Browse

browse by

73records

AC006050.3-003

alias symbols:

tissues lung

cancer type lung squamous cell cancer

LncRNA AC006050.3-003 is lower in partial response (PR) samples compared with the progressive disease (PD) samples. It is a valuable biomarker for differentiating PR patients from PD patients and might correlate with the sensitivity of chemotherapy in lung squamous cell carcinoma patients.


AC007403.1

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA AC007403.1 is up-regulated in non-small cell lung cancer (NSCLC), and may be potential biomarkers for predicting the tumorigenesis of NSCLC.


AFAP1-AS1

alias symbols:

tissues colorectum,esophagus,liver,lung,nasopharynx,pancreas

cancer type colorectal cancer,esophageal adenocarcinoma,esophageal squamous cell cancer,hepatic cancer,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,pancreatic ductal adenocarcinoma

LncRNA AFAP1-AS1 is significantly up-regulated in nasopharyngeal carcinoma (NPC), lung cancer, esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma, hepatic carcinoma (HCC), pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) tissues. In these cancers, up-regulated AFAP1-AS1 is correlated with poorer overall survival and clinicopathological parameters such as tumor size, lymph node metastasis, distant metastasis, advanced clinical stage etc. Knocking down AFAP1-AS1 can prohibit proliferation, migration and invasion of these cancer cells. In HCC cells, AFAP1-A...


AGAP2-AS1

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA AGAP2-AS1 is up-regulated in non-small cell lung cancer (NSCLC), and correlated with tumor size, advanced pathological stage and poor prognosis. AGAP2-AS1 can increase NSCLC cell proliferation, migration and invasion, but inhibit NSCLC cell apoptosis. Mechanistically, AGAP2-AS1 can repress LATS2 and KLF2 transcription via binding with EZH2 and LSD1.


AK001796

alias symbols:

tissues lung

cancer type lung cancer

LncRNA AK001796 is over-expressed in lung cancer cells and tumor tissues but down-regulated in resveratrol-treated lung cancer cells. Moreover, AK001796 can affect cell proliferation through the cell cycle, probably attributable to promoting the G1–S phase transition.


AK126698

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA AK126698 expression is down-regulated in human non-small cell lung cancer (NSCLC) tissues and cell lines, and correlated with a larger tumor size and advanced pathologic stage. Functionally, AK126698 overexpression represses cell proliferation and migration and induces apoptosis in NSCLC cells. Mechanistically, AK126698 inhibits Wnt/β-catenin signaling by suppressing FZD8. In addition, AK126698 exerts its biological function by negatively regulating β-catenin, c-myc and cyclin D1, and positively regulating Axin1 and E-cadherin. Moreover, downregulation of AK126698 may attribute to th...


ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


BANCR

alias symbols:

tissues colorectum,esophagus,liver,lung,others,stomach,thyroid

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,non-small-cell lung cancer,retinoblastoma,thyroid cancer

LncRNA BANCR expression is significantly higher in colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, melanoma, retinoblastoma and papillary thyroid carcinoma, while is lower in lung cancer. BANCR expression level is associated clinicopathological parameters such as lymph nodes metastasis and tumor stage and prognosis. Functionally, BANCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, BANCR can bind to EZH2. BANCR plays its function roles via regulating p38, JNK, NF-κB, ERK1/2, Raf-1, JN...


BC060912

alias symbols:

tissues lung

cancer type lung cancer

LncRNA BC060912 is expressed increasingly in human lung and other tumors. BC060912 is 1.2 kb in length and is composed of two exons. The expression of BC060912 is repressed by p53. Functionally, BC060912 suppresses cell apoptosis by interacting with the two DNA damage repair proteins, PARP1 and NPM1.


BC087858

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA BC087858 is up-regulated in non-small cell lung cancer and correlated with prognosis and acquired resistance to EGFR-TKIs. Down-regulating BC087858 partially restores gefitinib sensitivity in vitro. Functionally, BC087858 enhances cell invasion via promoting activation of PI3K/AKT pathway and EMT through the upregulation of Snail and ZEB1.


