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LA16c-313D11.11

alias symbols:

tissues endometrium

cancer type endometrial cancer

LncRNA LA16c-313D11.11 is down-regulated in endometrial carcinoma. Overexpression of LA16c-313D11.11 results in down-regulated expression and activity of miR-205-5p.


LCAL6

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LncRNA LCAL6 is up-regulated in lung adenocarcinoma (LUAD) and indicates poor survival of LUAD patients. LCAL6 can promote cell proliferation. The staining of Ki67, a proliferation marker is also stronger in tumor tissues.


LEIGC

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA LEIGC is down-regulated in gastric cancer. It consists of 2659bp with two exons. LEIGC significantly inhibits cell proliferation and migration of gastric cancer cells. LEIGC enhances chemosensitivity to 5-FU in gastric cancer. Moreover, LEIGC prevents EMT of gastric cancer via regulating E-cadherin, Vimentin, Snail, Slug, Zeb and Twist.


LET

alias symbols:

tissues cervix,esophagus,gallbladder,liver,nasopharynx,stomach

cancer type cervical cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,nasopharyngeal cancer

LncRNA LET is lower in nasopharyngeal carcinoma, esophageal squamous cell carcinoma, gallbladder cancer, gastric cancer, hepatic carcinoma,colorectal cancer,lung squamous cell cancer, and cervical cancer. LET expression level is associated with clinicopathological parameters such as pathological grade, clinical stage, lymph node metastasis, prognosis etc.. LET regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. LET play biological functions via negatively regulating Bcl-2 and positively regulates p53, p21, caspase-3, Bax. Moreover, LET can regulate hypoxia si...


LINC00052

alias symbols:

tissues liver

cancer type hepatic cancer

LINC00052 is down-regulated in hepatocellular carcinoma. It can inhibit cell invasion, migration and proliferation. NTRK3 is the target gene of LINC00052. Down-expression of NTRK3 could increase cell invasion, migration and proliferation. Meanwhile, LINC00052 could regulate NTRK3 expression by forming complementary base-pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR.


LINC00115

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LINC00115 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC00152

alias symbols:

tissues breast,kidney,liver,stomach

cancer type breast cancer,gastric cancer,hepatic cancer,renal clear cell cancer

LINC00152 is higher in breast cancer, gastric cancer, hepatocellular carcinoma and clear cell renal cell carcinoma. LINC00152 expression level is associated with clinicopathological parameters such as tumor size, differentiation grade, TNM stage, depth of invasion, prognosis etc.. Moreover, LINC00152 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Besides, LINC00152 can bind to EGFR and EpCAM. LINC00152 functions via negatively regulating E-cadherin, p15, p21 and positively regulating N-cadherin, Vimentin.


LINC00160

alias symbols:

tissues breast

cancer type breast cancer

LINC00160 is up-regulated in breast cancer and is up-regulated by E2. Moreover, LINC00160 is direct transcriptional targets of ERα, correlated with ERα expression in clinical samples, and shows prognostic significance in relation to breast cancer survival. Besides, silencing LINC00160 would result in the reduction of proliferation.


LINC00184

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA LINC00184 is highly expressed in human hepatic carcinoma (HCC) tumors and liver cancer stem cells (CSCs). In addition, LINC00184 is required for self-renewal of liver CSCs and tumor propagation in mice. Moreover, LINC00184 associates with β-catenin and the methyltransferase EZH2, thereby promoting β-catenin methylation. Methylation suppresses the ubiquitination of β-catenin and promotes its stability, thus leading to activation of Wnt-β-catenin signaling. Accordingly, the expression of LINC00184, EZH2 and Wnt-β-catenin targets are positively correlated with cancer severity and progno...


LINC00261

alias symbols:

tissues stomach

cancer type gastric cancer

LINC00261 is down-regulated in gastric cancer (GC) and correlated with invasion depth, tumor stage, lymphatic metastasis and prognosis. LINC00261 exhibits an insignificant effect on GC cell proliferation, but represses GC cell migration, invasion and metastasis. LINC00261 inhibits EMT via affecting EMT markers E-cadherin, N-cadherin, Vimentin, and FN1.


