL6 expression is an independent predictor of ccRCC aggressiveness and has significant hazard ratios [HRs] for predicting clinical outcome. Overexpression of TCL6 decreases proliferation and increases apoptosis compared to controls.


TCONS_l2_00022545

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA TCONS_l2_00022545 is up-regulated in metastasis colorectal cancer and significantly increases cell proliferation and migration.


THBS4-003

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA-thrombospondin 4 (THBS4)-003 is a processed transcript, which does not encode a protein product. LncRNA THBS4-003 is located at chromosome 5p14.1 and partially overlaps with the protein-coding gene, THBS4. The expression levels of THBS4 and lncRNA-THBS4-003 are significantly higher in prostate cancer (PC) tissues. THBS4 and lncRNA-THBS4-003 significantly promote the migratory and invasive abilities of the PCa cells. Functionally, lncRNA-THBS4-003 and THBS4 regulate levels of MMP-9 through the MAPK signaling pathway.


THUMPD3-AS1

alias symbols:

tissues lung,

cancer type lung cancer,

LncRNA THUMPD3-AS1 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


TINCR

alias symbols:

tissues colorectum,esophagus,stomach,

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,

LncRNA TINCR is higher in esophageal squamous cell carcinoma, gastric cancer and lower in colorectal cancer. TINCR expression level is associated with clinicopathological parameters such as invasion, lymph metastasis, TNM stage, differentiation etc.. TINCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TINCR can bind to EpCAM and STAU1. Moreover, TINCR negatively regulates c-Myc and positively regulates CLDN7, ANXA1.


TMPO-AS1

alias symbols:

tissues lung,

cancer type lung cancer,

LncRNA TMPO-AS1 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


TP73-AS1

alias symbols:

tissues esophagus,

cancer type esophageal squamous cell cancer,

LncRNA TP73-AS1 and BDH2 levels are generally up-regulated in esophageal cancer tissues and are strongly correlated with tumor location or TNM stage in clinical samples. LncRNA TP73-AS1 knockdown inhibits BDH2 expression whereas BDH2 knockdown represses esophageal cancer cell proliferation and induces apoptosis via the caspase-3dependent apoptotic pathway. Overexpression of BDH2 in lncRNA TP73-AS1 knockdown cells partially rescues cell proliferation rates and suppresses apoptosis. In mouse xenografts, tumor size is reduced in lncRNA TP73-ASI siRNA-transfected tumors. In addition, BDH2 or ln...


TRPM2-AS

alias symbols:

tissues prostate,

cancer type prostate cancer,

TRPM2-AS is an antisense transcript of TRPM2, which encodes an oxidative stress-activated ion channel, and overexpressed in prostate cancer (PCa). The high expression of TRPM2-AS and its related gene signature are found to be linked to poor clinical outcome. Mechanistically, TRPM2-AS knockdown leads to PCa cell apoptosis. Moreover, targets of existing drugs and treatments are found to be consistently associated with high TRPM2-AS levels in both targeted cells and patients, ultimately suggesting that the measurement of expression level of TRPM2-AS allows not only for the early identification...


TSLC1-AS1

alias symbols:

tissues nervous system,

cancer type glioma,

LncRNA TSLC1-AS1 and TSLC1 are both down-regulated in glioma tissue samples. Functionally, TSLC1-AS1 inhibits cell proliferation, migration and invasion. Moreover, TSLC1-AS1 is positively correlated with TSLC1. Besides, TSLC1-AS1 is also positively correlated with other tumor suppressors NF1, VHL, PIK3R1 and negatively correlated with the oncogene BRAF.


TSPEAR-AS2

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA TSPEAR-AS2 is up-regulated in gastric cancer and linked to tumor grade.


TUBA4B

alias symbols:

tissues lung,

cancer type non-small-cell lung cancer,

LncRNA TUBA4B is lower in non-small cell lung cancer (NSCLC) tissues and cell lines. The lower expression of TUBA4B is remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. Besides, overexpression of TUBA4B inhibits cell proliferation ability.


