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CASC2

Gene basic information

symbol CASC2
name cancer susceptibility 2 (non-protein coding)
location 10q26.11
alias_symbol
alias_name
Tissuecolorectum,kidney,lung,nervous system,
Cancercolorectal cancer,glioma,non-small-cell lung cancer,renal cancer,

Description

LncRNA CASC2 is lower in colorectal cancer (1), glioma (2), renal cell carcinoma (3), non-small cell lung cancer (NSCLC) (4). Its expression level is associated with clinicopathological parameters such as tumor size, TNM stage, prognosis etc. (4). Functionally, CASC2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis (2). Mechanistically, CASC2 can bind to miR-18a (1), miR-21 (2544626). Besides, CASC2 negatively regulates pSTAT3 and c-Myc (1).

Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CASC2 nervous system glioma down TS miR‑21 - + - - 25446261
1 CASC2 lung non-small-cell lung cancer down TS - + 26790438
2 CASC2 colorectum colorectal cancer down TS miR-18a pSTAT3-,c-Myc- - 27198161
3 CASC2 kidney renal cancer down TS miR‑21 27222255

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.1 0.1 0.9 0.3 0.2 0.1 0.6 0.0 0.0 0.5 0.1 0.6 0.4 0.0 2.0 0.5 CASC2

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.2 0.4 0.6 0.8 fpkm CASC2 type normal tumor

Expression profile in TCGA

Genomic feature visualization

Sequence

External link

entrez_id 255082
ucsc_id uc001ldm.5
Ensembl_gene_id ENSG00000177640
HGNC_id HGNC:22933
Omim_id 608598
cosmic
lncrnadb

Literature

[1]. Huang G, Wu X, Li S, Xu X, Zhu H, et al. (2016). The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer. Sci Rep 6: 26524. link pubmed
[2]. Wang P, Liu YH, Yao YL, Li Z, Li ZQ, et al. (2015). Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21. Cell Signal 27(2): 275-82. link pubmed
[3]. Cao Y, Xu R, Xu X, Zhou Y, Cui L, et al. (2016). Downregulation of lncRNA CASC2 by microRNA-21 increases the proliferation and migration of renal cell carcinoma cells. Mol Med Rep 14(1): 1019-25. link pubmed
[4]. He X, Liu Z, Su J, Yang J, Yin D, et al. (2016). Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer. Tumour Biol 37(7): 9503-10. link pubmed

© Bioinformatics Group of XTBG