LINC00265

alias symbols:

tissues lung

cancer type lung cancer

LINC00265 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC00310

alias symbols:

tissues breast

cancer type breast cancer

LINC00310 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


LINC00312

alias symbols:

tissues nasopharynx

cancer type nasopharyngeal cancer

In nasopharyngeal carcinoma, one study finds LINC00312 is down regulated in cancer tissues, but another finds it up-regulated in cancer tissue. LINC00312 involves with cancer cell migration and invasion. Besides, it can act as a prognosis predictor.


LINC00323

alias symbols:

tissues breast

cancer type breast cancer

LINC00323 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, their upregulation can predict recurrence.


LINC00342

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA LINC00342 is up-regulated in non-small cell lung cancer (NSCLC) and correlated with lymph node metastasis, TNM stages and poor overall survival. LINC00342 negatively correlates with PTEN, P53 and P21.


LINC00346

alias symbols:

tissues breast

cancer type breast cancer

LINC00346 is up-regulated in breast cancer and its expression level is associated with poor overall survival due to the copy number alteration.


LINC00467

alias symbols:

tissues nervous system

cancer type neuroblastoma

N-Myc suppresses LINC00467 gene expression through directly binding to the LINC00467 gene promoter and reducing LINC00467 promoter activity. Moreover, LINC00467 reduces RD3 mRNA expression. Besides, Affymetrix microarray analysis reveals that one of genes significantly up-regulated by LINC00467 siRNA is the tumor suppressor gene DKK1. Importantly, knocking-down LINC00467 expression with siRNA in neuroblastoma cells reduces the number of viable cells and increases the percentage of apoptotic cells, while co-transfection with DKK1 siRNA would block the effects.


LINC00472

alias symbols:

tissues breast

cancer type breast cancer

LINC00472 is a tumor suppressor gene in breast cancer. It can inhibit cell proliferation and migration.


LINC00473

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LINC00473 is consistently the most highly induced gene in LKB1-inactivated human primary non-small cell lung cancer (NSCLC) samples and derived cell lines. Elevated LINC00473 expression correlates with poor prognosis, and the sustained LINC00473 expression is required for the growth and survival of LKB1-inactivated NSCLC cells. Mechanistically, LINC00473 is induced by LKB1 inactivation and subsequent cyclic AMP-responsive element-binding protein (CREB)/CREB-regulated transcription coactivator (CRTC) activation.


LINC00574

alias symbols:

tissues breast

cancer type breast cancer

LINC00574 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


LINC00617

alias symbols:

tissues breast

cancer type breast cancer

Linc00617 is up-regulated in breast cancer tissues and associated tumor grade, lymph node metastasis and overall survival. Linc00617 promotes motility and invasion of breast cancer cells. Linc00617 can also influence EMT via affecting epithelial marker E-cadherin, N-cadherin and vimentin. Besides, ectopic expression of linc00617 can increase the binding of hnRNP-K at the promoter region of stemness factor Sox2.


LINC00628

alias symbols:

tissues stomach

cancer type gastric cancer

LINC00628 is down-regulated in gastric cancer (GC) and functions as a GC suppressor through suppressing proliferation, migration and colony formation of cancer cells. Furthermore, LINC00628 can also suppress the tumor size in mouse xenograft models. Mechanistically, although LINC00628 can negatively modulate LRRN2 expression, the GC suppressor function of LINC00628 is not LRRN2-dependent. Importantly, LINC00628 mainly locates in the nucleus and interacts with EZH2, and modulates genes expression by regulating H3K27me3 level.


LINC00629

alias symbols:

tissues others

cancer type choriocarcinoma

LINC00629 is long inter-genic non-coding RNAs mapped on chromosome X (Xq26), and highly expressed in reproductive tissues. Moreover, LINC00629 expression can be indirectly regulated by methylation. Besides, LINC00629 is evenly spread in JEG-3 choriocarcinoma cell line. In addition, LINC00629 can inhibit migration and invasion in JEG-3 choriocarcinoma cell line.


LINC00654

alias symbols:

tissues breast

cancer type breast cancer

LINC00654 is up-regulated in breast cancer and its expression level is associated with poor overall survival due to the copy number alteration.


