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91H

alias symbols:

tissues bone,breast,colorectum,esophagus

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,osteosarcoma

LncRNA 91H is the antisense of H19. It is expressed in the higher percentage of colorectal cancer, breast cancer and osteosarcoma. The high expression of 91H is significantly correlated with distant metastasis in colorectal cancer, and also correlated with advanced clinical stage, chemotherapy after surgery, and tumor size in osteosarcoma. There would be an obviously poorer prognosis if 91H expression rose in colorectal cancer and osteosarcoma patients. Functionally, 91H promotes the cellular proliferation, invasion and migration in both colorectal cancer and osteosarcoma. However, 91H is l...


AC096677.3-201

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA AC096677.3-201 is up-regulated in colorectal cancer (CRC). AC096677.3-201 can promote the cellular proliferation, S-phase arrest, migration and invasion, while inhibit the apoptosis in colon cancer.


AFAP1-AS1

alias symbols:

tissues colorectum,esophagus,liver,lung,nasopharynx,pancreas

cancer type colorectal cancer,esophageal adenocarcinoma,esophageal squamous cell cancer,hepatic cancer,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,pancreatic ductal adenocarcinoma

LncRNA AFAP1-AS1 is significantly up-regulated in nasopharyngeal carcinoma (NPC), lung cancer, esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma, hepatic carcinoma (HCC), pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) tissues. In these cancers, up-regulated AFAP1-AS1 is correlated with poorer overall survival and clinicopathological parameters such as tumor size, lymph node metastasis, distant metastasis, advanced clinical stage etc. Knocking down AFAP1-AS1 can prohibit proliferation, migration and invasion of these cancer cells. In HCC cells, AFAP1-A...


AK027294

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA AK027294 is up-regulated in colorectal cancer. AK027294 can negatively regulate caspase-3, caspase-8, while positively regulate Bcl-2, thus inhibit colorectal cancer cell apoptosis. Besides, AK027294 can promote cell migration by positively regulating MMP12, MMP9 and TWIST


AK123657

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA AK123657 is decreased in colorectal cancer. Functionally, AK123657 can decrease the proliferation and invasion of colorectal cancer cells.


ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


AOC4P

alias symbols:

tissues colorectum,liver

cancer type colorectal cancer,hepatic cancer

LncRNA AOC4P is down-regulated in hepatic carcinoma (HCC) samples and negatively correlated with smoking status, capsule invasion, vessel invasion, pathological stage and prognosis. Down-regulated expression of AOC4P can be looked as an independent prognostic factor for patients with HCC. Forced expression of AOC4P reduces cell proliferation and migration. Besides, AOC4P can bind to vimentin and enhances vimentin degradation, thus inhibit EMT. While in colon cancer, AOC4P is up-regulated. AOC4P interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its ubiquitination ...


ATB

alias symbols:

tissues breast,colorectum,kidney,liver,nervous system,pancreas,prostate,stomach

cancer type breast cancer,colorectal cancer,gastric cancer,glioma,hepatic cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA ATB plays a dual role in cancers. ATB is higher in breast cancer, gastric cancer, glioma, hepatocellular carcinoma, colon cancer, renal cell carcinoma and prostate carcinoma, but lower in pancreatic cancer. ATB expression is associated with clinicopathological parameters such as vascular invasion, lymph node metastasis, grades and prognosis etc.. Functionally, ATB regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ATB can regulate EMT by binding to miR-200 family members and regulate EMT markers expression level, for instance, ZE...


BANCR

alias symbols:

tissues colorectum,esophagus,liver,lung,others,stomach,thyroid

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,non-small-cell lung cancer,retinoblastoma,thyroid cancer

LncRNA BANCR expression is significantly higher in colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, melanoma, retinoblastoma and papillary thyroid carcinoma, while is lower in lung cancer. BANCR expression level is associated clinicopathological parameters such as lymph nodes metastasis and tumor stage and prognosis. Functionally, BANCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, BANCR can bind to EZH2. BANCR plays its function roles via regulating p38, JNK, NF-κB, ERK1/2, Raf-1, JN...


BX648207

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA BX648207 is decreased in colorectal cancer. Functionally, BX648207 can decrease colorectal cancer proliferation and invasion.


BX649059

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA BX649059 is decreased in colorectal cancer. Moreover, BX649059 can decrease colorectal cancer proliferation and invasion.


