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19records

RCCRT1

alias symbols:

tissues kidney

cancer type renal cancer

LncRNA RCCRT1 is up-regulated remarkably in renal cell carcinoma (RCC), particularly in high-grade RCC tissues and is associated with clinicopathologic findings such as tumor size, pathologic T stage, tumor grade, lymph node metastasis, and distant metastasis. Furthermore, depletion of RCCRT1 expression suppresses migration and invasion in RCC cell lines.


RGMB-AS1

alias symbols:

tissues lung

cancer type lung adenocarcinoma,non-small-cell lung cancer

LncRNA RGMB-AS1 is down-regulated in lung adenocarcinoma, and inhibits cell proliferation, migration and invasion. Further studies show that RGMB-AS1 may down-regulate RGMB expression though interacting with the exon2 sequence of RGMB. However, other study finds that RGMB-AS1 expression is significantly higher in non-small cell lung cancer (NSCLC) tissues and inversely correlated with RGMB mRNA. Both RGMB-AS1 and RGMB expression level are associated with the occurrence of differentiation status, lymph node metastases and TNM stage.


RHPN1-AS

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA RHPN1-AS is up-regulated in gastric cancer and linked to tumor grade.


RMEL3

alias symbols:

tissues others

cancer type melanoma

LncRNA RMEL3 expression is increased in melanoma and subcutaneous tumors compared to primary tumors. RMEL3 expression is also significantly increased in melanomas with a BRAFV600E mutation compared to those with a wild type BRAF or triple wild type for BRAF/RAS/NF1. Reverse phase protein array (RPPA) analysis finds that RMEL3 knockdown reduces cell cycle regulators (like pRB and Cyclin-B1) and anti-apoptotic proteins (like Bcl2), but increases p27 and some pro-apoptotic proteins as the example of caspase-8 and p38.


RMRP

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA RMRP level in tissue, plasma and gastric juices from patients with gastric cancer is significantly different from those from controls. Its level is significantly associated with Borrmann type and metastasis. RMRP in Plasma and gastric juice have higher sensitivity and specificity than commonly used markers. Knockdown of RMRP significantly inhibits cell proliferation. Moreover, RMRP is a sponge of miR-206, and modulates cell cycle by regulating Cyclin D2 expression.


RMST

alias symbols:

tissues breast

cancer type triple negative breast cancer

LncRNA RMST is down-regulated TNBC (triple negative breast cancer) and associated with prognosis of TNBC patients. However, the difference is not statistically significant.


RP11-119F7.4

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA RP11-119F7.4 expression is significantly down-regulated in the gastric cancer tissues and significantly associated with the macroscopic type and Lauren grade. However, no statistically significant differences are observed between RP11-119F7.4 expression and patient survival.


RP11-284N8.3.1

alias symbols:

tissues ovary

cancer type ovarian cancer

LncRNA RP11-284N8.3.1 is down-regulated in ovarian cancer. It could significantly divide late-stage patients into high- and low-risk groups. Moreover, RP11-284N8.3.1 expression level is associated with a decreased risk of survival. Low-risk groups always have higher expression level of RP11-284N8.3.1 than the high-risk groups. In addition, RP11-284N8.3.1 is significantly associated with patient progression-free survival. Besides, RP11-284N8.3.1 involves in immune- and cell-cycle-associated processes.


RP11-395G23.3

alias symbols:

tissues endometrium

cancer type endometrial cancer

LncRNA RP11-395G23.3 is down-regulated in endometrial carcinoma. Overexpression of RP11-395G23.3 results in down-regulated expression and activity of miR-205-5p.


RP11-397D12.4

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA RP11-397D12.4 is up-regulated in non-small cell lung cancer (NSCLC), and may be a potential biomarker for predicting the tumorigenesis of NSCLC.


