CAR10

Gene basic information

SymbolCAR10
Tissuelung,
Cancerxuanwei lung cancer,


Description

LncRNA CAR10 is up-regulated in Xuanwei lung cancer patients. CAR10 overexpression is associated with air pollution. A smoky coal combustion-generated carcinogen dibenz[a,h]anthracene up-regulates CAR10 by increasing transcription factor FoxF2 expression. CAR10 binds and stabilizes transcription factor Y-box-binding protein 1 (YB-1), leading to upregulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells. Moreover, CAR10 can promote cell growth and tumor growth (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CAR10 lung xuanwei lung cancer up onco YB-1 EGFR+,+FoxF2 + 27322209

Literature

[1]. Wei MM, Zhou YC, Wen ZS, Zhou B, Huang YC, et al. (2016). Long non-coding RNA stabilizes the Y-box-binding protein 1 and regulates the epidermal growth factor receptor to promote lung carcinogenesis. Oncotarget 7(37): 59556-59571. link pubmed



© Bioinformatics Group of XTBG