TUC339

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA TUC339 is up-regulated in hepatic carcinoma (HCC). TUC339 is functionally implicated in modulating tumor cell growth and adhesion. Suppression of TUC339 by siRNA reduces HCC cell proliferation, clonogenic growth, and growth in soft agar. Thus, inter-cellular transfer of TUC339 represents a unique signaling mechanism by which tumor cells can promote HCC growth and spread.


TUG1

alias symbols:

tissues bladder,bone,colorectum,esophagus,kidney,liver,lung,nervous system,stomach,

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,hepatoblastoma,non-small-cell lung cancer,osteosarcoma,renal cancer,

LncRNA TUG1 is higher in esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, osteosarcoma, colorectal cancer and bladder cancer, and lower in glioma andnon-small cell lung cancer (NSCLC). TUG1 expression level is associated with clinicopathological parameters such as invasion, lymph node metastasis, TNM stage, prognosis etc.. TUG1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TUG1 can bind to SP1 and PRC2. Moreover, TUG1 negatively regulates E-cadherin, miR-144, Bcl-2, KLF2 and positively regulates N-cadhe...


TUSC7

alias symbols:

tissues bone,colorectum,lung,pancreas,stomach,

cancer type colorectal cancer,gastric cancer,non-small-cell lung cancer,osteosarcoma,pancreatic ductal adenocarcinoma,

LncRNA TUSC7 is lower in colorectal cancer, osteosarcoma, pancreatic ductal adenocarcinoma, gastric cancer and non-small cell lung cancer. TUSC7 expression level is associated with clinicopathological parameters such as tumor size, tumor stage, distant metastasis and prognosis. Functionally, TUSC7 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, TUSC7 can bind to P53 and miR-211. Mechanistically, TUSC7 negatively regulates Cyclin D1, VEGF, Bcl2, miR-23b and positively regulates cyclin A2, cyclin B1, BCL2, BimEL.


UBC1

alias symbols:

tissues bladder,stomach,

cancer type bladder cancer,gastric cancer,

LncRNA UBC1 is significantly up-regulated in gastric cancer tissues and bladder cancer. Furthermore, high UBC1 expression is associated with clinicopathological parameter such as lymph-node metastasis, tumor size, TNM stage and poorer prognosis. Functionally, UBC1 promotes proliferation, motility and invasion of gastric cancer cells. Moreover, UBC1 acts in trans and binds to PRC2 complex and suppresses its target genes in bladder cancer cell.


UCA1

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach,

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer,

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


UFC1

alias symbols:

tissues liver,

cancer type hepatic cancer,

Level of the LncRNA UFC1 is increased in hepatic carcinoma (HCC) tissues compared with controls, and associated with tumor size, barcelona clinic liver cancer stage, and patient outcomes. Transgenic expression of the UFC1 in HCC cells promotes their proliferation and cell-cycle progression and inhibits apoptosis. Moreover, UFC1 interacts directly with the messenger RNA (mRNA) to stabilize protein HuR (encoded by ELAVL1) to increase levels of β-catenin (encoded by CTNNB1) mRNA and protein. However, there is a negative correlation between level of microRNA 34a and UFC1 in HCC tissues; microRN...


UMODL1-AS1

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA UMODL1-AS1 is up-regulated in breast cancer and its up-regulation is associated with poor overall survival due to copy number alteration. Moreover, its up-regulation can predict recurrence.


UNMIBC

alias symbols:

tissues bladder,

cancer type bladder cancer,

LncRNA UNMIBC is up-regulated in the primary non-muscle invasive bladder cancer and significantly associated with recurrence. Moreover, UNMIBC has a key role in G0/G1 arrest. Furthermore, RNA and chromatin immune-precipitation assays demonstrate that UNMIBC is physically associated with EZH2 and SUZ12, leading to an altered histone H3 lysine 27 methylation status of target genes.


USMycN

alias symbols:

tissues nervous system,

cancer type neuroblastoma,

LncRNA USMycN is co-amplified with MYCN in 88 of 341 human neuroblastoma tissues. USMycN RNA binds to the RNA-binding protein Nono, leading to N-Myc RNA upregulation and neuroblastoma cell proliferation. High levels of USMycN and NonO expression in human neuroblastoma tissues independently predict poor patient prognoses. Besides, treatment with antisense oligonucleotides targeting USMycN in neuroblastoma-bearing mice statistically significantly hinders tumor progression.


