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91H

alias symbols:

tissues bone,breast,colorectum,esophagus

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,osteosarcoma

LncRNA 91H is the antisense of H19. It is expressed in the higher percentage of colorectal cancer, breast cancer and osteosarcoma. The high expression of 91H is significantly correlated with distant metastasis in colorectal cancer, and also correlated with advanced clinical stage, chemotherapy after surgery, and tumor size in osteosarcoma. There would be an obviously poorer prognosis if 91H expression rose in colorectal cancer and osteosarcoma patients. Functionally, 91H promotes the cellular proliferation, invasion and migration in both colorectal cancer and osteosarcoma. However, 91H is l...


AK058003

alias symbols:

tissues breast,stomach

cancer type breast cancer,gastric cancer

LncRNA AK058003 is significantly higher in the breast cancer and hypoxia-induced gastric cancer. Its expression level is associated with lymph node metastasis and differentiation in breast cancer. AK058003 siRNA can reduce SNCG expression at both mRNA and protein levels. Functionally, AK058003 can promote proliferation, migration and invasion of breast cancer cells. In addition, AK058003 can promote hypoxia-induced migration and invasion of gastric cancer cells.


ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


APOC1P1-3

alias symbols:

tissues breast

cancer type breast cancer

LincRNA APOC1P1-3 is over-expressed in breast cancer tissues and cell lines. Hypomethylation in the C/G site may contribute to its upregulation. APOC1P1-3 expression is positively associated with tumor size. Upregulation of APOC1P1-3 inhibits cell apoptosis, but not affects cell cycles. Furthermore, the variation of APOC1P1-3 could affect caspase-3 activation. Besides, APOC1P1-3 can bind α-tubulin and modify its acetylation, thus inhibit cell apoptosis.


ARRDC1-AS1

alias symbols:

tissues breast

cancer type breast cancer

LncRNA ARRDC1-AS1 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


ATB

alias symbols:

tissues breast,colorectum,kidney,liver,nervous system,pancreas,prostate,stomach

cancer type breast cancer,colorectal cancer,gastric cancer,glioma,hepatic cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA ATB plays a dual role in cancers. ATB is higher in breast cancer, gastric cancer, glioma, hepatocellular carcinoma, colon cancer, renal cell carcinoma and prostate carcinoma, but lower in pancreatic cancer. ATB expression is associated with clinicopathological parameters such as vascular invasion, lymph node metastasis, grades and prognosis etc.. Functionally, ATB regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ATB can regulate EMT by binding to miR-200 family members and regulate EMT markers expression level, for instance, ZE...


BC016831

alias symbols:

tissues breast

cancer type triple negative breast cancer

LncRNA BC016831 is down-regulated in triple negative breast cancer (TNBC) and correlated with TNBC occurrence. Besides, it can be the potential biomarker for differentiating TNBC from non-TNBC.


BC040587

alias symbols:

tissues breast

cancer type breast cancer

LncRNA BC040587 is down-regulated in breast cancer tissues. Postmenopausal patients have a relatively low BC040587 expression. BC040587 level is significantly correlated with menopausal status, tumor differentiation and overall survival.


BC200

alias symbols:

tissues breast,esophagus,lung,ovary

cancer type breast cancer,esophageal cancer,non-small-cell lung cancer,ovarian cancer

LncRNA BC200 expression is increased in breast cancer, where the estrogen receptor (ER) interacts with the putative estrogen response elements (EREs) in the BC200 promoter to induce its transcription. In turn, BC200 can promote breast cancer cell proliferation. Besides, BC200 is also increased in esophageal cancer tissue and correlated with poor prognosis. While in ovarian cancer, BC200 is down-regulated and inhibits the proliferative ability of ovarian cancer cells. Besides, BC200 is associated with cell death induced by carboplatin. While in non-small cell lung cancer, BC200 is also up-re...


BCAR4

alias symbols:

tissues bone,breast

cancer type breast cancer,osteosarcoma

LncRNA BCAR4 is up-regulated in osteosarcoma tissues and correlated with large tumor size, advanced Enneking stage, lung metastasis and poor prognosis of osteosarcoma patients. Depletion of BCAR4 inhibits osteosarcoma cell proliferation and migration and inhibits GLI2-dependent gene transcription. BCAR4 transcript level is positively correlated with GLI2 target genes RPS3, IL6, MUC5AC, and TGF-β1. While in breast cancer, BCAR4 is also up-regulated. Moreover, BCAR4 can induce endocrine resistance but sensitise breast cancer to lapatinib.


