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FAL1

alias symbols:

tissues ovary,thyroid

cancer type ovarian cancer,thyroid cancer

LncRNA FAL1, its copy number and expression are correlated with outcomes in ovarian cancer. FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. The oncogenic activity of FAL1 is partially attributable to its repression of p21. FAL1-specific siRNAs significantly inhibit tumor growth. Besides, FAL1 expression is increased in thyroid cancer (PTC) and high FAL1 expression increases the risk of multifocality.


FAM74A3

alias symbols:

tissues breast

cancer type breast cancer

LncRNA FAM74A3 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


FAS-AS1

alias symbols:

tissues bone marrow

cancer type B-cell lymphoma

The alternative splicing of Fas in lymphomas is tightly regulated by a long-noncoding RNA FAS-AS1. Level of FAS-AS1 correlates inversely with production of sFas, and FAS-AS1 binding to the RBM5 inhibits RBM5-mediated exon 6 skipping. EZH2 hyper-methylates the FAS-AS1 promoter and represses the FAS-AS1 expression. EZH2-mediated repression of FAS-AS1 promoter can be released by DZNeP (3-Deazaneplanocin A) or overcome by ectopic expression of FAS-AS1, both of which increase the expression level of FAS-AS1 and correspondingly decrease expression of sFas. Treatment with Bruton's tyrosine kinase ...


FENDRR

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA FENDRR expression is down-regulated in gastric cancer tissues and cell lines, and histone deacetylation is involved in the downregulation of FENDRR. Low FENDRR group shows greater invasion depth, higher tumor stage, more frequent lymphatic metastasis and shorter overall survival than the high FENDRR expression group. FENDRR exhibits an insignificant effect on gastric cancer cell proliferation, but represses gastric cancer cell migration, invasion and metastasis. Fibronectin1 is negatively regulated by FENDRR at both mRNA and protein levels. Inhibition of FENDRR contributes to the act...


FER1L4

alias symbols:

tissues colorectum,endometrium,stomach

cancer type colorectal cancer,endometrial cancer,gastric cancer

LncRNA FER1L4 expression shows downregulation in colon cancer, endometrial carcinoma (EC)and gastric cancer. It is positively correlated with PTEN expression in endometrial carcinoma(EC)tissues and gastric cancer. The low FER1L4 level is associated with clinicopathologic parameters in gastric cancer and colon cancer. FER1L4 can also induce cell cycle arrest and promote cell apoptosis in these three cancer cell lines. At the molecular level, FER1L4 promotes PTEN expression with an inhibition of Akt phosphorylation. Besides, miR-106a-5p suppresses FER1L4 and PTEN.


FEZF1-AS1

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA FEZF1-AS1 is up-regulated in human colorectal carcinoma (CRC) tissues. High-level expression of FEZF1-AS1 is significantly associated with T-stage, lymph node metastasis, distant metastasis and poor prognosis in patients with CRC. FEZF1-AS1 promotes CRC cell proliferation, migration and invasion. Knockdown of FEZF1-AS1 promotes G1 arrest, but does not cause apoptosis in CRC cells. In vitro, knockdown of FEZF1-AS1 inhibits tumor growth and metastasis. At the molecular level, knockdown of FEZF1-AS1 decreases the expression of FEZF1 mRNA and protein.


FGF14-AS2

alias symbols:

tissues breast

cancer type breast cancer

LncRNA FGF14-AS2 is significantly down-regulated in breast cancer tissue. Reduced expression of FGF14-AS2 is correlated with larger tumor size, more lymph node metastasis and advanced clinical stage. Patients with lower FGF14-AS2 expression have a worse overall survival.


FGFR3-AS1

alias symbols:

tissues bone

cancer type osteosarcoma

LncRNA FGFR3-AS1 is up-regulated in osteosarcoma. Increased FGFR3-AS1 expression correlates with large tumor size, advanced Enneking stage, metastasis and poor survival. In addition, FGFR3-AS1 increases FGFR3 mRNA stability and up-regulates FGFR3 expression. Functionally, FGFR3-AS1 promotes the proliferation and cell cycle progression of osteosarcoma cells. Moreover, FGFR3-AS1 promotes xenograft tumor growth of osteosarcoma cells.


FOXCUT

alias symbols:

tissues breast,esophagus

cancer type breast cancer,esophageal squamous cell cancer

LncRNA FOXCUT is ove-rexpressed in basal-like breast cancer (BLBC) tissue specimens and esophageal squamous cell carcinoma, and positively correlated with FOXC1 mRNA level. FOXCUT can promote proliferation and migration in these two cancer cell lines. In addition, high expression of FOXCUT is correlated with age, poor differentiation, advanced lymph node classification, metastasis and poor prognosis in esophageal squamous cell carcinoma.


FOXD2-AS1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA FOXD2-AS1 is up-regulated in gastric cancer and linked to tumor grade, overall survival.


FR0348383

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA FR0348383 is up-regulated in over 70% of prostate cancer (PCa). FR0348383 score is correlated with an increasing probability of a positive biopsy. Multivariable logistic analysis indicates FR0348383 score is an independent predictor of PCa. In addition, the FR0348383 score would save 52.0% of avoidable biopsies without missing any high-grade cancers.


FRLnc1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA FRLnc1 expression is higher and up-regulated by FOXM1 in gastric cancer cells. FRLnc1 exhibits a significant effect on gastric cancer cell migration and metastasis. Besides, FRLnc1 positively regulates two EMT genes, TGF-β1 and Twist.


FTX

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA FTX is significantly up-regulated in colorectal cancer tissues, and correlated with differentiation grade, lymph vascular invasion, clinical stage and overall survival. Functional analyses show that upregulation of long non-coding RNA FTX significantly promotes growth, migration, invasion, and increases colony formation in colorectal cancer cells.