Uc001lsz

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA uc001lsz is reduced in gastric cancer cell lines and tissues. It is associated with TNM stage, and dys-regulated in early cancer and precancerous lesions. Thereby, uc001lsz may be a potential marker for the diagnosis of early gastric cancer.


WT1-AS

alias symbols:

tissues kidney,liver,stomach,

cancer type Wilms' tumour,gastric cancer,hepatic cancer,

LncRNA WT1-AS expression is significantly down-regulated in gastric cancer, hepatocellular carcinoma and Wilms' tumor. It is associated with tumor size and the clinicopathological stage. Functionally, it can inhibit cell proliferation, migration, and invasion. Furthermore, ectopic expression of WT1-AS can inhibit tumor growth and metastasis in vivo. Moreover, WT1-AS could modulate ERK protein phosphorylation and WT1 level.


XIST

alias symbols:

tissues breast,liver,nasopharynx,nervous system,

cancer type breast cancer,glioma,hepatic cancer,nasopharyngeal cancer,

LncRNA XIST is higher in glioma, nasopharyngeal carcinoma, and lower in breast cancer. XIST regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, XIST can bind to miR-152, miR-34a-5p. Moreover, XIST negatively regulates pAKT, OCT4 and positively regulates E2F3.


XLOC_010588

alias symbols:

tissues cervix,

cancer type cervical cancer,

LncRNA XLOC_010588 expression in cervical cancer is significantly down-regulated and correlated with FIGO stage, tumor size and SCC-Ag. Moreover, cervical cancer patients with XLOC_010588 lower expression have shown poorer prognosis. Functionally, ectopic expression of XLOC_010588 inhibits the proliferation of HeLa and SiHa cells. Western blot assays confirm that XLOC_010588 physically associates with c-Myc, consequently decreasing the expression of c-Myc. Besides, the expressions of XLOC_010588 and c-Myc are strongly correlated in cervical cancer tissues.


XLOC_010967

alias symbols:

tissues nervous system,

cancer type astrocytoma,

LncRNA XLOC_010967 is down-regulated in astrocytoma and significantly associated with poor patient survival.


Z38

alias symbols:

tissues breast,

cancer type breast cancer,

LncRNA Z38 is identified as a protein-coding sequence (isoform a) of the CLDND1 mRNAs, which is highly expressed in breast cancer. Moreover, inhibiting Z38 expression by gene silencing greatly suppresses breast cancer cell proliferation and tumorigenesis, and treatment with Z38 siRNAs significantly induces cell apoptosis and inhibits tumor growth.


ZEB1-AS1

alias symbols:

tissues esophagus,liver,

cancer type esophageal squamous cell cancer,hepatic cancer,

LNCRNA ZEB1-AS1 is up-regulated in esophageal squamous cell carcinoma (ESCC) tissues and associated with tumor grade, depth of invasion, lymph node metastasis and prognosis. In hepatic carcinoma, ZEB1-AS1 is frequently up-regulated in hepatocellular carcinoma (HCC) samples, especially in metastatic tumor tissues with its promoter hypomethylation. Aberrant methylation is tightly correlated with overexpression of ZEB1-AS1 in HCC. Patients with ZEB1-AS1 hypomethylation or with high ZEB1-AS1 expression have poor recurrence-free survival. Functionally, ZEB1-AS1 promotes tumor growth and metastas...


ZEB2NAT

alias symbols:

tissues bladder,

cancer type bladder cancer,

LncRNA ZEB2NAT is demonstrated to be essential for TGFβ1-dependent process. ZEB2NAT depletion reverses CAF-CM-induced EMT and invasion of cancer cells, as well as reduces the ZEB2 protein level. Consistently, TGFβ1 mRNA expression is positively correlated with ZEB2NAT transcript and ZEB2 protein level in human bladder cancer specimens.


ZFAS1

alias symbols:

tissues colorectum,liver,stomach,

cancer type colorectal cancer,gastric cancer,hepatic cancer,

LncRNA ZFAS1 is higher in colorectal cancer, gastric cancer and hepatocellular carcinoma. ZFAS1 expression level is associated with clinicopathological parameters such as lymphatic invasion, TNM stage, prognosis etc.. ZFAS1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, ZFAS1 can bind to EZH2, LSD1, CoREST, miR-150, miR-590-3p. Besides, ZFAS1 negatively regulates PARP and positively regulates ZEB1, MMP14, MMP16, cyclin B1 and p53.


