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ANRIL

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tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


BANCR

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tissues colorectum,esophagus,liver,lung,others,stomach,thyroid

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,non-small-cell lung cancer,retinoblastoma,thyroid cancer

LncRNA BANCR expression is significantly higher in colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, melanoma, retinoblastoma and papillary thyroid carcinoma, while is lower in lung cancer. BANCR expression level is associated clinicopathological parameters such as lymph nodes metastasis and tumor stage and prognosis. Functionally, BANCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, BANCR can bind to EZH2. BANCR plays its function roles via regulating p38, JNK, NF-κB, ERK1/2, Raf-1, JN...


CASC15

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tissues others

cancer type melanoma

LncRNA CASC15 RNA is up regulated in melanoma lines and up-regulated in a xenograft model of melanoma brain metastasis. RACE identifies an alternative CASC15 transcriptional start site and multiple splice variants. Moreover, CASC15 levels increase during melanoma progression and its expression in melanoma LN metastases is an independent predictor of disease recurrence and survival. Besides, siRNA knockdown experiments reveal that CASC15 regulates melanoma cell phenotype switching between proliferative and invasive states.


CPS1-IT1

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tissues liver,others

cancer type hepatic cancer,intrahepatic cholangiocarcinoma

LncRNA CPS1-IT1 is down-regulated in hepatocellular carcinoma and up-regulated in intrahepatic cholangiocarcinoma. It can affect cancer cell proliferation, migration and apoptosis. Besides, it can inhibit EMT of hepatocellular carcinoma cells.


GAS5

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tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


H19

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tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HOTAIR

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tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOTTIP

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tissues bone,colorectum,liver,lung,others,pancreas,prostate,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer

HOTTIP is higher in tongue squamous cell carcinoma,non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer(CRC), pancreatic cancer and osteosarcoma. HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis. HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, HOTTIP negatively regulates miR-125b and HOXA13, and positively regulates HOXA genes.


JPH1-7

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tissues others

cancer type head and neck squamous cell cancer

LncRNA JPH1-7 levels in head and neck squamous cell carcinoma (HNSCC) is up-regulated, and associated not only with poor prognosis, methyltransferase KMT2D (MLL1) mutation and concurrent TP53 mutation and 3p deletion, but also significantly correlated to advanced tumor stage. Furthermore, higher median JPH1-7 expression is observed among HPV-negative patients and patients reporting history of smoking. Knockdown of JPH1-7 reduces the expression of EMT-promoting genes for N-cadherin and Snail, as well as anti-apoptotic gene XIAP.


LINC00629

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tissues others

cancer type choriocarcinoma

LINC00629 is long inter-genic non-coding RNAs mapped on chromosome X (Xq26), and highly expressed in reproductive tissues. Moreover, LINC00629 expression can be indirectly regulated by methylation. Besides, LINC00629 is evenly spread in JEG-3 choriocarcinoma cell line. In addition, LINC00629 can inhibit migration and invasion in JEG-3 choriocarcinoma cell line.


LINC00673

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tissues lung,others,pancreas

cancer type melanoma,non-small-cell lung cancer,pancreatic cancer

LINC00673 expression is up-regulated in non-small cell lung cancer (NSCLC) tissues and associated with larger tumors, lymph node metastasis, more advanced tumors and prognosis. LINC00673 is localized in both the nucleus and cytosol. LINC00673 promotes NSCLC cell proliferation through regulating CDK6 expression. Moreover, LINC00673 silences NCALD transcription by binding with Histone demethylase lysine specific demethylase 1 (LSD1). In melanoma, LINC00673 is also up-regulated and associated with survival outcome. It can increase melanoma invasion. Further studies find that AR and Brn3a bind ...


Llme23

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tissues others

cancer type melanoma

LncRNA Llme23 is exclusively detected in human melanoma lines. It is found to bind immobilized PSF resin. Knocking down Llme23 remarkably suppresses the malignant property of YUSAC cells, accompanied by the repressed expression of proto-oncogene Rab23.