BC200

alias symbols:

tissues breast,esophagus,lung,ovary

cancer type breast cancer,esophageal cancer,non-small-cell lung cancer,ovarian cancer

LncRNA BC200 expression is increased in breast cancer, where the estrogen receptor (ER) interacts with the putative estrogen response elements (EREs) in the BC200 promoter to induce its transcription. In turn, BC200 can promote breast cancer cell proliferation. Besides, BC200 is also increased in esophageal cancer tissue and correlated with poor prognosis. While in ovarian cancer, BC200 is down-regulated and inhibits the proliferative ability of ovarian cancer cells. Besides, BC200 is associated with cell death induced by carboplatin. While in non-small cell lung cancer, BC200 is also up-re...


CAR10

alias symbols:

tissues lung

cancer type xuanwei lung cancer

LncRNA CAR10 is up-regulated in Xuanwei lung cancer patients. CAR10 overexpression is associated with air pollution. A smoky coal combustion-generated carcinogen dibenz[a,h]anthracene up-regulates CAR10 by increasing transcription factor FoxF2 expression. CAR10 binds and stabilizes transcription factor Y-box-binding protein 1 (YB-1), leading to upregulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells. Moreover, CAR10 can promote cell growth and tumor growth.


CASC2

alias symbols:

tissues colorectum,kidney,lung,nervous system

cancer type colorectal cancer,glioma,non-small-cell lung cancer,renal cancer

LncRNA CASC2 is lower in colorectal cancer, glioma, renal cell carcinoma, non-small cell lung cancer (NSCLC). Its expression level is associated with clinicopathological parameters such as tumor size, TNM stage, prognosis etc.. Functionally, CASC2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, CASC2 can bind to miR-18a, miR-21. Besides, CASC2 negatively regulates pSTAT3 and c-Myc.


CASC8

alias symbols:

tissues lung

cancer type lung cancer

The single nucleotide polymorphisms (SNP) CASC8 rs10505477 is greatly related to lung cancer risk in male and adenocarcinoma subgroups in recessive model. It is also closely correlated with platinum-based chemotherapy response in dominant model. Additionally, CASC8 rs10505477 polymorphism is significantly relevant to severe hematologic toxicity in non-small-cell lung cancer (NSCLC) subgroup in dominant model and in additive model. Furthermore, rs10505477 polymorphism is greatly associated with gastrointestinal toxicity in small cell lung cancer (SCLC) and cisplatin subgroups in dominant model.


CCAT1

alias symbols:

tissues bone marrow,breast,colorectum,endometrium,gallbladder,liver,lung,stomach

cancer type acute myelocytic leukemia,breast cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA CCAT1 is higher in breast cancer, colorectal cancer, gallbladder cancer, gastric cancer and hepatocellular carcinoma. CCAT1 expression level is associated with clinicopathological parameters such as differentiation grade, TNM stage, lymph node metastases, prognosis etc.. Functionally, CCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Further studies reveal that CCAT1 can bind to miRNA-218-5p, c-Myc and let-7. Moreover, CCAT1 can negatively regulate Bmi1, miR-490 and positively regulate c-Myc, HMGA2 and hnRNAP1.


CCAT2

alias symbols:

tissues breast,cervix,colorectum,esophagus,liver,lung,ovary,stomach

cancer type breast cancer,cervical cancer,cervical squamous cell cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,ovarian cancer

LncRNA CCAT2 is higher in breast cancer, esophageal squamous carcinoma, lung cancer, gastric cancer, cervical cancer and ovarian cancer. CCAT2 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, CCAT2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, CCAT2 is involves with chemotherapy response.


DLX6-AS1

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LncRNA DLX6-AS1 is significantly higher in lung adenocarcinoma (LAC) tissues compared to paired adjacent normal lung tissues. In addition, its expression level is correlated with both histological differentiation and TNM stage. Moreover, both mRNA and protein level of DLX6 are positively correlated with DLX6-AS1.