ZMAT1

alias symbols:

tissues stomach,

cancer type gastric cancer,

LncRNA ZMAT1 transcript variant 2 is down-regulated in gastric cancer tissues compared with adjacent normal tissues and inversely correlated with lymph node metastasis, depth of tumor invasion and tumor node metastasis stage. Moreover, ZMAT1 transcript variant 2 expression is an independent predictor for overall survival.


ZNF300P1

alias symbols:

tissues ovary,

cancer type type 2 epithelial ovarian cancer,

LncRNA ZNF300P1 is methylated in multiple ovarian cancer cell lines. Loss of ZNF300P1 results in decreased cell proliferation and colony formation. In addition, knockdown of the ZNF300P1 transcript results in aberrant and less persistent migration in wound healing assays due to a loss of cellular polarity. Moreover, ZNF300P1 has a potential function in metastasis of ovarian cancer cells to sites within the peritoneal cavity.


ZNRD1-AS1

alias symbols:

tissues liver,lung,

cancer type hepatic cancer,lung cancer,

The eQTLs SNPs in LncRNA ZNRD1-AS1 may influence both chronic HBV infection and hepatocellular carcinoma (HCC) development. Three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) is tested to investigate ZNRD1-AS1 with the risk of both chronic HBV infection and HCC. The results reveal that variant alleles of all the three SNPs increase host HCC risk, whereas variant allele of rs3757328 is only associated with HBV clearance. Moreover, the haplotype containing variant alleles of the three SNPs are significantly associated with both HCC development and HBV clearance. In-vitro experiments...


ZXF1

alias symbols:

tissues lung,

cancer type lung adenocarcinoma,

LncRNA ZXF1 level is remarkably increased in lung adenocarcinoma tissues compared with adjacent non-cancerous lung tissues, and up-regulated ZXF1 is correlated with lymph node metastasis, tumor pathological stage and the extent of lymph node metastasis. The 3-year overall survival rate of patients with higher ZXF1 levels is remarkably reduced compared with patients with lower ZXF1 levels. Inhibition of ZXF1 by siRNA decreases the migration and invasion of A549 cells in vitro, while there is no significant effect in cell proliferation.


ZXF2

alias symbols:

tissues lung,

cancer type lung adenocarcinoma,

LncRNA ZXF2 is higher in lung adenocarcinoma specimens and correlated with tumor lymph node metastasis and poor prognosis of the patients. Functionally, siRNA-ZXF2 treatment inhibits cell proliferation, leading to cell cycle arrest. The cell migration and invasion are suppressed by siRNA-ZXF2 treatment. Further biochemical studies reveal that the knockdown of ZXF2 leads to down-regulation of c-Myc signaling.


hDREH

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA DREH is down-regulated by hepatitis B virus X protein (HBx) that is significantly down-regulated in the livers of HBx transgenic mice. Human ortholog RNA of Dreh (hDREH) is frequently down-regulated in HBV-related hepatocellular carcinoma (HCC) tissues in comparison with the adjacent noncancerous hepatic tissues, and its decrement significantly correlates with poor survival of HCC patients. Besides, DREH can reverse the high-migration phenotype of Hepa1-6 cells by affecting the protein vimentin.


linc-POU3F3

alias symbols:

tissues colorectum,esophagus,nervous system,stomach,

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,

LncRNA POU3F3 is higher in colorectal cancer, glioma, esophageal squamous cell carcinoma and gastric cancer. POU3F3 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, POU3F3 is negatively regulated by EZH2. Besides, it negatively regulates p18, caspase-9, caspase-3, E-cadherin and positively regulates cyclin D1, CDK4, pRb, Rb, N-cadherin.


