CCAT2

Gene basic information

symbol CCAT2
name colon cancer associated transcript 2 (non-protein coding)
location 8q24.21
alias_symbol NCCP1|LINC00873
alias_name long intergenic non-protein coding RNA 873|non-coding RNA involved in cancer predisposition 1
Tissuebreast,cervix,colorectum,esophagus,liver,lung,ovary,stomach,
Cancerbreast cancer,cervical cancer,cervical squamous cell cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,hepatic cancer,lung cancer,non-small-cell lung cancer,ovarian cancer,


Description

LncRNA CCAT2 is higher in breast cancer (1), esophageal squamous carcinoma (2), lung cancer (3), gastric cancer (4), cervical cancer (5) and ovarian cancer (6). CCAT2 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc. (7, 2, 4, 6). Functionally, CCAT2 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis (7, 6). Besides, CCAT2 is involves with chemotherapy response (8).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CCAT2 colorectum colorectal cancer up onco WNT signaling MYC+,miR-17-5p+,miR-20a+ 23796952
1 CCAT2 breast breast cancer up onco + chemotherapy resistance,SNP 24077681
2 CCAT2 lung non-small-cell lung cancer up onco + + biomarker 24504682
3 CCAT2 stomach gastric cancer up onco - 25755774
4 CCAT2 esophagus esophageal squamous cell cancer up / - 25919911
5 CCAT2 breast breast cancer up onco Wnt/β-catenin + + - 26442763
6 CCAT2 cervix cervical squamous cell cancer up onco - 26722527
7 CCAT2 lung lung cancer / / SNP,chemotherapy resistance 26729200
8 CCAT2 cervix cervical cancer up onco + - 26983975
9 CCAT2 ovary ovarian cancer up onco + + + - 27283598
10 CCAT2 liver hepatic cancer up onco + - + 27347113

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue −0.04 −0.02 0.00 0.02 0.04 fpkm 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CCAT2

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Cai Y, He J, Zhang D (2015). Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway. Onco Targets Ther 8: 2657-64. link pubmed
[2]. Zhang X, Xu Y, He C, Guo X, Zhang J, et al. (2015). Elevated expression of CCAT2 is associated with poor prognosis in esophageal squamous cell carcinoma. J Surg Oncol 111(7): 834-9. link pubmed
[3]. Qiu M, Xu Y, Yang X, Wang J, Hu J, et al. (2014). CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. Tumour Biol 35(6): 5375-80. link pubmed
[4]. Wang CY, Hua L, Yao KH, Chen JT, Zhang JJ, et al. (2015). Long non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis. Int J Clin Exp Pathol 8(1): 779-85. link pubmed
[5]. Wu L, Jin L, Zhang W, Zhang L (2016). Roles of Long Non-Coding RNA CCAT2 in Cervical Cancer Cell Growth and Apoptosis. Med Sci Monit 22: 875-9. link pubmed
[6]. Huang S, Qing C, Huang Z, Zhu Y (2016). The long non-coding RNA CCAT2 is up-regulated in ovarian cancer and associated with poor prognosis. Diagn Pathol 11(1): 49. link pubmed
[7]. Chen X, Liu L, Zhu W (2015). Up-regulation of long non-coding RNA CCAT2 correlates with tumor metastasis and poor prognosis in cervical squamous cell cancer patients. Int J Clin Exp Pathol 8(10): 13261-6. link pubmed
[8]. Gong WJ, Yin JY, Li XP, Fang C, Xiao D, et al. (2016). Association of well-characterized lung cancer lncRNA polymorphisms with lung cancer susceptibility and platinum-based chemotherapy response. Tumour Biol 37(6): 8349-58. link pubmed



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