LINC00657

alias symbols:

tissues breast

cancer type breast cancer

LINC00657 is up-regulated in breast cancer. Its upregulation is associated with poor overall survival due to the copy number alteration. LINC00657 knockout significantly suppresses tumor cell growth and proliferation, suggesting that it plays an oncogenic role.


LINC00668

alias symbols:

tissues stomach

cancer type gastric cancer

LINC00668 is up-regulated in human gastric cancer tissues, and correlates with advanced invasion depth, TNM stage and poor prognosis. E2F1 can activate LINC00668 by directly binding to the LINC00668 promoter, with a positive correlation with the expression of LINC00668. Cell functional experiments show that LINC00668 can promote gastric cancer cell proliferation and accelerate cell cycle by binding to PRC2. Moreover, knockdown of LINC00668 can increase the expression of CKIs p15, p16, p21, p27 and p57.


LINC00673

alias symbols:

tissues lung,others,pancreas

cancer type melanoma,non-small-cell lung cancer,pancreatic cancer

LINC00673 expression is up-regulated in non-small cell lung cancer (NSCLC) tissues and associated with larger tumors, lymph node metastasis, more advanced tumors and prognosis. LINC00673 is localized in both the nucleus and cytosol. LINC00673 promotes NSCLC cell proliferation through regulating CDK6 expression. Moreover, LINC00673 silences NCALD transcription by binding with Histone demethylase lysine specific demethylase 1 (LSD1). In melanoma, LINC00673 is also up-regulated and associated with survival outcome. It can increase melanoma invasion. Further studies find that AR and Brn3a bind ...


LINC00675

alias symbols:

tissues pancreas

cancer type pancreatic ductal adenocarcinoma

Linc00675 is up-regulated in human pancreatic ductal adenocarcinoma (PDAC) cell lines and cancerous tissues, and significantly associated with lymph node metastasis, perineural invasion and overall survival. Besides, Linc00675 is a potential biomarker for predicting recurrence in PDAC patients. Cell functional experiments show that Linc00675 regulates proliferation of pancreatic cancer cells via negatively regulating Cyclin E and Cyclin A and positively regulating Cyclin D1 and CDK2. Moreover, Linc00675 regulates invasion ability and expression of epithelial-mesenchymal transition-related g...


LINC00704

alias symbols:

tissues breast

cancer type breast cancer

LINC00704 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its u-regulation can predict recurrence.


LINC00705

alias symbols:

tissues breast

cancer type breast cancer

LINC00705 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its up-regulation can predict recurrence.


LINC00857

alias symbols:

tissues lung

cancer type lung cancer

LINC00857 is overexpressed in lung adenocarcinoma, and predicts poor patient survival. LINC00857 promotes cancer cell proliferation and invasion. Besides, LINC00857 regulates cell cycle at the G1/S phase, potentially through CCNE1 and CDK2 regulation..


LINC00963

alias symbols:

tissues prostate

cancer type prostate cancer

LINC00963 is up-regulated in prostate cancer. Knockdown of LINC00963 attenuates cell proliferation, motility, invasion ability, the expression of EGFR and phosphorylation levels of AKT, and promotes cell apoptosis. In addition, LINC00963 is involved in the prostate cancer transition from androgen-dependent to androgen-independent and metastasis via the EGFR signaling pathway.


LINC00974

alias symbols:

tissues liver

cancer type hepatic cancer

LINC00974 is up-regulated with positively correlation with KRT19 (an lncRNA beyond the Flank10kb class with protein) in hepatic carcinoma (HCC). Both LINC00974 and KRT19 expression are significantly correlated with decreased tumor differentiation grade, increased tumor size, and metastasis. LINC00974 promotes cell proliferation and invasion. Besides, LINC00974 induces an inhibition of tumor growth and metastasis. Mechanistically, LINC00974 affects KRT19 expression by acting as a competing endogenous RNA (ceRNA) to interact with miR-642. In addition, NOTCH and TGF-β signal pathways are promo...


LINC00982

alias symbols:

tissues kidney,stomach

cancer type gastric cancer,renal clear cell cancer

The LINC00982 expression level is lower in gastric cancer tissues and correlated with invasion depth, TNM stage, regional lymph nodes metastasis and prognosis. LINC00982 exhibits significant effect on gastric cancer proliferation and cell cycle progression by positively regulating P15 and P16 at both mRNA and protein levels. While in clear cell renal cell carcinoma (ccRCC), LINC00982 is decreased and associated with poor prognosis. Moreover, high expression of LINC00982 is associated with a decreased risk of cancer-related death in univariate regression analysis, but LINC00982 could not pre...


