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P2RX7-V3

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tissues others

cancer type uveal melanoma

LncRNA P2RX7-V3 (P2RX7 variant 3) is a transcriptional variant transcribed from the P2RX7 gene locus, which is expressed at a high level in uveal melanoma (UM) cells. P2RX7-V3 silencing reveals that this variant acts as a necessary UM oncoRNA. Knockdown of P2RX7-V3 expression significantly suppresses tumor growth and cancer cell migration. Moreover, knockdown of P2RX7-V3 leads to decreased vimentin and increased E-cadherin. Besides, a genome-wide cDNA array reveals that a variety of genes are dysregulated following P2RX7-V3 silencing.


PACER

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tissues bone

cancer type osteosarcoma

LncRNA PACER is over-expressed in osteosarcoma tissues and cell lines. PACER knockdown inhibits the proliferation and invasion of human osteosarcoma cells. Downregulation of PACER significantly suppresses the expression of COX-2, and the effects of PACER on cell proliferation and invasion are rescued by COX-2 overexpression. Furthermore, COX-2 activation by PACER is NF-κB-dependent. Besides, the regulation of PACER by CCCTC-binding factor (CTCF) is associated with DNA methylation status.


PANDAR

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tissues bladder,breast,liver,lung,stomach

cancer type bladder cancer,breast cancer,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA PANDAR is higher in breast cancer, gastric cancer, hepatocellular carcinoma and bladder cancer, and lower in lung cancer. PANDAR expression level is associated with clinicopathological parameters such as depth of invasion lymphatic metastasis, histological grade, TNM stage and prognosis etc.. Functionally, PANDAR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, PANDAR negatively regulates p16 and Bcl-2.


PART1

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tissues stomach

cancer type gastric cancer

LncRNA PART1 is down-regulated in gastric cancer and linked to TNM stage.


PAUPAR

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tissues others

cancer type uveal melanoma

LncRNA PAUPAR is down regulated in uveal melanoma (UM). Further studies reveal that PAUPAR acts as a necessary UM suppressor and induces the silencing of HES1 expression, which significantly reduces tumor metastasis. Mechanistically, PAUPAR modulates HES1 expression by inhibiting histone H3K4 methylation.


PAX8-AS1

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tissues cervix

cancer type cervical cancer

LncRNA PAX8-AS1, a potential regulator of PAX8, contains specific single nucleotide polymorphisms (SNPs) that may represent expression quantitative trait loci (eQTLs) for PAX8. The study is conducted to identify the associations between two eQTLs SNPs (rs4848320 and rs1110839) and cervical cancer. The results reveal that variant allele T of rs4848320 and G of rs1110839 are associated with decreased risk of cervical cancer. Moreover, the haplotype containing variant alleles of the two SNPs significantly decreases the risk of cervical cancer compared to the most frequent haplotype.


PCA3

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tissues prostate

cancer type prostate cancer

LncRNA PCA3 is an antisense intronic lncRNA within a single PRUNE2 transcriptional unit. Levels of lncRNA PCA3 and PRUNE2 are inversely correlated in human prostate cancer specimens. Further studies reveal that PCA3 binds PRUNE2 pre-mRNA and regulates its expression. In addition, PCA3 functions as an oncogene in prostate cancer.


PCAT1

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tissues bladder,colorectum,esophagus,liver,lung,prostate

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,non-small-cell lung cancer,prostate cancer

LncRNA PCAT1 is higher in bladder cancer, esophageal squamous carcinoma colorectal cancer, hepatocellular carcinoma, lung cancer and prostate cancer. PCAT1 expression level is associated with clinicopathological parameters such as TNM stage, depth of tumor invasion, lymph node metastasis, prognosis etc.. Moreover, PCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, PCAT1 negatively regulates caspase-3.


PCAT29

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tissues prostate

cancer type prostate cancer

LncRNA PCAT29 is characterized along with its relationship to the androgen receptor. PCAT29 is suppressed by DHT and up-regulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increases proliferation and migration of prostate cancer cells, whereas PCAT29 overexpression confers the opposite effect and suppresses growth and metastases of prostate tumors. Finally, in prostate cancer patient specimens, low PCAT29 expression correlates with poor prognostic outcomes.


PCAT5

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tissues prostate

cancer type prostate cancer

LncRNA PCAT5 is up-regulated in prostate cancer and promotes growth, migration, and invasion of ERG-positive prostate cancer cells. Moreover, PCAT5 is under direct regulation by ERG.


PCAT6

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tissues lung

cancer type lung cancer

LncRNA PCAT6 is significantly increased in lung cancer tissues and correlates with metastasis and prognosis of lung cancer patients. PCAT6 significantly promotes cellular proliferation and metastasis, as well as inhibits early apoptosis of lung cancer cells. Molecular analysis reveals that PCAT6 regulates the expression of two pivotal cancer-related proteins, c-Myc and p53, in lung cancer cells. However, PCAT6 is not directly combined with c-Myc and p53 as confirmed by RNA immune-precipitation.


PCGEM1

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tissues prostate

cancer type prostate cancer

LncRNA PCGEM1 is up-regulated in prostate cancer and exhibits reciprocal regulation of miR-145. Transfection of the miR-145 expression vector and siRNA PCGEM1 inhibits tumor cell proliferation, migration, and invasion, and induces early apoptosis. Moreover, PCGEM1 is regulated by androgen receptor.