CCAT1

alias symbols:

tissues bone marrow,breast,colorectum,endometrium,gallbladder,liver,lung,stomach

cancer type acute myelocytic leukemia,breast cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA CCAT1 is higher in breast cancer, colorectal cancer, gallbladder cancer, gastric cancer and hepatocellular carcinoma. CCAT1 expression level is associated with clinicopathological parameters such as differentiation grade, TNM stage, lymph node metastases, prognosis etc.. Functionally, CCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Further studies reveal that CCAT1 can bind to miRNA-218-5p, c-Myc and let-7. Moreover, CCAT1 can negatively regulate Bmi1, miR-490 and positively regulate c-Myc, HMGA2 and hnRNAP1.


CCAT2

alias symbols:

tissues breast,cervix,colorectum,esophagus,liver,lung,ovary,stomach

cancer type breast cancer,cervical cancer,cervical squamous cell cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,ovarian cancer

LncRNA CCAT2 is higher in breast cancer, esophageal squamous carcinoma, lung cancer, gastric cancer, cervical cancer and ovarian cancer. CCAT2 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, CCAT2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, CCAT2 is involves with chemotherapy response.


EGOT

alias symbols:

tissues breast

cancer type breast cancer

LncRNA EGOT expression is lower in breast cancer compared with the adjacent noncancerous tissues, and low levels of EGOT expression are significantly correlated with larger tumor size, more lymph node metastasis and higher Ki-67 expression. Moreover, patients with low levels of EGOT expression show significantly worse prognosis for overall survival.


ENST00000515084

alias symbols:

tissues breast

cancer type breast cancer

LncRNA ENST00000515084 expression is predominantly cytoplasmic. The C allele of the rs12325489C>T polymorphism in the exonic regions of ENST00000515084 is associated with a significantly increased risk of breast cancer, compared with the rs12325489TT genotype. Biochemical analysis demonstrates that the C to T base change at rs12325489C>T disrupts the binding site for miRNA-370, thereby influencing the transcriptional activity of ENST00000515084 in vitro and in vivo, further affecting cell proliferation and tumor growth.


EPB41L4A-AS2

alias symbols:

tissues breast,kidney,lung

cancer type breast cancer,lung cancer,renal cancer

LncRNA EPB41L4A-AS2 is down-regulated in breast, renal and lung cancer. Low expression is correlated with larger tumor size, higher stage and grade, ER and PR negative expression. Besides, low expression is correlated with poorer survival of the three kinds of cancers. In addition, a better overall survival is observed in TP53 wild-type breast cancer patients with high EPB41L4A-AS2 expression, while the converse is found for breast cancer patients with a TP53 mutation. Furthermore, overexpression of EPB41L4A-AS2 inhibits tumor cell proliferation.


FAM74A3

alias symbols:

tissues breast

cancer type breast cancer

LncRNA FAM74A3 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


FGF14-AS2

alias symbols:

tissues breast

cancer type breast cancer

LncRNA FGF14-AS2 is significantly down-regulated in breast cancer tissue. Reduced expression of FGF14-AS2 is correlated with larger tumor size, more lymph node metastasis and advanced clinical stage. Patients with lower FGF14-AS2 expression have a worse overall survival.


FOXCUT

alias symbols:

tissues breast,esophagus

cancer type breast cancer,esophageal squamous cell cancer

LncRNA FOXCUT is ove-rexpressed in basal-like breast cancer (BLBC) tissue specimens and esophageal squamous cell carcinoma, and positively correlated with FOXC1 mRNA level. FOXCUT can promote proliferation and migration in these two cancer cell lines. In addition, high expression of FOXCUT is correlated with age, poor differentiation, advanced lymph node classification, metastasis and poor prognosis in esophageal squamous cell carcinoma.


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HAR1A

alias symbols:

tissues breast

cancer type breast cancer

LncRNA HAR1A is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


HCG11

alias symbols:

tissues breast,prostate

cancer type breast cancer,prostate cancer

LncRNA HCG11 is up-regulated in breast cancer and its upregulation is associated with poor overall survival duo to the copy number alteration. However, LncRNA HCG11 is down-regulated in prostate cancer. Downregulation of HCG11 is correlated with the age, LN status, preoperative PSA level, Gleason score and BCR in prostate cancer. Moreover, downregulation of HCG11 can predict a poor prognosis in prostate cancer.


