Browse

browse by

67records

AF085935

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA AF085935 increases in the serum of hepatic carcinoma (HCC) patients. AF085935 might be able to discriminate HCC or hepatitis B virus (HBV) patients from healthy controls, and even discriminate HCC patients from HBV patients.


AFAP1-AS1

alias symbols:

tissues colorectum,esophagus,liver,lung,nasopharynx,pancreas

cancer type colorectal cancer,esophageal adenocarcinoma,esophageal squamous cell cancer,hepatic cancer,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,pancreatic ductal adenocarcinoma

LncRNA AFAP1-AS1 is significantly up-regulated in nasopharyngeal carcinoma (NPC), lung cancer, esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma, hepatic carcinoma (HCC), pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) tissues. In these cancers, up-regulated AFAP1-AS1 is correlated with poorer overall survival and clinicopathological parameters such as tumor size, lymph node metastasis, distant metastasis, advanced clinical stage etc. Knocking down AFAP1-AS1 can prohibit proliferation, migration and invasion of these cancer cells. In HCC cells, AFAP1-A...


ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


AOC4P

alias symbols:

tissues colorectum,liver

cancer type colorectal cancer,hepatic cancer

LncRNA AOC4P is down-regulated in hepatic carcinoma (HCC) samples and negatively correlated with smoking status, capsule invasion, vessel invasion, pathological stage and prognosis. Down-regulated expression of AOC4P can be looked as an independent prognostic factor for patients with HCC. Forced expression of AOC4P reduces cell proliferation and migration. Besides, AOC4P can bind to vimentin and enhances vimentin degradation, thus inhibit EMT. While in colon cancer, AOC4P is up-regulated. AOC4P interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its ubiquitination ...


ATB

alias symbols:

tissues breast,colorectum,kidney,liver,nervous system,pancreas,prostate,stomach

cancer type breast cancer,colorectal cancer,gastric cancer,glioma,hepatic cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA ATB plays a dual role in cancers. ATB is higher in breast cancer, gastric cancer, glioma, hepatocellular carcinoma, colon cancer, renal cell carcinoma and prostate carcinoma, but lower in pancreatic cancer. ATB expression is associated with clinicopathological parameters such as vascular invasion, lymph node metastasis, grades and prognosis etc.. Functionally, ATB regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ATB can regulate EMT by binding to miR-200 family members and regulate EMT markers expression level, for instance, ZE...


BAIAP2-AS1

alias symbols:

tissues liver

cancer type hepatic cancer

BAIAP2-AS1 is a HBV-related-hepatocellular-carcinoma (HCC)-specific lncRNA, which up-regulated in HCC. BAIAP2-AS1 is a heat-to-head antisense lncRNA of BAIAP2. The expression of MAPKAP1 and RAF1 decreased after BAIPA2-AS1 silencing.


BANCR

alias symbols:

tissues colorectum,esophagus,liver,lung,others,stomach,thyroid

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,non-small-cell lung cancer,retinoblastoma,thyroid cancer

LncRNA BANCR expression is significantly higher in colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, melanoma, retinoblastoma and papillary thyroid carcinoma, while is lower in lung cancer. BANCR expression level is associated clinicopathological parameters such as lymph nodes metastasis and tumor stage and prognosis. Functionally, BANCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, BANCR can bind to EZH2. BANCR plays its function roles via regulating p38, JNK, NF-κB, ERK1/2, Raf-1, JN...


CCAT1

alias symbols:

tissues bone marrow,breast,colorectum,endometrium,gallbladder,liver,lung,stomach

cancer type acute myelocytic leukemia,breast cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA CCAT1 is higher in breast cancer, colorectal cancer, gallbladder cancer, gastric cancer and hepatocellular carcinoma. CCAT1 expression level is associated with clinicopathological parameters such as differentiation grade, TNM stage, lymph node metastases, prognosis etc.. Functionally, CCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Further studies reveal that CCAT1 can bind to miRNA-218-5p, c-Myc and let-7. Moreover, CCAT1 can negatively regulate Bmi1, miR-490 and positively regulate c-Myc, HMGA2 and hnRNAP1.


