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ABHD11-AS1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA ABHD11-AS1 is up-regulated in the gastric cancer tissues as well as the gastric juice of patients with gastric cancer. ABHD11-AS1 levels in gastric juice from GC patients are associated with gender, tumor size, tumor stage, Lauren type, blood CEA levels, and have a positive correlation with CA19-9 level. Besides, ABHD11-AS1 can also be used as a diagnostic marker for gastric cancer patients.


AC096655.1-002

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AC096655.1-002 is down-regulated in gastric carcinoma tissues. Its expression level is associated with patients' age, TNM stages, distant metastasis, differentiation, lymph node metastasis and depth of invasion. Furthermore, AC096655.1-002 may be used as a potential marker for the diagnosis of gastric adenocarcinoma.


AC130710

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AC130710 is up-regulated in gastric cancer, and associated with tumor size, TNM stages, distal metastasis and tissue CEA expression. It has one complementary binding site in the 3′-end with miR-129-5p, and thus could be suppressed by miR-129-5p expression.


AC138128.1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AC138128.1 is down-regulated in gastric cancer. There is no statistically significant association between AC138128.1 expression and clinical pathological features. However, it may have some potential diagnostic value.


AI364715

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AI364715 is down-regulated in gastric cancer tissues, and associated with tumor size, differentiation and venous invasion. Moreover, AI364715 expression level is significantly changed in dysplasia, the typical precancerous lesions. Hence, AI364715 may be a potential biomarker for the diagnosis of gastric cancer.


AK058003

alias symbols:

tissues breast,stomach

cancer type breast cancer,gastric cancer

LncRNA AK058003 is significantly higher in the breast cancer and hypoxia-induced gastric cancer. Its expression level is associated with lymph node metastasis and differentiation in breast cancer. AK058003 siRNA can reduce SNCG expression at both mRNA and protein levels. Functionally, AK058003 can promote proliferation, migration and invasion of breast cancer cells. In addition, AK058003 can promote hypoxia-induced migration and invasion of gastric cancer cells.


ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


AP001631.9

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA AP001631.9 is increased and positively correlated with the FOXM1 levels in gastric cancer cells. Overexpression of FRLnc1 enhances the migration and metastasis of gastric cancer cells.


ATB

alias symbols:

tissues breast,colorectum,kidney,liver,nervous system,pancreas,prostate,stomach

cancer type breast cancer,colorectal cancer,gastric cancer,glioma,hepatic cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA ATB plays a dual role in cancers. ATB is higher in breast cancer, gastric cancer, glioma, hepatocellular carcinoma, colon cancer, renal cell carcinoma and prostate carcinoma, but lower in pancreatic cancer. ATB expression is associated with clinicopathological parameters such as vascular invasion, lymph node metastasis, grades and prognosis etc.. Functionally, ATB regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, ATB can regulate EMT by binding to miR-200 family members and regulate EMT markers expression level, for instance, ZE...


ATP8B5P

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA ATP8B5P is up-regulated in gastric cancer and linked to tumor grade.


BANCR

alias symbols:

tissues colorectum,esophagus,liver,lung,others,stomach,thyroid

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,non-small-cell lung cancer,retinoblastoma,thyroid cancer

LncRNA BANCR expression is significantly higher in colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, melanoma, retinoblastoma and papillary thyroid carcinoma, while is lower in lung cancer. BANCR expression level is associated clinicopathological parameters such as lymph nodes metastasis and tumor stage and prognosis. Functionally, BANCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, BANCR can bind to EZH2. BANCR plays its function roles via regulating p38, JNK, NF-κB, ERK1/2, Raf-1, JN...


BC032469

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA BC032469 is up-regulated in gastric cancer tissues, and is clinically associated with tumor size, differentiation and survival of gastric cancer patients. Downregulation of BC032469 results in a significant inhibition of proliferation in vitro and in vivo. Mechanistically, BC032469 could up-regulate hTERT by directly binding to miR-1207-5p and effectively functioning as a sponge for miR-1207-5p


C21orF96

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA C21orF96 is over-expressed in positive lymph node and gastric cancer tissues, and associated with gross appearance, lymphatic metastasis and distal metastasis. Further studies find that C21orF96 promotes the tubular formation, migration and invasion.