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HULC

alias symbols:

tissues bone,bone marrow,breast,colorectum,esophagus,liver,nervous system,pancreas,stomach

cancer type B-cell lymphoma,colorectal cancer,esophageal cancer,gastric cancer,glioma,hepatic cancer,osteosarcoma,pancreatic cancer,triple negative breast cancer

HULC is higher in breast cancer, colorectal carcinoma, gastric cancer, liver cancer, osteosarcoma, pancreatic cancer and glioma. HULC expression level is associated with clinicopathological parameters such as staging and grading. HULC regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis, EMT. Mechanistically, HULC can bind to EZH2, CREB, IGF2BP1, CLOCK, miR-107, miR-200a-3p. Moreover, HULC negatively regulates NKD2, miR-372, miR-9, TNF-α, E-Cadherin, and positively regulates LC3-II/LC3-I, SPHK1, E2F1, Snail, ZEB1, ZO-1, pERK, pAKT, pmTOR, ESM-1, peIF4E, thereby...


JADE

alias symbols:

tissues breast

cancer type breast cancer

LncRNA JADE is induced after DNA damage in an ataxia-telangiectasia mutated (ATM)-dependent manner. JADE is up-regulated in human breast tumors. Knockdown of lncRNA-JADE significantly inhibits breast tumor growth. Mechanistically, JADE transcriptionally activates Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex. Consequently, lncRNA JADE induces histone H4 acetylation in the DDR.


LINC00152

alias symbols:

tissues breast,kidney,liver,stomach

cancer type breast cancer,gastric cancer,hepatic cancer,renal clear cell cancer

LINC00152 is higher in breast cancer, gastric cancer, hepatocellular carcinoma and clear cell renal cell carcinoma. LINC00152 expression level is associated with clinicopathological parameters such as tumor size, differentiation grade, TNM stage, depth of invasion, prognosis etc.. Moreover, LINC00152 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Besides, LINC00152 can bind to EGFR and EpCAM. LINC00152 functions via negatively regulating E-cadherin, p15, p21 and positively regulating N-cadherin, Vimentin.


LINC00160

alias symbols:

tissues breast

cancer type breast cancer

LINC00160 is up-regulated in breast cancer and is up-regulated by E2. Moreover, LINC00160 is direct transcriptional targets of ERα, correlated with ERα expression in clinical samples, and shows prognostic significance in relation to breast cancer survival. Besides, silencing LINC00160 would result in the reduction of proliferation.


LINC00310

alias symbols:

tissues breast

cancer type breast cancer

LINC00310 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


LINC00323

alias symbols:

tissues breast

cancer type breast cancer

LINC00323 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, their upregulation can predict recurrence.


LINC00346

alias symbols:

tissues breast

cancer type breast cancer

LINC00346 is up-regulated in breast cancer and its expression level is associated with poor overall survival due to the copy number alteration.


LINC00472

alias symbols:

tissues breast

cancer type breast cancer

LINC00472 is a tumor suppressor gene in breast cancer. It can inhibit cell proliferation and migration.


LINC00574

alias symbols:

tissues breast

cancer type breast cancer

LINC00574 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its upregulation can predict recurrence.


LINC00617

alias symbols:

tissues breast

cancer type breast cancer

Linc00617 is up-regulated in breast cancer tissues and associated tumor grade, lymph node metastasis and overall survival. Linc00617 promotes motility and invasion of breast cancer cells. Linc00617 can also influence EMT via affecting epithelial marker E-cadherin, N-cadherin and vimentin. Besides, ectopic expression of linc00617 can increase the binding of hnRNP-K at the promoter region of stemness factor Sox2.


LINC00654

alias symbols:

tissues breast

cancer type breast cancer

LINC00654 is up-regulated in breast cancer and its expression level is associated with poor overall survival due to the copy number alteration.


LINC00657

alias symbols:

tissues breast

cancer type breast cancer

LINC00657 is up-regulated in breast cancer. Its upregulation is associated with poor overall survival due to the copy number alteration. LINC00657 knockout significantly suppresses tumor cell growth and proliferation, suggesting that it plays an oncogenic role.


LINC00704

alias symbols:

tissues breast

cancer type breast cancer

LINC00704 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its u-regulation can predict recurrence.


LINC00705

alias symbols:

tissues breast

cancer type breast cancer

LINC00705 is up-regulated in breast cancer and its upregulation is associated with poor overall survival due to copy number alteration. Moreover, its up-regulation can predict recurrence.


LINC00993

alias symbols:

tissues breast

cancer type triple negative breast cancer

LINC00993 is higher in triple negative breast cancer and associated with the expression levels of ANKRD30A. Furthermore, the expression of LINC00993 is also associated with the expression of the estrogen receptor.