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

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tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MIR503HG

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tissues others

cancer type choriocarcinoma

LncRNA MIR503HG is long inter-genic non-coding RNAs mapped on chromosome X (Xq26) and highly expressed in reproductive tissues. Its expression can be indirectly regulated by methylation. Moreover, MIR503HG is predominantly found in nucleus. Besides, MIR503HG can inhibit migration and invasion in JEG-3 choriocarcinoma cell line.


P2RX7-V3

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tissues others

cancer type uveal melanoma

LncRNA P2RX7-V3 (P2RX7 variant 3) is a transcriptional variant transcribed from the P2RX7 gene locus, which is expressed at a high level in uveal melanoma (UM) cells. P2RX7-V3 silencing reveals that this variant acts as a necessary UM oncoRNA. Knockdown of P2RX7-V3 expression significantly suppresses tumor growth and cancer cell migration. Moreover, knockdown of P2RX7-V3 leads to decreased vimentin and increased E-cadherin. Besides, a genome-wide cDNA array reveals that a variety of genes are dysregulated following P2RX7-V3 silencing.


PAUPAR

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tissues others

cancer type uveal melanoma

LncRNA PAUPAR is down regulated in uveal melanoma (UM). Further studies reveal that PAUPAR acts as a necessary UM suppressor and induces the silencing of HES1 expression, which significantly reduces tumor metastasis. Mechanistically, PAUPAR modulates HES1 expression by inhibiting histone H3K4 methylation.


PICSAR

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tissues others

cancer type cutaneous squamous cell carcinoma

LncRNA PICSAR is up-regulated in cutaneous squamous cell carcinoma (cSCC) cells and is up-regulated by inhibition of p38α and p38δ mitogen-activated protein kinases. Further studies find that PICSAR is specifically expressed by tumor cells in cSCCs but not by keratinocytes in normal skin in vivo. Functionally, knockdown of PICSAR inhibits proliferation and migration of cSCC cells, and suppresses the growth of human cSCC xenografts in vivo. Furthermore, knockdown of PICSAR inhibits extracellular signal-regulated kinase 1/2 activity and up-regulates expression of dual specificity phosphatase ...


RMEL3

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tissues others

cancer type melanoma

LncRNA RMEL3 expression is increased in melanoma and subcutaneous tumors compared to primary tumors. RMEL3 expression is also significantly increased in melanomas with a BRAFV600E mutation compared to those with a wild type BRAF or triple wild type for BRAF/RAS/NF1. Reverse phase protein array (RPPA) analysis finds that RMEL3 knockdown reduces cell cycle regulators (like pRB and Cyclin-B1) and anti-apoptotic proteins (like Bcl2), but increases p27 and some pro-apoptotic proteins as the example of caspase-8 and p38.


SAMMSON

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tissues others

cancer type melanoma

LncRNA SAMMSON is up-regulated in melanoma. SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF, NRAS or TP53 mutational status. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function.


SPRY4-IT1

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tissues bladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma, glioma, melanoma, colorectal cancer, bladder cancer(25973088), clear cell renal cell carcinoma, lower in non-small cell lung cancer (NSCLC), but has dual roles in gastric cancer. SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc.. Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, SPRY4-IT1 negatively regulates E-cadherin, ZO-1 and positively re...


UCA1

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tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


numb

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tissues others

cancer type uveal melanoma

LncRNA-numb is encoded by the LOC101928143 gene, whose locus is in the upstream of the protein-coding gene numb and encodes two different transcripts, 635bp and 644bp in size. qRT-PCR shows that LncRNA-635 is significantly down-regulated in uveal melanoma (UM) cells compared with the control, while the lncRNA-644 transcript did not exist. Moreover, lncRNA- numb is modulated by HIC1.


p21

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tissues bone marrow,colorectum,liver,lung,nervous system,others

cancer type colorectal cancer,diffuse large B cell lymphoma,glioma,hepatic cancer,lung cancer,lymphoma,sarcoma

LncRNA p21 is lower in diffuse large B cell lymphoma, glioma, lung cancer, sarcoma, lymphoma, colorectal cancer and hepatic carcinoma. Its expression level is associated with prognosis. It can regulate cancer cell proliferation and apoptosis.