Gene basic information

Cancerprostate cancer,


LncRNA BX647187 is up-regulated in prostate cancer cells, which is positively regulated by Hec1. Further studies find that BX647187 is positive with the expression of caspase-3, caspase-9 and Bax, while negative with Bcl-2. But the expression of caspase-8 has no obvious change. These results indicate that BX647187 affects apoptosis via intrinsic apoptotic pathway (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 BX647187 prostate prostate cancer up onco +Hec1,caspase-3+,caspase-9+,Bax+,Bcl-2- - 26612002


[1]. Wang H, Gao X, Lu X, Wang Y, Ma C, et al. (2015). The mitotic regulator Hec1 is a critical modulator of prostate cancer through the long non-coding RNA BX647187 in vitro. Biosci Rep 35(6). link pubmed

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