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WT1-AS

alias symbols:

tissues kidney,liver,stomach

cancer type Wilms' tumour,gastric cancer,hepatic cancer

LncRNA WT1-AS expression is significantly down-regulated in gastric cancer, hepatocellular carcinoma and Wilms' tumor. It is associated with tumor size and the clinicopathological stage. Functionally, it can inhibit cell proliferation, migration, and invasion. Furthermore, ectopic expression of WT1-AS can inhibit tumor growth and metastasis in vivo. Moreover, WT1-AS could modulate ERK protein phosphorylation and WT1 level.