C17orf91

Gene basic information

symbol MIR22HG
name MIR22 host gene
location 17p13.3
alias_symbol MGC14376|DKFZp686O06159
alias_name
Tissueovary,
Cancerovarian cancer,


Description

LncRNA C17orf91 expression is elevated in omental metastases when compared with matched primary ovarian tumors. Increased expression of C17orf91 is associated with shorter progression- free survival. C17orf91 inhibition significantly decreases migration, invasion and viability of Hey cells. Mechanistically, C17orf91 repression could reduce the expression of KLF8 and SNAI2 at mRNA level, and reduce MYC at both protein and mRNA level (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 C17orf91 ovary ovarian cancer up onco MYC-,KLF8,SNAI2 + + + - 27535740

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 5 10 15 20 25 fpkm 5.0 12.0 4.0 14.0 3.0 10.0 24.0 2.0 8.0 12.0 3.0 10.0 3.0 2.0 6.0 15.0 C17orf91

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 5 10 15 20 25 fpkm C17orf91 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Li J, Yu H, Xi M, Lu X (2016). Long noncoding RNA C17orf91 is a potential prognostic marker and functions as an oncogene in ovarian cancer. J Ovarian Res 9(1): 49. link pubmed



© Bioinformatics Group of XTBG