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AATBC

alias symbols:

tissues bladder

cancer type bladder cancer

LncRNA AATBC is over-expressed in bladder cancer, associated with tumor development and aggressiveness. AATBC depletion leads to an obvious inhibitory effect on the cellular growth of bladder cancer, and inhibits tumor growth in NOD/SCID mice. Knockdown of AATBC leads to an increased expression of p18 but a decreased expression of cyclin D1, CDK4, and phosphorylated retinoblastoma (Rb). It can also result in the intrinsic apoptosis of bladder cancer cells by the enhanced cleavages of poly (ADP-ribose) polymerase (PARP), caspase-9 and caspase-3. It can also enhance the phosphorylation level ...


AB073614

alias symbols:

tissues nervous system,ovary

cancer type glioma,ovarian cancer

LncRNA AB073614 is up-regulated in ovarian cancer (OC) and glioma. The 5-year overall survival in OC patients with high expression of AB073614 is inferior to that with low expression in both OC and glioma patients. AB073614 is more highly expressed in high-grade than low-grade glioma tissues. Level of AB073614 is a potential prognostic marker for glioma patients. Knockdown of AB073614 inhibits the proliferation and invasion of OC cells, down-regulates the cell-growth- (PCNA), metastasis- (MMP-2, 9), epithelial-mesenchymal-transition-(EMT, β-catenin, Twist, Snail and FN1), anti-apoptosis- (B...


AB209630

alias symbols:

tissues larynx

cancer type hypopharyngeal squamous cell carcinoma

LncRNA AB209630 is down-regulated in hypopharyngeal squamous cell carcinoma. Increased expression of AB209630 significantly inhibits the cellular growth, metastasis and invasion, but stimulates apoptosis. In addition, patients with decreased expression of AB209630 have a significantly poorer prognosis than those with high AB209630 expression.


ABHD11-AS1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA ABHD11-AS1 is up-regulated in the gastric cancer tissues as well as the gastric juice of patients with gastric cancer. ABHD11-AS1 levels in gastric juice from GC patients are associated with gender, tumor size, tumor stage, Lauren type, blood CEA levels, and have a positive correlation with CA19-9 level. Besides, ABHD11-AS1 can also be used as a diagnostic marker for gastric cancer patients.


AC006050.3-003

alias symbols:

tissues lung

cancer type lung squamous cell cancer

LncRNA AC006050.3-003 is lower in partial response (PR) samples compared with the progressive disease (PD) samples. It is a valuable biomarker for differentiating PR patients from PD patients and might correlate with the sensitivity of chemotherapy in lung squamous cell carcinoma patients.


AC007403.1

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA AC007403.1 is up-regulated in non-small cell lung cancer (NSCLC), and may be potential biomarkers for predicting the tumorigenesis of NSCLC.


AC096655.1-002

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AC096655.1-002 is down-regulated in gastric carcinoma tissues. Its expression level is associated with patients' age, TNM stages, distant metastasis, differentiation, lymph node metastasis and depth of invasion. Furthermore, AC096655.1-002 may be used as a potential marker for the diagnosis of gastric adenocarcinoma.


AC096677.3-201

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA AC096677.3-201 is up-regulated in colorectal cancer (CRC). AC096677.3-201 can promote the cellular proliferation, S-phase arrest, migration and invasion, while inhibit the apoptosis in colon cancer.


AC104699.1.1

alias symbols:

tissues ovary

cancer type ovarian cancer

LncRNA AC104699.1.1 is down-regulated in ovarian cancer. It could significantly divide the late-stage patients into high- and low-risk groups. Moreover, the expression level of AC104699.1.1 is associated with a decreased risk of survival. Low-risk groups always have higher expression levels of AC104699.1.1 than the high-risk. In addition, AC104699.1.1 is significantly associated with patient progression-free survival. Besides, AC104699.1.1 is involved in immune- and cell cycle-associated processes.


AC130710

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AC130710 is up-regulated in gastric cancer, and associated with tumor size, TNM stages, distal metastasis and tissue CEA expression. It has one complementary binding site in the 3′-end with miR-129-5p, and thus could be suppressed by miR-129-5p expression.