CAHM

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA CAHM is hypermethylation in neoplastic colorectal tissue, and blood from CRC patients. CAHM methylation correlates with of loss expression of CAHM RNA in colorectal tissue and CRC cell lines. Moreover, CAHM methylation levels in blood reflect disease severity.


CASC11

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA CASC11 is up-regulated in colorectal cancer (CRC) tissues and increased CASC11 expression in CRC is associated with tumor size, serosal invasion, lymph metastasis, and the tumor–node–metastasis (TNM) stage. Functional experiments show that CASC11 can promote CRC cell proliferation and metastasis. Furthermore, CASC11 can target heterogeneous ribonucleoprotein K (hnRNP-K) to activate WNT/β-catenin signaling in CRC cells. In addition, c-Myc can directly bind to the promoter regions of CASC11 and increase promoter histone acetylation to enhance CASC11 expression.


CASC2

alias symbols:

tissues colorectum,kidney,lung,nervous system

cancer type colorectal cancer,glioma,non-small-cell lung cancer,renal cancer

LncRNA CASC2 is lower in colorectal cancer, glioma, renal cell carcinoma, non-small cell lung cancer (NSCLC). Its expression level is associated with clinicopathological parameters such as tumor size, TNM stage, prognosis etc.. Functionally, CASC2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, CASC2 can bind to miR-18a, miR-21. Besides, CASC2 negatively regulates pSTAT3 and c-Myc.


CCAL

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA CCAL is up-regulated in colorectal cancer (CRC) tissues and high CCAL level is associated with poor overall survival and a worse response to adjuvant chemotherapy. Further studies reveal that CCAL promotes CRC progression by targeting activator protein 2α (AP-2α), which in turn activates Wnt/β-catenin pathway. Moreover, CCAL induces multidrug resistance (MDR) through activating Wnt/β-catenin signaling by suppressing AP-2α and further up-regulating MDR1/P-gp expression. In addition, histone H3 methylation and deacetylases contribute to the upregulation of CCAL in CRC.


CCAT1

alias symbols:

tissues bone marrow,breast,colorectum,endometrium,gallbladder,liver,lung,stomach

cancer type acute myelocytic leukemia,breast cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA CCAT1 is higher in breast cancer, colorectal cancer, gallbladder cancer, gastric cancer and hepatocellular carcinoma. CCAT1 expression level is associated with clinicopathological parameters such as differentiation grade, TNM stage, lymph node metastases, prognosis etc.. Functionally, CCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Further studies reveal that CCAT1 can bind to miRNA-218-5p, c-Myc and let-7. Moreover, CCAT1 can negatively regulate Bmi1, miR-490 and positively regulate c-Myc, HMGA2 and hnRNAP1.


CCAT2

alias symbols:

tissues breast,cervix,colorectum,esophagus,liver,lung,ovary,stomach

cancer type breast cancer,cervical cancer,cervical squamous cell cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,ovarian cancer

LncRNA CCAT2 is higher in breast cancer, esophageal squamous carcinoma, lung cancer, gastric cancer, cervical cancer and ovarian cancer. CCAT2 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, CCAT2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, CCAT2 is involves with chemotherapy response.


CLMAT3

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA CLMAT3 is generally increased in human colorectal cancer (CRC) cell lines. Knockdown of CLMAT3 in CRC cells decreases cell growth, inhibits CRC cell cycle progression and induces apoptosis. Master G0/G1 regulators including Cdh1, CDKN1B (p27Kip1) and Skp2 are measured after CLMAT3 knockdown. The results show an increased Cdh1 expression by accelerating Skp2 degradation, which results in p27Kip accumulation.


CRNDE

alias symbols:

tissues colorectum,nervous system

cancer type colorectal cancer,glioma

LncRNA CRNDE is higher in glioma. CRNDE overexpression facilitates cell proliferation, migration, and invasion, while inhibits glioma cells apoptosis. CRNDE can bind to miR-384 and miR-186, and suppress their function. CRNDE knockdown results in a decrease of piwi-like RNA-mediated gene silencing 4 (PIWIL4) protein. Meanwhile, CRNDE decreases the expression levels of XIAP and PAK7 by binding to miR-186 and negatively regulating it. Exon microarrays shows substantially elevated expression across exons E2, E4, In4, E5, In5 and part of E6 of CRNDE in colorectal cancer tissues. Transcript isof...