CCAT2

alias symbols:

tissues breast,cervix,colorectum,esophagus,liver,lung,ovary,stomach

cancer type breast cancer,cervical cancer,cervical squamous cell cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,ovarian cancer

LncRNA CCAT2 is higher in breast cancer, esophageal squamous carcinoma, lung cancer, gastric cancer, cervical cancer and ovarian cancer. CCAT2 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, CCAT2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, CCAT2 is involves with chemotherapy response.


CPS1-IT1

alias symbols:

tissues liver,others

cancer type hepatic cancer,intrahepatic cholangiocarcinoma

LncRNA CPS1-IT1 is down-regulated in hepatocellular carcinoma and up-regulated in intrahepatic cholangiocarcinoma. It can affect cancer cell proliferation, migration and apoptosis. Besides, it can inhibit EMT of hepatocellular carcinoma cells.


DANCR

alias symbols:

tissues colorectum,liver,prostate

cancer type colorectal cancer,hepatic cancer,prostate cancer

LncRNA DANCR is up-regulated in colorectal cancer, hepatic cancer (HCC) and prostate cancer. Experiments show that DANCR markedly increases stemness features of HCC cells to promote tumorigenesis and intra-/extrahepatic tumor colonization. Conversely, DANCR knockdown attenuates the stem-cell properties and in-vivo interference with DANCR action leads to decreased tumor cell vitality, tumor shrinkage, and improved mouse survival. Additionally, DANCR relies largely on an association with CTNNB1. Besides, DANCR promotes prostate cancer invasion and metastasis through repressing the expression ...


DBH-AS1

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA DBH-AS1 is up-regulated in hepatocellular carcinoma (HCC) and high DBH-AS1 levels are positively correlated with tumor size and HBsAg. DBH-AS1 promotes HCC cell proliferation and tumor growth. DBH-AS1 also induces cell-cycle progression in HCC cells. Overexpression of DBH-AS1 in HepG2 cells elevates the expression of oncogenic cell-cycle regulators including CDK6, CCND1, CCNE1, but reduces the expression of cyclin-dependent protein kinase inhibitors including p16, p21, p27. Moreover, DBH-AS1 inhibits serum starvation-induced apoptosis of HCC cells. At the molecular level, DBH-AS1 act...


DILC

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA DILC is a non-coding transcript of protein coding gene DILC. It is down-regulated in liver cancer stem cells (LCSCs) and associated with poor prognosis. Lnc-DILC knockdown cells show elevated expression of LCSC markers and stemness-associated transcription factors, increased population of EpCAM+ or CD24+ cells and enhanced spheroid formation. In addition, lnc-DILC depletion facilitates hepatoma initiation and progression. These results indicate lnc-DILC could suppress LCSC expansion. Besides, lnc-DILC knockdown increases IL-6 autocrine signaling, and thus enhances the activation of I...


EGFR-AS1

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA EGFR-AS1 is up-regulated in hepatocellular carcinoma tissues and correlated with portal vein thrombosis, lymph metastasis and poor prognosis. EGFR-AS1 knockdown can decrease the expression of EGFR in vitro. In addition, growth hormone receptor (GHR) can promote the expression of EGFR and EGFR-AS1. Inhibition of EGFR-AS1 impedes cell proliferation, cell migration and EMT. EGFR-AS1 can also reduce E-cadherin and increase N-cadherin.


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HEIH

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA HEIH is up-regulated in hepatic carcinoma (HCC) and can be an independent prognostic factor for HCC patients. Functionally, HEIH can promote cell invasion. Moreover, HEIH is up regulated by SP1 and positively correlated with PCNA. Besides, HEIH associates with EZH2 and that this association is required for the expression of EZH2-regulated target genes.