LINC00993

alias symbols:

tissues breast

cancer type triple negative breast cancer

LINC00993 is higher in triple negative breast cancer and associated with the expression levels of ANKRD30A. Furthermore, the expression of LINC00993 is also associated with the expression of the estrogen receptor.


LINC01001

alias symbols:

tissues lung

cancer type lung cancer

LINC01001 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC01002

alias symbols:

tissues lung

cancer type lung cancer

LINC01002 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC01016

alias symbols:

tissues breast

cancer type breast cancer

LINC01016 is up-regulated in breast cancer and is up-regulated by E2. In addition, LINC01016 is direct transcriptional targets of ERα, correlated with ERα expression in clinical samples, and shows prognostic significance in relation to breast cancer survival.


LINC01133

alias symbols:

tissues colorectum,lung

cancer type colorectal cancer,lung squamous cell cancer,non-small-cell lung cancer

LINC01133 is down-regulated in colorectal cancer (CRC). LINC01133 is down-regulated by TGF-β, which could inhibit epithelial–mesenchymal transition (EMT) and metastasis in CRC cells. An alternative splicing factor SRSF6 is identified to directly interact with LINC01133, which promotes EMT and metastasis in CRC cells independent of LINC01133. LINC01133 expression is positively correlated with E-cadherin, and negatively correlated with Vimentin. Moreover, low LINC01133 expression is associated with poor survival in CRC samples. While in lung cancer, LINC01133 is up-regulated and associated wi...


LINC01207

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LINC01207 is up-regulated in lung adenocarcinoma (LAD) but no significant difference is observed in lung squamous cell cancer (LSCC). The expression level of LINC01207 is associated with TNM stage and survival time. LINC01207 can promote cell proliferation and inhibit apoptosis. Further study finds that LINC01207 inhibits apoptosis by binding to EZH2 and mediating H3K27-me3 at the promoter region of Bad.


LINC01225

alias symbols:

tissues liver

cancer type hepatic cancer

LINC01225 is up-regulated in hepatocellular carcinoma (HCC). High LINC01225 expression is significantly associated with tumor size, tumor differentiation grade, tumor capsular integrity, tumor TNM stage, metastasis and prognosis. LINC01225 promotes proliferation and invasion of HCC cells. Mechanism study finds LINC01225 can promote HCC growth and invasion via EGFR/MAPK pathway. More specifically, that LINC01225 could bind to EGFR, thereby increasing the protein level of EGFR.


LINC01852

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LINC01852 is greatly down-regulated in cancer tissues, and correlated with tumor diameter, lymph node metastasis and TNM stage. LINC01852 overexpression suppresses the proliferation, migration and ENT in non-small cell lung cancer (NSCLC) cell lines. Further studies find that P21 protein level is increased with LINC01852 overexpression. Moreover, LINC01852 overexpressing results in a marked increase in the E-cadherin protein level and a significantly decrease in expression of N-cadherin and vimentin.


LINP1

alias symbols:

tissues breast

cancer type triple negative breast cancer

LncRNA LINP1 expression is highly expressed in triple-negative breast cancer (TNBC) cell lines and distributes in both nuclear and cytoplasmic fractions of cells. Moreover, LINP1 expression is positively correlated with the RNA expression of EGFR and CDKN2A, and negatively correlated with RB1. Besides, the expression of LINP1 is significantly higher in those with TP53 mutations than with wild type (WT) TP53. In addition, LINP1 expression is activated by the EGF signaling pathway and repressed by the p53 signaling pathway. Further studies reveal that LINP1 associates with proteins in the NHE...


LOC100128164

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA LOC100128164 is down-regulated in gastric cancer and linked to tumor grade.


LOC100130476

alias symbols:

tissues esophagus,stomach

cancer type esophageal squamous cell cancer,gastric cardia adenocarcinoma

LOC100130476 is down-regulated in esophageal squamous cell carcinoma (ESCC) and gastric cancer. Its downregulation at least partly results from hypermethylation of CpG sites in exon 1 and its hypermethylation may have prognostic implication. Besides, it is involved with clinicopathological features.


