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T-ALL-R-LncR1

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tissues bone marrow

cancer type T acute lymphoblastic leukemia

LncRNA T-ALL-R-LncR1 is a non-coding transcript of protein coding gene PAWR. LncRNA T-ALL-R-LncR1 is not observed in human normal tissues, while in some tumor tissues indeed. T-ALL-R-LncR1 is markedly expressed in neoplastic T lymphocytes. T-ALL-R-LncR1 knockdown predisposes Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies reveal that T-ALL-R-LncR1 knockdown facilitates the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells.


TATDN1

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tissues lung

cancer type non-small-cell lung cancer

LncRNA TATDN1 is highly expressed in 95D cells and non-small cell lung cancer (NSCLC) tumor tissues compared to 95C cells. Knockdown of TATDN1-1 by shRNA significantly inhibits cell proliferation, adhesion, migration and invasion in 95D cells. Further mechanism study shows that TATDN1 knockdown suppresses the expression of E-cadherin, HER2, β-catenin and Ezrin. Moreover, knockdown of TATDN1 also inhibits tumor growth and metastasis in a 95D mouse model in vivo by inhibiting β-catenin and Ezrin.


TC0100223

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tissues ovary

cancer type ovarian cancer

LncRNA TC0100223 is downregulated in ERα+ ovarian cancer tissues and correlated with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade.


TC0101441

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tissues ovary

cancer type ovarian cancer

LncRNA TC0101441 is upregulated in ERα+ ovarian cancer tissues and correlated with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade. Furthermore, multivariate analysis indicates that TC0101441 is an independent prognostic factor for overall survival.


TC0101686

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tissues ovary

cancer type ovarian cancer

LncRNA TC0101686 is downregulated in ERα+ ovarian cancer tissues and correlated with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade.


TCF7

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tissues liver

cancer type hepatic cancer

LncRNA TCF7 that is highly expressed in hepatic carcinoma (HCC) tumors and liver cancer stem cells (CSCs). LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Moreover, IL-6 transcriptionally activates the expression of lncTCF7 in HCC cells by activating STAT3, a transcription activator which binds to the promoter region of lncTCF7. Furthermore, knocking-down STAT3 and inhibiting STAT3 activation reduce TCF7 expression. Important...


TCL6

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tissues kidney

cancer type renal clear cell cancer

LncRNA TCL6 is decreased in clear cell renal cell carcinoma (ccRCC). Kaplan-Meier analysis indicates that reduced expression of TCL6 is associated with pTNM stage and poor prognosis. Moreover, TCL6 expression is an independent predictor of ccRCC aggressiveness and has significant hazard ratios [HRs] for predicting clinical outcome. Overexpression of TCL6 decreases proliferation and increases apoptosis compared to controls.


TCONS_l2_00022545

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tissues colorectum

cancer type colorectal cancer

LncRNA TCONS_l2_00022545 is up-regulated in metastasis colorectal cancer and significantly increases cell proliferation and migration.


THBS4-003

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tissues prostate

cancer type prostate cancer

LncRNA-thrombospondin 4 (THBS4)-003 is a processed transcript, which does not encode a protein product. LncRNA THBS4-003 is located at chromosome 5p14.1 and partially overlaps with the protein-coding gene, THBS4. The expression levels of THBS4 and lncRNA-THBS4-003 are significantly higher in prostate cancer (PC) tissues. THBS4 and lncRNA-THBS4-003 significantly promote the migratory and invasive abilities of the PCa cells. Functionally, lncRNA-THBS4-003 and THBS4 regulate levels of MMP-9 through the MAPK signaling pathway.


THUMPD3-AS1

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tissues lung

cancer type lung cancer

LncRNA THUMPD3-AS1 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


TINCR

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tissues colorectum,esophagus,stomach

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer

LncRNA TINCR is higher in esophageal squamous cell carcinoma, gastric cancer and lower in colorectal cancer. TINCR expression level is associated with clinicopathological parameters such as invasion, lymph metastasis, TNM stage, differentiation etc.. TINCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TINCR can bind to EpCAM and STAU1. Moreover, TINCR negatively regulates c-Myc and positively regulates CLDN7, ANXA1.