DQ786227

alias symbols:

tissues lung

cancer type lung cancer

The role of lncRNA DQ786227 in transformed human bronchial epithelial cells induced by benzo(a)pyrene is investigated. The transformed cell model is established using the BEAS-2B cell line, the study finds that DQ786227 is high and changed during the transformation of BEAS-2B cells. Silencing of DQ786227 expression in malignant transformed BEAS-2B cells leads to inhibition of cell proliferation and colony formation, and increased apoptosis. Moreover, DQ786227 dramatically promotes the ability of BEAS-2B-T cells to form colonies in vitro and develop tumors in nude mice.


EPB41L4A-AS2

alias symbols:

tissues breast,kidney,lung

cancer type breast cancer,lung cancer,renal cancer

LncRNA EPB41L4A-AS2 is down-regulated in breast, renal and lung cancer. Low expression is correlated with larger tumor size, higher stage and grade, ER and PR negative expression. Besides, low expression is correlated with poorer survival of the three kinds of cancers. In addition, a better overall survival is observed in TP53 wild-type breast cancer patients with high EPB41L4A-AS2 expression, while the converse is found for breast cancer patients with a TP53 mutation. Furthermore, overexpression of EPB41L4A-AS2 inhibits tumor cell proliferation.


ERICH1-AS1

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA ERICH1-AS1 is significantly up-regulated in non-small cell lung cancer samples and can be used as diagnostic marker.


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


GAS6-AS1

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA GAS6-AS1 is down-regulated in non-small cell lung cancer (NSCLC) tissues. Furthermore, decreased GAS6-AS1 expression is negatively correlated with lymph node metastasis, advanced tumor node metastasis stage and prognosis. Also, GAS6-AS1 level is inversely correlated with GAS6 mRNA level.


GHSROS

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA GHSROS transcribes from the antisense strand of the ghrelin receptor gene, growth hormone secretagogue receptor (GHSR). GHSROS is up-regulated in lung cancer tissues. Functionally, GHSROS stimulates cell migration but has little effect on cell proliferation.


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HIF1A-AS1

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA HIF1A-AS1 is significantly increased in tumor tissues or serum from non-small cell lung cancer (NSCLC) patients. Moreover, serum level of HIF1A-AS1 is significantly decreased after surgical treatment as compared to pre-operative.


HMlincRNA717

alias symbols:

tissues lung,pancreas,stomach

cancer type gastric cancer,non-small-cell lung cancer,pancreatic cancer


HNF1A-AS1

alias symbols:

tissues esophagus,liver,lung,nasopharynx,stomach

cancer type esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung adenocarcinoma,nasopharyngeal cancer

LncRNA HNF1A-AS1 is up-regulated in lung adenocarcinoma tissues, nasopharyngeal carcinoma, oesophageal adenocarcinoma, hepatocellular carcinoma, and down-regulated in gastric cancer. HNF1A-AS1 expression levels are significantly associated with clinicopathological parameter. Further studies reveal that HNF1A-AS1 promotes cell proliferation and metastasis. Besides, HNF1A-AS1 can affect autophagy in hepatocellular carcinoma via negatively regulating ATG. At molecular level, HNF1A-AS1 regulates cell cycle via cyclin D1 and regulates EMT via regulating EMT markers. In addition, HNF1A-AS1 can bi...


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOTTIP

alias symbols:

tissues bone,colorectum,liver,lung,others,pancreas,prostate,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer

HOTTIP is higher in tongue squamous cell carcinoma,non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer(CRC), pancreatic cancer and osteosarcoma. HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis. HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, HOTTIP negatively regulates miR-125b and HOXA13, and positively regulates HOXA genes.


IRAIN

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA IRAIN is increased in non-small cell lung cancer. IRAIN can promote proliferation but has no effect on cell migration and apoptosis.