PCNA-AS1

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tissues liver,stomach

cancer type gastric cancer,hepatic cancer

PCNA-AS1, antisense to PCNA, is increased in gastric cancer tissues and associated with invasion. The expression level of PCNA-AS1 is also related with immunohistochemical biomarkers of BRCA1. While in hepatocellular carcinoma, PCNA-AS1 is significantly up-regulated in HCC and could promote tumor growth both in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability.


PEG10

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tissues bone marrow,esophagus

cancer type diffuse large B cell lymphoma,esophageal cancer

LncRNA PEG10 is higher in esophageal cancer tissues than in adjacent non-neoplastic tissues. This relatively high expression is significantly associated with the occurrence of lymph node metastases. Moreover, LncRNA PEG10 can promote proliferation and invasion, and inhibit apoptosis. While in diffuse large B cell lymphoma (DLBCL), PEG10 is up-regulated in DLBCL tumorous tissues and cell lines. Moreover, PEG10 is significantly correlated with B symptoms, IPI score, CHOP-like treatment and rituximab. In addition, PEG10 could be a diagnostic marker for distinguishing DLBCL from normal. Besides...


PICSAR

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tissues others

cancer type cutaneous squamous cell carcinoma

LncRNA PICSAR is up-regulated in cutaneous squamous cell carcinoma (cSCC) cells and is up-regulated by inhibition of p38α and p38δ mitogen-activated protein kinases. Further studies find that PICSAR is specifically expressed by tumor cells in cSCCs but not by keratinocytes in normal skin in vivo. Functionally, knockdown of PICSAR inhibits proliferation and migration of cSCC cells, and suppresses the growth of human cSCC xenografts in vivo. Furthermore, knockdown of PICSAR inhibits extracellular signal-regulated kinase 1/2 activity and up-regulates expression of dual specificity phosphatase ...


POU6F2-AS2

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tissues esophagus

cancer type esophageal squamous cell cancer

LncRNA POU6F2-AS2 is up-regulated in oesophageal squamous cell carcinoma (OSCC). Further studies reveal that POU6F2-AS2 is involved in the DNA damage response and regulates cells survival after ionizing radiation. Besides, POU6F2-AS2 interacts with Ybx1 protein and regulates its chromatin localization.


PRAL

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tissues liver

cancer type hepatic cancer

LncRNA PRAL, on chromosome 17p13.1, whose genomic alterations are significantly associated with reduced survival of hepatic carcinoma (HCC) patients. PRAL could inhibit HCC growth and induce apoptosis through p53. Subsequent investigations indicate that the three stem-loop motif at the 5' end of PRAL facilitates the combination of HSP90 with p53 and thus competitively inhibits MDM2-dependent p53 ubiquitination, resulting in enhanced p53 stability.


PRNCR1

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tissues colorectum,stomach

cancer type colorectal cancer,gastric cancer

LncRNA PRNCR1 is higher in colorectal cancer and regulates cancer cell proliferation. Single nucleotide polymorphisms (SNPs) in the lncRNA may influence the process of splicing and stability of mRNA conformation, resulting in altered cancer risk.


PTCSC2

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tissues thyroid

cancer type thyroid cancer

Transcripts of LncRNA PTCSC2 are down-regulated in papillary thyroid carcinoma (PTC). The risk allele [A] of rs965513 is significantly associated with low expression of unspliced PTCSC2, FOXE1, and TSHR in unaffected thyroid tissue. There exists a significant association of age and CLT with PTCSC2 unspliced transcript level. The correlation between the rs965513 genotype and the PTCSC2 unspliced transcript level remains significant after adjusting for age, gender, and CLT. Forced expression of PTCSC2 in the BCPAP cell line affects the expression of a subset of noncoding and coding transcript...


PTCSC3

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tissues thyroid

cancer type papillary thyroid cancer,thyroid cancer

LncRNA PTCSC3 expression is strongly down-regulated in thyroid tumor tissue. Its SNPs are associated with the risk of thyroid cancer. It can inhibit cell growth, migration, invasion, and affect the expression of genes involved in DNA replication, recombination and repair, cellular movement, tumor morphology and cell death.


PTENP1

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tissues liver,stomach

cancer type gastric cancer,hepatic cancer

LncRNA PTENP1 is a pseudogene of the tumor suppressor gene PTEN. PTENP1 and PTEN are down-regulated in several hepatocellular carcinoma (HCC) cells. Elevated level of PTENP1 and PTEN can suppress the oncogenic PI3K/AKT pathway, and inhibit cell proliferation, migration, invasion as well as induce autophagy and apoptosis. Over-expressed PTENP1 decoys oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62. In a word, PTENP1 can inhibit cell proliferation, elicit apoptosis and autophagy, and inhib...


PVT1

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tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...


PlncRNA-1

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tissues esophagus,liver,prostate

cancer type esophageal squamous cell cancer,hepatic cancer,prostate cancer

PlncRNA-1 is higher in esophageal squamous carcinoma, hepatic carcinoma and prostate cancer. Its expression level is associated with prognosis. Moreover, it can regulate cancer cell proliferation, invasion, apoptosis and EMT.


p21

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tissues bone marrow,colorectum,liver,lung,nervous system,others

cancer type colorectal cancer,diffuse large B cell lymphoma,glioma,hepatic cancer,lung cancer,lymphoma,sarcoma

LncRNA p21 is lower in diffuse large B cell lymphoma, glioma, lung cancer, sarcoma, lymphoma, colorectal cancer and hepatic carcinoma. Its expression level is associated with prognosis. It can regulate cancer cell proliferation and apoptosis.