LINC01016

alias symbols:

tissues breast

cancer type breast cancer

LINC01016 is up-regulated in breast cancer and is up-regulated by E2. In addition, LINC01016 is direct transcriptional targets of ERα, correlated with ERα expression in clinical samples, and shows prognostic significance in relation to breast cancer survival.


LINP1

alias symbols:

tissues breast

cancer type triple negative breast cancer

LncRNA LINP1 expression is highly expressed in triple-negative breast cancer (TNBC) cell lines and distributes in both nuclear and cytoplasmic fractions of cells. Moreover, LINP1 expression is positively correlated with the RNA expression of EGFR and CDKN2A, and negatively correlated with RB1. Besides, the expression of LINP1 is significantly higher in those with TP53 mutations than with wild type (WT) TP53. In addition, LINP1 expression is activated by the EGF signaling pathway and repressed by the p53 signaling pathway. Further studies reveal that LINP1 associates with proteins in the NHE...


LSINCT5

alias symbols:

tissues breast,ovary,stomach

cancer type breast cancer,gastric cancer,ovarian cancer

LSINCT5 is over-expressed in breast cancer, ovarian cancer gastric cancer and promotes cell proliferation.


Linc-ITGB1

alias symbols:

tissues breast,gallbladder

cancer type breast cancer,gallbladder cancer

LncRNA linc-ITGB1 is higher in breast cancer and gallbladder cancer. It regulates cancer cell proliferation, migration and invasion via regulating Cdc25C, Cyclin B1, E-cadherin, N-cadherin, vimentin and Snail.


LncRNA67

alias symbols:

tissues breast

cancer type breast cancer

LncRNA67 shows elevated expression in breast cancer. LncRNA67 increases the growth of MCF-7 cells. In addition, the study finds LncRNA67 may be important for estrogen-stimulated growth.


MA-LINC1

alias symbols:

tissues breast,lung

cancer type breast cancer,lung cancer


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MIR31HG

alias symbols:

tissues bladder,breast,colorectum,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,gastric cancer,triple negative breast cancer

LncRNA MIR31HG is higher in breast cancer, lower in colorectal cancer, triple negative reast Cancer, bladder cancer, and gastric cancer. It can regulate cancer cell proliferation, migration, invasion and apoptosis. Mechanistically, it can regulate E2F1 and p21.


MVIH

alias symbols:

tissues breast,liver,lung

cancer type breast cancer,hepatic cancer,non-small-cell lung cancer

LncRNA MVIH is up-regulated in breast cancer, non-small cell lung cancer (NSCLC) and hepatocellular carcinoma and high MVIH expression is correlated with Ki67 expression. Moreover, patients with high MVIH expression levels are associated with clinicopathologic parameters. In addition, up-regulated MVIH expression promotes cell proliferation, cell cycle and cell invasion, but inhibit cell apoptosis. Mechanistically, MVIH affects cell invasion via regulating the level of MMP2 and MMP9. Furthermore, MVIH could weaken the function of PGK1 in angiogenesis inhibition by reducing the secretion of ...


NBAT1

alias symbols:

tissues breast,kidney,nervous system

cancer type breast cancer,neuroblastoma,renal clear cell cancer

LncRNA NBAT1 is down-regulated in breast cancer and associated with tumor metastasis and poor patient prognosis. NBAT1 can inhibit migration and invasion of breast cancer cells. Mechanistic study shows that NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. Among them, DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2-dependent manner, and responsible for NBAT1's effects on inhibiting migration and invasion of breast cancer cells. While in neuroblastoma, CpG methylation and a high-risk neuroblastoma associated ...


NKILA

alias symbols:

tissues breast

cancer type breast cancer

LncRNA NKILA (NF-KappaB Interacting LncRNA) is decreased and associated with breast cancer metastasis and poor patient prognosis. Mechanism studies show that NKILA is up-regulated by NF-κB, binds to NF-κB/IκB, and directly masks phosphorylation motifs of IκB, thereby inhibiting IKK-induced IκB phosphorylation and NF-κB activation. NKILA interacts with NF-κB/IκB to form a stable complex. Importantly, NKILA is essential to prevent over-activation of NF-κB pathway in inflammation-stimulated breast epithelial cells.


PANDAR

alias symbols:

tissues bladder,breast,liver,lung,stomach

cancer type bladder cancer,breast cancer,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA PANDAR is higher in breast cancer, gastric cancer, hepatocellular carcinoma and bladder cancer, and lower in lung cancer. PANDAR expression level is associated with clinicopathological parameters such as depth of invasion lymphatic metastasis, histological grade, TNM stage and prognosis etc.. Functionally, PANDAR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, PANDAR negatively regulates p16 and Bcl-2.


