CCAT1

Gene basic information

symbol CCAT1
name colon cancer associated transcript 1 (non-protein coding)
location 8q24.21
alias_symbol CARLo-5|onco-lncRNA-40
alias_name
Tissuebone marrow,breast,colorectum,endometrium,gallbladder,liver,lung,stomach,
Canceracute myelocytic leukemia,breast cancer,colorectal cancer,endometrial cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,hepatic cancer,non-small-cell lung cancer,


Description

LncRNA CCAT1 is higher in breast cancer (1), colorectal cancer (2), gallbladder cancer (3), gastric cancer (4) and hepatocellular carcinoma (5). CCAT1 expression level is associated with clinicopathological parameters such as differentiation grade, TNM stage, lymph node metastases, prognosis etc. (1, 2, 3, 4, 5). Functionally, CCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis (2). Further studies reveal that CCAT1 can bind to miRNA-218-5p (3), c-Myc (4) and let-7 (5). Moreover, CCAT1 can negatively regulate Bmi1 (3), miR-490 (6) and positively regulate c-Myc (2), HMGA2 (5) and hnRNAP1 (6).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CCAT1 stomach gastric cancer up onco +c-Myc + + 23143645
1 CCAT1 colorectum colorectal cancer up onco TCF4,MYC CDKN1A- + SNP 24594601
2 CCAT1 colorectum colorectal cancer / / MYC CTCF- 24662484
3 CCAT1 lung non-small-cell lung cancer up onco p16-,p21-,p27-,Snail+,Twist+ + + + + - 25129441
4 CCAT1 colorectum colorectal cancer up onco +c-Myc + + + 25185650
5 CCAT1 stomach gastric adenocarcinoma up / SNP 25561974
6 CCAT1 gallbladder gallbladder cancer up onco miRNA-218-5p- Bmi1- 25569100
7 CCAT1 stomach gastric cancer up onco ERK/MAPK pathway p27-,p21-,p16-,caspase-3-,Bax-,Bcl-2+ + - 25674211
8 CCAT1 liver hepatic cancer up onco let-7 HMGA2+,c-Myc+ + + - 25884472
9 CCAT1 colorectum colorectal cancer up onco E-cadherin-,N-cadherin+ + 26064266
10 CCAT1 liver hepatic cancer up onco + + + 26191246
11 CCAT1 liver hepatic cancer / onco c-Myc - 26225650
12 CCAT1 liver hepatic cancer up onco + + - 26433964
13 CCAT1 breast breast cancer up onco - biomarker 26464701
14 CCAT1 colorectum colorectal cancer / / cMYC - chemotherapy resistance 26752646
15 CCAT1 colorectum colorectal cancer / / biomarker 26823726
16 CCAT1 stomach gastric cancer / onco miR-490-,hnRNAP1+ + 26825578
17 CCAT1 bone marrow acute myelocytic leukemia up onco miR-155 c-Myc+ 26923190
18 CCAT1 endometrium endometrial cancer up / - SNP 27432114

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.1 0.2 0.3 0.4 0.5 0.6 fpkm 0.3 0.5 0.2 0.3 0.1 0.1 0.4 0.0 0.6 0.1 0.1 0.2 0.1 0.1 0.2 0.1 CCAT1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 fpkm CCAT1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Zhang XF, Liu T, Li Y, Li S (2015). Overexpression of long non-coding RNA CCAT1 is a novel biomarker of poor prognosis in patients with breast cancer. Int J Clin Exp Pathol 8(8): 9440-5. link pubmed
[2]. He X, Tan X, Wang X, Jin H, Liu L, et al. (2014). C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion. Tumour Biol 35(12): 12181-8. link pubmed
[3]. Ma MZ, Chu BF, Zhang Y, Weng MZ, Qin YY, et al. (2015). Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p. Cell Death Dis 6: e1583. link pubmed
[4]. Yang F, Xue X, Bi J, Zheng L, Zhi K, et al. (2013). Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. J Cancer Res Clin Oncol 139(3): 437-45. link pubmed
[5]. Deng L, Yang SB, Xu FF, Zhang JH (2015). Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge. J Exp Clin Cancer Res 34: 18. link pubmed
[6]. Zhou B, Wang Y, Jiang J, Jiang H, Song J, et al. (2016). The long noncoding RNA colon cancer-associated transcript-1/miR-490 axis regulates gastric cancer cell migration by targeting hnRNPA1. IUBMB Life 68(3): 201-10. link pubmed



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