Browse

browse by

28records

AS-RBM15

alias symbols:

tissues bone marrow

cancer type acute myelocytic leukemia

AS-RBM15 is an antisense lncRNA of RBM15. AS-RBM15 can promote megakaryocyte (MK) terminal differentiation. The exon 1 of AS-RBM15 is essential for MK differentiation while the repeat element in this antisense RNA is dispensable. In addition, AS-RBM15 could up-regulates RBM15 protein level. Moreover, RBM15 and AS-RBM15 are both regulated by RUNX1 and RUNX1-ETO. RUNX1 activates the transcription of RBM15 and AS-RBM15, while RUNX1-ETO in reverse.


BALR-2

alias symbols:

tissues bone marrow

cancer type B acute lymphoblastic leukemia

BALR-2 is significantly up-regulated in B-acute lymphoblastic leukemia (B-ALL) patients when compared to normal CD19+ cells. Meanwhile, BALR-2 expression is significantly higher in B-ALL patients that are unresponsive to prednisone as opposed to those responsive. High BALR-2 expression is associated with inferior overall survival. In addition, BALR-2 is a nucleocytoplasmic lncRNA whose expression is regulated by glucocorticoid treatment. Knockdown of BALR-2 results in growth inhibition and increased apoptosis and increased expression of JUN and BIM.


BALR-6

alias symbols:

tissues bone marrow

cancer type B-lymphoblastic leukemia

During normal B cell development, lncRNA BALR-6 is dynamically expressed, with high expression in pre-B cells and subsequent down-regulation. BALR-6 knockdown inhibits proliferation of human B-acute lymphoblastic leukemia (B-ALL) cell lines. Constitutively expressed BALR-6 supports cell survival and proliferation. Moreover, BALR-6 can up-regulate SP1 and CREB1 level.


CCAT1

alias symbols:

tissues bone marrow,breast,colorectum,endometrium,gallbladder,liver,lung,stomach

cancer type acute myelocytic leukemia,breast cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA CCAT1 is higher in breast cancer, colorectal cancer, gallbladder cancer, gastric cancer and hepatocellular carcinoma. CCAT1 expression level is associated with clinicopathological parameters such as differentiation grade, TNM stage, lymph node metastases, prognosis etc.. Functionally, CCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Further studies reveal that CCAT1 can bind to miRNA-218-5p, c-Myc and let-7. Moreover, CCAT1 can negatively regulate Bmi1, miR-490 and positively regulate c-Myc, HMGA2 and hnRNAP1.


CCDC26

alias symbols:

tissues bone marrow,pancreas

cancer type myeloid leukemia,pancreatic cancer

LncRNA CCDC26 is higher in pancreatic cancer (PC) cells and tissues. CCDC26 expression is correlated with tumor size and tumor number. Patients with higher CCDC26 expression have shorter overall survival time. Knockdown of CCDC26 suppresses PC cells proliferation and induces apoptosis via suppressing PCNA and Bcl2. In leukemia cell lines, CCDC26 is expressed in cells derived from acute myelocytic leukemia (AML), acute monocytic leukemia and chronic myelogenous leukemia (CML). Very low expression is observed in megakaryoblastic cells derived from leukemia accompanied with Down’s syndrome (C...


DLEU2

alias symbols:

tissues bone marrow

cancer type chronic lymphocytic leukemia

LncRNA DLEU2 is lost in CLL 13q14.3 deletion cases. Mature miR-15a/miR-16-1 are produced in a drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1. In addition, DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way.


FAS-AS1

alias symbols:

tissues bone marrow

cancer type B-cell lymphoma

The alternative splicing of Fas in lymphomas is tightly regulated by a long-noncoding RNA FAS-AS1. Level of FAS-AS1 correlates inversely with production of sFas, and FAS-AS1 binding to the RBM5 inhibits RBM5-mediated exon 6 skipping. EZH2 hyper-methylates the FAS-AS1 promoter and represses the FAS-AS1 expression. EZH2-mediated repression of FAS-AS1 promoter can be released by DZNeP (3-Deazaneplanocin A) or overcome by ectopic expression of FAS-AS1, both of which increase the expression level of FAS-AS1 and correspondingly decrease expression of sFas. Treatment with Bruton's tyrosine kinase ...