TMPO-AS1

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tissues lung

cancer type lung cancer

LncRNA TMPO-AS1 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


TP73-AS1

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tissues esophagus

cancer type esophageal squamous cell cancer

LncRNA TP73-AS1 and BDH2 levels are generally up-regulated in esophageal cancer tissues and are strongly correlated with tumor location or TNM stage in clinical samples. LncRNA TP73-AS1 knockdown inhibits BDH2 expression whereas BDH2 knockdown represses esophageal cancer cell proliferation and induces apoptosis via the caspase-3dependent apoptotic pathway. Overexpression of BDH2 in lncRNA TP73-AS1 knockdown cells partially rescues cell proliferation rates and suppresses apoptosis. In mouse xenografts, tumor size is reduced in lncRNA TP73-ASI siRNA-transfected tumors. In addition, BDH2 or ln...


TRPM2-AS

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tissues prostate

cancer type prostate cancer

TRPM2-AS is an antisense transcript of TRPM2, which encodes an oxidative stress-activated ion channel, and overexpressed in prostate cancer (PCa). The high expression of TRPM2-AS and its related gene signature are found to be linked to poor clinical outcome. Mechanistically, TRPM2-AS knockdown leads to PCa cell apoptosis. Moreover, targets of existing drugs and treatments are found to be consistently associated with high TRPM2-AS levels in both targeted cells and patients, ultimately suggesting that the measurement of expression level of TRPM2-AS allows not only for the early identification...


TSLC1-AS1

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tissues nervous system

cancer type glioma

LncRNA TSLC1-AS1 and TSLC1 are both down-regulated in glioma tissue samples. Functionally, TSLC1-AS1 inhibits cell proliferation, migration and invasion. Moreover, TSLC1-AS1 is positively correlated with TSLC1. Besides, TSLC1-AS1 is also positively correlated with other tumor suppressors NF1, VHL, PIK3R1 and negatively correlated with the oncogene BRAF.


TSPEAR-AS2

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tissues stomach

cancer type gastric cancer

LncRNA TSPEAR-AS2 is up-regulated in gastric cancer and linked to tumor grade.


TUBA4B

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tissues lung

cancer type non-small-cell lung cancer

LncRNA TUBA4B is lower in non-small cell lung cancer (NSCLC) tissues and cell lines. The lower expression of TUBA4B is remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. Besides, overexpression of TUBA4B inhibits cell proliferation ability.


TUC339

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tissues liver

cancer type hepatic cancer

LncRNA TUC339 is up-regulated in hepatic carcinoma (HCC). TUC339 is functionally implicated in modulating tumor cell growth and adhesion. Suppression of TUC339 by siRNA reduces HCC cell proliferation, clonogenic growth, and growth in soft agar. Thus, inter-cellular transfer of TUC339 represents a unique signaling mechanism by which tumor cells can promote HCC growth and spread.


TUG1

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tissues bladder,bone,colorectum,esophagus,kidney,liver,lung,nervous system,stomach

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,hepatoblastoma,non-small-cell lung cancer,osteosarcoma,renal cancer

LncRNA TUG1 is higher in esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, osteosarcoma, colorectal cancer and bladder cancer, and lower in glioma andnon-small cell lung cancer (NSCLC). TUG1 expression level is associated with clinicopathological parameters such as invasion, lymph node metastasis, TNM stage, prognosis etc.. TUG1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TUG1 can bind to SP1 and PRC2. Moreover, TUG1 negatively regulates E-cadherin, miR-144, Bcl-2, KLF2 and positively regulates N-cadhe...


TUSC7

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tissues bone,colorectum,lung,pancreas,stomach

cancer type colorectal cancer,gastric cancer,non-small-cell lung cancer,osteosarcoma,pancreatic ductal adenocarcinoma

LncRNA TUSC7 is lower in colorectal cancer, osteosarcoma, pancreatic ductal adenocarcinoma, gastric cancer and non-small cell lung cancer. TUSC7 expression level is associated with clinicopathological parameters such as tumor size, tumor stage, distant metastasis and prognosis. Functionally, TUSC7 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, TUSC7 can bind to P53 and miR-211. Mechanistically, TUSC7 negatively regulates Cyclin D1, VEGF, Bcl2, miR-23b and positively regulates cyclin A2, cyclin B1, BCL2, BimEL.


treRNA

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tissues liver

cancer type hepatic cancer

LncRNA treRNA is negatively correlated with miR-190a expression level in hepatocellular carcinoma (HCC) tissues. After the miR-190 inhibitor (anti-190) is transfected into HCC cells, there are significantly increased expression level of treRNA. Inhibition of EMT via miR-190a mediates treRNA silencing in HCC cells.