LCAL6

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LncRNA LCAL6 is up-regulated in lung adenocarcinoma (LUAD) and indicates poor survival of LUAD patients. LCAL6 can promote cell proliferation. The staining of Ki67, a proliferation marker is also stronger in tumor tissues.


LINC00115

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LINC00115 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC00265

alias symbols:

tissues lung

cancer type lung cancer

LINC00265 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC00342

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA LINC00342 is up-regulated in non-small cell lung cancer (NSCLC) and correlated with lymph node metastasis, TNM stages and poor overall survival. LINC00342 negatively correlates with PTEN, P53 and P21.


LINC00473

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LINC00473 is consistently the most highly induced gene in LKB1-inactivated human primary non-small cell lung cancer (NSCLC) samples and derived cell lines. Elevated LINC00473 expression correlates with poor prognosis, and the sustained LINC00473 expression is required for the growth and survival of LKB1-inactivated NSCLC cells. Mechanistically, LINC00473 is induced by LKB1 inactivation and subsequent cyclic AMP-responsive element-binding protein (CREB)/CREB-regulated transcription coactivator (CRTC) activation.


LINC00673

alias symbols:

tissues lung,others,pancreas

cancer type melanoma,non-small-cell lung cancer,pancreatic cancer

LINC00673 expression is up-regulated in non-small cell lung cancer (NSCLC) tissues and associated with larger tumors, lymph node metastasis, more advanced tumors and prognosis. LINC00673 is localized in both the nucleus and cytosol. LINC00673 promotes NSCLC cell proliferation through regulating CDK6 expression. Moreover, LINC00673 silences NCALD transcription by binding with Histone demethylase lysine specific demethylase 1 (LSD1). In melanoma, LINC00673 is also up-regulated and associated with survival outcome. It can increase melanoma invasion. Further studies find that AR and Brn3a bind ...


LINC00857

alias symbols:

tissues lung

cancer type lung cancer

LINC00857 is overexpressed in lung adenocarcinoma, and predicts poor patient survival. LINC00857 promotes cancer cell proliferation and invasion. Besides, LINC00857 regulates cell cycle at the G1/S phase, potentially through CCNE1 and CDK2 regulation..


LINC01001

alias symbols:

tissues lung

cancer type lung cancer

LINC01001 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC01002

alias symbols:

tissues lung

cancer type lung cancer

LINC01002 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


LINC01133

alias symbols:

tissues colorectum,lung

cancer type colorectal cancer,lung squamous cell cancer,non-small-cell lung cancer

LINC01133 is down-regulated in colorectal cancer (CRC). LINC01133 is down-regulated by TGF-β, which could inhibit epithelial–mesenchymal transition (EMT) and metastasis in CRC cells. An alternative splicing factor SRSF6 is identified to directly interact with LINC01133, which promotes EMT and metastasis in CRC cells independent of LINC01133. LINC01133 expression is positively correlated with E-cadherin, and negatively correlated with Vimentin. Moreover, low LINC01133 expression is associated with poor survival in CRC samples. While in lung cancer, LINC01133 is up-regulated and associated wi...


LINC01207

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LINC01207 is up-regulated in lung adenocarcinoma (LAD) but no significant difference is observed in lung squamous cell cancer (LSCC). The expression level of LINC01207 is associated with TNM stage and survival time. LINC01207 can promote cell proliferation and inhibit apoptosis. Further study finds that LINC01207 inhibits apoptosis by binding to EZH2 and mediating H3K27-me3 at the promoter region of Bad.


LINC01852

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LINC01852 is greatly down-regulated in cancer tissues, and correlated with tumor diameter, lymph node metastasis and TNM stage. LINC01852 overexpression suppresses the proliferation, migration and ENT in non-small cell lung cancer (NSCLC) cell lines. Further studies find that P21 protein level is increased with LINC01852 overexpression. Moreover, LINC01852 overexpressing results in a marked increase in the E-cadherin protein level and a significantly decrease in expression of N-cadherin and vimentin.