HNF1A-AS1

alias symbols:

tissues esophagus,liver,lung,nasopharynx,stomach

cancer type esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung adenocarcinoma,nasopharyngeal cancer

LncRNA HNF1A-AS1 is up-regulated in lung adenocarcinoma tissues, nasopharyngeal carcinoma, oesophageal adenocarcinoma, hepatocellular carcinoma, and down-regulated in gastric cancer. HNF1A-AS1 expression levels are significantly associated with clinicopathological parameter. Further studies reveal that HNF1A-AS1 promotes cell proliferation and metastasis. Besides, HNF1A-AS1 can affect autophagy in hepatocellular carcinoma via negatively regulating ATG. At molecular level, HNF1A-AS1 regulates cell cycle via cyclin D1 and regulates EMT via regulating EMT markers. In addition, HNF1A-AS1 can bi...


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOTTIP

alias symbols:

tissues bone,colorectum,liver,lung,others,pancreas,prostate,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer

HOTTIP is higher in tongue squamous cell carcinoma,non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer(CRC), pancreatic cancer and osteosarcoma. HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis. HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, HOTTIP negatively regulates miR-125b and HOXA13, and positively regulates HOXA genes.


HULC

alias symbols:

tissues bone,bone marrow,breast,colorectum,esophagus,liver,nervous system,pancreas,stomach

cancer type B-cell lymphoma,colorectal cancer,esophageal cancer,gastric cancer,glioma,hepatic cancer,osteosarcoma,pancreatic cancer,triple negative breast cancer

HULC is higher in breast cancer, colorectal carcinoma, gastric cancer, liver cancer, osteosarcoma, pancreatic cancer and glioma. HULC expression level is associated with clinicopathological parameters such as staging and grading. HULC regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis, EMT. Mechanistically, HULC can bind to EZH2, CREB, IGF2BP1, CLOCK, miR-107, miR-200a-3p. Moreover, HULC negatively regulates NKD2, miR-372, miR-9, TNF-α, E-Cadherin, and positively regulates LC3-II/LC3-I, SPHK1, E2F1, Snail, ZEB1, ZO-1, pERK, pAKT, pmTOR, ESM-1, peIF4E, thereby...


IGF-IIR-AS

alias symbols:

tissues liver

cancer type hepatic cancer

After simultaneously transfecting both IGF-IR and LncRNA IGF-IIR-AS antisense into hepatoma cell SMMC-7721, the tumor cells show morphological and biological changes. The results reveal that IGF-IR and IGF-IIR-AS transfection can partly reverse malignant behaviors of SMMC-7721 cells.


KCNQ1OT1

alias symbols:

tissues liver

cancer type hepatic cancer

By thoroughly analyzing 510 hepatocellular carcinoma (HCC) cases and 1014 healthy controls in a Chinese population, the study identifies a novel short tandem repeat (STR) polymorphism (rs35622507) within the KCNQ1OT1 coding region and evaluates its association with HCC susceptibility. Logistic regression analysis shows that, compared with individuals carrying the homozygote 10–10 genotype, those heterozygote subjects who carry only one allele 10 have a significantly decreased risk of HCC, with the risk decreases even further in those without allele 10. Furthermore, genotype–phenotype correl...


LET

alias symbols:

tissues cervix,esophagus,gallbladder,liver,nasopharynx,stomach

cancer type cervical cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,nasopharyngeal cancer

LncRNA LET is lower in nasopharyngeal carcinoma, esophageal squamous cell carcinoma, gallbladder cancer, gastric cancer, hepatic carcinoma,colorectal cancer,lung squamous cell cancer, and cervical cancer. LET expression level is associated with clinicopathological parameters such as pathological grade, clinical stage, lymph node metastasis, prognosis etc.. LET regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. LET play biological functions via negatively regulating Bcl-2 and positively regulates p53, p21, caspase-3, Bax. Moreover, LET can regulate hypoxia si...