CCAT1

alias symbols:

tissues bone marrow,breast,colorectum,endometrium,gallbladder,liver,lung,stomach

cancer type acute myelocytic leukemia,breast cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA CCAT1 is higher in breast cancer, colorectal cancer, gallbladder cancer, gastric cancer and hepatocellular carcinoma. CCAT1 expression level is associated with clinicopathological parameters such as differentiation grade, TNM stage, lymph node metastases, prognosis etc.. Functionally, CCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Further studies reveal that CCAT1 can bind to miRNA-218-5p, c-Myc and let-7. Moreover, CCAT1 can negatively regulate Bmi1, miR-490 and positively regulate c-Myc, HMGA2 and hnRNAP1.


CCAT2

alias symbols:

tissues breast,cervix,colorectum,esophagus,liver,lung,ovary,stomach

cancer type breast cancer,cervical cancer,cervical squamous cell cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,ovarian cancer

LncRNA CCAT2 is higher in breast cancer, esophageal squamous carcinoma, lung cancer, gastric cancer, cervical cancer and ovarian cancer. CCAT2 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, CCAT2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Besides, CCAT2 is involves with chemotherapy response.


CTD-2108O9.1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA CTD-2108O9.1 is lower in gastric cancer tissues and cell lines. Moreover, the transwell assay shows that the number of cells capable of passing through the matrigel is significantly reduced after CTD-2108O9.1 transfection. However, CTD-2108O9.1 overexpression does not significantly influence cell proliferation and cell cycle progression. Lastly, western blot and real-time PCR analysis suggests that CTD-2108O9.1 is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level.


FENDRR

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA FENDRR expression is down-regulated in gastric cancer tissues and cell lines, and histone deacetylation is involved in the downregulation of FENDRR. Low FENDRR group shows greater invasion depth, higher tumor stage, more frequent lymphatic metastasis and shorter overall survival than the high FENDRR expression group. FENDRR exhibits an insignificant effect on gastric cancer cell proliferation, but represses gastric cancer cell migration, invasion and metastasis. Fibronectin1 is negatively regulated by FENDRR at both mRNA and protein levels. Inhibition of FENDRR contributes to the act...


FER1L4

alias symbols:

tissues colorectum,endometrium,stomach

cancer type colorectal cancer,endometrial cancer,gastric cancer

LncRNA FER1L4 expression shows downregulation in colon cancer, endometrial carcinoma (EC)and gastric cancer. It is positively correlated with PTEN expression in endometrial carcinoma(EC)tissues and gastric cancer. The low FER1L4 level is associated with clinicopathologic parameters in gastric cancer and colon cancer. FER1L4 can also induce cell cycle arrest and promote cell apoptosis in these three cancer cell lines. At the molecular level, FER1L4 promotes PTEN expression with an inhibition of Akt phosphorylation. Besides, miR-106a-5p suppresses FER1L4 and PTEN.


FOXD2-AS1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA FOXD2-AS1 is up-regulated in gastric cancer and linked to tumor grade, overall survival.


FRLnc1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA FRLnc1 expression is higher and up-regulated by FOXM1 in gastric cancer cells. FRLnc1 exhibits a significant effect on gastric cancer cell migration and metastasis. Besides, FRLnc1 positively regulates two EMT genes, TGF-β1 and Twist.


GAPLINC

alias symbols:

tissues colorectum,stomach

cancer type colorectal cancer,gastric cancer

LncRNA GAPLINC is up-regulated in gastric cancer and colorectal cancer. Up regulated GAPLINC is associated with tumor size, lymph node status and survival time of gastric cancer patients, and predicts poor prognosis of colorectal cancer. GAPLINC promotes proliferation and invasion of these two cancer cells. In gastric cancer, GAPLINC regulates cell invasion by controlling CD44 expression via competing for miR211-3p, while in colorectal cancer, GAPLINC regulates cell invasion through binding to PSF and NONO.


GAS5

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,endometrium,kidney,liver,lung,nervous system,others,ovary,pancreas,pleura,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,malignant pleural mesothelioma,mantle cell lymphoma cell,melanoma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer

LncRNA GAS5 is a tumor suppressor gene. GAS5 level is significantly down-regulated in glioma, melanoma, mantle cell lymphoma cell, lung cancer, malignant pleural mesothelioma, breast cancer, gastric cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, endometrial cancer, bladder cancer, prostate cancer and renal cell carcinoma. Low GAS5 level is associated with tumor size, lymph node metastasis, TNM stage, deeper depth of invasion and poor prognosis. Functionally, GAS5 can inhibit proliferation, migration, invasion and apoptosis of various cancer cells. It can direct...


