symbol | CASC2 |
name | cancer susceptibility 2 (non-protein coding) |
location | 10q26.11 |
alias_symbol | |
alias_name |
Tissue | colorectum,kidney,lung,nervous system, |
Cancer | colorectal cancer,glioma,non-small-cell lung cancer,renal cancer, |
LncRNA CASC2 is lower in colorectal cancer (1), glioma (2), renal cell carcinoma (3), non-small cell lung cancer (NSCLC) (4). Its expression level is associated with clinicopathological parameters such as tumor size, TNM stage, prognosis etc. (4). Functionally, CASC2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis (2). Mechanistically, CASC2 can bind to miR-18a (1), miR-21 (2544626). Besides, CASC2 negatively regulates pSTAT3 and c-Myc (1).
LncRNA | tissue | cancer type | expression level | oncogene/suppress gene | pathway | binding gene/factor | associated gene/factor | proliferation | apoptosis | migration | EMT | invasion | metastasis | prognosis | tag | PMID | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 | CASC2 | nervous system | glioma | down | TS | miR‑21 | - | + | - | - | 25446261 | ||||||
1 | CASC2 | lung | non-small-cell lung cancer | down | TS | - | + | 26790438 | |||||||||
2 | CASC2 | colorectum | colorectal cancer | down | TS | miR-18a | pSTAT3-,c-Myc- | - | 27198161 | ||||||||
3 | CASC2 | kidney | renal cancer | down | TS | miR‑21 | 27222255 |
Expression profile in human body map
Expression profile in TCGA
entrez_id | 255082 |
ucsc_id | uc001ldm.5 |
Ensembl_gene_id | ENSG00000177640 |
HGNC_id | HGNC:22933 |
Omim_id | 608598 |
cosmic | |
lncrnadb |
[1]. Huang G, Wu X, Li S, Xu X, Zhu H, et al. (2016). The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer. Sci Rep 6: 26524. link pubmed
[2]. Wang P, Liu YH, Yao YL, Li Z, Li ZQ, et al. (2015). Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21. Cell Signal 27(2): 275-82. link pubmed
[3]. Cao Y, Xu R, Xu X, Zhou Y, Cui L, et al. (2016). Downregulation of lncRNA CASC2 by microRNA-21 increases the proliferation and migration of renal cell carcinoma cells. Mol Med Rep 14(1): 1019-25. link pubmed
[4]. He X, Liu Z, Su J, Yang J, Yin D, et al. (2016). Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer. Tumour Biol 37(7): 9503-10. link pubmed