LINC00052

alias symbols:

tissues liver

cancer type hepatic cancer

LINC00052 is down-regulated in hepatocellular carcinoma. It can inhibit cell invasion, migration and proliferation. NTRK3 is the target gene of LINC00052. Down-expression of NTRK3 could increase cell invasion, migration and proliferation. Meanwhile, LINC00052 could regulate NTRK3 expression by forming complementary base-pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR.


LINC00152

alias symbols:

tissues breast,kidney,liver,stomach

cancer type breast cancer,gastric cancer,hepatic cancer,renal clear cell cancer

LINC00152 is higher in breast cancer, gastric cancer, hepatocellular carcinoma and clear cell renal cell carcinoma. LINC00152 expression level is associated with clinicopathological parameters such as tumor size, differentiation grade, TNM stage, depth of invasion, prognosis etc.. Moreover, LINC00152 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Besides, LINC00152 can bind to EGFR and EpCAM. LINC00152 functions via negatively regulating E-cadherin, p15, p21 and positively regulating N-cadherin, Vimentin.


LINC00184

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA LINC00184 is highly expressed in human hepatic carcinoma (HCC) tumors and liver cancer stem cells (CSCs). In addition, LINC00184 is required for self-renewal of liver CSCs and tumor propagation in mice. Moreover, LINC00184 associates with β-catenin and the methyltransferase EZH2, thereby promoting β-catenin methylation. Methylation suppresses the ubiquitination of β-catenin and promotes its stability, thus leading to activation of Wnt-β-catenin signaling. Accordingly, the expression of LINC00184, EZH2 and Wnt-β-catenin targets are positively correlated with cancer severity and progno...


LINC00974

alias symbols:

tissues liver

cancer type hepatic cancer

LINC00974 is up-regulated with positively correlation with KRT19 (an lncRNA beyond the Flank10kb class with protein) in hepatic carcinoma (HCC). Both LINC00974 and KRT19 expression are significantly correlated with decreased tumor differentiation grade, increased tumor size, and metastasis. LINC00974 promotes cell proliferation and invasion. Besides, LINC00974 induces an inhibition of tumor growth and metastasis. Mechanistically, LINC00974 affects KRT19 expression by acting as a competing endogenous RNA (ceRNA) to interact with miR-642. In addition, NOTCH and TGF-β signal pathways are promo...


LINC01225

alias symbols:

tissues liver

cancer type hepatic cancer

LINC01225 is up-regulated in hepatocellular carcinoma (HCC). High LINC01225 expression is significantly associated with tumor size, tumor differentiation grade, tumor capsular integrity, tumor TNM stage, metastasis and prognosis. LINC01225 promotes proliferation and invasion of HCC cells. Mechanism study finds LINC01225 can promote HCC growth and invasion via EGFR/MAPK pathway. More specifically, that LINC01225 could bind to EGFR, thereby increasing the protein level of EGFR.


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MT1DP

alias symbols:

tissues liver

cancer type hepatic cancer


MVIH

alias symbols:

tissues breast,liver,lung

cancer type breast cancer,hepatic cancer,non-small-cell lung cancer

LncRNA MVIH is up-regulated in breast cancer, non-small cell lung cancer (NSCLC) and hepatocellular carcinoma and high MVIH expression is correlated with Ki67 expression. Moreover, patients with high MVIH expression levels are associated with clinicopathologic parameters. In addition, up-regulated MVIH expression promotes cell proliferation, cell cycle and cell invasion, but inhibit cell apoptosis. Mechanistically, MVIH affects cell invasion via regulating the level of MMP2 and MMP9. Furthermore, MVIH could weaken the function of PGK1 in angiogenesis inhibition by reducing the secretion of ...


NEAT1

alias symbols:

tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach

cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer

LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...