LOC728228

alias symbols:

tissues lung

cancer type lung cancer

LncRNA LOC728228 is up-regulated in the anti-benzo(a) pyrene-7,8-diol-9,10-epoxide (anti-BPDE)-transformed human bronchial epithelial cell line (16HBE-T cells) relative to its expression in control untransformed16HBE (16HBE-N) cells. LOC728228 knockdown inhibits cell proliferation, causes G0/G1-phase cell-cycle arrest, reduces cellular migration, suppresses colony formation and inhibits tumor growth in a nude mouse xenograft model. In addition, LOC728228 knockdown also suppresses cyclin D1 expression, and the depletion of cyclin D1 induces G0/G1-phase cell-cycle arrest and inhibits cell pro...


LUADT1

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LncRNA LUADT1 is up-regulated in lung adenocarcinoma (LUAD), and correlated with the tumor stage, but not with N stage or TNM stage. LUADT1 promotes cell proliferation via regulating cyclin D1, cyclin-dependent kinase 4 (CDK4), cyclin-dependent kinase 6 (CDK6) and Ki67. In addition, LUADT1 binds to SUZ12 and epigenetically inhibits p27 expression by mediating H3K27 trimethylation at the promoter region of p27.


LUCAT1

alias symbols:

tissues lung

cancer type lung cancer,non-small-cell lung cancer

LncRNA LUCAT1 can be induced by cigarette smoke extract (CSE) both in vitro and in vivo and is elevated in numerous lung cancer cell lines. It is located in chromosome 5 with four exons and three introns. The expression of LUCAT1 is regulated transcriptionally by nuclear factor erythroid 2-related factor (NRF2). A nuclear factor erythroid-derived 2 (NF-E2) motif is identified in the promoter region that shows binding to NRF2 after its activation. Functionally, the siRNA knockdown of LUCAT1 in human bronchial epithelial cells shows a significant potentiation of cytotoxicity induced by CSE in...


MA-LINC1

alias symbols:

tissues breast,lung

cancer type breast cancer,lung cancer


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MIR4697HG

alias symbols:

tissues lung

cancer type lung cancer

LncRNA MIR4697HG is up-regulated in lung adenocarcinoma and significantly associated with clinical features. MIR4697HG is expressed at higher levels in the relapsed patients.


MVIH

alias symbols:

tissues breast,liver,lung

cancer type breast cancer,hepatic cancer,non-small-cell lung cancer

LncRNA MVIH is up-regulated in breast cancer, non-small cell lung cancer (NSCLC) and hepatocellular carcinoma and high MVIH expression is correlated with Ki67 expression. Moreover, patients with high MVIH expression levels are associated with clinicopathologic parameters. In addition, up-regulated MVIH expression promotes cell proliferation, cell cycle and cell invasion, but inhibit cell apoptosis. Mechanistically, MVIH affects cell invasion via regulating the level of MMP2 and MMP9. Furthermore, MVIH could weaken the function of PGK1 in angiogenesis inhibition by reducing the secretion of ...


NEAT1

alias symbols:

tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach

cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer

LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...


NFYC-AS1

alias symbols:

tissues lung

cancer type lung cancer

LncRNA NFYC-AS1 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


PANDAR

alias symbols:

tissues bladder,breast,liver,lung,stomach

cancer type bladder cancer,breast cancer,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA PANDAR is higher in breast cancer, gastric cancer, hepatocellular carcinoma and bladder cancer, and lower in lung cancer. PANDAR expression level is associated with clinicopathological parameters such as depth of invasion lymphatic metastasis, histological grade, TNM stage and prognosis etc.. Functionally, PANDAR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, PANDAR negatively regulates p16 and Bcl-2.


