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91H

alias symbols:

tissues bone,breast,colorectum,esophagus

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,osteosarcoma

LncRNA 91H is the antisense of H19. It is expressed in the higher percentage of colorectal cancer, breast cancer and osteosarcoma. The high expression of 91H is significantly correlated with distant metastasis in colorectal cancer, and also correlated with advanced clinical stage, chemotherapy after surgery, and tumor size in osteosarcoma. There would be an obviously poorer prognosis if 91H expression rose in colorectal cancer and osteosarcoma patients. Functionally, 91H promotes the cellular proliferation, invasion and migration in both colorectal cancer and osteosarcoma. However, 91H is l...


BCAR4

alias symbols:

tissues bone,breast

cancer type breast cancer,osteosarcoma

LncRNA BCAR4 is up-regulated in osteosarcoma tissues and correlated with large tumor size, advanced Enneking stage, lung metastasis and poor prognosis of osteosarcoma patients. Depletion of BCAR4 inhibits osteosarcoma cell proliferation and migration and inhibits GLI2-dependent gene transcription. BCAR4 transcript level is positively correlated with GLI2 target genes RPS3, IL6, MUC5AC, and TGF-β1. While in breast cancer, BCAR4 is also up-regulated. Moreover, BCAR4 can induce endocrine resistance but sensitise breast cancer to lapatinib.


EWSAT1

alias symbols:

tissues bone

cancer type Ewing sarcoma

LncRNA EWSAT1 is up-regulated by EWS-FLI1 in primary pediatric human mesenchymal progenitor cells (pMPCs). Inhibition of EWSAT1 expression diminishes the ability of Ewing sarcoma cell lines to proliferate, whereas EWSAT1 inhibition has no effect on other cell types tested. In addition, heterogeneous nuclear ribonucleoprotein (HNRNPK) is an RNA-binding protein that interacts with EWSAT1 and overlap in HNRNPK-repressed genes and those repressed by EWS-FLI1 and EWSAT1.


FGFR3-AS1

alias symbols:

tissues bone

cancer type osteosarcoma

LncRNA FGFR3-AS1 is up-regulated in osteosarcoma. Increased FGFR3-AS1 expression correlates with large tumor size, advanced Enneking stage, metastasis and poor survival. In addition, FGFR3-AS1 increases FGFR3 mRNA stability and up-regulates FGFR3 expression. Functionally, FGFR3-AS1 promotes the proliferation and cell cycle progression of osteosarcoma cells. Moreover, FGFR3-AS1 promotes xenograft tumor growth of osteosarcoma cells.


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HIF2PUT

alias symbols:

tissues bone,colorectum

cancer type colorectal cancer,osteosarcoma

LncRNA HIF2PUT is significantly correlated with HIF-2α in colorectal cancer (CRC) tissues. Knockdown of HIF2PUT blocks the HIF-2α expression and inhibits the CSC properties in CRC cell lines. HIF2PUT small interfering RNA transfection results in decreased stemness genes expression, retarded migration, impaired ability of colony and spheroid formation ability, and invasion of the cells. In osteosarcoma, HIF2PUT also functions as an inhibitor of osteosarcoma stem cells.


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOTTIP

alias symbols:

tissues bone,colorectum,liver,lung,others,pancreas,prostate,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer

HOTTIP is higher in tongue squamous cell carcinoma,non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer(CRC), pancreatic cancer and osteosarcoma. HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis. HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, HOTTIP negatively regulates miR-125b and HOXA13, and positively regulates HOXA genes.


HULC

alias symbols:

tissues bone,bone marrow,breast,colorectum,esophagus,liver,nervous system,pancreas,stomach

cancer type B-cell lymphoma,colorectal cancer,esophageal cancer,gastric cancer,glioma,hepatic cancer,osteosarcoma,pancreatic cancer,triple negative breast cancer

HULC is higher in breast cancer, colorectal carcinoma, gastric cancer, liver cancer, osteosarcoma, pancreatic cancer and glioma. HULC expression level is associated with clinicopathological parameters such as staging and grading. HULC regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis, EMT. Mechanistically, HULC can bind to EZH2, CREB, IGF2BP1, CLOCK, miR-107, miR-200a-3p. Moreover, HULC negatively regulates NKD2, miR-372, miR-9, TNF-α, E-Cadherin, and positively regulates LC3-II/LC3-I, SPHK1, E2F1, Snail, ZEB1, ZO-1, pERK, pAKT, pmTOR, ESM-1, peIF4E, thereby...


