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ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


ATB

alias symbols:

tissues breast,colorectum,kidney,liver,nervous system,pancreas,prostate,stomach

cancer type breast cancer,colorectal cancer,gastric cancer,glioma,hepatic cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA ATB plays a dual role in cancers. ATB is higher in breast cancer, gastric cancer, glioma, hepatocellular carcinoma, colon cancer, renal cell carcinoma and prostate carcinoma, but lower in pancreatic cancer. ATB expression is associated with clinicopathological parameters such as vascular invasion, lymph node metastasis, grades and prognosis etc.. Functionally, ATB regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ATB can regulate EMT by binding to miR-200 family members and regulate EMT markers expression level, for instance, ZE...


BX647187

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA BX647187 is up-regulated in prostate cancer cells, which is positively regulated by Hec1. Further studies find that BX647187 is positive with the expression of caspase-3, caspase-9 and Bax, while negative with Bcl-2. But the expression of caspase-8 has no obvious change. These results indicate that BX647187 affects apoptosis via intrinsic apoptotic pathway.


CTB-89H12.4

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA CTB-89H12.4 is up-regulated in prostate cancer cell lines. Depletion of PTEN transcript by siRNAs reduces the expression of CTB-89H12.4. The depletion of CTB-89H12.4 transcripts also reduces the expression of two other protein-coding genes (PCGs), VAPA and SERINC1, sponge-mRNAs of PTEN.


CTBP1-AS

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA CTBP1-AS is an androgen-responsive long ncRNA, located in the antisense (AS) region of C-terminal binding protein 1 (CTBP1), which is a co-repressor for androgen receptor. CTBP1-AS is predominantly localized in the nucleus and its expression is generally up-regulated in prostate cancer. CTBP1-AS promotes both hormone-dependent and castration-resistant tumor growth. Mechanistically, CTBP1-AS directly represses CTBP1 expression by recruiting the RNA-binding transcriptional repressor PSF together with histone deacetylases. CTBP1-AS also exhibits global androgen-dependent functions by in...


DANCR

alias symbols:

tissues colorectum,liver,prostate

cancer type colorectal cancer,hepatic cancer,prostate cancer

LncRNA DANCR is up-regulated in colorectal cancer, hepatic cancer (HCC) and prostate cancer. Experiments show that DANCR markedly increases stemness features of HCC cells to promote tumorigenesis and intra-/extrahepatic tumor colonization. Conversely, DANCR knockdown attenuates the stem-cell properties and in-vivo interference with DANCR action leads to decreased tumor cell vitality, tumor shrinkage, and improved mouse survival. Additionally, DANCR relies largely on an association with CTNNB1. Besides, DANCR promotes prostate cancer invasion and metastasis through repressing the expression ...


FR0348383

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA FR0348383 is up-regulated in over 70% of prostate cancer (PCa). FR0348383 score is correlated with an increasing probability of a positive biopsy. Multivariable logistic analysis indicates FR0348383 score is an independent predictor of PCa. In addition, the FR0348383 score would save 52.0% of avoidable biopsies without missing any high-grade cancers.


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HCG11

alias symbols:

tissues breast,prostate

cancer type breast cancer,prostate cancer

LncRNA HCG11 is up-regulated in breast cancer and its upregulation is associated with poor overall survival duo to the copy number alteration. However, LncRNA HCG11 is down-regulated in prostate cancer. Downregulation of HCG11 is correlated with the age, LN status, preoperative PSA level, Gleason score and BCR in prostate cancer. Moreover, downregulation of HCG11 can predict a poor prognosis in prostate cancer.


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOTTIP

alias symbols:

tissues bone,colorectum,liver,lung,others,pancreas,prostate,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer

HOTTIP is higher in tongue squamous cell carcinoma,non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer(CRC), pancreatic cancer and osteosarcoma. HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis. HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, HOTTIP negatively regulates miR-125b and HOXA13, and positively regulates HOXA genes.


LINC00963

alias symbols:

tissues prostate

cancer type prostate cancer

LINC00963 is up-regulated in prostate cancer. Knockdown of LINC00963 attenuates cell proliferation, motility, invasion ability, the expression of EGFR and phosphorylation levels of AKT, and promotes cell apoptosis. In addition, LINC00963 is involved in the prostate cancer transition from androgen-dependent to androgen-independent and metastasis via the EGFR signaling pathway.


LOC400891

alias symbols:

tissues prostate

cancer type prostate cancer

LOC400891 is higher in prostate cancer (PCa) tissues and cells. The patients with higher LOC400891 expression have advanced clinical features and a shorter biochemical recurrence-free survival time. Furthermore, multivariate analysis shows that the status of LOC400891 expression is an independent predictor of biochemical recurrence-free survival in PCa. Functionally, knockdown of LOC400891 could inhibit cell proliferation, migration and invasion. Mechanistically, LOC400891 is involved in the promotion of PCa cell proliferation and seems to be mediated by modulation of the PI3K-AKT-mTOR path...