RP11-434D9.1

alias symbols:

tissues breast

cancer type triple negative breast cancer

LncRNA RP11-434D9.1 is down-regulated in triple negative breast cancer (TNBC) and correlated with TNBC occurrence. Besides, it can be a potential biomarker to differentiate TNBC from non-TNBC.


RP11-445H22.4

alias symbols:

tissues breast

cancer type breast cancer

LncRNA RP11-445H22.4 is significantly increased in breast cancer. Its expression levels are correlated with estrogen receptor (ER), progesterone receptor (PR), and menopausal status of the breast cancer patients (p < 0.05). For the detection of breast cancer, the use of RP11-445H22.4 shows a remarkable improvement compared with the clinical serum carcinoembryonic antigen.


RP11-462C24.1

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA RP11-462C24.1 expression level is lower in colorectal cancer (CRC) tissues. Furthermore, its expression level is lower in CRC patients with metastasis than those without metastasis. In addition, low expression of RP11-462C24.1 significantly correlates with more distant metastasis. Besides, RP11-462C24.1 is an independent predictor for patients’ prognosis and low expression of RP11-462C24.1 has a poor disease-free survival.


RPL13AP23

alias symbols:

tissues pancreas

cancer type pancreatic cancer

RPL13AP23 expression level is remarkably decreased in pancreatic ductal adenocarcinoma (PDAC) tissues and associated with tumor node metastasis stage, lymph node metastasis and prognosis. Besides, enforced expression of RPL13AP23 suppresses PDAC cells' invasion. Moreover, overexpression of RPL13AP23 significantly increases both mRNA and protein level of OS-9. The lncRNA RPL13AP23 inhibits tumor invasion by suppressing HIF-1α expression through modulating OS-9 function.


RPLP0P2

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA RPLP0P2 is up-regulated in gastric cancer and negatively associated with overall survival.


RPS24P1

alias symbols:

tissues nasopharynx

cancer type nasopharyngeal cancer

RPS24P1 is down-regulated in metastatic nasopharyngeal carcinoma (NPC) and high RPS24P1 expression level is associated with disease progression among NPC patients.


RSU1P2

alias symbols:

tissues cervix

cancer type cervical cancer

LncRNA RSU1P2 is up-regulated in human cervical cancer tissues. RSU1P2 promotes the proliferation, cell cycle progression, invasion, migration, and EMT and reduces apoptosis. At molecular level, upregulation of RSU1P2 results in the downregulation of E-cadherin and the upregulation of vimentin and ICAM-1. Besides, RSU1P2, by binding let-7a, acts as a decoy to abolish the miRNA-repressing activity on IGF1R, N-myc and EphA4 3′UTR.


RUNXOR

alias symbols:

tissues bone marrow

cancer type acute myelocytic leukemia

LncRNA RUNXOR is transcribed as unspliced transcript from an upstream overlapping promoter. RUNXOR is up-regulated in acute myelocytic leukemia (AML) samples and in response to Ara-C treatment. RUNXOR utilizes its 3'-terminal fragment to directly interact with the RUNX1 promoter and enhancer, and participates in the orchestration of an intra-chromosomal loop. The 3' region of RUNXOR also participates in long-range inter-chromosomal interactions with chromatin regions that are involved in multiple RUNX1 translocations.


RoR

alias symbols: lincRNA-ST8SIA3, lincRNA-RoR, ROR

tissues breast,colorectum,liver,nasopharynx,nervous system,pancreas

cancer type breast cancer,colorectal cancer,glioma,hepatic cancer,nasopharyngeal cancer,pancreatic cancer,triple negative breast cancer

LncRNA ROR is higher in breast cancer(24922071), pancreatic cancer, colon cancer, nasopharyngeal carcinoma and lower in glioma. ROR expression level is associated with clinicopathological parameters such as tumor size, prognosis. ROR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ROR can bind to miR-145. Moreover, ROR negatively regulates E-cadherin and KLF4, while positively regulates ZEB1, ZEB2, vimentin, fibronectin, N-cadherin, and SOX11.