tissues breast,liver,nasopharynx,nervous system
cancer type breast cancer,glioma,hepatic cancer,nasopharyngeal cancer
LncRNA XIST is higher in glioma, nasopharyngeal carcinoma, and lower in breast cancer. XIST regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, XIST can bind to miR-152, miR-34a-5p. Moreover, XIST negatively regulates pAKT, OCT4 and positively regulates E2F3.
cancer type cervical cancer
LncRNA XLOC_010588 expression in cervical cancer is significantly down-regulated and correlated with FIGO stage, tumor size and SCC-Ag. Moreover, cervical cancer patients with XLOC_010588 lower expression have shown poorer prognosis. Functionally, ectopic expression of XLOC_010588 inhibits the proliferation of HeLa and SiHa cells. Western blot assays confirm that XLOC_010588 physically associates with c-Myc, consequently decreasing the expression of c-Myc. Besides, the expressions of XLOC_010588 and c-Myc are strongly correlated in cervical cancer tissues.