|Cancer||xuanwei lung cancer,|
LncRNA CAR10 is up-regulated in Xuanwei lung cancer patients. CAR10 overexpression is associated with air pollution. A smoky coal combustion-generated carcinogen dibenz[a,h]anthracene up-regulates CAR10 by increasing transcription factor FoxF2 expression. CAR10 binds and stabilizes transcription factor Y-box-binding protein 1 (YB-1), leading to upregulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells. Moreover, CAR10 can promote cell growth and tumor growth (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|0||CAR10||lung||xuanwei lung cancer||up||onco||YB-1||EGFR+,+FoxF2||+||27322209|