PANDAR

alias symbols:

tissues bladder,breast,liver,lung,stomach

cancer type bladder cancer,breast cancer,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA PANDAR is higher in breast cancer, gastric cancer, hepatocellular carcinoma and bladder cancer, and lower in lung cancer. PANDAR expression level is associated with clinicopathological parameters such as depth of invasion lymphatic metastasis, histological grade, TNM stage and prognosis etc.. Functionally, PANDAR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, PANDAR negatively regulates p16 and Bcl-2.


PCAT1

alias symbols:

tissues bladder,colorectum,esophagus,liver,lung,prostate

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,non-small-cell lung cancer,prostate cancer

LncRNA PCAT1 is higher in bladder cancer, esophageal squamous carcinoma colorectal cancer, hepatocellular carcinoma, lung cancer and prostate cancer. PCAT1 expression level is associated with clinicopathological parameters such as TNM stage, depth of tumor invasion, lymph node metastasis, prognosis etc.. Moreover, PCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, PCAT1 negatively regulates caspase-3.


PCNA-AS1

alias symbols:

tissues liver,stomach

cancer type gastric cancer,hepatic cancer

PCNA-AS1, antisense to PCNA, is increased in gastric cancer tissues and associated with invasion. The expression level of PCNA-AS1 is also related with immunohistochemical biomarkers of BRCA1. While in hepatocellular carcinoma, PCNA-AS1 is significantly up-regulated in HCC and could promote tumor growth both in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability.


PRAL

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA PRAL, on chromosome 17p13.1, whose genomic alterations are significantly associated with reduced survival of hepatic carcinoma (HCC) patients. PRAL could inhibit HCC growth and induce apoptosis through p53. Subsequent investigations indicate that the three stem-loop motif at the 5' end of PRAL facilitates the combination of HSP90 with p53 and thus competitively inhibits MDM2-dependent p53 ubiquitination, resulting in enhanced p53 stability.


PTENP1

alias symbols:

tissues liver,stomach

cancer type gastric cancer,hepatic cancer

LncRNA PTENP1 is a pseudogene of the tumor suppressor gene PTEN. PTENP1 and PTEN are down-regulated in several hepatocellular carcinoma (HCC) cells. Elevated level of PTENP1 and PTEN can suppress the oncogenic PI3K/AKT pathway, and inhibit cell proliferation, migration, invasion as well as induce autophagy and apoptosis. Over-expressed PTENP1 decoys oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62. In a word, PTENP1 can inhibit cell proliferation, elicit apoptosis and autophagy, and inhib...


PVT1

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...


PlncRNA-1

alias symbols:

tissues esophagus,liver,prostate

cancer type esophageal squamous cell cancer,hepatic cancer,prostate cancer

PlncRNA-1 is higher in esophageal squamous carcinoma, hepatic carcinoma and prostate cancer. Its expression level is associated with prognosis. Moreover, it can regulate cancer cell proliferation, invasion, apoptosis and EMT.


RoR

alias symbols: lincRNA-ST8SIA3, lincRNA-RoR, ROR

tissues breast,colorectum,liver,nasopharynx,nervous system,pancreas

cancer type breast cancer,colorectal cancer,glioma,hepatic cancer,nasopharyngeal cancer,pancreatic cancer,triple negative breast cancer

LncRNA ROR is higher in breast cancer(24922071), pancreatic cancer, colon cancer, nasopharyngeal carcinoma and lower in glioma. ROR expression level is associated with clinicopathological parameters such as tumor size, prognosis. ROR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ROR can bind to miR-145. Moreover, ROR negatively regulates E-cadherin and KLF4, while positively regulates ZEB1, ZEB2, vimentin, fibronectin, N-cadherin, and SOX11.