PVT1

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...


RMST

alias symbols:

tissues breast

cancer type triple negative breast cancer

LncRNA RMST is down-regulated TNBC (triple negative breast cancer) and associated with prognosis of TNBC patients. However, the difference is not statistically significant.


RP11-434D9.1

alias symbols:

tissues breast

cancer type triple negative breast cancer

LncRNA RP11-434D9.1 is down-regulated in triple negative breast cancer (TNBC) and correlated with TNBC occurrence. Besides, it can be a potential biomarker to differentiate TNBC from non-TNBC.


RP11-445H22.4

alias symbols:

tissues breast

cancer type breast cancer

LncRNA RP11-445H22.4 is significantly increased in breast cancer. Its expression levels are correlated with estrogen receptor (ER), progesterone receptor (PR), and menopausal status of the breast cancer patients (p < 0.05). For the detection of breast cancer, the use of RP11-445H22.4 shows a remarkable improvement compared with the clinical serum carcinoembryonic antigen.


RoR

alias symbols: lincRNA-ST8SIA3, lincRNA-RoR, ROR

tissues breast,colorectum,liver,nasopharynx,nervous system,pancreas

cancer type breast cancer,colorectal cancer,glioma,hepatic cancer,nasopharyngeal cancer,pancreatic cancer,triple negative breast cancer

LncRNA ROR is higher in breast cancer(24922071), pancreatic cancer, colon cancer, nasopharyngeal carcinoma and lower in glioma. ROR expression level is associated with clinicopathological parameters such as tumor size, prognosis. ROR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ROR can bind to miR-145. Moreover, ROR negatively regulates E-cadherin and KLF4, while positively regulates ZEB1, ZEB2, vimentin, fibronectin, N-cadherin, and SOX11.


SOX2OT

alias symbols:

tissues breast,colorectum,esophagus,liver,lung

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,lung cancer

LncRNA SOX2OT is higher in breast cancer, lung cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma and colorectal cancer. SOX2OT expression level is negatively correlated with prognosis. SOX2OT regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, Sox2ot positively regulates EZH2, Cyclin B1, Cdc2, SOX2 and OCT4.


SPRY4-IT1

alias symbols:

tissues bladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma, glioma, melanoma, colorectal cancer, bladder cancer(25973088), clear cell renal cell carcinoma, lower in non-small cell lung cancer (NSCLC), but has dual roles in gastric cancer. SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc.. Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, SPRY4-IT1 negatively regulates E-cadherin, ZO-1 and positively re...


SRA

alias symbols:

tissues breast

cancer type breast cancer

 LncRNA SRA, locates on chromosome 5q31.3 and contains five exons and four introns. It is a non-coding transcript of protein coding gene SRA1. The study evaluates the association between two haplotype tagging SNPs (htSNPs) (rs10463297, rs801460) of the whole LncRNA SRA sequence and breast cancer risk. The results show that rs10463297 TC genotype significantly increases BC risk compared with CC genotype in both the codominant and recessive genetic models. Both TC, TC + CC genotypes of rs10463297 and GA, AA, GA+AA genotypes of rs801460 are significantly associated with estrogen receptor (ER) ...


UCA1

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


UMODL1-AS1

alias symbols:

tissues breast

cancer type breast cancer

LncRNA UMODL1-AS1 is up-regulated in breast cancer and its up-regulation is associated with poor overall survival due to copy number alteration. Moreover, its up-regulation can predict recurrence.


XIST

alias symbols:

tissues breast,liver,nasopharynx,nervous system

cancer type breast cancer,glioma,hepatic cancer,nasopharyngeal cancer

LncRNA XIST is higher in glioma, nasopharyngeal carcinoma, and lower in breast cancer. XIST regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, XIST can bind to miR-152, miR-34a-5p. Moreover, XIST negatively regulates pAKT, OCT4 and positively regulates E2F3.


Z38

alias symbols:

tissues breast

cancer type breast cancer

LncRNA Z38 is identified as a protein-coding sequence (isoform a) of the CLDND1 mRNAs, which is highly expressed in breast cancer. Moreover, inhibiting Z38 expression by gene silencing greatly suppresses breast cancer cell proliferation and tumorigenesis, and treatment with Z38 siRNAs significantly induces cell apoptosis and inhibits tumor growth.


uc.63

alias symbols:

tissues breast

cancer type breast cancer

Transcribed ultra-conserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultra-conserved stretches in the human genome. uc.63 is one specific T-UCRs which is up-regulated and associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Moreover, uc.63 can inhibit apoptosis of breast cancer cells.