GATA6-AS1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA GATA6-AS1 is down-regulated in gastric cancer, and its down-regulation is associated with poor survival in gastric cancer patients. Ectopic overexpression of GATA6-AS1 inhibits metastasis-related phenotypes and decreases the concentration of extracellular MMP9.


GClnc1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA GClnc1 is up-regulated and associated with tumorigenesis, tumor size, metastasis, and poor prognosis in gastric cancer. GClnc1 affects gastric cancer cell proliferation, invasiveness, and metastasis in multiple gastric cancer models. Mechanistically, GClnc1 binds WDR5 (a key component of histone methyltransferase complex) and KAT2A histone acetyltransferase, acting as a modular scaffold of WDR5 and KAT2A complexes to coordinate their localization and specify the histone modification pattern on the target genes, including SOD2, and consequently to alter gastric cancer cell biology.


GHET1

alias symbols:

tissues bladder,colorectum,stomach

cancer type bladder cancer,colorectal cancer,gastric cancer

LncRNA GHET1 is up-regulated in bladder cancer, colorectal cancer and gastric cancer. Increased GHET1 expression is correlated with advanced tumor status, grade and poor prognosis of bladder cancer and gastric cancer. Functionally, GHET1 promotes cell proliferation and invasion. Mechanistically, GHET1 negatively regulates p16 and p21, thus promoting cell proliferation. Moreover, GHET1 increases expression of vimentin, Snail, Slug, Twist, ZEB1 and fibronectin (mesenchymal marker) and decreases E-cadherin protein level (epithelial marker). As a consequence, EMT is promoted, and cancer cell in...


GUCY1B2

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA GUCY1B2 is up-regulated in gastric cancer and linked to tumor grade.


H19

alias symbols:

tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HIF1A-AS2

alias symbols:

tissues bladder,stomach

cancer type bladder cancer,gastric cancer

LncRNA HIF1A-AS2 is up-regulated in gastric cancer (GC) and bladder cancer. Overexpression of HIF1A-AS2 is significantly associated with tumor invasion, lymph node metastasis, higher TNM stage and shorter overall survival (OS) time. Besides, HIF1A-AS2 can promote the proliferation of GC cells and promote cell proliferation, migration and inhibit cell apoptosis in bladder cancer.


HMlincRNA717

alias symbols:

tissues lung,pancreas,stomach

cancer type gastric cancer,non-small-cell lung cancer,pancreatic cancer


HNF1A-AS1

alias symbols:

tissues esophagus,liver,lung,nasopharynx,stomach

cancer type esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung adenocarcinoma,nasopharyngeal cancer

LncRNA HNF1A-AS1 is up-regulated in lung adenocarcinoma tissues, nasopharyngeal carcinoma, oesophageal adenocarcinoma, hepatocellular carcinoma, and down-regulated in gastric cancer. HNF1A-AS1 expression levels are significantly associated with clinicopathological parameter. Further studies reveal that HNF1A-AS1 promotes cell proliferation and metastasis. Besides, HNF1A-AS1 can affect autophagy in hepatocellular carcinoma via negatively regulating ATG. At molecular level, HNF1A-AS1 regulates cell cycle via cyclin D1 and regulates EMT via regulating EMT markers. In addition, HNF1A-AS1 can bi...


HOTAIR

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


HOTTIP

alias symbols:

tissues bone,colorectum,liver,lung,others,pancreas,prostate,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,osteosarcoma,pancreatic cancer,prostate cancer,tongue squamous cell cancer

HOTTIP is higher in tongue squamous cell carcinoma,non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer(CRC), pancreatic cancer and osteosarcoma. HOTTIP expression level is associated with clinicopathological parameters such as tumor size, tumor depth, lymph node metastasis, clinical stage and prognosis. HOTTIP regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, HOTTIP negatively regulates miR-125b and HOXA13, and positively regulates HOXA genes.


HOXA-AS2

alias symbols:

tissues bone marrow,stomach

cancer type gastric cancer,promyelocytic leukemia

LncRNA HOXA-AS2 is up-regulated in human gastric cancer (GC) tissues and promyelocytic leukemia cells. In addition, HOXA-AS2 expression is induced by IFN-γ and TNF-α in neutrophils. Overexpression of HOXA-AS2 is associated with tumor size, TNM stage and poor prognosis of GC. HOXA-AS2 promotes cell proliferation and inhibits cell apoptosis. HOXA-AS2 epigenetically silences P21, PLK3 and DDIT3 transcription by binding with EZH2.


