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AB073614

alias symbols:

tissues nervous system,ovary

cancer type glioma,ovarian cancer

LncRNA AB073614 is up-regulated in ovarian cancer (OC) and glioma. The 5-year overall survival in OC patients with high expression of AB073614 is inferior to that with low expression in both OC and glioma patients. AB073614 is more highly expressed in high-grade than low-grade glioma tissues. Level of AB073614 is a potential prognostic marker for glioma patients. Knockdown of AB073614 inhibits the proliferation and invasion of OC cells, down-regulates the cell-growth- (PCNA), metastasis- (MMP-2, 9), epithelial-mesenchymal-transition-(EMT, β-catenin, Twist, Snail and FN1), anti-apoptosis- (B...


ADAMTS9-AS2

alias symbols:

tissues nervous system

cancer type glioma

ADAMTS9-AS2 is an antisense overlapping lncRNA against ADAMTS9, and mostly located in the upstream of ADAMTS9. ADAMTS9-AS2 is down-regulated in glioma tissue samples and associated with poor prognosis. Its expression is positively correlated with ADAMTS9 and DNMT3A, but negatively with DNMT1. Mechanistically, it may modulate the expression of ADAMTS9. Moreover, ADAMTS9-AS2 expression levels are evidently increased in 5-aza-dC (DNA demethylating agent) groups. Overexpression of ADAMTS9-AS2 can inhibit migration and invasion of glioma cells.


ATB

alias symbols:

tissues breast,colorectum,kidney,liver,nervous system,pancreas,prostate,stomach

cancer type breast cancer,colorectal cancer,gastric cancer,glioma,hepatic cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA ATB plays a dual role in cancers. ATB is higher in breast cancer, gastric cancer, glioma, hepatocellular carcinoma, colon cancer, renal cell carcinoma and prostate carcinoma, but lower in pancreatic cancer. ATB expression is associated with clinicopathological parameters such as vascular invasion, lymph node metastasis, grades and prognosis etc.. Functionally, ATB regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ATB can regulate EMT by binding to miR-200 family members and regulate EMT markers expression level, for instance, ZE...


BC002811

alias symbols:

tissues nervous system

cancer type astrocytoma

LncRNA BC002811 is down-regulated in astrocytoma and significantly associated with poor patient survival.


CASC2

alias symbols:

tissues colorectum,kidney,lung,nervous system

cancer type colorectal cancer,glioma,non-small-cell lung cancer,renal cancer

LncRNA CASC2 is lower in colorectal cancer, glioma, renal cell carcinoma, non-small cell lung cancer (NSCLC). Its expression level is associated with clinicopathological parameters such as tumor size, TNM stage, prognosis etc.. Functionally, CASC2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, CASC2 can bind to miR-18a, miR-21. Besides, CASC2 negatively regulates pSTAT3 and c-Myc.


CRNDE

alias symbols:

tissues colorectum,nervous system

cancer type colorectal cancer,glioma

LncRNA CRNDE is higher in glioma. CRNDE overexpression facilitates cell proliferation, migration, and invasion, while inhibits glioma cells apoptosis. CRNDE can bind to miR-384 and miR-186, and suppress their function. CRNDE knockdown results in a decrease of piwi-like RNA-mediated gene silencing 4 (PIWIL4) protein. Meanwhile, CRNDE decreases the expression levels of XIAP and PAK7 by binding to miR-186 and negatively regulating it. Exon microarrays shows substantially elevated expression across exons E2, E4, In4, E5, In5 and part of E6 of CRNDE in colorectal cancer tissues. Transcript isof...


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HOTAIR

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tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOXA11-AS

alias symbols:

tissues nervous system,ovary

cancer type epithelial ovarian cancer,glioma

HOXA11-AS acts as an oncogene in glioma and tumor suppressor gene in epithelial ovarian cancer. HOXA11-AS can regulate cancer cell proliferation, migration, invasion and apoptosis.