CTD903

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA CTD903 expression is up-regulated in colorectal cancer tissues. The higher CTD903 group shows more percentages of colon cancers comparing with rectum cancers, less mucinous tumors, and smaller tumor size. CTD903 high expression group has a significantly longer recurrence-free survival (RFS). Overexpression of CTD903 impairs cell invasion, migration and proliferation. CTD903 represses Wnt/β-catenin signaling and inhibits EMT-associated transcription factors twist and snail expression.


DACOR1

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA DACOR1 is down-regulated in colon cancer cells and DACOR1 induction appears to enhance DNA methylation at multiple loci without affecting DNMT1 protein level. Moreover, expression of DACOR1 leads to higher level of epithelial markers tight junction protein 1 (TJP1) protein, but not E-Cadherin. Besides, DACOR1 induction reduces the clonogenic potential of colon cancer cells.


DANCR

alias symbols:

tissues colorectum,liver,prostate

cancer type colorectal cancer,hepatic cancer,prostate cancer

LncRNA DANCR is up-regulated in colorectal cancer, hepatic cancer (HCC) and prostate cancer. Experiments show that DANCR markedly increases stemness features of HCC cells to promote tumorigenesis and intra-/extrahepatic tumor colonization. Conversely, DANCR knockdown attenuates the stem-cell properties and in-vivo interference with DANCR action leads to decreased tumor cell vitality, tumor shrinkage, and improved mouse survival. Additionally, DANCR relies largely on an association with CTNNB1. Besides, DANCR promotes prostate cancer invasion and metastasis through repressing the expression ...


DQ786243

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA DQ786243 is significantly up-regulated in the colorectal cancer (CRC) tissues. DQ786243 can promote CRC cell proliferation, migration and invasion, and inhibit apoptosis. Mechanistically, DQ786243 promotes cell proliferation via increasing the expression of Cyclin B1, CDC2 and p-CDC2, promotes EMT via suppressing E-cadherin expression but decreasing expression of Vimentin and N-cadherin, inhibits cell apoptosis via increasing the expression of the anti-apoptotic protein Bcl-2 but decreasing the expression of the pro-apoptotic proteins caspase-9 and caspase-3 and Bax.


FER1L4

alias symbols:

tissues colorectum,endometrium,stomach

cancer type colorectal cancer,endometrial cancer,gastric cancer

LncRNA FER1L4 expression shows downregulation in colon cancer, endometrial carcinoma (EC)and gastric cancer. It is positively correlated with PTEN expression in endometrial carcinoma(EC)tissues and gastric cancer. The low FER1L4 level is associated with clinicopathologic parameters in gastric cancer and colon cancer. FER1L4 can also induce cell cycle arrest and promote cell apoptosis in these three cancer cell lines. At the molecular level, FER1L4 promotes PTEN expression with an inhibition of Akt phosphorylation. Besides, miR-106a-5p suppresses FER1L4 and PTEN.


FEZF1-AS1

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA FEZF1-AS1 is up-regulated in human colorectal carcinoma (CRC) tissues. High-level expression of FEZF1-AS1 is significantly associated with T-stage, lymph node metastasis, distant metastasis and poor prognosis in patients with CRC. FEZF1-AS1 promotes CRC cell proliferation, migration and invasion. Knockdown of FEZF1-AS1 promotes G1 arrest, but does not cause apoptosis in CRC cells. In vitro, knockdown of FEZF1-AS1 inhibits tumor growth and metastasis. At the molecular level, knockdown of FEZF1-AS1 decreases the expression of FEZF1 mRNA and protein.


FTX

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA FTX is significantly up-regulated in colorectal cancer tissues, and correlated with differentiation grade, lymph vascular invasion, clinical stage and overall survival. Functional analyses show that upregulation of long non-coding RNA FTX significantly promotes growth, migration, invasion, and increases colony formation in colorectal cancer cells.


GAPLINC

alias symbols:

tissues colorectum,stomach

cancer type colorectal cancer,gastric cancer

LncRNA GAPLINC is up-regulated in gastric cancer and colorectal cancer. Up regulated GAPLINC is associated with tumor size, lymph node status and survival time of gastric cancer patients, and predicts poor prognosis of colorectal cancer. GAPLINC promotes proliferation and invasion of these two cancer cells. In gastric cancer, GAPLINC regulates cell invasion by controlling CD44 expression via competing for miR211-3p, while in colorectal cancer, GAPLINC regulates cell invasion through binding to PSF and NONO.


