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tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


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tissues thyroid

cancer type papillary thyroid cancer

LncRNA HAGLROS-201 is up-regulated in papillary thyroid carcinoma (PTC). It can promote PTC cell proliferation and motility.


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tissues breast

cancer type breast cancer

LncRNA HAR1A is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


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tissues breast,prostate

cancer type breast cancer,prostate cancer

LncRNA HCG11 is up-regulated in breast cancer and its upregulation is associated with poor overall survival duo to the copy number alteration. However, LncRNA HCG11 is down-regulated in prostate cancer. Downregulation of HCG11 is correlated with the age, LN status, preoperative PSA level, Gleason score and BCR in prostate cancer. Moreover, downregulation of HCG11 can predict a poor prognosis in prostate cancer.


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tissues liver

cancer type hepatic cancer

LncRNA HEIH is up-regulated in hepatic carcinoma (HCC) and can be an independent prognostic factor for HCC patients. Functionally, HEIH can promote cell invasion. Moreover, HEIH is up regulated by SP1 and positively correlated with PCNA. Besides, HEIH associates with EZH2 and that this association is required for the expression of EZH2-regulated target genes.


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tissues lung

cancer type non-small-cell lung cancer

LncRNA HIF1A-AS1 is significantly increased in tumor tissues or serum from non-small cell lung cancer (NSCLC) patients. Moreover, serum level of HIF1A-AS1 is significantly decreased after surgical treatment as compared to pre-operative.


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tissues bladder,stomach

cancer type bladder cancer,gastric cancer

LncRNA HIF1A-AS2 is up-regulated in gastric cancer (GC) and bladder cancer. Overexpression of HIF1A-AS2 is significantly associated with tumor invasion, lymph node metastasis, higher TNM stage and shorter overall survival (OS) time. Besides, HIF1A-AS2 can promote the proliferation of GC cells and promote cell proliferation, migration and inhibit cell apoptosis in bladder cancer.


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tissues bone,colorectum

cancer type colorectal cancer,osteosarcoma

LncRNA HIF2PUT is significantly correlated with HIF-2α in colorectal cancer (CRC) tissues. Knockdown of HIF2PUT blocks the HIF-2α expression and inhibits the CSC properties in CRC cell lines. HIF2PUT small interfering RNA transfection results in decreased stemness genes expression, retarded migration, impaired ability of colony and spheroid formation ability, and invasion of the cells. In osteosarcoma, HIF2PUT also functions as an inhibitor of osteosarcoma stem cells.


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tissues lung,pancreas,stomach

cancer type gastric cancer,non-small-cell lung cancer,pancreatic cancer


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tissues esophagus,liver,lung,nasopharynx,stomach

cancer type esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung adenocarcinoma,nasopharyngeal cancer

LncRNA HNF1A-AS1 is up-regulated in lung adenocarcinoma tissues, nasopharyngeal carcinoma, oesophageal adenocarcinoma, hepatocellular carcinoma, and down-regulated in gastric cancer. HNF1A-AS1 expression levels are significantly associated with clinicopathological parameter. Further studies reveal that HNF1A-AS1 promotes cell proliferation and metastasis. Besides, HNF1A-AS1 can affect autophagy in hepatocellular carcinoma via negatively regulating ATG. At molecular level, HNF1A-AS1 regulates cell cycle via cyclin D1 and regulates EMT via regulating EMT markers. In addition, HNF1A-AS1 can bi...


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tissues ovary

cancer type epithelial ovarian cancer

LncRNA HOST2 is up-regulated in epithelial ovarian cancer (EOC). Functionally, HOST2 promotes EOC cell migration, invasion and proliferation, while has no significant effect on the rate of cell apoptosis. HOST2 is a molecular sponge for let-7b and is repressed by let-7b. Moreover, HOST2 enhances the endogenous expression of metastasis-promoting genes that are targeted by let-7b.


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tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


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tissues bone marrow,colorectum

cancer type acute myelocytic leukemia,acute promyelocytic leukemia,colorectal cancer

HOTAIRM1 is higher in acute myelocytic leukemia (AML), granulocytic, lower in colorectal cancer. Its expression level is associated with prognosis. It can regulate cancer cell proliferation. Moreover, it is regulated by PU.1.


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tissues bone,colorectum,liver,lung,others,pancreas,prostate,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer

HOTTIP is higher in tongue squamous cell carcinoma,non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer(CRC), pancreatic cancer and osteosarcoma. HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis. HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, HOTTIP negatively regulates miR-125b and HOXA13, and positively regulates HOXA genes.


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tissues bone marrow,stomach

cancer type gastric cancer,promyelocytic leukemia

LncRNA HOXA-AS2 is up-regulated in human gastric cancer (GC) tissues and promyelocytic leukemia cells. In addition, HOXA-AS2 expression is induced by IFN-γ and TNF-α in neutrophils. Overexpression of HOXA-AS2 is associated with tumor size, TNM stage and poor prognosis of GC. HOXA-AS2 promotes cell proliferation and inhibits cell apoptosis. HOXA-AS2 epigenetically silences P21, PLK3 and DDIT3 transcription by binding with EZH2.


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tissues nervous system,ovary

cancer type epithelial ovarian cancer,glioma

HOXA11-AS acts as an oncogene in glioma and tumor suppressor gene in epithelial ovarian cancer. HOXA11-AS can regulate cancer cell proliferation, migration, invasion and apoptosis.


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tissues bladder,nervous system

cancer type bladder cancer,neuroblastoma

LncRNA HOXD-AS1 is up-regulated in bladder cancer and neuroblastoma. HOXD-AS1 is positively correlated with tumor size, histological grade and TNM stage in bladder cancer. HOXD-AS1 can promote bladder cancer cell proliferation, migration and inhibit apoptosis. HOXD-AS1 is up-regulated by retinoic acid in SH-SY5Y neuroblastoma cell line. Besides, HOXD-AS1 expression is regulated by PI3K/Akt signaling pathway.


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tissues bone,bone marrow,breast,colorectum,esophagus,liver,nervous system,pancreas,stomach

cancer type B-cell lymphoma,colorectal cancer,esophageal cancer,gastric cancer,glioma,hepatic cancer,osteosarcoma,pancreatic cancer,triple negative breast cancer

HULC is higher in breast cancer, colorectal carcinoma, gastric cancer, liver cancer, osteosarcoma, pancreatic cancer and glioma. HULC expression level is associated with clinicopathological parameters such as staging and grading. HULC regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis, EMT. Mechanistically, HULC can bind to EZH2, CREB, IGF2BP1, CLOCK, miR-107, miR-200a-3p. Moreover, HULC negatively regulates NKD2, miR-372, miR-9, TNF-α, E-Cadherin, and positively regulates LC3-II/LC3-I, SPHK1, E2F1, Snail, ZEB1, ZO-1, pERK, pAKT, pmTOR, ESM-1, peIF4E, thereby...


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tissues liver

cancer type hepatic cancer

LncRNA DREH is down-regulated by hepatitis B virus X protein (HBx) that is significantly down-regulated in the livers of HBx transgenic mice. Human ortholog RNA of Dreh (hDREH) is frequently down-regulated in HBV-related hepatocellular carcinoma (HCC) tissues in comparison with the adjacent noncancerous hepatic tissues, and its decrement significantly correlates with poor survival of HCC patients. Besides, DREH can reverse the high-migration phenotype of Hepa1-6 cells by affecting the protein vimentin.