HOXD-AS1

alias symbols:

tissues bladder,nervous system

cancer type bladder cancer,neuroblastoma

LncRNA HOXD-AS1 is up-regulated in bladder cancer and neuroblastoma. HOXD-AS1 is positively correlated with tumor size, histological grade and TNM stage in bladder cancer. HOXD-AS1 can promote bladder cancer cell proliferation, migration and inhibit apoptosis. HOXD-AS1 is up-regulated by retinoic acid in SH-SY5Y neuroblastoma cell line. Besides, HOXD-AS1 expression is regulated by PI3K/Akt signaling pathway.


HULC

alias symbols:

tissues bone,bone marrow,breast,colorectum,esophagus,liver,nervous system,pancreas,stomach

cancer type B-cell lymphoma,colorectal cancer,esophageal cancer,gastric cancer,glioma,hepatic cancer,osteosarcoma,pancreatic cancer,triple negative breast cancer

HULC is higher in breast cancer, colorectal carcinoma, gastric cancer, liver cancer, osteosarcoma, pancreatic cancer and glioma. HULC expression level is associated with clinicopathological parameters such as staging and grading. HULC regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis, EMT. Mechanistically, HULC can bind to EZH2, CREB, IGF2BP1, CLOCK, miR-107, miR-200a-3p. Moreover, HULC negatively regulates NKD2, miR-372, miR-9, TNF-α, E-Cadherin, and positively regulates LC3-II/LC3-I, SPHK1, E2F1, Snail, ZEB1, ZO-1, pERK, pAKT, pmTOR, ESM-1, peIF4E, thereby...


LINC00467

alias symbols:

tissues nervous system

cancer type neuroblastoma

N-Myc suppresses LINC00467 gene expression through directly binding to the LINC00467 gene promoter and reducing LINC00467 promoter activity. Moreover, LINC00467 reduces RD3 mRNA expression. Besides, Affymetrix microarray analysis reveals that one of genes significantly up-regulated by LINC00467 siRNA is the tumor suppressor gene DKK1. Importantly, knocking-down LINC00467 expression with siRNA in neuroblastoma cells reduces the number of viable cells and increases the percentage of apoptotic cells, while co-transfection with DKK1 siRNA would block the effects.


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MDC1-AS

alias symbols:

tissues bladder,nervous system

cancer type bladder cancer,glioma

LncRNA MDC1-AS is up-regulated in bladder cancer and glioma and positively associated with MDC1. It has a role on cell proliferation.


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MIR100HG

alias symbols:

tissues bone marrow,nervous system

cancer type acute megakaryocytic leukemia,neuroblastoma

LncRNA MIR100HG is higher in acute megakaryocytic leukemia (AMKL), lower in neuroblastoma. It can regulate cancer cell proliferation.


NBAT1

alias symbols:

tissues breast,kidney,nervous system

cancer type breast cancer,neuroblastoma,renal clear cell cancer

LncRNA NBAT1 is down-regulated in breast cancer and associated with tumor metastasis and poor patient prognosis. NBAT1 can inhibit migration and invasion of breast cancer cells. Mechanistic study shows that NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. Among them, DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2-dependent manner, and responsible for NBAT1's effects on inhibiting migration and invasion of breast cancer cells. While in neuroblastoma, CpG methylation and a high-risk neuroblastoma associated ...


NEAT1

alias symbols:

tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach

cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer

LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...


NR_002809

alias symbols:

tissues nervous system

cancer type astrocytoma

LncRNA NR_002809 is up-regulated in astrocytoma and associated with advanced clinical stages and poor patient survival.


RoR

alias symbols: lincRNA-ST8SIA3, lincRNA-RoR, ROR

tissues breast,colorectum,liver,nasopharynx,nervous system,pancreas

cancer type breast cancer,colorectal cancer,glioma,hepatic cancer,nasopharyngeal cancer,pancreatic cancer,triple negative breast cancer

LncRNA ROR is higher in breast cancer(24922071), pancreatic cancer, colon cancer, nasopharyngeal carcinoma and lower in glioma. ROR expression level is associated with clinicopathological parameters such as tumor size, prognosis. ROR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ROR can bind to miR-145. Moreover, ROR negatively regulates E-cadherin and KLF4, while positively regulates ZEB1, ZEB2, vimentin, fibronectin, N-cadherin, and SOX11.


