Gene basic information

Cancercolorectal cancer,


LncRNA CCAL is up-regulated in colorectal cancer (CRC) tissues and high CCAL level is associated with poor overall survival and a worse response to adjuvant chemotherapy. Further studies reveal that CCAL promotes CRC progression by targeting activator protein 2α (AP-2α), which in turn activates Wnt/β-catenin pathway. Moreover, CCAL induces multidrug resistance (MDR) through activating Wnt/β-catenin signaling by suppressing AP-2α and further up-regulating MDR1/P-gp expression. In addition, histone H3 methylation and deacetylases contribute to the upregulation of CCAL in CRC (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CCAL colorectum colorectal cancer up onco Wnt/β-catenin pathway+ MDR1/P-gp+,AP-2α- - chemotherapy resistance 25994219


[1]. Ma Y, Yang Y, Wang F, Moyer MP, Wei Q, et al. (2016). Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α. Gut 65(9): 1494-504. link pubmed

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