HULC

alias symbols:

tissues bone,bone marrow,breast,colorectum,esophagus,liver,nervous system,pancreas,stomach

cancer type B-cell lymphoma,colorectal cancer,esophageal cancer,gastric cancer,glioma,hepatic cancer,osteosarcoma,pancreatic cancer,triple negative breast cancer

HULC is higher in breast cancer, colorectal carcinoma, gastric cancer, liver cancer, osteosarcoma, pancreatic cancer and glioma. HULC expression level is associated with clinicopathological parameters such as staging and grading. HULC regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis, EMT. Mechanistically, HULC can bind to EZH2, CREB, IGF2BP1, CLOCK, miR-107, miR-200a-3p. Moreover, HULC negatively regulates NKD2, miR-372, miR-9, TNF-α, E-Cadherin, and positively regulates LC3-II/LC3-I, SPHK1, E2F1, Snail, ZEB1, ZO-1, pERK, pAKT, pmTOR, ESM-1, peIF4E, thereby...


KRT18P55

alias symbols:

tissues stomach

cancer type intestinal-type gastric cancer

LncRNA KRT18P55 is up-regulated in gastric cancer (GC) cell lines and tissue samples. Additionally, increased expression of KRT18P55 is related to the progression of intestinal type. Finally, KRT18P55 shows potential diagnostic value for GC patients.


KRT7-AS

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA KRT7-AS is higher in gastric cancer and positively with KRT7 expression. KRT7-AS can control KRT7 expression at both the RNA and protein levels. In addition, by forming an RNA duplex, KRT7-AS can increase the stability of mRNA KRT7. Moreover, KRT7-AS can promote proliferation and migration of gastric cancer cells.


LEIGC

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA LEIGC is down-regulated in gastric cancer. It consists of 2659bp with two exons. LEIGC significantly inhibits cell proliferation and migration of gastric cancer cells. LEIGC enhances chemosensitivity to 5-FU in gastric cancer. Moreover, LEIGC prevents EMT of gastric cancer via regulating E-cadherin, Vimentin, Snail, Slug, Zeb and Twist.


LET

alias symbols:

tissues cervix,esophagus,gallbladder,liver,nasopharynx,stomach

cancer type cervical cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,nasopharyngeal cancer

LncRNA LET is lower in nasopharyngeal carcinoma, esophageal squamous cell carcinoma, gallbladder cancer, gastric cancer, hepatic carcinoma,colorectal cancer,lung squamous cell cancer, and cervical cancer. LET expression level is associated with clinicopathological parameters such as pathological grade, clinical stage, lymph node metastasis, prognosis etc.. LET regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. LET play biological functions via negatively regulating Bcl-2 and positively regulates p53, p21, caspase-3, Bax. Moreover, LET can regulate hypoxia si...


LINC00152

alias symbols:

tissues breast,kidney,liver,stomach

cancer type breast cancer,gastric cancer,hepatic cancer,renal clear cell cancer

LINC00152 is higher in breast cancer, gastric cancer, hepatocellular carcinoma and clear cell renal cell carcinoma. LINC00152 expression level is associated with clinicopathological parameters such as tumor size, differentiation grade, TNM stage, depth of invasion, prognosis etc.. Moreover, LINC00152 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Besides, LINC00152 can bind to EGFR and EpCAM. LINC00152 functions via negatively regulating E-cadherin, p15, p21 and positively regulating N-cadherin, Vimentin.


LINC00261

alias symbols:

tissues stomach

cancer type gastric cancer

LINC00261 is down-regulated in gastric cancer (GC) and correlated with invasion depth, tumor stage, lymphatic metastasis and prognosis. LINC00261 exhibits an insignificant effect on GC cell proliferation, but represses GC cell migration, invasion and metastasis. LINC00261 inhibits EMT via affecting EMT markers E-cadherin, N-cadherin, Vimentin, and FN1.


LINC00628

alias symbols:

tissues stomach

cancer type gastric cancer

LINC00628 is down-regulated in gastric cancer (GC) and functions as a GC suppressor through suppressing proliferation, migration and colony formation of cancer cells. Furthermore, LINC00628 can also suppress the tumor size in mouse xenograft models. Mechanistically, although LINC00628 can negatively modulate LRRN2 expression, the GC suppressor function of LINC00628 is not LRRN2-dependent. Importantly, LINC00628 mainly locates in the nucleus and interacts with EZH2, and modulates genes expression by regulating H3K27me3 level.