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


GHET1

alias symbols:

tissues bladder,colorectum,stomach

cancer type bladder cancer,colorectal cancer,gastric cancer

LncRNA GHET1 is up-regulated in bladder cancer, colorectal cancer and gastric cancer. Increased GHET1 expression is correlated with advanced tumor status, grade and poor prognosis of bladder cancer and gastric cancer. Functionally, GHET1 promotes cell proliferation and invasion. Mechanistically, GHET1 negatively regulates p16 and p21, thus promoting cell proliferation. Moreover, GHET1 increases expression of vimentin, Snail, Slug, Twist, ZEB1 and fibronectin (mesenchymal marker) and decreases E-cadherin protein level (epithelial marker). As a consequence, EMT is promoted, and cancer cell in...


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HIF2PUT

alias symbols:

tissues bone,colorectum

cancer type colorectal cancer,osteosarcoma

LncRNA HIF2PUT is significantly correlated with HIF-2α in colorectal cancer (CRC) tissues. Knockdown of HIF2PUT blocks the HIF-2α expression and inhibits the CSC properties in CRC cell lines. HIF2PUT small interfering RNA transfection results in decreased stemness genes expression, retarded migration, impaired ability of colony and spheroid formation ability, and invasion of the cells. In osteosarcoma, HIF2PUT also functions as an inhibitor of osteosarcoma stem cells.


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOTAIRM1

alias symbols:

tissues bone marrow,colorectum

cancer type acute myelocytic leukemia,acute promyelocytic leukemia,colorectal cancer

HOTAIRM1 is higher in acute myelocytic leukemia (AML), granulocytic, lower in colorectal cancer. Its expression level is associated with prognosis. It can regulate cancer cell proliferation. Moreover, it is regulated by PU.1.


HOTTIP

alias symbols:

tissues bone,colorectum,liver,lung,others,pancreas,prostate,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer

HOTTIP is higher in tongue squamous cell carcinoma,non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer(CRC), pancreatic cancer and osteosarcoma. HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis. HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, HOTTIP negatively regulates miR-125b and HOXA13, and positively regulates HOXA genes.


HULC

alias symbols:

tissues bone,bone marrow,breast,colorectum,esophagus,liver,nervous system,pancreas,stomach

cancer type B-cell lymphoma,colorectal cancer,esophageal cancer,gastric cancer,glioma,hepatic cancer,osteosarcoma,pancreatic cancer,triple negative breast cancer

HULC is higher in breast cancer, colorectal carcinoma, gastric cancer, liver cancer, osteosarcoma, pancreatic cancer and glioma. HULC expression level is associated with clinicopathological parameters such as staging and grading. HULC regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis, EMT. Mechanistically, HULC can bind to EZH2, CREB, IGF2BP1, CLOCK, miR-107, miR-200a-3p. Moreover, HULC negatively regulates NKD2, miR-372, miR-9, TNF-α, E-Cadherin, and positively regulates LC3-II/LC3-I, SPHK1, E2F1, Snail, ZEB1, ZO-1, pERK, pAKT, pmTOR, ESM-1, peIF4E, thereby...


LINC01133

alias symbols:

tissues colorectum,lung

cancer type colorectal cancer,lung squamous cell cancer,non-small-cell lung cancer

LINC01133 is down-regulated in colorectal cancer (CRC). LINC01133 is down-regulated by TGF-β, which could inhibit epithelial–mesenchymal transition (EMT) and metastasis in CRC cells. An alternative splicing factor SRSF6 is identified to directly interact with LINC01133, which promotes EMT and metastasis in CRC cells independent of LINC01133. LINC01133 expression is positively correlated with E-cadherin, and negatively correlated with Vimentin. Moreover, low LINC01133 expression is associated with poor survival in CRC samples. While in lung cancer, LINC01133 is up-regulated and associated wi...


LOC100190940

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA LOC100190940 is up-regulated in primary colorectal cancer and significantly increases cell proliferation and migration.


LOC100287225

alias symbols:

tissues colorectum

cancer type colorectal cancer

LOC100287225 is not only expressed in the intestinal tissue, but has also been misregulated during tumorigenesis. Moreover, the relative expression level of LOC100287225 RNA is significantly lower in tumor tissues compared with adjacent tumor-free tissues. The RNA expression level of LOC100287225 does not show significant correlation with clinical characteristics.