linc-VLDLR

alias symbols:

tissues liver,

cancer type hepatic cancer,

Linc-VLDLR is significantly up-regulated in malignant hepatocytes. Exposure of HCC cells to diverse anticancer agents such as sorafenib, camptothecin, and doxorubicin increases linc-VLDLR expression in cells as well as extracellular vesicles (EV) released from these cells. Incubation with EVs reduces chemotherapy-induced cell death and also increases linc-VLDLR expression in recipient cells. RNAi-mediated knockdown of linc-VLDLR decreases cell viability and abrogates cell-cycle progression. Moreover, knockdown of linc-VLDLR reduces expression of ABCG2 (ATP-binding cassette, subfamily G memb...


linc223

alias symbols:

tissues bone marrow,

cancer type acute myelocytic leukemia,

Linc-223, the host transcript of miR-223, is down-regulated in acute myelocytic leukemia (AML) and its expression is associated with myeloid differentiation. It has two splicing variants, named linc-223-1 and linc-223-2. Through qPCR, linc-223 is significantly induced during monocytic differentiation. Linc-223 can stimulate differentiation of AML cells, while diminishing their proliferation rate. Linc-223 might act as a competing endogenous RNA (ceRNA) for miR-125-5p. There exists a specific crosstalk between linc-223 and IRF4 mRNA through competition for miR-125-5p binding.


lnc-MX1-1

alias symbols:

tissues prostate,

cancer type prostate cancer,

LncRNA MX1-1 is over-expressed in prostate cancer tissues and correlated between PSA, Gleason score, metastasis, and recurrence free survival. Moreover, knockdown of lnc-MX1-1 reduces both proliferation and invasiveness of prostate cancer cells.


lnc-URHC

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA URHC expression is increased in hepatocellular carcinoma (HCC) tissues and cells, its higher expression is correlated with poor overall survival. Functionally, URHC promotes cell proliferation and inhibits apoptosis. At molecular level, the study finds the ZAK gene, which is located near URHC on the same chromosome, is negatively correlated with URHC. Then, they confirm that URHC promotes HCC growth through ZAK via the ERK/MAPK signaling pathway.


lnc-WRAP53

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA WRAP53 is significantly higher in sera of hepatic carcinoma (HCC) than those with chronic hepatitis C virus (HCV) infection or healthy volunteers. Increased expression of WRAP53 is associated with advanced clinical parameters in HCC. Besides, WRAP53 is a significant independent prognostic marker in relapse-free survival. In addition, UCA1 and WRAP53 up-regulation may serve as novel serum biomarkers for HCC diagnosis and prognosis.


lnc-ZNF180-2

alias symbols:

tissues kidney,

cancer type renal clear cell cancer,

LncRNA ZNF180-2 levels are similar in localized renal clear cell carcinoma (ccRCC) and normal renal tissue, but significantly increased in advanced ccRCC tissue. Furthermore, ZNF180-2 expression level is an independent predictor for progression-free survival, cancer-specific survival and overall survival in ccRCC patients.


n336928

alias symbols:

tissues bladder,

cancer type bladder cancer,

LncRNA n336928 is significantly higher in bladder cancer tissues compared to that in adjacent noncancerous tissues, and correlated with bladder tumor stage, histological grade and overall survival time. Moreover, n336928 can be an independent prognostic factor for overall survival for bladder cancer patients.


n375709

alias symbols:

tissues nasopharynx,

cancer type nasopharyngeal cancer,

LncRNA n375709 is the most significantly overexpressed in nasopharyngeal carcinoma (NPC). Inhibition of lncRNA n375709 increases the paclitaxel sensitivity in NPC cells.


n377360

alias symbols:

tissues bone,

cancer type osteosarcoma,

LncRNA n377360 is up-regulated in osteosarcoma tissues. In line with this, suppression of n377360 expression by siRNA significantly impairs cell proliferation potential of osteosarcoma cells.


ncRAN

alias symbols:

tissues bladder,colorectum,

cancer type bladder cancer,colorectal cancer,

LncRNA ncRAN is higher in bladder cancer and lower in colorectal cancer. It can regulate cancer cell proliferation, migration, and invasion.


ncRuPAR

alias symbols:

tissues colorectum,stomach,

cancer type colorectal cancer,gastric cancer,

LncRNA ncRuPAR is lower in colorectal cancer and gastric cancer and is associated with clinicopathological parameters.