LINC00668

alias symbols:

tissues stomach

cancer type gastric cancer

LINC00668 is up-regulated in human gastric cancer tissues, and correlates with advanced invasion depth, TNM stage and poor prognosis. E2F1 can activate LINC00668 by directly binding to the LINC00668 promoter, with a positive correlation with the expression of LINC00668. Cell functional experiments show that LINC00668 can promote gastric cancer cell proliferation and accelerate cell cycle by binding to PRC2. Moreover, knockdown of LINC00668 can increase the expression of CKIs p15, p16, p21, p27 and p57.


LINC00982

alias symbols:

tissues kidney,stomach

cancer type gastric cancer,renal clear cell cancer

The LINC00982 expression level is lower in gastric cancer tissues and correlated with invasion depth, TNM stage, regional lymph nodes metastasis and prognosis. LINC00982 exhibits significant effect on gastric cancer proliferation and cell cycle progression by positively regulating P15 and P16 at both mRNA and protein levels. While in clear cell renal cell carcinoma (ccRCC), LINC00982 is decreased and associated with poor prognosis. Moreover, high expression of LINC00982 is associated with a decreased risk of cancer-related death in univariate regression analysis, but LINC00982 could not pre...


LOC100128164

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA LOC100128164 is down-regulated in gastric cancer and linked to tumor grade.


LOC100130476

alias symbols:

tissues esophagus,stomach

cancer type esophageal squamous cell cancer,gastric cardia adenocarcinoma

LOC100130476 is down-regulated in esophageal squamous cell carcinoma (ESCC) and gastric cancer. Its downregulation at least partly results from hypermethylation of CpG sites in exon 1 and its hypermethylation may have prognostic implication. Besides, it is involved with clinicopathological features.


LOC105378009

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA LOC105378009 and serum and glucocorticoid-inducible kinase 1 (SGK1) are elevated in T cell either within the gastric cancer tissues or peripheral T cells, and associated with Helicobacter pylori infection and high-salt diet (HSD). Within T cells, Helicobacter pylori (Hp) infection and high-salt diet can up-regulated SGK1 expression, which in turn enhances the expression of LOC105378009 through JunB activation. Expression of LOC105378009 can further enhance transcription of SGK1 through cis-regulatory mode. Moreover, LOC105378009 can induce Th2 and Th17, whilereduce Th1 differentiatio...


LOC553137

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA LOC553137 is up-regulated in gastric cancer and linked to lymphatic metastasis.


LSINCT5

alias symbols:

tissues breast,ovary,stomach

cancer type breast cancer,gastric cancer,ovarian cancer

LSINCT5 is over-expressed in breast cancer, ovarian cancer gastric cancer and promotes cell proliferation.


MALAT1

alias symbols: mascRNA, LINC00047, NCRNA00047,PRO1073, HCN, NEAT2, MALAT-1

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,esophageal cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,middle thoracic esophageal cancer,multiple myeloma,nasopharyngeal cancer,neuroblastoma,non-small cell lung cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,renal clear cell cancer,tongue cancer,triple negative breast cancer

MALAT1 is a well-studied long non-coding RNA. It acts as an oncogene in multiple cancers. It is higher in glioma,tongue cancer, oral squamous cell carcinoma, esophageal cancer, lung cancer, breast cancer, gastric cancer, hepatic carcinoma, multiple myeloma, gallbladder cancer, osteosarcoma, pancreatic cancer, colorectal cancer, prostate cancer, bladder cancer, renal cell carcinoma, cervical cancer and ovarian cancer. MALAT1 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, vascular invasion, lymph node metastasis, prognosis. Functionally, MALA...


MEG3

alias symbols:

tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


MIR31HG

alias symbols:

tissues bladder,breast,colorectum,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,gastric cancer,triple negative breast cancer

LncRNA MIR31HG is higher in breast cancer, lower in colorectal cancer, triple negative reast Cancer, bladder cancer, and gastric cancer. It can regulate cancer cell proliferation, migration, invasion and apoptosis. Mechanistically, it can regulate E2F1 and p21.


