CCDC26

Gene basic information

symbol CCDC26
name CCDC26 long non-coding RNA
location 8q24.21
alias_symbol MGC27434|RAM
alias_name retinoic acid modulator
Tissuebone marrow,pancreas,
Cancermyeloid leukemia,pancreatic cancer,


Description

LncRNA CCDC26 is higher in pancreatic cancer (PC) cells and tissues. CCDC26 expression is correlated with tumor size and tumor number. Patients with higher CCDC26 expression have shorter overall survival time. Knockdown of CCDC26 suppresses PC cells proliferation and induces apoptosis via suppressing PCNA and Bcl2 (1).
In leukemia cell lines, CCDC26 is expressed in cells derived from acute myelocytic leukemia (AML), acute monocytic leukemia and chronic myelogenous leukemia (CML). Very low expression is observed in megakaryoblastic cells derived from leukemia accompanied with Down’s syndrome (CMK) and in monocytic leukemia cells derived from histiocytic lymphoma. No expression is observed in T lymphocytic leukemia cells, Burkitt’s lymphoma cells or nonhematopoietic cells. These results indicate expression of CCDC26 is strictly limited to myeloid cell lines of hematopoietic origin. CCDC26 knockdown (KD) cells grow slowly in high concentrations of serum and show prolonged survival under serum depletion. The amount of KIT protein is increased in all KD cells. ISCK03, an inhibitor of KIT, prevents survival of CCDC26-KD cells under low-serum conditions (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CCDC26 bone marrow myeloid leukemia up / KIT- + 25928165
1 CCDC26 pancreas pancreatic cancer up onco PCNA+,Bcl-2+ + - - 27470572

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.000 0.025 0.050 0.075 0.100 0.125 0.150 0.175 0.200 fpkm 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CCDC26

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.01 0.02 0.03 0.04 fpkm CCDC26 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Peng W, Jiang A (2016). Long noncoding RNA CCDC26 as a potential predictor biomarker contributes to tumorigenesis in pancreatic cancer. Biomed Pharmacother 83: 712-717. link pubmed
[2]. Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A, et al. (2015). Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression. Mol Cancer 14: 90. link pubmed



© Bioinformatics Group of XTBG