Gene basic information

Cancerxuanwei lung cancer,


LncRNA CAR10 is up-regulated in Xuanwei lung cancer patients. CAR10 overexpression is associated with air pollution. A smoky coal combustion-generated carcinogen dibenz[a,h]anthracene up-regulates CAR10 by increasing transcription factor FoxF2 expression. CAR10 binds and stabilizes transcription factor Y-box-binding protein 1 (YB-1), leading to upregulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells. Moreover, CAR10 can promote cell growth and tumor growth (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CAR10 lung xuanwei lung cancer up onco YB-1 EGFR+,+FoxF2 + 27322209


[1]. Wei MM, Zhou YC, Wen ZS, Zhou B, Huang YC, et al. (2016). Long non-coding RNA stabilizes the Y-box-binding protein 1 and regulates the epidermal growth factor receptor to promote lung carcinogenesis. Oncotarget 7(37): 59556-59571. link pubmed

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