LOC100506178

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA LOC100506178 is significantly up-regulated in colorectal cancer and correlated with poor overall survival of the patients.


Lnc34a

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA Lnc34a is enriched in colon cancer stem cells (CCSCs) and initiates asymmetric division by directly targeting the microRNA miR-34a to cause its spatial imbalance. Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent of its upstream regulator, p53. Lnc34a level affects CCSC self-renewal and colorectal cancer (CRC) growth in xenograft models. Moreover, Lnc34a is up-regulated in late-stage CRCs, contributing to epigenetic miR-34a silencing and CRC proliferation.


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MIR31HG

alias symbols:

tissues bladder,breast,colorectum,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,gastric cancer,triple negative breast cancer

LncRNA MIR31HG is higher in breast cancer, lower in colorectal cancer, triple negative reast Cancer, bladder cancer, and gastric cancer. It can regulate cancer cell proliferation, migration, invasion and apoptosis. Mechanistically, it can regulate E2F1 and p21.


NEAT1

alias symbols:

tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach

cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer

LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...


PCAT1

alias symbols:

tissues bladder,colorectum,esophagus,liver,lung,prostate

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,non-small-cell lung cancer,prostate cancer

LncRNA PCAT1 is higher in bladder cancer, esophageal squamous carcinoma colorectal cancer, hepatocellular carcinoma, lung cancer and prostate cancer. PCAT1 expression level is associated with clinicopathological parameters such as TNM stage, depth of tumor invasion, lymph node metastasis, prognosis etc.. Moreover, PCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, PCAT1 negatively regulates caspase-3.


PRNCR1

alias symbols:

tissues colorectum,stomach

cancer type colorectal cancer,gastric cancer

LncRNA PRNCR1 is higher in colorectal cancer and regulates cancer cell proliferation. Single nucleotide polymorphisms (SNPs) in the lncRNA may influence the process of splicing and stability of mRNA conformation, resulting in altered cancer risk.


PVT1

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...


RP11-462C24.1

alias symbols:

tissues colorectum

cancer type colorectal cancer

LncRNA RP11-462C24.1 expression level is lower in colorectal cancer (CRC) tissues. Furthermore, its expression level is lower in CRC patients with metastasis than those without metastasis. In addition, low expression of RP11-462C24.1 significantly correlates with more distant metastasis. Besides, RP11-462C24.1 is an independent predictor for patients’ prognosis and low expression of RP11-462C24.1 has a poor disease-free survival.


RoR

alias symbols: lincRNA-ST8SIA3, lincRNA-RoR, ROR

tissues breast,colorectum,liver,nasopharynx,nervous system,pancreas

cancer type breast cancer,colorectal cancer,glioma,hepatic cancer,nasopharyngeal cancer,pancreatic cancer,triple negative breast cancer

LncRNA ROR is higher in breast cancer(24922071), pancreatic cancer, colon cancer, nasopharyngeal carcinoma and lower in glioma. ROR expression level is associated with clinicopathological parameters such as tumor size, prognosis. ROR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ROR can bind to miR-145. Moreover, ROR negatively regulates E-cadherin and KLF4, while positively regulates ZEB1, ZEB2, vimentin, fibronectin, N-cadherin, and SOX11.


SOX2OT

alias symbols:

tissues breast,colorectum,esophagus,liver,lung

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,lung cancer

LncRNA SOX2OT is higher in breast cancer, lung cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma and colorectal cancer. SOX2OT expression level is negatively correlated with prognosis. SOX2OT regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, Sox2ot positively regulates EZH2, Cyclin B1, Cdc2, SOX2 and OCT4.


SPRY4-IT1

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tissues bladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma, glioma, melanoma, colorectal cancer, bladder cancer(25973088), clear cell renal cell carcinoma, lower in non-small cell lung cancer (NSCLC), but has dual roles in gastric cancer. SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc.. Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, SPRY4-IT1 negatively regulates E-cadherin, ZO-1 and positively re...


TCONS_l2_00022545

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tissues colorectum

cancer type colorectal cancer

LncRNA TCONS_l2_00022545 is up-regulated in metastasis colorectal cancer and significantly increases cell proliferation and migration.