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MFI2-AS

alias symbols:

tissues bone

cancer type osteosarcoma

LncRNA MFI2-AS is significantly overexpressed in human osteosarcoma tissues. Knockdown of lncRNA MFI2-AS expression suppresses cell proliferation, migration and invasion, and induces cell apoptosis. Furthermore, the expression of forkhead box P4 (FOXP4) is significantly increased and it is positively associated with MFI2-AS expression in tumor tissues. In addition, knockdown of FOXP4 expression by RNA interference strategy inhibits osteosarcoma cell proliferation, migration and invasion, and promotes cell apoptosis.


ODRUL

alias symbols:

tissues bone

cancer type osteosarcoma

LncRNA ODRUL is the most increasingly expressed in the doxorubicin-resistant osteosarcoma (OS) cell line. Moreover, ODRUL is higher in different doxorubicin-resistant OS cell lines and lower in different doxorubicin-sensitive OS cell lines. In addition, ODRUL is increased in specimens of OS patients with a poor chemoresponse and lung metastasis. Furthermore, ODRUL inhibition could inhibit OS cell proliferation, migration, and partly reverse doxorubicin resistance in vitro. Besides, the expression of classical drug resistance-related ATP-binding cassette, subfamily B, member 1 (ABCB1) gene i...


PACER

alias symbols:

tissues bone

cancer type osteosarcoma

LncRNA PACER is over-expressed in osteosarcoma tissues and cell lines. PACER knockdown inhibits the proliferation and invasion of human osteosarcoma cells. Downregulation of PACER significantly suppresses the expression of COX-2, and the effects of PACER on cell proliferation and invasion are rescued by COX-2 overexpression. Furthermore, COX-2 activation by PACER is NF-κB-dependent. Besides, the regulation of PACER by CCCTC-binding factor (CTCF) is associated with DNA methylation status.


SNHG12

alias symbols:

tissues bone,endometrium

cancer type endometrial cancer,osteosarcoma

SNHG12 is up-regulated in endometrial carcinoma and osteosarcoma tissues and cell lines. AMOT mRNA expression level is positively correlated with SNHG12 expression level. SNHG12 promotes cell proliferation, migration and inhibits apoptosis.


TUG1

alias symbols:

tissues bladder,bone,colorectum,esophagus,kidney,liver,lung,nervous system,stomach

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,hepatoblastoma,non-small-cell lung cancer,osteosarcoma,renal cancer

LncRNA TUG1 is higher in esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, osteosarcoma, colorectal cancer and bladder cancer, and lower in glioma andnon-small cell lung cancer (NSCLC). TUG1 expression level is associated with clinicopathological parameters such as invasion, lymph node metastasis, TNM stage, prognosis etc.. TUG1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TUG1 can bind to SP1 and PRC2. Moreover, TUG1 negatively regulates E-cadherin, miR-144, Bcl-2, KLF2 and positively regulates N-cadhe...


TUSC7

alias symbols:

tissues bone,colorectum,lung,pancreas,stomach

cancer type colorectal cancer,gastric cancer,non-small-cell lung cancer,osteosarcoma,pancreatic ductal adenocarcinoma

LncRNA TUSC7 is lower in colorectal cancer, osteosarcoma, pancreatic ductal adenocarcinoma, gastric cancer and non-small cell lung cancer. TUSC7 expression level is associated with clinicopathological parameters such as tumor size, tumor stage, distant metastasis and prognosis. Functionally, TUSC7 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, TUSC7 can bind to P53 and miR-211. Mechanistically, TUSC7 negatively regulates Cyclin D1, VEGF, Bcl2, miR-23b and positively regulates cyclin A2, cyclin B1, BCL2, BimEL.


UCA1

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


n377360

alias symbols:

tissues bone

cancer type osteosarcoma

LncRNA n377360 is up-regulated in osteosarcoma tissues. In line with this, suppression of n377360 expression by siRNA significantly impairs cell proliferation potential of osteosarcoma cells.