PCAT1

alias symbols:

tissues bladder,colorectum,esophagus,liver,lung,prostate

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,non-small-cell lung cancer,prostate cancer

LncRNA PCAT1 is higher in bladder cancer, esophageal squamous carcinoma colorectal cancer, hepatocellular carcinoma, lung cancer and prostate cancer. PCAT1 expression level is associated with clinicopathological parameters such as TNM stage, depth of tumor invasion, lymph node metastasis, prognosis etc.. Moreover, PCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, PCAT1 negatively regulates caspase-3.


PCAT6

alias symbols:

tissues lung

cancer type lung cancer

LncRNA PCAT6 is significantly increased in lung cancer tissues and correlates with metastasis and prognosis of lung cancer patients. PCAT6 significantly promotes cellular proliferation and metastasis, as well as inhibits early apoptosis of lung cancer cells. Molecular analysis reveals that PCAT6 regulates the expression of two pivotal cancer-related proteins, c-Myc and p53, in lung cancer cells. However, PCAT6 is not directly combined with c-Myc and p53 as confirmed by RNA immune-precipitation.


PVT1

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...


RGMB-AS1

alias symbols:

tissues lung

cancer type lung adenocarcinoma,non-small-cell lung cancer

LncRNA RGMB-AS1 is down-regulated in lung adenocarcinoma, and inhibits cell proliferation, migration and invasion. Further studies show that RGMB-AS1 may down-regulate RGMB expression though interacting with the exon2 sequence of RGMB. However, other study finds that RGMB-AS1 expression is significantly higher in non-small cell lung cancer (NSCLC) tissues and inversely correlated with RGMB mRNA. Both RGMB-AS1 and RGMB expression level are associated with the occurrence of differentiation status, lymph node metastases and TNM stage.


RP11-397D12.4

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA RP11-397D12.4 is up-regulated in non-small cell lung cancer (NSCLC), and may be a potential biomarker for predicting the tumorigenesis of NSCLC.


SBF2-AS1

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA SBF2-AS1 is significantly up-regulated in non-small cell lung cancer (NSCLC) and a high expression level of SBF2-AS1 is correlated with lymph node metastasis and advanced TNM stage. SBF2-AS1 promotes proliferation, migration and metastasis of NSCLC cells. At molecular level, the study finds that SBF2-AS1 controls the cell cycle by inhibiting P21 via binding to SUZ12 region of P21.


SNHG10

alias symbols:

tissues lung

cancer type lung cancer

LncRNA SNHG10 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


SOX2OT

alias symbols:

tissues breast,colorectum,esophagus,liver,lung

cancer type breast cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,lung cancer

LncRNA SOX2OT is higher in breast cancer, lung cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma and colorectal cancer. SOX2OT expression level is negatively correlated with prognosis. SOX2OT regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, Sox2ot positively regulates EZH2, Cyclin B1, Cdc2, SOX2 and OCT4.


SPRY4-IT1

alias symbols:

tissues bladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma, glioma, melanoma, colorectal cancer, bladder cancer(25973088), clear cell renal cell carcinoma, lower in non-small cell lung cancer (NSCLC), but has dual roles in gastric cancer. SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc.. Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, SPRY4-IT1 negatively regulates E-cadherin, ZO-1 and positively re...


TATDN1

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA TATDN1 is highly expressed in 95D cells and non-small cell lung cancer (NSCLC) tumor tissues compared to 95C cells. Knockdown of TATDN1-1 by shRNA significantly inhibits cell proliferation, adhesion, migration and invasion in 95D cells. Further mechanism study shows that TATDN1 knockdown suppresses the expression of E-cadherin, HER2, β-catenin and Ezrin. Moreover, knockdown of TATDN1 also inhibits tumor growth and metastasis in a 95D mouse model in vivo by inhibiting β-catenin and Ezrin.


THUMPD3-AS1

alias symbols:

tissues lung

cancer type lung cancer

LncRNA THUMPD3-AS1 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


TMPO-AS1

alias symbols:

tissues lung

cancer type lung cancer

LncRNA TMPO-AS1 is up-regulated in lung adenocarcinoma and significantly associated with survival time.