SNHG1

alias symbols:

tissues liver,nervous system

cancer type astrocytoma,hepatic cancer

LncRNA SNHG1 is up-regulated in hepatocellular carcinoma (HCC) tissues and astrocytoma tissues. High SNHG1 expression is correlated with large tumor size, poor differentiation, aggressive BCLC stage, and poor prognosis. SNHG1 promotes HCC cells proliferation, cell cycle progression and inhibits HCC cells apoptosis. Further experiments reveal that SNHG1 promotes HCC cells proliferation through inhibiting p53 and p53-target genes expression.


SPRY4-IT1

alias symbols:

tissues bladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma, glioma, melanoma, colorectal cancer, bladder cancer(25973088), clear cell renal cell carcinoma, lower in non-small cell lung cancer (NSCLC), but has dual roles in gastric cancer. SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc.. Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, SPRY4-IT1 negatively regulates E-cadherin, ZO-1 and positively re...


TSLC1-AS1

alias symbols:

tissues nervous system

cancer type glioma

LncRNA TSLC1-AS1 and TSLC1 are both down-regulated in glioma tissue samples. Functionally, TSLC1-AS1 inhibits cell proliferation, migration and invasion. Moreover, TSLC1-AS1 is positively correlated with TSLC1. Besides, TSLC1-AS1 is also positively correlated with other tumor suppressors NF1, VHL, PIK3R1 and negatively correlated with the oncogene BRAF.


TUG1

alias symbols:

tissues bladder,bone,colorectum,esophagus,kidney,liver,lung,nervous system,stomach

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,hepatoblastoma,non-small-cell lung cancer,osteosarcoma,renal cancer

LncRNA TUG1 is higher in esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, osteosarcoma, colorectal cancer and bladder cancer, and lower in glioma andnon-small cell lung cancer (NSCLC). TUG1 expression level is associated with clinicopathological parameters such as invasion, lymph node metastasis, TNM stage, prognosis etc.. TUG1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TUG1 can bind to SP1 and PRC2. Moreover, TUG1 negatively regulates E-cadherin, miR-144, Bcl-2, KLF2 and positively regulates N-cadhe...


USMycN

alias symbols:

tissues nervous system

cancer type neuroblastoma

LncRNA USMycN is co-amplified with MYCN in 88 of 341 human neuroblastoma tissues. USMycN RNA binds to the RNA-binding protein Nono, leading to N-Myc RNA upregulation and neuroblastoma cell proliferation. High levels of USMycN and NonO expression in human neuroblastoma tissues independently predict poor patient prognoses. Besides, treatment with antisense oligonucleotides targeting USMycN in neuroblastoma-bearing mice statistically significantly hinders tumor progression.


XIST

alias symbols:

tissues breast,liver,nasopharynx,nervous system

cancer type breast cancer,glioma,hepatic cancer,nasopharyngeal cancer

LncRNA XIST is higher in glioma, nasopharyngeal carcinoma, and lower in breast cancer. XIST regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, XIST can bind to miR-152, miR-34a-5p. Moreover, XIST negatively regulates pAKT, OCT4 and positively regulates E2F3.


XLOC_010967

alias symbols:

tissues nervous system

cancer type astrocytoma

LncRNA XLOC_010967 is down-regulated in astrocytoma and significantly associated with poor patient survival.


linc-POU3F3

alias symbols:

tissues colorectum,esophagus,nervous system,stomach

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma

LncRNA POU3F3 is higher in colorectal cancer, glioma, esophageal squamous cell carcinoma and gastric cancer. POU3F3 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, POU3F3 is negatively regulated by EZH2. Besides, it negatively regulates p18, caspase-9, caspase-3, E-cadherin and positively regulates cyclin D1, CDK4, pRb, Rb, N-cadherin.


p21

alias symbols:

tissues bone marrow,colorectum,liver,lung,nervous system,others

cancer type colorectal cancer,diffuse large B cell lymphoma,glioma,hepatic cancer,lung cancer,lymphoma,sarcoma

LncRNA p21 is lower in diffuse large B cell lymphoma, glioma, lung cancer, sarcoma, lymphoma, colorectal cancer and hepatic carcinoma. Its expression level is associated with prognosis. It can regulate cancer cell proliferation and apoptosis.