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SAMMSON

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tissues others

cancer type melanoma

LncRNA SAMMSON is up-regulated in melanoma. SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF, NRAS or TP53 mutational status. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function.


SARCC

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tissues kidney

cancer type renal cancer

LncRNA SARCC is differentially regulated by hypoxia in a von Hippel-Lindau (VHL)-dependent manner both in renal cell carcinoma (RCC) cell culture and clinical specimens. SARCC can suppress hypoxic cell cycle progression in the VHL-mutant RCC cells while derepress it in the VHL-restored RCC cells. Mechanism dissection reveals that SARCC can post-transcriptionally regulate androgen receptor (AR) by physically binding and destablizing AR protein to suppress AR/HIF-2α/C-MYC signals. In return, HIF-2α can transcriptionally regulate the SARCC expression via binding to hypoxia-responsive elements ...


SBF2-AS1

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tissues lung

cancer type non-small-cell lung cancer

LncRNA SBF2-AS1 is significantly up-regulated in non-small cell lung cancer (NSCLC) and a high expression level of SBF2-AS1 is correlated with lymph node metastasis and advanced TNM stage. SBF2-AS1 promotes proliferation, migration and metastasis of NSCLC cells. At molecular level, the study finds that SBF2-AS1 controls the cell cycle by inhibiting P21 via binding to SUZ12 region of P21.


SChLAP1

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tissues bladder,prostate

cancer type bladder cancer,prostate cancer

LncRNA SChLAP1 is higher in bladder cancer and prostate cancer. SChLAP1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, SChLAP1 can bind to SWI/SNF chromatin-modifying complex and negatively regulates SNF5.


SDMGC

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tissues stomach

cancer type gastric cancer

Expression levels of LncRNA SDMGC and its target gene TRIM16 are up-regulated in the distant metastasis tissues, compared with primary gastric cancer (GC) tissues, two of which are positive correlation. SDMGC and TRIM16 can promote cell invasion and migration. However, the research finds they have little effect on proliferation, cell cycle, colony formation, and apoptosis.


SLC26A4-AS1

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tissues stomach

cancer type gastric cancer

LncRNA SLC26A4-AS1 is down-regulated in gastric cancer and linked to tumor grade.


SMIM10L2A

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tissues stomach

cancer type gastric cancer

LncRNA SMIM10L2A is down-regulated in gastric cancer and positively correlated with overall survival.


SMIM10L2B

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tissues stomach

cancer type gastric cancer

LncRNA SMIM10L2B is down-regulated and positively correlated with overall survival.


SNHG1

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tissues liver,nervous system

cancer type astrocytoma,hepatic cancer

LncRNA SNHG1 is up-regulated in hepatocellular carcinoma (HCC) tissues and astrocytoma tissues. High SNHG1 expression is correlated with large tumor size, poor differentiation, aggressive BCLC stage, and poor prognosis. SNHG1 promotes HCC cells proliferation, cell cycle progression and inhibits HCC cells apoptosis. Further experiments reveal that SNHG1 promotes HCC cells proliferation through inhibiting p53 and p53-target genes expression.


SNHG10

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tissues lung

cancer type lung cancer

LncRNA SNHG10 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


SNHG12

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tissues bone,endometrium

cancer type endometrial cancer,osteosarcoma

SNHG12 is up-regulated in endometrial carcinoma and osteosarcoma tissues and cell lines. AMOT mRNA expression level is positively correlated with SNHG12 expression level. SNHG12 promotes cell proliferation, migration and inhibits apoptosis.


SNHG15

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tissues liver,stomach

cancer type gastric cancer,hepatic cancer

LncRNA SNHG15 is up-regulated in gastric cancer (GC) and hepatocellular carcinoma (HCC). Furthermore, increased SNHG15 expression is correlated with clinicopathologic feature and prognosis. Functionally, SNHG15 expression can promote cell proliferation and invasion and inhibit apoptosis. Mechanistically, SNHG15 promotes cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression.


SNHG20

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tissues liver

cancer type hepatic cancer

LncRNA SNHG20 is remarkably up-regulated in hepatocellular carcinoma (HCC) tissues. The expression of SNHG20 is associated with tumor size, clinical stage, overall survival, disease-free survival and prognosis. Functionally, SNHG20 significantly promotes cellular proliferation, migration, and invasion.