MRUL

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA MRUL, locates 400 kb downstream of ABCB1 (ATP-binding cassette, subfamily B, member 1), is significantly up-regulated in two multidrug-resistant gastric cancer (GC) cell sublines, SGC7901/ADR and SGC7901/VCR. Furthermore, the relative expression level of MRUL in GC tissues is negatively correlated with growth inhibition rates of GC specimens treated with chemotherapeutic drugs and indicates a poor prognosis for GC patients. MRUL knockdown in SGC7901/ADR and SGC7901/VCR cells leads to increased rates of apoptosis, increased accumulation, and reduced doxorubicin (Adriamycin [ADR]) rele...


NEAT1

alias symbols:

tissues bladder,bone marrow,colorectum,esophagus,larynx,liver,lung,nasopharynx,nervous system,ovary,prostate,stomach

cancer type acute promyelocytic leukemia,bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer

LncRNA NEAT1 is an oncogene and it is higher in glioma, laryngeal squamous cell cancer, esophageal squamous cell carcinoma, lung cancer, gastric cancer, hepatic carcinoma, colorectal cancer, bladder cancer and ovarian cancer. NEAT1 expression level is associated with clinicopathological parameters such as differentiation, lymph node metastasis, TNM stage prognosis. NEAT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, NEAT1 can bind to miR-449b-5p, hsa-miR-377-3p, miR‐124‐3p and HuR. Furthermore, NEAT1 negatively regulates CDK6, Zo-1...


OR3A4

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA OR3A4 is up-regulated in gastric cancer tissues, and significantly associated with metastasis. Enhanced OR3A4 expression in gastric cancer cells promotes cell migration and invasion. Moreover, enhanced OR3A4 expression in gastric cancer cells promotes tubule formation in human umbilical vein endothelial cells (HUVECs), thus promoting vasculogenic mimicrybin and angiogenesis of gastric cancer. Mechanism studies show that OR3A4 promotes tumorigenicity and peritoneal spreading of gastric cancer involves PDLIM2 downregulation.


PANDAR

alias symbols:

tissues bladder,breast,liver,lung,stomach

cancer type bladder cancer,breast cancer,gastric cancer,hepatic cancer,non-small-cell lung cancer

LncRNA PANDAR is higher in breast cancer, gastric cancer, hepatocellular carcinoma and bladder cancer, and lower in lung cancer. PANDAR expression level is associated with clinicopathological parameters such as depth of invasion lymphatic metastasis, histological grade, TNM stage and prognosis etc.. Functionally, PANDAR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, PANDAR negatively regulates p16 and Bcl-2.


PART1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA PART1 is down-regulated in gastric cancer and linked to TNM stage.


PCNA-AS1

alias symbols:

tissues liver,stomach

cancer type gastric cancer,hepatic cancer

PCNA-AS1, antisense to PCNA, is increased in gastric cancer tissues and associated with invasion. The expression level of PCNA-AS1 is also related with immunohistochemical biomarkers of BRCA1. While in hepatocellular carcinoma, PCNA-AS1 is significantly up-regulated in HCC and could promote tumor growth both in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability.


PRNCR1

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tissues colorectum,stomach

cancer type colorectal cancer,gastric cancer

LncRNA PRNCR1 is higher in colorectal cancer and regulates cancer cell proliferation. Single nucleotide polymorphisms (SNPs) in the lncRNA may influence the process of splicing and stability of mRNA conformation, resulting in altered cancer risk.


PTENP1

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tissues liver,stomach

cancer type gastric cancer,hepatic cancer

LncRNA PTENP1 is a pseudogene of the tumor suppressor gene PTEN. PTENP1 and PTEN are down-regulated in several hepatocellular carcinoma (HCC) cells. Elevated level of PTENP1 and PTEN can suppress the oncogenic PI3K/AKT pathway, and inhibit cell proliferation, migration, invasion as well as induce autophagy and apoptosis. Over-expressed PTENP1 decoys oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62. In a word, PTENP1 can inhibit cell proliferation, elicit apoptosis and autophagy, and inhib...


PVT1

alias symbols:

tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...


RHPN1-AS

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tissues stomach

cancer type gastric cancer

LncRNA RHPN1-AS is up-regulated in gastric cancer and linked to tumor grade.


RMRP

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA RMRP level in tissue, plasma and gastric juices from patients with gastric cancer is significantly different from those from controls. Its level is significantly associated with Borrmann type and metastasis. RMRP in Plasma and gastric juice have higher sensitivity and specificity than commonly used markers. Knockdown of RMRP significantly inhibits cell proliferation. Moreover, RMRP is a sponge of miR-206, and modulates cell cycle by regulating Cyclin D2 expression.