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOTAIRM1

alias symbols:

tissues bone marrow,colorectum

cancer type acute myelocytic leukemia,acute promyelocytic leukemia,colorectal cancer

HOTAIRM1 is higher in acute myelocytic leukemia (AML), granulocytic, lower in colorectal cancer. Its expression level is associated with prognosis. It can regulate cancer cell proliferation. Moreover, it is regulated by PU.1.


HOXA-AS2

alias symbols:

tissues bone marrow,stomach

cancer type gastric cancer,promyelocytic leukemia

LncRNA HOXA-AS2 is up-regulated in human gastric cancer (GC) tissues and promyelocytic leukemia cells. In addition, HOXA-AS2 expression is induced by IFN-γ and TNF-α in neutrophils. Overexpression of HOXA-AS2 is associated with tumor size, TNM stage and poor prognosis of GC. HOXA-AS2 promotes cell proliferation and inhibits cell apoptosis. HOXA-AS2 epigenetically silences P21, PLK3 and DDIT3 transcription by binding with EZH2.


HULC

alias symbols:

tissues bone,bone marrow,breast,colorectum,esophagus,liver,nervous system,pancreas,stomach

cancer type B-cell lymphoma,colorectal cancer,esophageal cancer,gastric cancer,glioma,hepatic cancer,osteosarcoma,pancreatic cancer,triple negative breast cancer

HULC is higher in breast cancer, colorectal carcinoma, gastric cancer, liver cancer, osteosarcoma, pancreatic cancer and glioma. HULC expression level is associated with clinicopathological parameters such as staging and grading. HULC regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis, EMT. Mechanistically, HULC can bind to EZH2, CREB, IGF2BP1, CLOCK, miR-107, miR-200a-3p. Moreover, HULC negatively regulates NKD2, miR-372, miR-9, TNF-α, E-Cadherin, and positively regulates LC3-II/LC3-I, SPHK1, E2F1, Snail, ZEB1, ZO-1, pERK, pAKT, pmTOR, ESM-1, peIF4E, thereby...


LUNAR1

alias symbols:

tissues bone marrow

cancer type diffuse large B cell lymphoma

LncRNA LUNAR1 is down regulated in diffuse large B-cell lymphoma. It can inhibit cell proliferation via regulating E2F1, cyclin D1 and p21


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MINCR

alias symbols:

tissues bone marrow,gallbladder

cancer type Burkitt lymphoma,gallbladder cancer

LncRNA MINCR has the highest and most significant positively correlated with MYC expression level. It has the MYC binding regions around its transcriptional start site (TSS) in burkitt lymphoma (BL) cells and P493-6 cells, with increasing peak intensity in MYC high conditions in P493-6 cells. Moreover, MINCR has all of the marks associated with open chromatin and active transcription in normal and malignant B cells. Besides, the expression of MINCR is reduced after MYC knockdown in BL cell lines. Functionally, MINCR knockdown is associated with impairment in cell cycle progression. Differen...


MIR100HG

alias symbols:

tissues bone marrow,nervous system

cancer type acute megakaryocytic leukemia,neuroblastoma

LncRNA MIR100HG is higher in acute megakaryocytic leukemia (AMKL), lower in neuroblastoma. It can regulate cancer cell proliferation.


MONC

alias symbols:

tissues bone marrow

cancer type acute megakaryocytic leukemia

LncRNA MONC is highly expressed in acute megakaryocytic leukemia (AMKL) blasts and is mainly localized in the nucleus and its expression is correlated with the corresponding miRNA clusters. Knockdown of MONC impedes leukemic growth of AMKL cell lines. MONC interferes with hematopoietic lineage decisions and enhances the proliferation of immature erythroid progenitor cells.


