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ANRIL

alias symbols:

tissues bladder,breast,cervix,colorectum,esophagus,gallbladder,liver,lung,nasopharynx,others,ovary,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,cervical cancer,colorectal cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,ovarian cancer,prostate cancer,thyroid cancer

ANRIL is an oncogene in multiple cancers. It is significantly up-regulated in nasopharyngeal carcinoma (NPC), thyroid cancer, non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, colorectal cancer, breast cancer, serous ovarian cancer (SOC), bladder cancer, and prostate cancer. Overexpression of ANRIL is associated with clinicopathological parameters such as tumor size, TNM stage etc. and can be identified as a prognostic predictor. Functionally, ANRIL can promote the proliferation, migration and invasion of ca...


BANCR

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tissues colorectum,esophagus,liver,lung,others,stomach,thyroid

cancer type colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,melanoma,non-small-cell lung cancer,retinoblastoma,thyroid cancer

LncRNA BANCR expression is significantly higher in colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, melanoma, retinoblastoma and papillary thyroid carcinoma, while is lower in lung cancer. BANCR expression level is associated clinicopathological parameters such as lymph nodes metastasis and tumor stage and prognosis. Functionally, BANCR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Mechanistically, BANCR can bind to EZH2. BANCR plays its function roles via regulating p38, JNK, NF-κB, ERK1/2, Raf-1, JN...


ENST00000537266

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tissues thyroid

cancer type papillary thyroid cancer

LncRNA ENST00000537266 is up-regulated in papillary thyroid carcinoma (PTC). It can promote PTC cell proliferation and motility.


FAL1

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tissues ovary,thyroid

cancer type ovarian cancer,thyroid cancer

LncRNA FAL1, its copy number and expression are correlated with outcomes in ovarian cancer. FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. The oncogenic activity of FAL1 is partially attributable to its repression of p21. FAL1-specific siRNAs significantly inhibit tumor growth. Besides, FAL1 expression is increased in thyroid cancer (PTC) and high FAL1 expression increases the risk of multifocality.


GAS8-AS1

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tissues thyroid

cancer type papillary thyroid cancer

LncRNA GAS8-AS1 is the secondary most frequently altered gene and acts as a novel tumor suppressor in papillary thyroid carcinoma (PTC). As a mutation hotspot, the c.713A>G/714T>C dinucleotide substitution is found among most patients with GAS8-AS1 mutations and associated with advanced PTC disease. Interestingly, the wild-type GAS8-AS1 (A713T714) shows consistently higher capability to inhibit cancer cell growth compared to the mutated type (G713C714).


H19

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tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer

LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell...


HAGLROS-201

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tissues thyroid

cancer type papillary thyroid cancer

LncRNA HAGLROS-201 is up-regulated in papillary thyroid carcinoma (PTC). It can promote PTC cell proliferation and motility.


HOTAIR

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tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer

HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTA...


LOC100507661

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tissues thyroid

cancer type thyroid cancer

LOC100507661 is strongly up-regulated in thyroid cancer tissues relative to paired contralateral normal tissue. Moreover, LOC100507661 is easily detectable in papillary and anaplastic thyroid cancer cell lines, but not in the follicular thyroid cancer cell line. Stable overexpression of LOC100507661 promotes cell proliferation, migration, and invasion of thyroid cancer cells. In addition, Lymph node metastasis and BRAF V600E mutations are more frequent in papillary thyroid cancers with high LOC100507661 expression.


MEG3

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tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,gallbladder,kidney,liver,lung,nervous system,others,ovary,pancreas,prostate,stomach,thyroid

cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,lung adenocarcinoma,lung cancer,myelodysplastic syndrome,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer,tongue squamous cell cancer

MEG3 is a well-studied tumor suppressor gene. It is lower in thyroid carcinoma, lung cancer, gastric cancer, hepatic carcinoma, osteosarcoma, pancreatic cancer, colorectal cancer, renal cell carcinoma, prostate cancer, cervical carcinoma and endometrial carcinoma. MEG3 expression level is associated with clinicopathological parameters such as tumor size, TNM stage, lymph node metastasis, prognosis. Cell functional studies reveal that MEG3 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis. At molecular level, MEG3 can bind to miR-181 and Rac1. Moreover, MEG3 ...


NAMA

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tissues thyroid

cancer type papillary thyroid cancer

LncRNA NAMA is weakly expressed in several human tissues, and the spliced forms are primarily detected in testis. It is inducible by inhibition of the MAP kinase pathway, growth arrest and DNA damage. Besides, the attenuated BRAF signal results in induction of NAMA.


NONHSAT037832

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tissues thyroid

cancer type thyroid cancer

LncRNA NONHSAT037832 is significantly decreased in thyroid cancer (PTC) tissues and PTC cell lines. Down-regulated NONHSAT037832 is significantly associated with lymph node metastasis and tumor size. Moreover, NONHSAT037832 has diagnostic value.


NR_036575.1

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tissues thyroid

cancer type thyroid cancer

LncRNA NR_036575.1 is a ncRNA transcript of PDE4C. LncRNA NR_036575.1 is over-expressed in papillary thyroid cancer (PTC) tissues and TPC1 cells. Up-regulated NR_036575.1 is associated with tumor size and extrathyroidal extension in PTC. In addition, NR_036575.1 promotes cell proliferation and migration.


PTCSC2

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tissues thyroid

cancer type thyroid cancer

Transcripts of LncRNA PTCSC2 are down-regulated in papillary thyroid carcinoma (PTC). The risk allele [A] of rs965513 is significantly associated with low expression of unspliced PTCSC2, FOXE1, and TSHR in unaffected thyroid tissue. There exists a significant association of age and CLT with PTCSC2 unspliced transcript level. The correlation between the rs965513 genotype and the PTCSC2 unspliced transcript level remains significant after adjusting for age, gender, and CLT. Forced expression of PTCSC2 in the BCPAP cell line affects the expression of a subset of noncoding and coding transcript...


PTCSC3

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tissues thyroid

cancer type papillary thyroid cancer,thyroid cancer

LncRNA PTCSC3 expression is strongly down-regulated in thyroid tumor tissue. Its SNPs are associated with the risk of thyroid cancer. It can inhibit cell growth, migration, invasion, and affect the expression of genes involved in DNA replication, recombination and repair, cellular movement, tumor morphology and cell death.


PVT1

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tissues bladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid

cancer type acute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL), malignant pleural mesothelioma, non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, cervical cancer(27232880), gastric cancer, pancreatic cancer, colorectal cancer, bladder cancer and renal carcinoma. PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc.. Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. At molecular level, PVT1 can bind to EZH2. Moreover, PVT1 negatively regulates miR...