TUBA4B

alias symbols:

tissues lung

cancer type non-small-cell lung cancer

LncRNA TUBA4B is lower in non-small cell lung cancer (NSCLC) tissues and cell lines. The lower expression of TUBA4B is remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. Besides, overexpression of TUBA4B inhibits cell proliferation ability.


TUG1

alias symbols:

tissues bladder,bone,colorectum,esophagus,kidney,liver,lung,nervous system,stomach

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,hepatoblastoma,non-small-cell lung cancer,osteosarcoma,renal cancer

LncRNA TUG1 is higher in esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, osteosarcoma, colorectal cancer and bladder cancer, and lower in glioma andnon-small cell lung cancer (NSCLC). TUG1 expression level is associated with clinicopathological parameters such as invasion, lymph node metastasis, TNM stage, prognosis etc.. TUG1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TUG1 can bind to SP1 and PRC2. Moreover, TUG1 negatively regulates E-cadherin, miR-144, Bcl-2, KLF2 and positively regulates N-cadhe...


TUSC7

alias symbols:

tissues bone,colorectum,lung,pancreas,stomach

cancer type colorectal cancer,gastric cancer,non-small-cell lung cancer,osteosarcoma,pancreatic ductal adenocarcinoma

LncRNA TUSC7 is lower in colorectal cancer, osteosarcoma, pancreatic ductal adenocarcinoma, gastric cancer and non-small cell lung cancer. TUSC7 expression level is associated with clinicopathological parameters such as tumor size, tumor stage, distant metastasis and prognosis. Functionally, TUSC7 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, TUSC7 can bind to P53 and miR-211. Mechanistically, TUSC7 negatively regulates Cyclin D1, VEGF, Bcl2, miR-23b and positively regulates cyclin A2, cyclin B1, BCL2, BimEL.


UCA1

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


ZNRD1-AS1

alias symbols:

tissues liver,lung

cancer type hepatic cancer,lung cancer

The eQTLs SNPs in LncRNA ZNRD1-AS1 may influence both chronic HBV infection and hepatocellular carcinoma (HCC) development. Three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) is tested to investigate ZNRD1-AS1 with the risk of both chronic HBV infection and HCC. The results reveal that variant alleles of all the three SNPs increase host HCC risk, whereas variant allele of rs3757328 is only associated with HBV clearance. Moreover, the haplotype containing variant alleles of the three SNPs are significantly associated with both HCC development and HBV clearance. In-vitro experiments...


ZXF1

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LncRNA ZXF1 level is remarkably increased in lung adenocarcinoma tissues compared with adjacent non-cancerous lung tissues, and up-regulated ZXF1 is correlated with lymph node metastasis, tumor pathological stage and the extent of lymph node metastasis. The 3-year overall survival rate of patients with higher ZXF1 levels is remarkably reduced compared with patients with lower ZXF1 levels. Inhibition of ZXF1 by siRNA decreases the migration and invasion of A549 cells in vitro, while there is no significant effect in cell proliferation.


ZXF2

alias symbols:

tissues lung

cancer type lung adenocarcinoma

LncRNA ZXF2 is higher in lung adenocarcinoma specimens and correlated with tumor lymph node metastasis and poor prognosis of the patients. Functionally, siRNA-ZXF2 treatment inhibits cell proliferation, leading to cell cycle arrest. The cell migration and invasion are suppressed by siRNA-ZXF2 treatment. Further biochemical studies reveal that the knockdown of ZXF2 leads to down-regulation of c-Myc signaling.


p21

alias symbols:

tissues bone marrow,colorectum,liver,lung,nervous system,others

cancer type colorectal cancer,diffuse large B cell lymphoma,glioma,hepatic cancer,lung cancer,lymphoma,sarcoma

LncRNA p21 is lower in diffuse large B cell lymphoma, glioma, lung cancer, sarcoma, lymphoma, colorectal cancer and hepatic carcinoma. Its expression level is associated with prognosis. It can regulate cancer cell proliferation and apoptosis.