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AB073614

alias symbols:

tissues nervous system,ovary

cancer type glioma,ovarian cancer

LncRNA AB073614 is up-regulated in ovarian cancer (OC) and glioma. The 5-year overall survival in OC patients with high expression of AB073614 is inferior to that with low expression in both OC and glioma patients. AB073614 is more highly expressed in high-grade than low-grade glioma tissues. Level of AB073614 is a potential prognostic marker for glioma patients. Knockdown of AB073614 inhibits the proliferation and invasion of OC cells, down-regulates the cell-growth- (PCNA), metastasis- (MMP-2, 9), epithelial-mesenchymal-transition-(EMT, β-catenin, Twist, Snail and FN1), anti-apoptosis- (B...


AC104699.1.1

alias symbols:

tissues ovary

cancer type ovarian cancer

LncRNA AC104699.1.1 is down-regulated in ovarian cancer. It could significantly divide the late-stage patients into high- and low-risk groups. Moreover, the expression level of AC104699.1.1 is associated with a decreased risk of survival. Low-risk groups always have higher expression levels of AC104699.1.1 than the high-risk. In addition, AC104699.1.1 is significantly associated with patient progression-free survival. Besides, AC104699.1.1 is involved in immune- and cell cycle-associated processes.


ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


BACE1-AS

alias symbols:

tissues ovary

cancer type ovarian cancer

LncRNA BACE1-AS in the anisomycin-treated ovarian cancer stem cells (OCSCs) is significantly elevated compared to the dimethylsulfoxide (DMSO) treated OCSCs or untreated OCSCs after 72 h. Anisomycin can stimulate expression of BACE1-AS and apoptosis-related proteins in OCSCs. Moreover, anisomycin can inhibit OCSCs xenograft growth. Accordingly, silencing of lncRNA BACE1-AS expression can weaken the effects of anisomycin in OCSCs.


BC200

alias symbols:

tissues breast,esophagus,lung,ovary

cancer type breast cancer,esophageal cancer,non-small-cell lung cancer,ovarian cancer

LncRNA BC200 expression is increased in breast cancer, where the estrogen receptor (ER) interacts with the putative estrogen response elements (EREs) in the BC200 promoter to induce its transcription. In turn, BC200 can promote breast cancer cell proliferation. Besides, BC200 is also increased in esophageal cancer tissue and correlated with poor prognosis. While in ovarian cancer, BC200 is down-regulated and inhibits the proliferative ability of ovarian cancer cells. Besides, BC200 is associated with cell death induced by carboplatin. While in non-small cell lung cancer, BC200 is also up-re...


C17orf91

alias symbols:

tissues ovary

cancer type ovarian cancer

LncRNA C17orf91 expression is elevated in omental metastases when compared with matched primary ovarian tumors. Increased expression of C17orf91 is associated with shorter progression- free survival. C17orf91 inhibition significantly decreases migration, invasion and viability of Hey cells. Mechanistically, C17orf91 repression could reduce the expression of KLF8 and SNAI2 at mRNA level, and reduce MYC at both protein and mRNA level.


CCAT2

alias symbols:

tissues breast,cervix,colorectum,esophagus,liver,lung,ovary,stomach

cancer type breast cancer,cervical cancer,cervical squamous cell cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,ovarian cancer

LncRNA CCAT2 is higher in breast cancer, esophageal squamous carcinoma, lung cancer, gastric cancer, cervical cancer and ovarian cancer. CCAT2 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, CCAT2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, CCAT2 is involves with chemotherapy response.


FAL1

alias symbols:

tissues ovary,thyroid

cancer type ovarian cancer,thyroid cancer

LncRNA FAL1, its copy number and expression are correlated with outcomes in ovarian cancer. FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. The oncogenic activity of FAL1 is partially attributable to its repression of p21. FAL1-specific siRNAs significantly inhibit tumor growth. Besides, FAL1 expression is increased in thyroid cancer (PTC) and high FAL1 expression increases the risk of multifocality.


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HOST2

alias symbols:

tissues ovary

cancer type epithelial ovarian cancer

LncRNA HOST2 is up-regulated in epithelial ovarian cancer (EOC). Functionally, HOST2 promotes EOC cell migration, invasion and proliferation, while has no significant effect on the rate of cell apoptosis. HOST2 is a molecular sponge for let-7b and is repressed by let-7b. Moreover, HOST2 enhances the endogenous expression of metastasis-promoting genes that are targeted by let-7b.


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOXA11-AS

alias symbols:

tissues nervous system,ovary

cancer type epithelial ovarian cancer,glioma

HOXA11-AS acts as an oncogene in glioma and tumor suppressor gene in epithelial ovarian cancer. HOXA11-AS can regulate cancer cell proliferation, migration, invasion and apoptosis.


LSINCT5

alias symbols:

tissues breast,ovary,stomach

cancer type breast cancer,gastric cancer,ovarian cancer

LSINCT5 is over-expressed in breast cancer, ovarian cancer gastric cancer and promotes cell proliferation.


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


NEAT1

alias symbols:

tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach

cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer

LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...


PVT1

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...


RP11-284N8.3.1

alias symbols:

tissues ovary

cancer type ovarian cancer

LncRNA RP11-284N8.3.1 is down-regulated in ovarian cancer. It could significantly divide late-stage patients into high- and low-risk groups. Moreover, RP11-284N8.3.1 expression level is associated with a decreased risk of survival. Low-risk groups always have higher expression level of RP11-284N8.3.1 than the high-risk groups. In addition, RP11-284N8.3.1 is significantly associated with patient progression-free survival. Besides, RP11-284N8.3.1 involves in immune- and cell-cycle-associated processes.


TC0100223

alias symbols:

tissues ovary

cancer type ovarian cancer

LncRNA TC0100223 is downregulated in ERα+ ovarian cancer tissues and correlated with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade.


TC0101441

alias symbols:

tissues ovary

cancer type ovarian cancer

LncRNA TC0101441 is upregulated in ERα+ ovarian cancer tissues and correlated with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade. Furthermore, multivariate analysis indicates that TC0101441 is an independent prognostic factor for overall survival.


TC0101686

alias symbols:

tissues ovary

cancer type ovarian cancer

LncRNA TC0101686 is downregulated in ERα+ ovarian cancer tissues and correlated with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade.


UCA1

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


ZNF300P1

alias symbols:

tissues ovary

cancer type type 2 epithelial ovarian cancer

LncRNA ZNF300P1 is methylated in multiple ovarian cancer cell lines. Loss of ZNF300P1 results in decreased cell proliferation and colony formation. In addition, knockdown of the ZNF300P1 transcript results in aberrant and less persistent migration in wound healing assays due to a loss of cellular polarity. Moreover, ZNF300P1 has a potential function in metastasis of ovarian cancer cells to sites within the peritoneal cavity.