TINCR

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tissues colorectum,esophagus,stomach

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer

LncRNA TINCR is higher in esophageal squamous cell carcinoma, gastric cancer and lower in colorectal cancer. TINCR expression level is associated with clinicopathological parameters such as invasion, lymph metastasis, TNM stage, differentiation etc.. TINCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TINCR can bind to EpCAM and STAU1. Moreover, TINCR negatively regulates c-Myc and positively regulates CLDN7, ANXA1.


TUG1

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tissues bladder,bone,colorectum,esophagus,kidney,liver,lung,nervous system,stomach

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,hepatoblastoma,non-small-cell lung cancer,osteosarcoma,renal cancer

LncRNA TUG1 is higher in esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, osteosarcoma, colorectal cancer and bladder cancer, and lower in glioma andnon-small cell lung cancer (NSCLC). TUG1 expression level is associated with clinicopathological parameters such as invasion, lymph node metastasis, TNM stage, prognosis etc.. TUG1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TUG1 can bind to SP1 and PRC2. Moreover, TUG1 negatively regulates E-cadherin, miR-144, Bcl-2, KLF2 and positively regulates N-cadhe...


TUSC7

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tissues bone,colorectum,lung,pancreas,stomach

cancer type colorectal cancer,gastric cancer,non-small-cell lung cancer,osteosarcoma,pancreatic ductal adenocarcinoma

LncRNA TUSC7 is lower in colorectal cancer, osteosarcoma, pancreatic ductal adenocarcinoma, gastric cancer and non-small cell lung cancer. TUSC7 expression level is associated with clinicopathological parameters such as tumor size, tumor stage, distant metastasis and prognosis. Functionally, TUSC7 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, TUSC7 can bind to P53 and miR-211. Mechanistically, TUSC7 negatively regulates Cyclin D1, VEGF, Bcl2, miR-23b and positively regulates cyclin A2, cyclin B1, BCL2, BimEL.


UCA1

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tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


ZFAS1

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tissues colorectum,liver,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer

LncRNA ZFAS1 is higher in colorectal cancer, gastric cancer and hepatocellular carcinoma. ZFAS1 expression level is associated with clinicopathological parameters such as lymphatic invasion, TNM stage, prognosis etc.. ZFAS1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, ZFAS1 can bind to EZH2, LSD1, CoREST, miR-150, miR-590-3p. Besides, ZFAS1 negatively regulates PARP and positively regulates ZEB1, MMP14, MMP16, cyclin B1 and p53.


linc-POU3F3

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tissues colorectum,esophagus,nervous system,stomach

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma

LncRNA POU3F3 is higher in colorectal cancer, glioma, esophageal squamous cell carcinoma and gastric cancer. POU3F3 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, POU3F3 is negatively regulated by EZH2. Besides, it negatively regulates p18, caspase-9, caspase-3, E-cadherin and positively regulates cyclin D1, CDK4, pRb, Rb, N-cadherin.


ncRAN

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tissues bladder,colorectum

cancer type bladder cancer,colorectal cancer

LncRNA ncRAN is higher in bladder cancer and lower in colorectal cancer. It can regulate cancer cell proliferation, migration, and invasion.


ncRuPAR

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tissues colorectum,stomach

cancer type colorectal cancer,gastric cancer

LncRNA ncRuPAR is lower in colorectal cancer and gastric cancer and is associated with clinicopathological parameters.


p21

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tissues bone marrow,colorectum,liver,lung,nervous system,others

cancer type colorectal cancer,diffuse large B cell lymphoma,glioma,hepatic cancer,lung cancer,lymphoma,sarcoma

LncRNA p21 is lower in diffuse large B cell lymphoma, glioma, lung cancer, sarcoma, lymphoma, colorectal cancer and hepatic carcinoma. Its expression level is associated with prognosis. It can regulate cancer cell proliferation and apoptosis.


snaR

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tissues colorectum

cancer type colorectal cancer

LncRNA snaR is down-regulated in 5-FU-resistant colon cancer cells. Downregulation of snaR decreases cell death after 5-FU treatment, which indicates that snaR loss decreases in-vitro sensitivity to 5-FU.


uc002kmd.1

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tissues colorectum

cancer type colorectal cancer

LncRNA uc002kmd.1 expression is usually highly expressed in colorectal cancer. Through a series of experiments, the results show that uc002kmd.1 regulates CD44 as a molecular decoy for miR211-3p. Moreover, LncRNA-uc002kmd.1 modulates cell growth.