CLMAT3

Gene basic information

SymbolCLMAT3
Tissuecolorectum,
Cancercolorectal cancer,


Description

LncRNA CLMAT3 is generally increased in human colorectal cancer (CRC) cell lines. Knockdown of CLMAT3 in CRC cells decreases cell growth, inhibits CRC cell cycle progression and induces apoptosis. Master G0/G1 regulators including Cdh1, CDKN1B (p27Kip1) and Skp2 are measured after CLMAT3 knockdown. The results show an increased Cdh1 expression by accelerating Skp2 degradation, which results in p27Kip accumulation (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 CLMAT3 colorectum colorectal cancer up / - 26050227
1 CLMAT3 colorectum colorectal cancer up onco Cdh1-,p27Kip+,Skp2 degration+ + - 27391344

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 fpkm 0.2 0.2 0.0 0.8 0.0 0.1 0.1 0.0 0.0 0.1 0.2 0.3 0.0 0.0 0.3 0.1 CLMAT3

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.02 0.04 0.06 0.08 fpkm CLMAT3 type normal tumor

Expression profile in TCGA


Sequence

Literature

[1]. Ye LC, Chen T, Zhu DX, Lv SX, Qiu JJ, et al. (2016). Downregulated long non-coding RNA CLMAT3 promotes the proliferation of colorectal cancer cells by targeting regulators of the cell cycle pathway. Oncotarget 7(37): 58931-58938. link pubmed



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