SNHG1

alias symbols:

tissues liver,nervous system

cancer type astrocytoma,hepatic cancer

LncRNA SNHG1 is up-regulated in hepatocellular carcinoma (HCC) tissues and astrocytoma tissues. High SNHG1 expression is correlated with large tumor size, poor differentiation, aggressive BCLC stage, and poor prognosis. SNHG1 promotes HCC cells proliferation, cell cycle progression and inhibits HCC cells apoptosis. Further experiments reveal that SNHG1 promotes HCC cells proliferation through inhibiting p53 and p53-target genes expression.


SNHG15

alias symbols:

tissues liver,stomach

cancer type gastric cancer,hepatic cancer

LncRNA SNHG15 is up-regulated in gastric cancer (GC) and hepatocellular carcinoma (HCC). Furthermore, increased SNHG15 expression is correlated with clinicopathologic feature and prognosis. Functionally, SNHG15 expression can promote cell proliferation and invasion and inhibit apoptosis. Mechanistically, SNHG15 promotes cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression.


SNHG20

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA SNHG20 is remarkably up-regulated in hepatocellular carcinoma (HCC) tissues. The expression of SNHG20 is associated with tumor size, clinical stage, overall survival, disease-free survival and prognosis. Functionally, SNHG20 significantly promotes cellular proliferation, migration, and invasion.


SNHG3

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA SNHG3 is significantly up-regulated in hepatocellular carcinoma (HCC) tissues, which is consistent with the results of two independent HCC cohorts from The Cancer Genome Atlas (TCGA) and Oncomine databases. Furthermore, SNHG3 expression is significantly correlated with tumor size, portal vein tumor thrombus and relapse. The high expression level of SNHG3 is markedly correlated with overall survival, recurrence-free survival and disease-free survival. Besides, multivariate analysis indicates that SNHG3 expression is an independent prognostic factor for HCC patients.


SOX2OT

alias symbols:

tissues breast,colorectum,esophagus,liver,lung

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,lung cancer

LncRNA SOX2OT is higher in breast cancer, lung cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma and colorectal cancer. SOX2OT expression level is negatively correlated with prognosis. SOX2OT regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, Sox2ot positively regulates EZH2, Cyclin B1, Cdc2, SOX2 and OCT4.


SPRY4-IT1

alias symbols:

tissues bladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma, glioma, melanoma, colorectal cancer, bladder cancer(25973088), clear cell renal cell carcinoma, lower in non-small cell lung cancer (NSCLC), but has dual roles in gastric cancer. SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc.. Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, SPRY4-IT1 negatively regulates E-cadherin, ZO-1 and positively re...


SRHC

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA SRHC is down-regulated in hepatocellular carcinoma (HCC) and a lower SRHC expression level is significantly more frequent in tissues with a high serum of a-fetoprotein level and a low degree of differentiated tumors. Furthermore, the promoter region of SRHC contains a CpG-rich island, and SRHC is down-regulated in tumors by DNA methylation.


TCF7

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA TCF7 that is highly expressed in hepatic carcinoma (HCC) tumors and liver cancer stem cells (CSCs). LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Moreover, IL-6 transcriptionally activates the expression of lncTCF7 in HCC cells by activating STAT3, a transcription activator which binds to the promoter region of lncTCF7. Furthermore, knocking-down STAT3 and inhibiting STAT3 activation reduce TCF7 expression. Important...


TUC339

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA TUC339 is up-regulated in hepatic carcinoma (HCC). TUC339 is functionally implicated in modulating tumor cell growth and adhesion. Suppression of TUC339 by siRNA reduces HCC cell proliferation, clonogenic growth, and growth in soft agar. Thus, inter-cellular transfer of TUC339 represents a unique signaling mechanism by which tumor cells can promote HCC growth and spread.