RP11-119F7.4

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tissues stomach

cancer type gastric cancer

LncRNA RP11-119F7.4 expression is significantly down-regulated in the gastric cancer tissues and significantly associated with the macroscopic type and Lauren grade. However, no statistically significant differences are observed between RP11-119F7.4 expression and patient survival.


RPLP0P2

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tissues stomach

cancer type gastric cancer

LncRNA RPLP0P2 is up-regulated in gastric cancer and negatively associated with overall survival.


SDMGC

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tissues stomach

cancer type gastric cancer

Expression levels of LncRNA SDMGC and its target gene TRIM16 are up-regulated in the distant metastasis tissues, compared with primary gastric cancer (GC) tissues, two of which are positive correlation. SDMGC and TRIM16 can promote cell invasion and migration. However, the research finds they have little effect on proliferation, cell cycle, colony formation, and apoptosis.


SLC26A4-AS1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA SLC26A4-AS1 is down-regulated in gastric cancer and linked to tumor grade.


SMIM10L2A

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA SMIM10L2A is down-regulated in gastric cancer and positively correlated with overall survival.


SMIM10L2B

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA SMIM10L2B is down-regulated and positively correlated with overall survival.


SNHG15

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tissues liver,stomach

cancer type gastric cancer,hepatic cancer

LncRNA SNHG15 is up-regulated in gastric cancer (GC) and hepatocellular carcinoma (HCC). Furthermore, increased SNHG15 expression is correlated with clinicopathologic feature and prognosis. Functionally, SNHG15 expression can promote cell proliferation and invasion and inhibit apoptosis. Mechanistically, SNHG15 promotes cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression.


SNHG5

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA SNHG5 is significantly down-regulated in gastric cancer (GC), and significantly associated with the formation of a tumor embolus and tumor, node and metastasis (TNM) stage. Functionally, SNHG5 suppresses GC cell proliferation and metastasis. Furthermore, SNHG5 exerts its function through interacting with MTA2, preventing the translocation of MTA2 from the cytoplasm into the nucleus. SNHG5 overexpression leads to significant increase in the acetylation levels of histone H3 and p53, indicating that SNHG5 might affect acetylation by trapping MTA2 in the cytosol, thereby interfering with...


SPRY4-IT1

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tissues bladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach

cancer type bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma, glioma, melanoma, colorectal cancer, bladder cancer(25973088), clear cell renal cell carcinoma, lower in non-small cell lung cancer (NSCLC), but has dual roles in gastric cancer. SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc.. Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, SPRY4-IT1 negatively regulates E-cadherin, ZO-1 and positively re...


SUMO1P3

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tissues bladder,stomach

cancer type bladder cancer,gastric cancer

LncRNA SUMO1P3 is significantly up-regulated in bladder cancer tissues and gastric cancer. Moreover, up-regulated SUMO1P3 expression is correlated with clinicopathological parameters. Furthermore, SUMO1P3 can promote cell proliferation, migration and inhibit apoptosis of bladder cancer cells.


TINCR

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tissues colorectum,esophagus,stomach

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer

LncRNA TINCR is higher in esophageal squamous cell carcinoma, gastric cancer and lower in colorectal cancer. TINCR expression level is associated with clinicopathological parameters such as invasion, lymph metastasis, TNM stage, differentiation etc.. TINCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TINCR can bind to EpCAM and STAU1. Moreover, TINCR negatively regulates c-Myc and positively regulates CLDN7, ANXA1.


TSPEAR-AS2

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tissues stomach

cancer type gastric cancer

LncRNA TSPEAR-AS2 is up-regulated in gastric cancer and linked to tumor grade.


TUG1

alias symbols:

tissues bladder,bone,colorectum,esophagus,kidney,liver,lung,nervous system,stomach

cancer type bladder cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,hepatoblastoma,non-small-cell lung cancer,osteosarcoma,renal cancer

LncRNA TUG1 is higher in esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, osteosarcoma, colorectal cancer and bladder cancer, and lower in glioma andnon-small cell lung cancer (NSCLC). TUG1 expression level is associated with clinicopathological parameters such as invasion, lymph node metastasis, TNM stage, prognosis etc.. TUG1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, TUG1 can bind to SP1 and PRC2. Moreover, TUG1 negatively regulates E-cadherin, miR-144, Bcl-2, KLF2 and positively regulates N-cadhe...