AC138128.1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AC138128.1 is down-regulated in gastric cancer. There is no statistically significant association between AC138128.1 expression and clinical pathological features. However, it may have some potential diagnostic value.


ADAMTS9-AS2

alias symbols:

tissues nervous system

cancer type glioma

ADAMTS9-AS2 is an antisense overlapping lncRNA against ADAMTS9, and mostly located in the upstream of ADAMTS9. ADAMTS9-AS2 is down-regulated in glioma tissue samples and associated with poor prognosis. Its expression is positively correlated with ADAMTS9 and DNMT3A, but negatively with DNMT1. Mechanistically, it may modulate the expression of ADAMTS9. Moreover, ADAMTS9-AS2 expression levels are evidently increased in 5-aza-dC (DNA demethylating agent) groups. Overexpression of ADAMTS9-AS2 can inhibit migration and invasion of glioma cells.


AF085935

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA AF085935 increases in the serum of hepatic carcinoma (HCC) patients. AF085935 might be able to discriminate HCC or hepatitis B virus (HBV) patients from healthy controls, and even discriminate HCC patients from HBV patients.


AF339813

alias symbols:

tissues pancreas

cancer type pancreatic cancer

LncRNA AF339813 is significantly increased in pancreatic cancer (PC) tissues and positively regulated by NUF2. AF339813 plays a pivotal role in the proliferation and apoptosis of PC cells. With treatment of siRNA-AF339813, the expression of Caspase-3, Caspase-9 and Bax are significantly increased and Bcl-2 is significantly decreased. Besides, siRNA-AF339813 can also lead to a decrease in cyclins D1 and CDK4/CDK6.


AFAP1-AS1

alias symbols:

tissues colorectum,esophagus,liver,lung,nasopharynx,pancreas

cancer type colorectal cancer,esophageal adenocarcinoma,esophageal squamous cell cancer,hepatic cancer,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,pancreatic ductal adenocarcinoma

LncRNA AFAP1-AS1 is significantly up-regulated in nasopharyngeal carcinoma (NPC), lung cancer, esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma, hepatic carcinoma (HCC), pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) tissues. In these cancers, up-regulated AFAP1-AS1 is correlated with poorer overall survival and clinicopathological parameters such as tumor size, lymph node metastasis, distant metastasis, advanced clinical stage etc. Knocking down AFAP1-AS1 can prohibit proliferation, migration and invasion of these cancer cells. In HCC cells, AFAP1-A...


AGAP2-AS1

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA AGAP2-AS1 is up-regulated in non-small cell lung cancer (NSCLC), and correlated with tumor size, advanced pathological stage and poor prognosis. AGAP2-AS1 can increase NSCLC cell proliferation, migration and invasion, but inhibit NSCLC cell apoptosis. Mechanistically, AGAP2-AS1 can repress LATS2 and KLF2 transcription via binding with EZH2 and LSD1.


AI364715

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AI364715 is down-regulated in gastric cancer tissues, and associated with tumor size, differentiation and venous invasion. Moreover, AI364715 expression level is significantly changed in dysplasia, the typical precancerous lesions. Hence, AI364715 may be a potential biomarker for the diagnosis of gastric cancer.


AK001796

alias symbols:

tissues lung

cancer type lung cancer

LncRNA AK001796 is over-expressed in lung cancer cells and tumor tissues but down-regulated in resveratrol-treated lung cancer cells. Moreover, AK001796 can affect cell proliferation through the cell cycle, probably attributable to promoting the G1–S phase transition.


AK027294

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA AK027294 is up-regulated in colorectal cancer. AK027294 can negatively regulate caspase-3, caspase-8, while positively regulate Bcl-2, thus inhibit colorectal cancer cell apoptosis. Besides, AK027294 can promote cell migration by positively regulating MMP12, MMP9 and TWIST


AK058003

alias symbols:

tissues breast,stomach

cancer type breast cancer,gastric cancer

LncRNA AK058003 is significantly higher in the breast cancer and hypoxia-induced gastric cancer. Its expression level is associated with lymph node metastasis and differentiation in breast cancer. AK058003 siRNA can reduce SNCG expression at both mRNA and protein levels. Functionally, AK058003 can promote proliferation, migration and invasion of breast cancer cells. In addition, AK058003 can promote hypoxia-induced migration and invasion of gastric cancer cells.