LOC100190940

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA LOC100190940 is up-regulated in primary colorectal cancer and significantly increases cell proliferation and migration.


LOC100287225

alias symbols:

tissues colorectum

cancer type colorectal cancer

LOC100287225 is not only expressed in the intestinal tissue, but has also been misregulated during tumorigenesis. Moreover, the relative expression level of LOC100287225 RNA is significantly lower in tumor tissues compared with adjacent tumor-free tissues. The RNA expression level of LOC100287225 does not show significant correlation with clinical characteristics.


LOC100506178

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA LOC100506178 is significantly up-regulated in colorectal cancer and correlated with poor overall survival of the patients.


LOC100507661

alias symbols:

tissues thyroid

cancer type thyroid cancer

LOC100507661 is strongly up-regulated in thyroid cancer tissues relative to paired contralateral normal tissue. Moreover, LOC100507661 is easily detectable in papillary and anaplastic thyroid cancer cell lines, but not in the follicular thyroid cancer cell line. Stable overexpression of LOC100507661 promotes cell proliferation, migration, and invasion of thyroid cancer cells. In addition, Lymph node metastasis and BRAF V600E mutations are more frequent in papillary thyroid cancers with high LOC100507661 expression.


LOC105378009

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA LOC105378009 and serum and glucocorticoid-inducible kinase 1 (SGK1) are elevated in T cell either within the gastric cancer tissues or peripheral T cells, and associated with Helicobacter pylori infection and high-salt diet (HSD). Within T cells, Helicobacter pylori (Hp) infection and high-salt diet can up-regulated SGK1 expression, which in turn enhances the expression of LOC105378009 through JunB activation. Expression of LOC105378009 can further enhance transcription of SGK1 through cis-regulatory mode. Moreover, LOC105378009 can induce Th2 and Th17, whilereduce Th1 differentiatio...


LOC389641

alias symbols:

tissues pancreas

cancer type pancreatic ductal adenocarcinoma

LncRNA LOC389641 is increased in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines. LOC389641 is significantly associated with TNM stage and lymph node metastasis and also an independent factor for the prognosis of PDAC individual. LOC389641 increases proliferation, migration and invasion, but inhibits apoptosis of PDAC cells. LOC389641 is positively correlated with Ki67, thus promotes cell proliferation. Moreover, LOC389641 increases tumor invasion by regulating EMT-related epithelial marker E-cadherin and the mesenchymal markers vimentin and snail. The study also finds that T...


LOC400891

alias symbols:

tissues prostate

cancer type prostate cancer

LOC400891 is higher in prostate cancer (PCa) tissues and cells. The patients with higher LOC400891 expression have advanced clinical features and a shorter biochemical recurrence-free survival time. Furthermore, multivariate analysis shows that the status of LOC400891 expression is an independent predictor of biochemical recurrence-free survival in PCa. Functionally, knockdown of LOC400891 could inhibit cell proliferation, migration and invasion. Mechanistically, LOC400891 is involved in the promotion of PCa cell proliferation and seems to be mediated by modulation of the PI3K-AKT-mTOR path...


LOC401317

alias symbols:

tissues nasopharynx

cancer type nasopharyngeal cancer

LOC401317 is the most up-regulated in nasopharyngeal carcinoma cell line (HNE2) with TP53 overexpression. Further studies indicated that LOC401317 is directly regulated by p53 and that ectopic expression of LOC401317 inhibits HNE2 cell proliferation by inducing cell cycle arrest and apoptosis. LOC401317 inhibits cell cycle progression by increasing p21 expression and decreasing cyclin D1 and cyclin E1 expression, and promotes apoptosis through the induction of poly(ADP-ribose) polymerase and caspase-3 cleavage.


LOC553137

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA LOC553137 is up-regulated in gastric cancer and linked to lymphatic metastasis.


