cancer type breast cancer
LncRNA Z38 is identified as a protein-coding sequence (isoform a) of the CLDND1 mRNAs, which is highly expressed in breast cancer. Moreover, inhibiting Z38 expression by gene silencing greatly suppresses breast cancer cell proliferation and tumorigenesis, and treatment with Z38 siRNAs significantly induces cell apoptosis and inhibits tumor growth.
cancer type esophageal squamous cell cancer,hepatic cancer
LNCRNA ZEB1-AS1 is up-regulated in esophageal squamous cell carcinoma (ESCC) tissues and associated with tumor grade, depth of invasion, lymph node metastasis and prognosis. In hepatic carcinoma, ZEB1-AS1 is frequently up-regulated in hepatocellular carcinoma (HCC) samples, especially in metastatic tumor tissues with its promoter hypomethylation. Aberrant methylation is tightly correlated with overexpression of ZEB1-AS1 in HCC. Patients with ZEB1-AS1 hypomethylation or with high ZEB1-AS1 expression have poor recurrence-free survival. Functionally, ZEB1-AS1 promotes tumor growth and metastas...
cancer type bladder cancer
LncRNA ZEB2NAT is demonstrated to be essential for TGFβ1-dependent process. ZEB2NAT depletion reverses CAF-CM-induced EMT and invasion of cancer cells, as well as reduces the ZEB2 protein level. Consistently, TGFβ1 mRNA expression is positively correlated with ZEB2NAT transcript and ZEB2 protein level in human bladder cancer specimens.
cancer type colorectal cancer,gastric cancer,hepatic cancer
LncRNA ZFAS1 is higher in colorectal cancer, gastric cancer and hepatocellular carcinoma. ZFAS1 expression level is associated with clinicopathological parameters such as lymphatic invasion, TNM stage, prognosis etc.. ZFAS1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, ZFAS1 can bind to EZH2, LSD1, CoREST, miR-150, miR-590-3p. Besides, ZFAS1 negatively regulates PARP and positively regulates ZEB1, MMP14, MMP16, cyclin B1 and p53.
cancer type gastric cancer
LncRNA ZMAT1 transcript variant 2 is down-regulated in gastric cancer tissues compared with adjacent normal tissues and inversely correlated with lymph node metastasis, depth of tumor invasion and tumor node metastasis stage. Moreover, ZMAT1 transcript variant 2 expression is an independent predictor for overall survival.
cancer type type 2 epithelial ovarian cancer
LncRNA ZNF300P1 is methylated in multiple ovarian cancer cell lines. Loss of ZNF300P1 results in decreased cell proliferation and colony formation. In addition, knockdown of the ZNF300P1 transcript results in aberrant and less persistent migration in wound healing assays due to a loss of cellular polarity. Moreover, ZNF300P1 has a potential function in metastasis of ovarian cancer cells to sites within the peritoneal cavity.
cancer type hepatic cancer,lung cancer
The eQTLs SNPs in LncRNA ZNRD1-AS1 may influence both chronic HBV infection and hepatocellular carcinoma (HCC) development. Three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) is tested to investigate ZNRD1-AS1 with the risk of both chronic HBV infection and HCC. The results reveal that variant alleles of all the three SNPs increase host HCC risk, whereas variant allele of rs3757328 is only associated with HBV clearance. Moreover, the haplotype containing variant alleles of the three SNPs are significantly associated with both HCC development and HBV clearance. In-vitro experiments...
cancer type lung adenocarcinoma
LncRNA ZXF1 level is remarkably increased in lung adenocarcinoma tissues compared with adjacent non-cancerous lung tissues, and up-regulated ZXF1 is correlated with lymph node metastasis, tumor pathological stage and the extent of lymph node metastasis. The 3-year overall survival rate of patients with higher ZXF1 levels is remarkably reduced compared with patients with lower ZXF1 levels. Inhibition of ZXF1 by siRNA decreases the migration and invasion of A549 cells in vitro, while there is no significant effect in cell proliferation.
cancer type lung adenocarcinoma
LncRNA ZXF2 is higher in lung adenocarcinoma specimens and correlated with tumor lymph node metastasis and poor prognosis of the patients. Functionally, siRNA-ZXF2 treatment inhibits cell proliferation, leading to cell cycle arrest. The cell migration and invasion are suppressed by siRNA-ZXF2 treatment. Further biochemical studies reveal that the knockdown of ZXF2 leads to down-regulation of c-Myc signaling.