TUSC7

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tissues bone,colorectum,lung,pancreas,stomach

cancer type colorectal cancer,gastric cancer,non-small-cell lung cancer,osteosarcoma,pancreatic ductal adenocarcinoma

LncRNA TUSC7 is lower in colorectal cancer, osteosarcoma, pancreatic ductal adenocarcinoma, gastric cancer and non-small cell lung cancer. TUSC7 expression level is associated with clinicopathological parameters such as tumor size, tumor stage, distant metastasis and prognosis. Functionally, TUSC7 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, TUSC7 can bind to P53 and miR-211. Mechanistically, TUSC7 negatively regulates Cyclin D1, VEGF, Bcl2, miR-23b and positively regulates cyclin A2, cyclin B1, BCL2, BimEL.


UBC1

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tissues bladder,stomach

cancer type bladder cancer,gastric cancer

LncRNA UBC1 is significantly up-regulated in gastric cancer tissues and bladder cancer. Furthermore, high UBC1 expression is associated with clinicopathological parameter such as lymph-node metastasis, tumor size, TNM stage and poorer prognosis. Functionally, UBC1 promotes proliferation, motility and invasion of gastric cancer cells. Moreover, UBC1 acts in trans and binds to PRC2 complex and suppresses its target genes in bladder cancer cell.


UCA1

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tissues bladder,bone,bone marrow,breast,colorectum,esophagus,kidney,liver,lung,others,ovary,prostate,stomach

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,melanoma,non-small-cell lung cancer,osteosarcoma,ovarian cancer,prostate cancer,renal cancer,tongue squamous cell cancer

LncRNA UCA1 is higher in lung cancer, breast cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, ovarian cancer, bladder cancer, renal cell carcinoma, while has dual roles in esophageal squamous cell carcinoma. UCA1 expression level is associated with clinicopathological parameters such as differentiation, tumor size, invasion depth, TNM stage, prognosis etc.. UCA1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, UCA1 can bind to Ets-2, C/EBPα,BRG1(24993775),hnRNPI and miRNAs. Moreover, UCA1 re...


Uc001lsz

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA uc001lsz is reduced in gastric cancer cell lines and tissues. It is associated with TNM stage, and dys-regulated in early cancer and precancerous lesions. Thereby, uc001lsz may be a potential marker for the diagnosis of early gastric cancer.


WT1-AS

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tissues kidney,liver,stomach

cancer type Wilms' tumour,gastric cancer,hepatic cancer

LncRNA WT1-AS expression is significantly down-regulated in gastric cancer, hepatocellular carcinoma and Wilms' tumor. It is associated with tumor size and the clinicopathological stage. Functionally, it can inhibit cell proliferation, migration, and invasion. Furthermore, ectopic expression of WT1-AS can inhibit tumor growth and metastasis in vivo. Moreover, WT1-AS could modulate ERK protein phosphorylation and WT1 level.


ZFAS1

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tissues colorectum,liver,stomach

cancer type colorectal cancer,gastric cancer,hepatic cancer

LncRNA ZFAS1 is higher in colorectal cancer, gastric cancer and hepatocellular carcinoma. ZFAS1 expression level is associated with clinicopathological parameters such as lymphatic invasion, TNM stage, prognosis etc.. ZFAS1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. Mechanistically, ZFAS1 can bind to EZH2, LSD1, CoREST, miR-150, miR-590-3p. Besides, ZFAS1 negatively regulates PARP and positively regulates ZEB1, MMP14, MMP16, cyclin B1 and p53.


ZMAT1

alias symbols:

tissues stomach

cancer type gastric cancer

LncRNA ZMAT1 transcript variant 2 is down-regulated in gastric cancer tissues compared with adjacent normal tissues and inversely correlated with lymph node metastasis, depth of tumor invasion and tumor node metastasis stage. Moreover, ZMAT1 transcript variant 2 expression is an independent predictor for overall survival.


linc-POU3F3

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tissues colorectum,esophagus,nervous system,stomach

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma

LncRNA POU3F3 is higher in colorectal cancer, glioma, esophageal squamous cell carcinoma and gastric cancer. POU3F3 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, POU3F3 is negatively regulated by EZH2. Besides, it negatively regulates p18, caspase-9, caspase-3, E-cadherin and positively regulates cyclin D1, CDK4, pRb, Rb, N-cadherin.


ncRuPAR

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tissues colorectum,stomach

cancer type colorectal cancer,gastric cancer

LncRNA ncRuPAR is lower in colorectal cancer and gastric cancer and is associated with clinicopathological parameters.