AK123657

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA AK123657 is decreased in colorectal cancer. Functionally, AK123657 can decrease the proliferation and invasion of colorectal cancer cells.


AK126698

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA AK126698 expression is down-regulated in human non-small cell lung cancer (NSCLC) tissues and cell lines, and correlated with a larger tumor size and advanced pathologic stage. Functionally, AK126698 overexpression represses cell proliferation and migration and induces apoptosis in NSCLC cells. Mechanistically, AK126698 inhibits Wnt/β-catenin signaling by suppressing FZD8. In addition, AK126698 exerts its biological function by negatively regulating β-catenin, c-myc and cyclin D1, and positively regulating Axin1 and E-cadherin. Moreover, downregulation of AK126698 may attribute to th...


AK294004

alias symbols:

tissues nasopharynx

cancer type nasopharyngeal cancer

LncRNA AK294004 is up-regulated in irradiation (IR) group indicated both by microarray and qRT-PCR, but reversal in IR + curcumin group (up-regulated by qRT-PCR while down-regulated by microarray). Mechanistically, AK294004 directly targets CCND1 using its exon 1, but not the exon 2 part, leading to the decreased of CCND1 expression.


ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


AOC4P

alias symbols:

tissues colorectum,liver

cancer type colorectal cancer,hepatic cancer

LncRNA AOC4P is down-regulated in hepatic carcinoma (HCC) samples and negatively correlated with smoking status, capsule invasion, vessel invasion, pathological stage and prognosis. Down-regulated expression of AOC4P can be looked as an independent prognostic factor for patients with HCC. Forced expression of AOC4P reduces cell proliferation and migration. Besides, AOC4P can bind to vimentin and enhances vimentin degradation, thus inhibit EMT. While in colon cancer, AOC4P is up-regulated. AOC4P interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its ubiquitination ...


AP001631.9

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AP001631.9 is increased and positively correlated with the FOXM1 levels in gastric cancer cells. Overexpression of FRLnc1 enhances the migration and metastasis of gastric cancer cells.


APOC1P1-3

alias symbols:

tissues breast

cancer type breast cancer

LincRNA APOC1P1-3 is over-expressed in breast cancer tissues and cell lines. Hypomethylation in the C/G site may contribute to its upregulation. APOC1P1-3 expression is positively associated with tumor size. Upregulation of APOC1P1-3 inhibits cell apoptosis, but not affects cell cycles. Furthermore, the variation of APOC1P1-3 could affect caspase-3 activation. Besides, APOC1P1-3 can bind α-tubulin and modify its acetylation, thus inhibit cell apoptosis.


ARRDC1-AS1

alias symbols:

tissues breast

cancer type breast cancer

LncRNA ARRDC1-AS1 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


AS-RBM15

alias symbols:

tissues bone marrow

cancer type acute myelocytic leukemia

AS-RBM15 is an antisense lncRNA of RBM15. AS-RBM15 can promote megakaryocyte (MK) terminal differentiation. The exon 1 of AS-RBM15 is essential for MK differentiation while the repeat element in this antisense RNA is dispensable. In addition, AS-RBM15 could up-regulates RBM15 protein level. Moreover, RBM15 and AS-RBM15 are both regulated by RUNX1 and RUNX1-ETO. RUNX1 activates the transcription of RBM15 and AS-RBM15, while RUNX1-ETO in reverse.


ATB

alias symbols:

tissues breast,colorectum,kidney,liver,nervous system,pancreas,prostate,stomach

cancer type breast cancer,colorectal cancer,gastric cancer,glioma,hepatic cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA ATB plays a dual role in cancers. ATB is higher in breast cancer, gastric cancer, glioma, hepatocellular carcinoma, colon cancer, renal cell carcinoma and prostate carcinoma, but lower in pancreatic cancer. ATB expression is associated with clinicopathological parameters such as vascular invasion, lymph node metastasis, grades and prognosis etc.. Functionally, ATB regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ATB can regulate EMT by binding to miR-200 family members and regulate EMT markers expression level, for instance, ZE...


ATP8B5P

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA ATP8B5P is up-regulated in gastric cancer and linked to tumor grade.