LncRNA CLMAT3 is generally increased in human colorectal cancer (CRC) cell lines. Knockdown of CLMAT3 in CRC cells decreases cell growth, inhibits CRC cell cycle progression and induces apoptosis. Master G0/G1 regulators including Cdh1, CDKN1B (p27Kip1) and Skp2 are measured after CLMAT3 knockdown. The results show an increased Cdh1 expression by accelerating Skp2 degradation, which results in p27Kip accumulation (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|1||CLMAT3||colorectum||colorectal cancer||up||onco||Cdh1-,p27Kip+,Skp2 degration+||+||-||27391344|
Expression profile in human body map
Expression profile in TCGA