LOC572558

alias symbols:

tissues bladder

cancer type bladder cancer

LOC572558 expression is markedly decreased in bladder cancer tissues and bladder cancer cell lines. Moreover, ectopic expression of LOC572558 inhibits cell proliferation and motility, induces S phase arrest of the cell cycle and promotes cell apoptosis in bladder cancer cell lines. Further studies verify that overexpression of LOC572558 is associated with dephosphorylation of AKT, MDM2 and phosphorylation of p53 protein.


LOC728228

alias symbols:

tissues lung

cancer type lung cancer

LncRNA LOC728228 is up-regulated in the anti-benzo(a) pyrene-7,8-diol-9,10-epoxide (anti-BPDE)-transformed human bronchial epithelial cell line (16HBE-T cells) relative to its expression in control untransformed16HBE (16HBE-N) cells. LOC728228 knockdown inhibits cell proliferation, causes G0/G1-phase cell-cycle arrest, reduces cellular migration, suppresses colony formation and inhibits tumor growth in a nude mouse xenograft model. In addition, LOC728228 knockdown also suppresses cyclin D1 expression, and the depletion of cyclin D1 induces G0/G1-phase cell-cycle arrest and inhibits cell pro...


LOC728606

alias symbols:

tissues prostate

cancer type prostate cancer

LOC728606 is up-regulated in prostate cancer (PCa). LOC728606 is detectable in plasma samples and increases incrementally from healthy individuals to those with localized and metastatic PCa. The study identifies a LOC728606-associated expression signature (PES), which is highly PCa-specific and activated in metastatic vs. primary PCa samples. The PES is significantly associated with androgen receptor (AR) signaling. Accordingly, AR activation dramatically up-regulates LOC728606 expression in vitro and in vivo. LOC728606 silencing significantly inhibits PCa cell proliferation and triggers ca...


LSINCT5

alias symbols:

tissues breast,ovary,stomach

cancer type breast cancer,gastric cancer,ovarian cancer

LSINCT5 is over-expressed in breast cancer, ovarian cancer gastric cancer and promotes cell proliferation.


LUADT1

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LncRNA LUADT1 is up-regulated in lung adenocarcinoma (LUAD), and correlated with the tumor stage, but not with N stage or TNM stage. LUADT1 promotes cell proliferation via regulating cyclin D1, cyclin-dependent kinase 4 (CDK4), cyclin-dependent kinase 6 (CDK6) and Ki67. In addition, LUADT1 binds to SUZ12 and epigenetically inhibits p27 expression by mediating H3K27 trimethylation at the promoter region of p27.


LUCAT1

alias symbols:

tissues lung

cancer type lung cancer,non-small-cell lung cancer

LncRNA LUCAT1 can be induced by cigarette smoke extract (CSE) both in vitro and in vivo and is elevated in numerous lung cancer cell lines. It is located in chromosome 5 with four exons and three introns. The expression of LUCAT1 is regulated transcriptionally by nuclear factor erythroid 2-related factor (NRF2). A nuclear factor erythroid-derived 2 (NF-E2) motif is identified in the promoter region that shows binding to NRF2 after its activation. Functionally, the siRNA knockdown of LUCAT1 in human bronchial epithelial cells shows a significant potentiation of cytotoxicity induced by CSE in...


LUNAR1

alias symbols:

tissues bone marrow

cancer type diffuse large B cell lymphoma

LncRNA LUNAR1 is down regulated in diffuse large B-cell lymphoma. It can inhibit cell proliferation via regulating E2F1, cyclin D1 and p21


Linc-ITGB1

alias symbols:

tissues breast,gallbladder

cancer type breast cancer,gallbladder cancer

LncRNA linc-ITGB1 is higher in breast cancer and gallbladder cancer. It regulates cancer cell proliferation, migration and invasion via regulating Cdc25C, Cyclin B1, E-cadherin, N-cadherin, vimentin and Snail.


Llme23

alias symbols:

tissues others

cancer type melanoma

LncRNA Llme23 is exclusively detected in human melanoma lines. It is found to bind immobilized PSF resin. Knocking down Llme23 remarkably suppresses the malignant property of YUSAC cells, accompanied by the repressed expression of proto-oncogene Rab23.


Lnc-CC3

alias symbols:

tissues cervix

cancer type cervical cancer

LncRNA CC3 is up-regulated in cervical cancer and higher in stage III specimens compared to the other stages. Lnc-CC3 can promote cell migration and invasion. Moreover, it can affect EMT via increasing slug expression and reducing the expression of the epithelial cell marker E-cadherin.