NALT

alias symbols:

tissues bone marrow

cancer type T acute lymphoblastic leukemia

LncRNA NALT is located near NOTCH1 within 100 bp away. Upregulation of NALT is associated with NOTCH1 in human pediatric T cell acute lymphoblastic leukemia (T ALL) samples. Increased expression of NALT dramatically promotes cell proliferation in cell lines. Further xenograft tumor also indicates the growth inducing affection of NALT while could be partial reversed by gamma-secretase inhibitors (GSI). Besides, through sorting the side-population cells in T ALL cells treated with NALT shRNA could decrease the percentage of side population (SP) cell which companied by the down-regulation of N...


NEAT1

alias symbols:

tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach

cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer

LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...


PEG10

alias symbols:

tissues bone marrow,esophagus

cancer type diffuse large B cell lymphoma,esophageal cancer

LncRNA PEG10 is higher in esophageal cancer tissues than in adjacent non-neoplastic tissues. This relatively high expression is significantly associated with the occurrence of lymph node metastases. Moreover, LncRNA PEG10 can promote proliferation and invasion, and inhibit apoptosis. While in diffuse large B cell lymphoma (DLBCL), PEG10 is up-regulated in DLBCL tumorous tissues and cell lines. Moreover, PEG10 is significantly correlated with B symptoms, IPI score, CHOP-like treatment and rituximab. In addition, PEG10 could be a diagnostic marker for distinguishing DLBCL from normal. Besides...


PVT1

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...


RUNXOR

alias symbols:

tissues bone marrow

cancer type acute myelocytic leukemia

LncRNA RUNXOR is transcribed as unspliced transcript from an upstream overlapping promoter. RUNXOR is up-regulated in acute myelocytic leukemia (AML) samples and in response to Ara-C treatment. RUNXOR utilizes its 3'-terminal fragment to directly interact with the RUNX1 promoter and enhancer, and participates in the orchestration of an intra-chromosomal loop. The 3' region of RUNXOR also participates in long-range inter-chromosomal interactions with chromatin regions that are involved in multiple RUNX1 translocations.


T-ALL-R-LncR1

alias symbols:

tissues bone marrow

cancer type T acute lymphoblastic leukemia

LncRNA T-ALL-R-LncR1 is a non-coding transcript of protein coding gene PAWR. LncRNA T-ALL-R-LncR1 is not observed in human normal tissues, while in some tumor tissues indeed. T-ALL-R-LncR1 is markedly expressed in neoplastic T lymphocytes. T-ALL-R-LncR1 knockdown predisposes Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies reveal that T-ALL-R-LncR1 knockdown facilitates the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells.


UCA1

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


linc223

alias symbols:

tissues bone marrow

cancer type acute myelocytic leukemia

Linc-223, the host transcript of miR-223, is down-regulated in acute myelocytic leukemia (AML) and its expression is associated with myeloid differentiation. It has two splicing variants, named linc-223-1 and linc-223-2. Through qPCR, linc-223 is significantly induced during monocytic differentiation. Linc-223 can stimulate differentiation of AML cells, while diminishing their proliferation rate. Linc-223 might act as a competing endogenous RNA (ceRNA) for miR-125-5p. There exists a specific crosstalk between linc-223 and IRF4 mRNA through competition for miR-125-5p binding.


p21

alias symbols:

tissues bone marrow,colorectum,liver,lung,nervous system,others

cancer type colorectal cancer,diffuse large B cell lymphoma,glioma,hepatic cancer,lung cancer,lymphoma,sarcoma

LncRNA p21 is lower in diffuse large B cell lymphoma, glioma, lung cancer, sarcoma, lymphoma, colorectal cancer and hepatic carcinoma. Its expression level is associated with prognosis. It can regulate cancer cell proliferation and apoptosis.