LOC728606

alias symbols:

tissues prostate

cancer type prostate cancer

LOC728606 is up-regulated in prostate cancer (PCa). LOC728606 is detectable in plasma samples and increases incrementally from healthy individuals to those with localized and metastatic PCa. The study identifies a LOC728606-associated expression signature (PES), which is highly PCa-specific and activated in metastatic vs. primary PCa samples. The PES is significantly associated with androgen receptor (AR) signaling. Accordingly, AR activation dramatically up-regulates LOC728606 expression in vitro and in vivo. LOC728606 silencing significantly inhibits PCa cell proliferation and triggers ca...


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


NEAT1

alias symbols:

tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach

cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer

LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...


PCA3

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA PCA3 is an antisense intronic lncRNA within a single PRUNE2 transcriptional unit. Levels of lncRNA PCA3 and PRUNE2 are inversely correlated in human prostate cancer specimens. Further studies reveal that PCA3 binds PRUNE2 pre-mRNA and regulates its expression. In addition, PCA3 functions as an oncogene in prostate cancer.


PCAT1

alias symbols:

tissues bladder,colorectum,esophagus,liver,lung,prostate

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,non-small-cell lung cancer,prostate cancer

LncRNA PCAT1 is higher in bladder cancer, esophageal squamous carcinoma colorectal cancer, hepatocellular carcinoma, lung cancer and prostate cancer. PCAT1 expression level is associated with clinicopathological parameters such as TNM stage, depth of tumor invasion, lymph node metastasis, prognosis etc.. Moreover, PCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, PCAT1 negatively regulates caspase-3.


PCAT29

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA PCAT29 is characterized along with its relationship to the androgen receptor. PCAT29 is suppressed by DHT and up-regulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increases proliferation and migration of prostate cancer cells, whereas PCAT29 overexpression confers the opposite effect and suppresses growth and metastases of prostate tumors. Finally, in prostate cancer patient specimens, low PCAT29 expression correlates with poor prognostic outcomes.


PCAT5

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA PCAT5 is up-regulated in prostate cancer and promotes growth, migration, and invasion of ERG-positive prostate cancer cells. Moreover, PCAT5 is under direct regulation by ERG.


PCGEM1

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA PCGEM1 is up-regulated in prostate cancer and exhibits reciprocal regulation of miR-145. Transfection of the miR-145 expression vector and siRNA PCGEM1 inhibits tumor cell proliferation, migration, and invasion, and induces early apoptosis. Moreover, PCGEM1 is regulated by androgen receptor.


PlncRNA-1

alias symbols:

tissues esophagus,liver,prostate

cancer type esophageal squamous cell cancer,hepatic cancer,prostate cancer

PlncRNA-1 is higher in esophageal squamous carcinoma, hepatic carcinoma and prostate cancer. Its expression level is associated with prognosis. Moreover, it can regulate cancer cell proliferation, invasion, apoptosis and EMT.


SChLAP1

alias symbols:

tissues bladder,prostate

cancer type bladder cancer,prostate cancer

LncRNA SChLAP1 is higher in bladder cancer and prostate cancer. SChLAP1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, SChLAP1 can bind to SWI/SNF chromatin-modifying complex and negatively regulates SNF5.


SOCS2-AS1

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA SOCS2-AS1 is higher in castration-resistant prostate cancer model cells, i.e. long-term androgen-deprived (LTAD) cells, than in parental androgen-dependent LNCaP cells. SOCS2-AS1 promotes castration-resistant and androgen-dependent cell growth. Moreover, SOCS2-AS1 knockdown up-regulates genes related to the apoptosis pathway, including tumor necrosis factor superfamily 10 (TNFSF10), and sensitizes prostate cancer cells to docetaxel treatment. Besides, SOCS2-AS1 promotes androgen signaling by modulating the epigenetic control for AR target genes including TNFSF10.


THBS4-003

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA-thrombospondin 4 (THBS4)-003 is a processed transcript, which does not encode a protein product. LncRNA THBS4-003 is located at chromosome 5p14.1 and partially overlaps with the protein-coding gene, THBS4. The expression levels of THBS4 and lncRNA-THBS4-003 are significantly higher in prostate cancer (PC) tissues. THBS4 and lncRNA-THBS4-003 significantly promote the migratory and invasive abilities of the PCa cells. Functionally, lncRNA-THBS4-003 and THBS4 regulate levels of MMP-9 through the MAPK signaling pathway.


TRPM2-AS

alias symbols:

tissues prostate

cancer type prostate cancer

TRPM2-AS is an antisense transcript of TRPM2, which encodes an oxidative stress-activated ion channel, and overexpressed in prostate cancer (PCa). The high expression of TRPM2-AS and its related gene signature are found to be linked to poor clinical outcome. Mechanistically, TRPM2-AS knockdown leads to PCa cell apoptosis. Moreover, targets of existing drugs and treatments are found to be consistently associated with high TRPM2-AS levels in both targeted cells and patients, ultimately suggesting that the measurement of expression level of TRPM2-AS allows not only for the early identification...


UCA1

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


lnc-MX1-1

alias symbols:

tissues prostate

cancer type prostate cancer

LncRNA MX1-1 is over-expressed in prostate cancer tissues and correlated between PSA, Gleason score, metastasis, and recurrence free survival. Moreover, knockdown of lnc-MX1-1 reduces both proliferation and invasiveness of prostate cancer cells.