TUG1

alias symbols:

tissues bladder,bone,colorectum,esophagus,kidney,liver,lung,nervous system,stomach

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,hepatoblastoma,non-small-cell lung cancer,osteosarcoma,renal cancer

LncRNA TUG1 is higher in esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, osteosarcoma, colorectal cancer and bladder cancer, and lower in glioma andnon-small cell lung cancer (NSCLC). TUG1 expression level is associated with clinicopathological parameters such as invasion, lymph node metastasis, TNM stage, prognosis etc.. TUG1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TUG1 can bind to SP1 and PRC2. Moreover, TUG1 negatively regulates E-cadherin, miR-144, Bcl-2, KLF2 and positively regulates N-cadhe...


UCA1

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


UFC1

alias symbols:

tissues liver

cancer type hepatic cancer

Level of the LncRNA UFC1 is increased in hepatic carcinoma (HCC) tissues compared with controls, and associated with tumor size, barcelona clinic liver cancer stage, and patient outcomes. Transgenic expression of the UFC1 in HCC cells promotes their proliferation and cell-cycle progression and inhibits apoptosis. Moreover, UFC1 interacts directly with the messenger RNA (mRNA) to stabilize protein HuR (encoded by ELAVL1) to increase levels of β-catenin (encoded by CTNNB1) mRNA and protein. However, there is a negative correlation between level of microRNA 34a and UFC1 in HCC tissues; microRN...


WT1-AS

alias symbols:

tissues kidney,liver,stomach

cancer type Wilms' tumour,gastric cancer,hepatic cancer

LncRNA WT1-AS expression is significantly down-regulated in gastric cancer, hepatocellular carcinoma and Wilms' tumor. It is associated with tumor size and the clinicopathological stage. Functionally, it can inhibit cell proliferation, migration, and invasion. Furthermore, ectopic expression of WT1-AS can inhibit tumor growth and metastasis in vivo. Moreover, WT1-AS could modulate ERK protein phosphorylation and WT1 level.


XIST

alias symbols:

tissues breast,liver,nasopharynx,nervous system

cancer type breast cancer,glioma,hepatic cancer,nasopharyngeal cancer

LncRNA XIST is higher in glioma, nasopharyngeal carcinoma, and lower in breast cancer. XIST regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, XIST can bind to miR-152, miR-34a-5p. Moreover, XIST negatively regulates pAKT, OCT4 and positively regulates E2F3.


ZEB1-AS1

alias symbols:

tissues esophagus,liver

cancer type esophageal squamous cell cancer,hepatic cancer

LNCRNA ZEB1-AS1 is up-regulated in esophageal squamous cell carcinoma (ESCC) tissues and associated with tumor grade, depth of invasion, lymph node metastasis and prognosis. In hepatic carcinoma, ZEB1-AS1 is frequently up-regulated in hepatocellular carcinoma (HCC) samples, especially in metastatic tumor tissues with its promoter hypomethylation. Aberrant methylation is tightly correlated with overexpression of ZEB1-AS1 in HCC. Patients with ZEB1-AS1 hypomethylation or with high ZEB1-AS1 expression have poor recurrence-free survival. Functionally, ZEB1-AS1 promotes tumor growth and metastas...


ZFAS1

alias symbols:

tissues colorectum,liver,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer

LncRNA ZFAS1 is higher in colorectal cancer, gastric cancer and hepatocellular carcinoma. ZFAS1 expression level is associated with clinicopathological parameters such as lymphatic invasion, TNM stage, prognosis etc.. ZFAS1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, ZFAS1 can bind to EZH2, LSD1, CoREST, miR-150, miR-590-3p. Besides, ZFAS1 negatively regulates PARP and positively regulates ZEB1, MMP14, MMP16, cyclin B1 and p53.


