CASC15

Gene basic information

symbol CASC15
name cancer susceptibility 15 (non-protein coding)
location 6p22.3
alias_symbol lnc-SOX4-1
alias_name
Tissueothers,
Cancermelanoma,


Description

LncRNA CASC15 RNA is up regulated in melanoma lines and up-regulated in a xenograft model of melanoma brain metastasis. RACE identifies an alternative CASC15 transcriptional start site and multiple splice variants. Moreover, CASC15 levels increase during melanoma progression and its expression in melanoma LN metastases is an independent predictor of disease recurrence and survival. Besides, siRNA knockdown experiments reveal that CASC15 regulates melanoma cell phenotype switching between proliferative and invasive states (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CASC15 others melanoma up onco + + - 26016895

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.2 0.4 0.6 0.8 1.0 fpkm 0.1 0.4 1.0 0.6 0.2 0.1 0.4 0.1 0.0 0.4 0.1 1.0 0.6 0.1 0.4 0.1 CASC15

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 fpkm CASC15 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Lessard L, Liu M, Marzese DM, Wang H, Chong K, et al. (2015). The CASC15 Long Intergenic Noncoding RNA Locus Is Involved in Melanoma Progression and Phenotype Switching. J Invest Dermatol 135(10): 2464-74. link pubmed



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