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MA-LINC1

alias symbols:

tissues breast,lung

cancer type breast cancer,lung cancer


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MDC1-AS

alias symbols:

tissues bladder,nervous system

cancer type bladder cancer,glioma

LncRNA MDC1-AS is up-regulated in bladder cancer and glioma and positively associated with MDC1. It has a role on cell proliferation.


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MFI2-AS

alias symbols:

tissues bone

cancer type osteosarcoma

LncRNA MFI2-AS is significantly overexpressed in human osteosarcoma tissues. Knockdown of lncRNA MFI2-AS expression suppresses cell proliferation, migration and invasion, and induces cell apoptosis. Furthermore, the expression of forkhead box P4 (FOXP4) is significantly increased and it is positively associated with MFI2-AS expression in tumor tissues. In addition, knockdown of FOXP4 expression by RNA interference strategy inhibits osteosarcoma cell proliferation, migration and invasion, and promotes cell apoptosis.


MINCR

alias symbols:

tissues bone marrow,gallbladder

cancer type Burkitt lymphoma,gallbladder cancer

LncRNA MINCR has the highest and most significant positively correlated with MYC expression level. It has the MYC binding regions around its transcriptional start site (TSS) in burkitt lymphoma (BL) cells and P493-6 cells, with increasing peak intensity in MYC high conditions in P493-6 cells. Moreover, MINCR has all of the marks associated with open chromatin and active transcription in normal and malignant B cells. Besides, the expression of MINCR is reduced after MYC knockdown in BL cell lines. Functionally, MINCR knockdown is associated with impairment in cell cycle progression. Differen...


MIR100HG

alias symbols:

tissues bone marrow,nervous system

cancer type acute megakaryocytic leukemia,neuroblastoma

LncRNA MIR100HG is higher in acute megakaryocytic leukemia (AMKL), lower in neuroblastoma. It can regulate cancer cell proliferation.


MIR31HG

alias symbols:

tissues bladder,breast,colorectum,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,gastric cancer,triple negative breast cancer

LncRNA MIR31HG is higher in breast cancer, lower in colorectal cancer, triple negative reast Cancer, bladder cancer, and gastric cancer. It can regulate cancer cell proliferation, migration, invasion and apoptosis. Mechanistically, it can regulate E2F1 and p21.


MIR4697HG

alias symbols:

tissues lung

cancer type lung cancer

LncRNA MIR4697HG is up-regulated in lung adenocarcinoma and significantly associated with clinical features. MIR4697HG is expressed at higher levels in the relapsed patients.


MIR503HG

alias symbols:

tissues others

cancer type choriocarcinoma

LncRNA MIR503HG is long inter-genic non-coding RNAs mapped on chromosome X (Xq26) and highly expressed in reproductive tissues. Its expression can be indirectly regulated by methylation. Moreover, MIR503HG is predominantly found in nucleus. Besides, MIR503HG can inhibit migration and invasion in JEG-3 choriocarcinoma cell line.


MONC

alias symbols:

tissues bone marrow

cancer type acute megakaryocytic leukemia

LncRNA MONC is highly expressed in acute megakaryocytic leukemia (AMKL) blasts and is mainly localized in the nucleus and its expression is correlated with the corresponding miRNA clusters. Knockdown of MONC impedes leukemic growth of AMKL cell lines. MONC interferes with hematopoietic lineage decisions and enhances the proliferation of immature erythroid progenitor cells.


MRUL

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA MRUL, locates 400 kb downstream of ABCB1 (ATP-binding cassette, subfamily B, member 1), is significantly up-regulated in two multidrug-resistant gastric cancer (GC) cell sublines, SGC7901/ADR and SGC7901/VCR. Furthermore, the relative expression level of MRUL in GC tissues is negatively correlated with growth inhibition rates of GC specimens treated with chemotherapeutic drugs and indicates a poor prognosis for GC patients. MRUL knockdown in SGC7901/ADR and SGC7901/VCR cells leads to increased rates of apoptosis, increased accumulation, and reduced doxorubicin (Adriamycin [ADR]) rele...


MT1DP

alias symbols:

tissues liver

cancer type hepatic cancer


MVIH

alias symbols:

tissues breast,liver,lung

cancer type breast cancer,hepatic cancer,non-small-cell lung cancer

LncRNA MVIH is up-regulated in breast cancer, non-small cell lung cancer (NSCLC) and hepatocellular carcinoma and high MVIH expression is correlated with Ki67 expression. Moreover, patients with high MVIH expression levels are associated with clinicopathologic parameters. In addition, up-regulated MVIH expression promotes cell proliferation, cell cycle and cell invasion, but inhibit cell apoptosis. Mechanistically, MVIH affects cell invasion via regulating the level of MMP2 and MMP9. Furthermore, MVIH could weaken the function of PGK1 in angiogenesis inhibition by reducing the secretion of ...