ZNRD1-AS1

alias symbols:

tissues liver,lung

cancer type hepatic cancer,lung cancer

The eQTLs SNPs in LncRNA ZNRD1-AS1 may influence both chronic HBV infection and hepatocellular carcinoma (HCC) development. Three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) is tested to investigate ZNRD1-AS1 with the risk of both chronic HBV infection and HCC. The results reveal that variant alleles of all the three SNPs increase host HCC risk, whereas variant allele of rs3757328 is only associated with HBV clearance. Moreover, the haplotype containing variant alleles of the three SNPs are significantly associated with both HCC development and HBV clearance. In-vitro experiments...


hDREH

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA DREH is down-regulated by hepatitis B virus X protein (HBx) that is significantly down-regulated in the livers of HBx transgenic mice. Human ortholog RNA of Dreh (hDREH) is frequently down-regulated in HBV-related hepatocellular carcinoma (HCC) tissues in comparison with the adjacent noncancerous hepatic tissues, and its decrement significantly correlates with poor survival of HCC patients. Besides, DREH can reverse the high-migration phenotype of Hepa1-6 cells by affecting the protein vimentin.


linc-VLDLR

alias symbols:

tissues liver

cancer type hepatic cancer

Linc-VLDLR is significantly up-regulated in malignant hepatocytes. Exposure of HCC cells to diverse anticancer agents such as sorafenib, camptothecin, and doxorubicin increases linc-VLDLR expression in cells as well as extracellular vesicles (EV) released from these cells. Incubation with EVs reduces chemotherapy-induced cell death and also increases linc-VLDLR expression in recipient cells. RNAi-mediated knockdown of linc-VLDLR decreases cell viability and abrogates cell-cycle progression. Moreover, knockdown of linc-VLDLR reduces expression of ABCG2 (ATP-binding cassette, subfamily G memb...


lnc-URHC

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA URHC expression is increased in hepatocellular carcinoma (HCC) tissues and cells, its higher expression is correlated with poor overall survival. Functionally, URHC promotes cell proliferation and inhibits apoptosis. At molecular level, the study finds the ZAK gene, which is located near URHC on the same chromosome, is negatively correlated with URHC. Then, they confirm that URHC promotes HCC growth through ZAK via the ERK/MAPK signaling pathway.


lnc-WRAP53

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA WRAP53 is significantly higher in sera of hepatic carcinoma (HCC) than those with chronic hepatitis C virus (HCV) infection or healthy volunteers. Increased expression of WRAP53 is associated with advanced clinical parameters in HCC. Besides, WRAP53 is a significant independent prognostic marker in relapse-free survival. In addition, UCA1 and WRAP53 up-regulation may serve as novel serum biomarkers for HCC diagnosis and prognosis.


p21

alias symbols:

tissues bone marrow,colorectum,liver,lung,nervous system,others

cancer type colorectal cancer,diffuse large B cell lymphoma,glioma,hepatic cancer,lung cancer,lymphoma,sarcoma

LncRNA p21 is lower in diffuse large B cell lymphoma, glioma, lung cancer, sarcoma, lymphoma, colorectal cancer and hepatic carcinoma. Its expression level is associated with prognosis. It can regulate cancer cell proliferation and apoptosis.


treRNA

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA treRNA is negatively correlated with miR-190a expression level in hepatocellular carcinoma (HCC) tissues. After the miR-190 inhibitor (anti-190) is transfected into HCC cells, there are significantly increased expression level of treRNA. Inhibition of EMT via miR-190a mediates treRNA silencing in HCC cells.


uc002mbe.2

alias symbols:

tissues liver

cancer type hepatic cancer

LncRNA uc002mbe.2 expression level is significantly lower in the hepatic carcinoma (HCC) cell lines and liver cancer tissues. The histone deacetylase inhibitor (TSA) induces uc002mbe.2 expression that is positively correlated with the apoptotic effect of TSA in HCC cells. In addition, knocking down the expression of uc002mbe.2 significantly reduces TSA-induced apoptosis of Huh7cells.


uc003wbd

alias symbols:

tissues liver

cancer type hepatic cancer

Serum leve of lncRNA uc003wbd is increased in the patients with hepatic carcinoma (HCC) and hepatitis B viral (HBV). uc003wbd might be able to discriminate HCC patients or HBV patients from healthy controls and discriminate HCC patients from HBV patients.