numb

alias symbols:

tissues others,

cancer type uveal melanoma,

LncRNA-numb is encoded by the LOC101928143 gene, whose locus is in the upstream of the protein-coding gene numb and encodes two different transcripts, 635bp and 644bp in size. qRT-PCR shows that LncRNA-635 is significantly down-regulated in uveal melanoma (UM) cells compared with the control, while the lncRNA-644 transcript did not exist. Moreover, lncRNA- numb is modulated by HIC1.


p21

alias symbols:

tissues bone marrow,colorectum,liver,lung,nervous system,others,

cancer type colorectal cancer,diffuse large B cell lymphoma,glioma,hepatic cancer,lung cancer,lymphoma,sarcoma,

LncRNA p21 is lower in diffuse large B cell lymphoma, glioma, lung cancer, sarcoma, lymphoma, colorectal cancer and hepatic carcinoma. Its expression level is associated with prognosis. It can regulate cancer cell proliferation and apoptosis.


snaR

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA snaR is down-regulated in 5-FU-resistant colon cancer cells. Downregulation of snaR decreases cell death after 5-FU treatment, which indicates that snaR loss decreases in-vitro sensitivity to 5-FU.


treRNA

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA treRNA is negatively correlated with miR-190a expression level in hepatocellular carcinoma (HCC) tissues. After the miR-190 inhibitor (anti-190) is transfected into HCC cells, there are significantly increased expression level of treRNA. Inhibition of EMT via miR-190a mediates treRNA silencing in HCC cells.


uc.63

alias symbols:

tissues breast,

cancer type breast cancer,

Transcribed ultra-conserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultra-conserved stretches in the human genome. uc.63 is one specific T-UCRs which is up-regulated and associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Moreover, uc.63 can inhibit apoptosis of breast cancer cells.


uc002kmd.1

alias symbols:

tissues colorectum,

cancer type colorectal cancer,

LncRNA uc002kmd.1 expression is usually highly expressed in colorectal cancer. Through a series of experiments, the results show that uc002kmd.1 regulates CD44 as a molecular decoy for miR211-3p. Moreover, LncRNA-uc002kmd.1 modulates cell growth.


uc002mbe.2

alias symbols:

tissues liver,

cancer type hepatic cancer,

LncRNA uc002mbe.2 expression level is significantly lower in the hepatic carcinoma (HCC) cell lines and liver cancer tissues. The histone deacetylase inhibitor (TSA) induces uc002mbe.2 expression that is positively correlated with the apoptotic effect of TSA in HCC cells. In addition, knocking down the expression of uc002mbe.2 significantly reduces TSA-induced apoptosis of Huh7cells.


uc002yug.2

alias symbols:

tissues esophagus,

cancer type esophageal cancer,

LncRNA uc002yug.2 is commonly over-expressed in esophageal cancer (ESCC) compared with paired peritumoral tissue in eastern and southern Chinese populations. The expression levels of uc002yug.2 in ESCC might be a prognostic factor for survival. Moreover, uc002yug.2 promotes a combination of RUNX1 and alternative splicing (AS) factors in the nucleus to produce more RUNX1a, the short isoform and inhibitor of RUNX1, and reduces CEBPα (CCAAT/enhancer-binding protein-α) gene expression, thereby promoting ESCC progression.


uc003opf.1

alias symbols:

tissues esophagus,

cancer type esophageal squamous cell cancer,

Significant differences are found between patients and controls in the genotype frequencies for the rs11752942A>G site in the uc003opf.1 exon. Compared with the rs11752942AA genotype, AG and GG genotypes have a significantly reduced risk of esophageal squamous cell carcinoma (ESCC). Biochemical analysis demonstrates that, when compared with the A allele, the rs11752942 G allele could markedly attenuate the level of uc003opf.1 both in vivo and in vitro by binding with micro-RNA-149, thereby affecting cell proliferation and tumor growth.


uc003wbd

alias symbols:

tissues liver,

cancer type hepatic cancer,

Serum leve of lncRNA uc003wbd is increased in the patients with hepatic carcinoma (HCC) and hepatitis B viral (HBV). uc003wbd might be able to discriminate HCC patients or HBV patients from healthy controls and discriminate HCC patients from HBV patients.