SNHG3

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tissues liver

cancer type hepatic cancer

LncRNA SNHG3 is significantly up-regulated in hepatocellular carcinoma (HCC) tissues, which is consistent with the results of two independent HCC cohorts from The Cancer Genome Atlas (TCGA) and Oncomine databases. Furthermore, SNHG3 expression is significantly correlated with tumor size, portal vein tumor thrombus and relapse. The high expression level of SNHG3 is markedly correlated with overall survival, recurrence-free survival and disease-free survival. Besides, multivariate analysis indicates that SNHG3 expression is an independent prognostic factor for HCC patients.


SNHG5

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tissues stomach

cancer type gastric cancer

LncRNA SNHG5 is significantly down-regulated in gastric cancer (GC), and significantly associated with the formation of a tumor embolus and tumor, node and metastasis (TNM) stage. Functionally, SNHG5 suppresses GC cell proliferation and metastasis. Furthermore, SNHG5 exerts its function through interacting with MTA2, preventing the translocation of MTA2 from the cytoplasm into the nucleus. SNHG5 overexpression leads to significant increase in the acetylation levels of histone H3 and p53, indicating that SNHG5 might affect acetylation by trapping MTA2 in the cytosol, thereby interfering with...


SOCS2-AS1

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tissues prostate

cancer type prostate cancer

LncRNA SOCS2-AS1 is higher in castration-resistant prostate cancer model cells, i.e. long-term androgen-deprived (LTAD) cells, than in parental androgen-dependent LNCaP cells. SOCS2-AS1 promotes castration-resistant and androgen-dependent cell growth. Moreover, SOCS2-AS1 knockdown up-regulates genes related to the apoptosis pathway, including tumor necrosis factor superfamily 10 (TNFSF10), and sensitizes prostate cancer cells to docetaxel treatment. Besides, SOCS2-AS1 promotes androgen signaling by modulating the epigenetic control for AR target genes including TNFSF10.


SOX2OT

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tissues breast,colorectum,esophagus,liver,lung

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,lung cancer

LncRNA SOX2OT is higher in breast cancer, lung cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma and colorectal cancer. SOX2OT expression level is negatively correlated with prognosis. SOX2OT regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, Sox2ot positively regulates EZH2, Cyclin B1, Cdc2, SOX2 and OCT4.


SPRY4-IT1

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tissues bladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma, glioma, melanoma, colorectal cancer, bladder cancer(25973088), clear cell renal cell carcinoma, lower in non-small cell lung cancer (NSCLC), but has dual roles in gastric cancer. SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc.. Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, SPRY4-IT1 negatively regulates E-cadherin, ZO-1 and positively re...


SRA

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tissues breast

cancer type breast cancer

 LncRNA SRA, locates on chromosome 5q31.3 and contains five exons and four introns. It is a non-coding transcript of protein coding gene SRA1. The study evaluates the association between two haplotype tagging SNPs (htSNPs) (rs10463297, rs801460) of the whole LncRNA SRA sequence and breast cancer risk. The results show that rs10463297 TC genotype significantly increases BC risk compared with CC genotype in both the codominant and recessive genetic models. Both TC, TC + CC genotypes of rs10463297 and GA, AA, GA+AA genotypes of rs801460 are significantly associated with estrogen receptor (ER) ...


SRHC

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tissues liver

cancer type hepatic cancer

LncRNA SRHC is down-regulated in hepatocellular carcinoma (HCC) and a lower SRHC expression level is significantly more frequent in tissues with a high serum of a-fetoprotein level and a low degree of differentiated tumors. Furthermore, the promoter region of SRHC contains a CpG-rich island, and SRHC is down-regulated in tumors by DNA methylation.


SUMO1P3

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tissues bladder,stomach

cancer type bladder cancer,gastric cancer

LncRNA SUMO1P3 is significantly up-regulated in bladder cancer tissues and gastric cancer. Moreover, up-regulated SUMO1P3 expression is correlated with clinicopathological parameters. Furthermore, SUMO1P3 can promote cell proliferation, migration and inhibit apoptosis of bladder cancer cells.


snaR

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tissues colorectum

cancer type colorectal cancer

LncRNA snaR is down-regulated in 5-FU-resistant colon cancer cells. Downregulation of snaR decreases cell death after 5-FU treatment, which indicates that snaR loss decreases in-vitro sensitivity to 5-FU.