tissues bone marrow
cancer type T acute lymphoblastic leukemia
LncRNA NALT is located near NOTCH1 within 100 bp away. Upregulation of NALT is associated with NOTCH1 in human pediatric T cell acute lymphoblastic leukemia (T ALL) samples. Increased expression of NALT dramatically promotes cell proliferation in cell lines. Further xenograft tumor also indicates the growth inducing affection of NALT while could be partial reversed by gamma-secretase inhibitors (GSI). Besides, through sorting the side-population cells in T ALL cells treated with NALT shRNA could decrease the percentage of side population (SP) cell which companied by the down-regulation of N...
cancer type papillary thyroid cancer
LncRNA NAMA is weakly expressed in several human tissues, and the spliced forms are primarily detected in testis. It is inducible by inhibition of the MAP kinase pathway, growth arrest and DNA damage. Besides, the attenuated BRAF signal results in induction of NAMA.
tissues breast,kidney,nervous system
cancer type breast cancer,neuroblastoma,renal clear cell cancer
LncRNA NBAT1 is down-regulated in breast cancer and associated with tumor metastasis and poor patient prognosis. NBAT1 can inhibit migration and invasion of breast cancer cells. Mechanistic study shows that NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. Among them, DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2-dependent manner, and responsible for NBAT1's effects on inhibiting migration and invasion of breast cancer cells. While in neuroblastoma, CpG methylation and a high-risk neuroblastoma associated ...
tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach
cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer
LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...
cancer type lung cancer
LncRNA NFYC-AS1 is up-regulated in lung adenocarcinoma and significantly associated with survival time.
cancer type breast cancer
LncRNA NKILA (NF-KappaB Interacting LncRNA) is decreased and associated with breast cancer metastasis and poor patient prognosis. Mechanism studies show that NKILA is up-regulated by NF-κB, binds to NF-κB/IκB, and directly masks phosphorylation motifs of IκB, thereby inhibiting IKK-induced IκB phosphorylation and NF-κB activation. NKILA interacts with NF-κB/IκB to form a stable complex. Importantly, NKILA is essential to prevent over-activation of NF-κB pathway in inflammation-stimulated breast epithelial cells.
cancer type thyroid cancer
LncRNA NONHSAT037832 is significantly decreased in thyroid cancer (PTC) tissues and PTC cell lines. Down-regulated NONHSAT037832 is significantly associated with lymph node metastasis and tumor size. Moreover, NONHSAT037832 has diagnostic value.
cancer type renal clear cell cancer
LncRNA NONHSAT123350 is down-regulated renal clear cell carcinoma (RCCC) and is involved in the pathogenesis of RCCC. Its expression level is closely related to disease-free survival (DFS) and overall survival (OS) in patients without distant metastasis.
tissues nervous system
cancer type astrocytoma
LncRNA NR_002809 is up-regulated in astrocytoma and associated with advanced clinical stages and poor patient survival.
cancer type thyroid cancer
LncRNA NR_036575.1 is a ncRNA transcript of PDE4C. LncRNA NR_036575.1 is over-expressed in papillary thyroid cancer (PTC) tissues and TPC1 cells. Up-regulated NR_036575.1 is associated with tumor size and extrathyroidal extension in PTC. In addition, NR_036575.1 promotes cell proliferation and migration.
cancer type pancreatic cancer
LncRNA NUTF2P3-001 is over-expressed in pancreatic cancer and chronic pancreatitis tissues, which positively correlates with tumor size, tumor differentiation, TNM stage, lymphatic invasion, distant metastasis and survival time of patients. Knockdown of lncRNA-NUTF2P3-001 inhibits viability, proliferation and invasion in pancreatic cancer cell, accompanying with decreased KRAS expression. Mechanism studies show that NUTF2P3-001 regulates KRAS expression through competitively binding with miR-3923. Moreover, NUTF2P3-001 is transcriptionally up-regulated by HIF-1α in hypoxia.
cancer type bladder cancer
LncRNA n336928 is significantly higher in bladder cancer tissues compared to that in adjacent noncancerous tissues, and correlated with bladder tumor stage, histological grade and overall survival time. Moreover, n336928 can be an independent prognostic factor for overall survival for bladder cancer patients.
cancer type nasopharyngeal cancer
LncRNA n375709 is the most significantly overexpressed in nasopharyngeal carcinoma (NPC). Inhibition of lncRNA n375709 increases the paclitaxel sensitivity in NPC cells.
cancer type osteosarcoma
LncRNA n377360 is up-regulated in osteosarcoma tissues. In line with this, suppression of n377360 expression by siRNA significantly impairs cell proliferation potential of osteosarcoma cells.
cancer type bladder cancer,colorectal cancer
LncRNA ncRAN is higher in bladder cancer and lower in colorectal cancer. It can regulate cancer cell proliferation, migration, and invasion.
cancer type colorectal cancer,gastric cancer
LncRNA ncRuPAR is lower in colorectal cancer and gastric cancer and is associated with clinicopathological parameters.
cancer type uveal melanoma
LncRNA-numb is encoded by the LOC101928143 gene, whose locus is in the upstream of the protein-coding gene numb and encodes two different transcripts, 635bp and 644bp in size. qRT-PCR shows that LncRNA-635 is significantly down-regulated in uveal melanoma (UM) cells compared with the control, while the lncRNA-644 transcript did not exist. Moreover, lncRNA- numb is modulated by HIC1.