|name||CCDC26 long non-coding RNA|
|alias_name||retinoic acid modulator|
|Cancer||myeloid leukemia,pancreatic cancer,|
LncRNA CCDC26 is higher in pancreatic cancer (PC) cells and tissues. CCDC26 expression is correlated with tumor size and tumor number. Patients with higher CCDC26 expression have shorter overall survival time. Knockdown of CCDC26 suppresses PC cells proliferation and induces apoptosis via suppressing PCNA and Bcl2 (1).
In leukemia cell lines, CCDC26 is expressed in cells derived from acute myelocytic leukemia (AML), acute monocytic leukemia and chronic myelogenous leukemia (CML). Very low expression is observed in megakaryoblastic cells derived from leukemia accompanied with Down’s syndrome (CMK) and in monocytic leukemia cells derived from histiocytic lymphoma. No expression is observed in T lymphocytic leukemia cells, Burkitt’s lymphoma cells or nonhematopoietic cells. These results indicate expression of CCDC26 is strictly limited to myeloid cell lines of hematopoietic origin. CCDC26 knockdown (KD) cells grow slowly in high concentrations of serum and show prolonged survival under serum depletion. The amount of KIT protein is increased in all KD cells. ISCK03, an inhibitor of KIT, prevents survival of CCDC26-KD cells under low-serum conditions (2).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|0||CCDC26||bone marrow||myeloid leukemia||up||/||KIT-||+||25928165|
Expression profile in human body map
Expression profile in TCGA
. Peng W, Jiang A (2016). Long noncoding RNA CCDC26 as a potential predictor biomarker contributes to tumorigenesis in pancreatic cancer. Biomed Pharmacother 83: 712-717. link pubmed
. Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A, et al. (2015). Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression. Mol Cancer 14: 90. link pubmed