Lnc34a

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA Lnc34a is enriched in colon cancer stem cells (CCSCs) and initiates asymmetric division by directly targeting the microRNA miR-34a to cause its spatial imbalance. Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent of its upstream regulator, p53. Lnc34a level affects CCSC self-renewal and colorectal cancer (CRC) growth in xenograft models. Moreover, Lnc34a is up-regulated in late-stage CRCs, contributing to epigenetic miR-34a silencing and CRC proliferation.


LncRNA67

alias symbols:

tissues breast

cancer type breast cancer

LncRNA67 shows elevated expression in breast cancer. LncRNA67 increases the growth of MCF-7 cells. In addition, the study finds LncRNA67 may be important for estrogen-stimulated growth.


linc-POU3F3

alias symbols:

tissues colorectum,esophagus,nervous system,stomach

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma

LncRNA POU3F3 is higher in colorectal cancer, glioma, esophageal squamous cell carcinoma and gastric cancer. POU3F3 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, POU3F3 is negatively regulated by EZH2. Besides, it negatively regulates p18, caspase-9, caspase-3, E-cadherin and positively regulates cyclin D1, CDK4, pRb, Rb, N-cadherin.


linc-VLDLR

alias symbols:

tissues liver

cancer type hepatic cancer

Linc-VLDLR is significantly up-regulated in malignant hepatocytes. Exposure of HCC cells to diverse anticancer agents such as sorafenib, camptothecin, and doxorubicin increases linc-VLDLR expression in cells as well as extracellular vesicles (EV) released from these cells. Incubation with EVs reduces chemotherapy-induced cell death and also increases linc-VLDLR expression in recipient cells. RNAi-mediated knockdown of linc-VLDLR decreases cell viability and abrogates cell-cycle progression. Moreover, knockdown of linc-VLDLR reduces expression of ABCG2 (ATP-binding cassette, subfamily G memb...


linc223

alias symbols:

tissues bone marrow

cancer type acute myelocytic leukemia

Linc-223, the host transcript of miR-223, is down-regulated in acute myelocytic leukemia (AML) and its expression is associated with myeloid differentiation. It has two splicing variants, named linc-223-1 and linc-223-2. Through qPCR, linc-223 is significantly induced during monocytic differentiation. Linc-223 can stimulate differentiation of AML cells, while diminishing their proliferation rate. Linc-223 might act as a competing endogenous RNA (ceRNA) for miR-125-5p. There exists a specific crosstalk between linc-223 and IRF4 mRNA through competition for miR-125-5p binding.


lnc-MX1-1

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA MX1-1 is over-expressed in prostate cancer tissues and correlated between PSA, Gleason score, metastasis, and recurrence free survival. Moreover, knockdown of lnc-MX1-1 reduces both proliferation and invasiveness of prostate cancer cells.


lnc-URHC

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA URHC expression is increased in hepatocellular carcinoma (HCC) tissues and cells, its higher expression is correlated with poor overall survival. Functionally, URHC promotes cell proliferation and inhibits apoptosis. At molecular level, the study finds the ZAK gene, which is located near URHC on the same chromosome, is negatively correlated with URHC. Then, they confirm that URHC promotes HCC growth through ZAK via the ERK/MAPK signaling pathway.


lnc-WRAP53

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA WRAP53 is significantly higher in sera of hepatic carcinoma (HCC) than those with chronic hepatitis C virus (HCV) infection or healthy volunteers. Increased expression of WRAP53 is associated with advanced clinical parameters in HCC. Besides, WRAP53 is a significant independent prognostic marker in relapse-free survival. In addition, UCA1 and WRAP53 up-regulation may serve as novel serum biomarkers for HCC diagnosis and prognosis.


lnc-ZNF180-2

alias symbols:

tissues kidney

cancer type renal clear cell cancer

LncRNA ZNF180-2 levels are similar in localized renal clear cell carcinoma (ccRCC) and normal renal tissue, but significantly increased in advanced ccRCC tissue. Furthermore, ZNF180-2 expression level is an independent predictor for progression-free survival, cancer-specific survival and overall survival in ccRCC patients.