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UBC1

alias symbols:

tissues bladder,stomach

cancer type bladder cancer,gastric cancer

LncRNA UBC1 is significantly up-regulated in gastric cancer tissues and bladder cancer. Furthermore, high UBC1 expression is associated with clinicopathological parameter such as lymph-node metastasis, tumor size, TNM stage and poorer prognosis. Functionally, UBC1 promotes proliferation, motility and invasion of gastric cancer cells. Moreover, UBC1 acts in trans and binds to PRC2 complex and suppresses its target genes in bladder cancer cell.


UCA1

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


UFC1

alias symbols:

tissues liver

cancer type hepatic cancer

Level of the LncRNA UFC1 is increased in hepatic carcinoma (HCC) tissues compared with controls, and associated with tumor size, barcelona clinic liver cancer stage, and patient outcomes. Transgenic expression of the UFC1 in HCC cells promotes their proliferation and cell-cycle progression and inhibits apoptosis. Moreover, UFC1 interacts directly with the messenger RNA (mRNA) to stabilize protein HuR (encoded by ELAVL1) to increase levels of β-catenin (encoded by CTNNB1) mRNA and protein. However, there is a negative correlation between level of microRNA 34a and UFC1 in HCC tissues; microRN...


UMODL1-AS1

alias symbols:

tissues breast

cancer type breast cancer

LncRNA UMODL1-AS1 is up-regulated in breast cancer and its up-regulation is associated with poor overall survival due to copy number alteration. Moreover, its up-regulation can predict recurrence.


UNMIBC

alias symbols:

tissues bladder

cancer type bladder cancer

LncRNA UNMIBC is up-regulated in the primary non-muscle invasive bladder cancer and significantly associated with recurrence. Moreover, UNMIBC has a key role in G0/G1 arrest. Furthermore, RNA and chromatin immune-precipitation assays demonstrate that UNMIBC is physically associated with EZH2 and SUZ12, leading to an altered histone H3 lysine 27 methylation status of target genes.


USMycN

alias symbols:

tissues nervous system

cancer type neuroblastoma

LncRNA USMycN is co-amplified with MYCN in 88 of 341 human neuroblastoma tissues. USMycN RNA binds to the RNA-binding protein Nono, leading to N-Myc RNA upregulation and neuroblastoma cell proliferation. High levels of USMycN and NonO expression in human neuroblastoma tissues independently predict poor patient prognoses. Besides, treatment with antisense oligonucleotides targeting USMycN in neuroblastoma-bearing mice statistically significantly hinders tumor progression.


Uc001lsz

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA uc001lsz is reduced in gastric cancer cell lines and tissues. It is associated with TNM stage, and dys-regulated in early cancer and precancerous lesions. Thereby, uc001lsz may be a potential marker for the diagnosis of early gastric cancer.


uc.63

alias symbols:

tissues breast

cancer type breast cancer

Transcribed ultra-conserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultra-conserved stretches in the human genome. uc.63 is one specific T-UCRs which is up-regulated and associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Moreover, uc.63 can inhibit apoptosis of breast cancer cells.


uc002kmd.1

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA uc002kmd.1 expression is usually highly expressed in colorectal cancer. Through a series of experiments, the results show that uc002kmd.1 regulates CD44 as a molecular decoy for miR211-3p. Moreover, LncRNA-uc002kmd.1 modulates cell growth.


uc002mbe.2

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA uc002mbe.2 expression level is significantly lower in the hepatic carcinoma (HCC) cell lines and liver cancer tissues. The histone deacetylase inhibitor (TSA) induces uc002mbe.2 expression that is positively correlated with the apoptotic effect of TSA in HCC cells. In addition, knocking down the expression of uc002mbe.2 significantly reduces TSA-induced apoptosis of Huh7cells.


uc002yug.2

alias symbols:

tissues esophagus

cancer type esophageal cancer

LncRNA uc002yug.2 is commonly over-expressed in esophageal cancer (ESCC) compared with paired peritumoral tissue in eastern and southern Chinese populations. The expression levels of uc002yug.2 in ESCC might be a prognostic factor for survival. Moreover, uc002yug.2 promotes a combination of RUNX1 and alternative splicing (AS) factors in the nucleus to produce more RUNX1a, the short isoform and inhibitor of RUNX1, and reduces CEBPα (CCAAT/enhancer-binding protein-α) gene expression, thereby promoting ESCC progression.


uc003opf.1

alias symbols:

tissues esophagus

cancer type esophageal squamous cell cancer

Significant differences are found between patients and controls in the genotype frequencies for the rs11752942A>G site in the uc003opf.1 exon. Compared with the rs11752942AA genotype, AG and GG genotypes have a significantly reduced risk of esophageal squamous cell carcinoma (ESCC). Biochemical analysis demonstrates that, when compared with the A allele, the rs11752942 G allele could markedly attenuate the level of uc003opf.1 both in vivo and in vitro by binding with micro-RNA-149, thereby affecting cell proliferation and tumor growth.


uc003wbd

alias symbols:

tissues liver

cancer type hepatic cancer

Serum leve of lncRNA uc003wbd is increased in the patients with hepatic carcinoma (HCC) and hepatitis B viral (HBV). uc003wbd might be able to discriminate HCC patients or HBV patients from healthy controls and discriminate HCC patients from HBV patients.